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Items: 38


Chemokine receptor antagonists: novel therapeutics for inflammation and AIDS.

Ponath PD.

Expert Opin Investig Drugs. 1998 Jan;7(1):1-18.


The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner.

Sabroe I, Jorritsma A, Stubbs VE, Xanthou G, Jopling LA, Ponath PD, Williams TJ, Murphy PM, Pease JE.

Eur J Immunol. 2005 Apr;35(4):1301-10.


Induction of immunological tolerance/hyporesponsiveness in baboons with a nondepleting CD4 antibody.

Winsor-Hines D, Merrill C, O'Mahony M, Rao PE, Cobbold SP, Waldmann H, Ringler DJ, Ponath PD.

J Immunol. 2004 Oct 1;173(7):4715-23.


Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis.

Bocchino V, Bertorelli G, Bertrand CP, Ponath PD, Newman W, Franco C, Marruchella A, Merlini S, Del Donno M, Zhuo X, Olivieri D.

Allergy. 2002 Jan;57(1):17-22.


CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.

Papadakis KA, Prehn J, Moreno ST, Cheng L, Kouroumalis EA, Deem R, Breaverman T, Ponath PD, Andrew DP, Green PH, Hodge MR, Binder SW, Targan SR.

Gastroenterology. 2001 Aug;121(2):246-54.


Characterization of the CC chemokine receptor 3 on human keratinocytes.

Petering H, Kluthe C, Dulkys Y, Kiehl P, Ponath PD, Kapp A, Elsner J.

J Invest Dermatol. 2001 Apr;116(4):549-55.


The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors.

Nibbs RJ, Kriehuber E, Ponath PD, Parent D, Qin S, Campbell JD, Henderson A, Kerjaschki D, Maurer D, Graham GJ, Rot A.

Am J Pathol. 2001 Mar;158(3):867-77.


Expression of the C-C chemokine receptor CCR3 in human airway epithelial cells.

Stellato C, Brummet ME, Plitt JR, Shahabuddin S, Baroody FM, Liu MC, Ponath PD, Beck LA.

J Immunol. 2001 Feb 1;166(3):1457-61.


CCR3 blockade as a new therapy for asthma.

Bertrand CP, Ponath PD.

Expert Opin Investig Drugs. 2000 Jan;9(1):43-52. Review.


The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system.

Papadakis KA, Prehn J, Nelson V, Cheng L, Binder SW, Ponath PD, Andrew DP, Targan SR.

J Immunol. 2000 Nov 1;165(9):5069-76.


Monoclonal antibodies to chemokine receptors.

Ponath PD, Kassam N, Qin S.

Methods Mol Biol. 2000;138:231-42. No abstract available.


Transwell chemotaxis.

Ponath PD, Wang J, Heath H.

Methods Mol Biol. 2000;138:113-20. No abstract available.


Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis.

Zabel BA, Agace WW, Campbell JJ, Heath HM, Parent D, Roberts AI, Ebert EC, Kassam N, Qin S, Zovko M, LaRosa GJ, Yang LL, Soler D, Butcher EC, Ponath PD, Parker CM, Andrew DP.

J Exp Med. 1999 Nov 1;190(9):1241-56.


Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.

Sabroe I, Hartnell A, Jopling LA, Bel S, Ponath PD, Pease JE, Collins PD, Williams TJ.

J Immunol. 1999 Mar 1;162(5):2946-55.


Cloning and characterization of the guinea pig eosinophil eotaxin receptor, C-C chemokine receptor-3: blockade using a monoclonal antibody in vivo.

Sabroe I, Conroy DM, Gerard NP, Li Y, Collins PD, Post TW, Jose PJ, Williams TJ, Gerard CJ, Ponath PD.

J Immunol. 1998 Dec 1;161(11):6139-47.


Human eotaxin induces alpha 4 and beta 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4.

Sanz MJ, Ponath PD, Mackay CR, Newman W, Miyasaka M, Tamatani T, Flanagan BF, Lobb RR, Williams TJ, Nourshargh S, Jose PJ.

J Immunol. 1998 Apr 1;160(7):3569-76.


High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa GJ, Rao P, Ponath PD, Baggiolini M, Dahinden CA.

J Clin Invest. 1997 Sep 1;100(5):1137-43.


Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines.

Stellato C, Collins P, Ponath PD, Soler D, Newman W, La Rosa G, Li H, White J, Schwiebert LM, Bickel C, Liu M, Bochner BS, Williams T, Schleimer RP.

J Clin Invest. 1997 Mar 1;99(5):926-36.


Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239.

Marcon L, Choe H, Martin KA, Farzan M, Ponath PD, Wu L, Newman W, Gerard N, Gerard C, Sodroski J.

J Virol. 1997 Mar;71(3):2522-7.


Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

Heath H, Qin S, Rao P, Wu L, LaRosa G, Kassam N, Ponath PD, Mackay CR.

J Clin Invest. 1997 Jan 15;99(2):178-84.


The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.

Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J.

Cell. 1996 Jun 28;85(7):1135-48.


Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.

Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR.

J Exp Med. 1996 Jun 1;183(6):2437-48.


Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1.

Reimold AM, Ponath PD, Li YS, Hardy RR, David CS, Strominger JL, Glimcher LH.

J Exp Med. 1996 Feb 1;183(2):393-401.


Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.

Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR.

J Clin Invest. 1996 Feb 1;97(3):604-12.


The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes.

Ponath PD, Fass D, Liou HC, Glimcher LH, Strominger JL.

J Biol Chem. 1993 Aug 15;268(23):17074-82.


Interferon-gamma response region in the promoter of the class II MHC gene, DPA.

Sugawara M, Ponath PD, Yang Z, Strominger JL.

Hum Immunol. 1992 Nov;35(3):157-64.


Delineation of a previously unrecognized cis-acting element required for HLA class II gene expression.

Sugawara M, Ponath PD, Shin J, Yang Z, Strominger JL.

Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10347-51.


Interferon gamma response region in the promoter of the human DPA gene.

Yang Z, Sugawara M, Ponath PD, Wessendorf L, Banerji J, Li Y, Strominger JL.

Proc Natl Acad Sci U S A. 1990 Dec;87(23):9226-30.


Regulation of the class II-associated invariant chain gene in normal and mutant B lymphocytes.

Doyle C, Ford PJ, Ponath PD, Spies T, Strominger JL.

Proc Natl Acad Sci U S A. 1990 Jun;87(12):4590-4.


Restriction enzyme polymorphisms in V kappa and J kappa genes of inbred and wild mice.

Gottlieb PD, Boyd RT, Ponath PD, Goldrick MM.

Curr Top Microbiol Immunol. 1986;127:186-92. No abstract available.


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