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266 results

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Page 1
A PON for All Seasons: Comparing Paraoxonase Enzyme Substrates, Activity and Action including the Role of PON3 in Health and Disease.
Mohammed CJ, Lamichhane S, Connolly JA, Soehnlen SM, Khalaf FK, Malhotra D, Haller ST, Isailovic D, Kennedy DJ. Mohammed CJ, et al. Antioxidants (Basel). 2022 Mar 19;11(3):590. doi: 10.3390/antiox11030590. Antioxidants (Basel). 2022. PMID: 35326240 Free PMC article. Review.
All three PONs have antioxidant potential and play an important anti-atherosclerotic role in several diseases including cardiovascular diseases. PON3 is the last member of the family to be discovered and is also the least studied of the three genes. Unlike the other isofor …
All three PONs have antioxidant potential and play an important anti-atherosclerotic role in several diseases including cardiovascular disea …
PON1 Hypermethylation and PON3 Hypomethylation are Associated with Risk of Cerebral Infarction.
Xiao J, Li X, Yuan Q, Zhang S, Qu K, Wu B, Wang Y, Duan S. Xiao J, et al. Curr Neurovasc Res. 2019;16(2):115-122. doi: 10.2174/1567202616666190412154407. Curr Neurovasc Res. 2019. PMID: 30977447
CONCLUSION: PON1 and PON3 promoter methylation levels in peripheral blood were closely related. PON1 and PON3 methylation were associated with the risk of cerebral infarction in men. ...
CONCLUSION: PON1 and PON3 promoter methylation levels in peripheral blood were closely related. PON1 and PON3 methylation were …
PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis.
Shih DM, Yu JM, Vergnes L, Dali-Youcef N, Champion MD, Devarajan A, Zhang P, Castellani LW, Brindley DN, Jamey C, Auwerx J, Reddy ST, Ford DA, Reue K, Lusis AJ. Shih DM, et al. FASEB J. 2015 Apr;29(4):1185-97. doi: 10.1096/fj.14-260570. Epub 2014 Dec 4. FASEB J. 2015. PMID: 25477283 Free PMC article.
The mice were generally healthy but exhibited quantitative alterations in bile acid metabolism and a 37% increased body weight compared to the wild-type mice on a high fat diet. PON3 was enriched in the mitochondria-associated membrane fraction of hepatocytes. PON3 …
The mice were generally healthy but exhibited quantitative alterations in bile acid metabolism and a 37% increased body weight compared to t …
Expression of PON1, PON2, PON3 and MPO Genes in Patients with Depressive Disorders.
Bliźniewska-Kowalska K, Gałecki P, Su KP, Halaris A, Szemraj J, Gałecka M. Bliźniewska-Kowalska K, et al. J Clin Med. 2022 Jun 9;11(12):3321. doi: 10.3390/jcm11123321. J Clin Med. 2022. PMID: 35743392 Free PMC article.
Background: Taking into account the role of oxidative stress in neurodegeneration, we sought to evaluate the expression of genes for select enzymes with antioxidant properties (paraoxonases PON1, PON2 and PON3 and myeloperoxidase MPO) at the mRNA and protein levels in pati …
Background: Taking into account the role of oxidative stress in neurodegeneration, we sought to evaluate the expression of genes for select …
Pathophysiologic Processes and Novel Biomarkers Associated With Congestion in Heart Failure.
Pandhi P, Ter Maaten JM, Anker SD, Ng LL, Metra M, Samani NJ, Lang CC, Dickstein K, de Boer RA, van Veldhuisen DJ, Voors AA, Sama IE. Pandhi P, et al. JACC Heart Fail. 2022 Sep;10(9):623-632. doi: 10.1016/j.jchf.2022.05.013. JACC Heart Fail. 2022. PMID: 36049813 Free article.

FGF-23, FGF-21, CA-125, soluble ST2, GDF-15, FABP4, IL-6, and BNP were the strongest up-regulated proteins (fold change [FC] >1.30, false discovery rate [FDR], P < 0.05). KITLG, EGF, and PON3 were the strongest down-regulated proteins (FC <-1.30, FDR P < 0.05).

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FGF-23, FGF-21, CA-125, soluble ST2, GDF-15, FABP4, IL-6, and BNP were the strongest up-regulated proteins (fold change [FC] >1.30, false …
Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis.
Shih DM, Xia YR, Yu JM, Lusis AJ. Shih DM, et al. Adv Exp Med Biol. 2010;660:73-87. doi: 10.1007/978-1-60761-350-3_8. Adv Exp Med Biol. 2010. PMID: 20221872 Free PMC article.
PON3 is a member of the paraoxonase gene family that includes PON1 and PON2. For example, PON3 and PON1 share approximately 60% identity at the amino acid level. ...
PON3 is a member of the paraoxonase gene family that includes PON1 and PON2. For example, PON3 and PON1 share approximately 60 …
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.
Schweikert EM, Devarajan A, Witte I, Wilgenbus P, Amort J, Förstermann U, Shabazian A, Grijalva V, Shih DM, Farias-Eisner R, Teiber JF, Reddy ST, Horke S. Schweikert EM, et al. Cell Death Differ. 2012 Sep;19(9):1549-60. doi: 10.1038/cdd.2012.35. Epub 2012 Mar 23. Cell Death Differ. 2012. PMID: 22441669 Free PMC article.
PON3 is found overexpressed in various human tumors and diminishes mitochondrial superoxide formation. ...Moreover, PON3 impaired ER stress-induced apoptotic MAPK signaling and CHOP induction. ...
PON3 is found overexpressed in various human tumors and diminishes mitochondrial superoxide formation. ...Moreover, PON3 impai …
Differentially methylated regions (DMRs) in PON3 gene between responders and non-responders to a weight loss dietary intervention: a new tool for precision management of obesity.
Salas-Pérez F, Cuevas-Sierra A, Cuervo M, Goni L, Milagro FI, Martínez JA, Riezu-Boj JI. Salas-Pérez F, et al. Epigenetics. 2022 Jan;17(1):81-92. doi: 10.1080/15592294.2021.1873629. Epub 2021 Jan 25. Epigenetics. 2022. PMID: 33427034 Free PMC article.
To analyse the implication of these 11 CpGs on weight loss, a z-score was performed as a measure of DMR methylation. This analysis showed a correlation between PON3 DNA methylation and BMI loss. This z-score negatively correlated with PON3 protein serum levels. Tota …
To analyse the implication of these 11 CpGs on weight loss, a z-score was performed as a measure of DMR methylation. This analysis showed a …
Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis.
Riedmaier S, Klein K, Winter S, Hofmann U, Schwab M, Zanger UM. Riedmaier S, et al. Front Pharmacol. 2011 Jul 27;2:41. doi: 10.3389/fphar.2011.00041. eCollection 2011. Front Pharmacol. 2011. PMID: 21852972 Free PMC article.
PON1 and PON3 were strongly correlated to each other (r(s) = 0.60) but PON1 was shown to be more extensively glycosylated than PON3. In addition a novel splice-variant of PON3 was identified. Genotyping of 40 polymorphisms within the PON-locus identified PON1 …
PON1 and PON3 were strongly correlated to each other (r(s) = 0.60) but PON1 was shown to be more extensively glycosylated than PON …
266 results