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Items: 1 to 50 of 86

1.

NOTCH activation promotes valve formation by regulating the endocardial secretome.

Torregrosa-Carrión R, Luna-Zurita L, García-Marqués F, D'Amato G, Piñeiro-Sabarís R, Bonzón-Kulichenko E, Vázquez J, de la Pompa JL.

Mol Cell Proteomics. 2019 Jun 27. pii: mcp.RA119.001492. doi: 10.1074/mcp.RA119.001492. [Epub ahead of print]

2.

Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells.

Andrés-Delgado L, Ernst A, Galardi-Castilla M, Bazaga D, Peralta M, Münch J, González-Rosa JM, Marques I, Tessadori F, de la Pompa JL, Vermot J, Mercader N.

Development. 2019 Jul 4;146(13). pii: dev174961. doi: 10.1242/dev.174961.

3.

Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis.

Neri T, Hiriart E, van Vliet PP, Faure E, Norris RA, Farhat B, Jagla B, Lefrancois J, Sugi Y, Moore-Morris T, Zaffran S, Faustino RS, Zambon AC, Desvignes JP, Salgado D, Levine RA, de la Pompa JL, Terzic A, Evans SM, Markwald R, Pucéat M.

Nat Commun. 2019 Apr 26;10(1):1929. doi: 10.1038/s41467-019-09459-5.

4.

Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function.

Salguero-Jiménez A, Grego-Bessa J, D'Amato G, Jiménez-Borreguero LJ, de la Pompa JL.

PLoS One. 2018 Dec 31;13(12):e0203100. doi: 10.1371/journal.pone.0203100. eCollection 2018.

5.

Notch and interacting signalling pathways in cardiac development, disease, and regeneration.

MacGrogan D, Münch J, de la Pompa JL.

Nat Rev Cardiol. 2018 Nov;15(11):685-704. doi: 10.1038/s41569-018-0100-2. Review.

PMID:
30287945
6.

Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development.

García-León MJ, Fuentes P, de la Pompa JL, Toribio ML.

Development. 2018 Aug 13;145(16). pii: dev165597. doi: 10.1242/dev.165597.

7.

Bmp2 and Notch cooperate to pattern the embryonic endocardium.

Papoutsi T, Luna-Zurita L, Prados B, Zaffran S, de la Pompa JL.

Development. 2018 Jul 2;145(13). pii: dev163378. doi: 10.1242/dev.163378.

8.

Intercellular Signaling in Cardiac Development and Disease: The NOTCH pathway.

Luxán G, D’Amato G, de la Pompa JL.

In: Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 12.
2016 Jun 25.

9.

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.

Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP.

Nature. 2018 May;557(7705):439-445. doi: 10.1038/s41586-018-0110-6. Epub 2018 May 9.

PMID:
29743679
10.

Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity.

Prados B, Gómez-Apiñániz P, Papoutsi T, Luxán G, Zaffran S, Pérez-Pomares JM, de la Pompa JL.

Cell Death Dis. 2018 Mar 14;9(3):399. doi: 10.1038/s41419-018-0442-z.

11.

Deletion of Fstl1 (Follistatin-Like 1) From the Endocardial/Endothelial Lineage Causes Mitral Valve Disease.

Prakash S, Borreguero LJJ, Sylva M, Flores Ruiz L, Rezai F, Gunst QD, de la Pompa JL, Ruijter JM, van den Hoff MJB.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):e116-e130. doi: 10.1161/ATVBAHA.117.309089. Epub 2017 Jul 13.

PMID:
28705792
12.

Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.

Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z.

Nat Med. 2017 May;23(5):601-610. doi: 10.1038/nm.4315. Epub 2017 Apr 17.

PMID:
28414328
13.

Retraction: Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.

Gonzalez-Valdes I, Hidalgo I, Bujarrabal A, Lara-Pezzi E, Padron-Barthe L, Garcia-Pavia P, Gómez-Del Arco P, Redondo JM, Ruiz-Cabello JM, Jimenez-Borreguero LJ, Enriquez JA, de la Pompa JL, Hidalgo A, Gonzalez S.

Nat Commun. 2017 Mar 7;8:14006. doi: 10.1038/ncomms14006. No abstract available.

14.

Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heart.

Münch J, Grivas D, González-Rajal Á, Torregrosa-Carrión R, de la Pompa JL.

Development. 2017 Apr 15;144(8):1425-1440. doi: 10.1242/dev.143362. Epub 2017 Feb 27.

15.

Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis.

Nus M, Martínez-Poveda B, MacGrogan D, Chevre R, D'Amato G, Sbroggio M, Rodríguez C, Martínez-González J, Andrés V, Hidalgo A, de la Pompa JL.

Cardiovasc Res. 2016 Nov 1;112(2):568-580. doi: 10.1093/cvr/cvw193.

PMID:
27496872
16.

Notch signalling in ventricular chamber development and cardiomyopathy.

D'Amato G, Luxán G, de la Pompa JL.

FEBS J. 2016 Dec;283(23):4223-4237. doi: 10.1111/febs.13773. Epub 2016 Jun 22. Review.

17.

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.

Gómez-Del Arco P, Perdiguero E, Yunes-Leites PS, Acín-Pérez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jiménez-Alcázar M, Segalés J, López-Maderuelo D, Ornés B, Jiménez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Muñoz-Cánoves P, Redondo JM.

Cell Metab. 2016 May 10;23(5):881-92. doi: 10.1016/j.cmet.2016.04.008.

18.

Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis.

MacGrogan D, D'Amato G, Travisano S, Martinez-Poveda B, Luxán G, Del Monte-Nieto G, Papoutsi T, Sbroggio M, Bou V, Gomez-Del Arco P, Gómez MJ, Zhou B, Redondo JM, Jiménez-Borreguero LJ, de la Pompa JL.

Circ Res. 2016 May 13;118(10):1480-97. doi: 10.1161/CIRCRESAHA.115.308077. Epub 2016 Apr 7.

PMID:
27056911
19.

Morphogenesis of myocardial trabeculae in the mouse embryo.

Captur G, Wilson R, Bennett MF, Luxán G, Nasis A, de la Pompa JL, Moon JC, Mohun TJ.

J Anat. 2016 Aug;229(2):314-25. doi: 10.1111/joa.12465. Epub 2016 Mar 29.

20.

Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology--a position statement of the development, anatomy, and pathology ESC Working Group.

Pérez-Pomares JM, de la Pompa JL, Franco D, Henderson D, Ho SY, Houyel L, Kelly RG, Sedmera D, Sheppard M, Sperling S, Thiene G, van den Hoff M, Basso C.

Cardiovasc Res. 2016 Feb 1;109(2):204-16. doi: 10.1093/cvr/cvv251. Epub 2016 Jan 11. Review.

PMID:
26811390
21.

Sequential Notch activation regulates ventricular chamber development.

D'Amato G, Luxán G, del Monte-Nieto G, Martínez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jiménez-Borreguero LJ, de la Pompa JL.

Nat Cell Biol. 2016 Jan;18(1):7-20. doi: 10.1038/ncb3280. Epub 2015 Dec 7.

22.

Endocardial Notch Signaling in Cardiac Development and Disease.

Luxán G, D'Amato G, MacGrogan D, de la Pompa JL.

Circ Res. 2016 Jan 8;118(1):e1-e18. doi: 10.1161/CIRCRESAHA.115.305350. Epub 2015 Dec 3. Review.

PMID:
26635389
23.

Corrigendum: Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.

Gonzalez-Valdes I, Hidalgo I, Bujarrabal A, Lara-Pezzi E, Padron-Barthe L, Garcia-Pavia P, Gómez-del Arco P, Redondo JM, Ruiz-Cabello JM, Jimenez-Borreguero LJ, Enriquez JA, de la Pompa JL, Hidalgo A, Gonzalez S.

Nat Commun. 2015 May 14;6:7242. doi: 10.1038/ncomms8242. No abstract available.

PMID:
25971354
24.

Msx1CreERT2 knock-In allele: A useful tool to target embryonic and adult cardiac valves.

Papoutsi T, Odelin G, Moore-Morris T, Pucéat M, de la Pompa JL, Robert B, Zaffran S.

Genesis. 2015 May;53(5):337-45. doi: 10.1002/dvg.22856.

PMID:
25950518
25.

Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.

Gonzalez-Valdes I, Hidalgo I, Bujarrabal A, Lara-Pezzi E, Padron-Barthe L, Garcia-Pavia P, Gómez-del Arco P, Redondo JM, Ruiz-Cabello JM, Jimenez-Borreguero LJ, Enriquez JA, de la Pompa JL, Hidalgo A, Gonzalez S.

Nat Commun. 2015 Mar 9;6:6473. doi: 10.1038/ncomms7473. Erratum in: Nat Commun. 2015;6:7242. Gomez, P [corrected to Gómez-del Arco, P]. Retraction in: Nat Commun. 2017 Mar 07;8:14006.

26.

NOTCH pathway inactivation promotes bladder cancer progression.

Maraver A, Fernandez-Marcos PJ, Cash TP, Mendez-Pertuz M, Dueñas M, Maietta P, Martinelli P, Muñoz-Martin M, Martínez-Fernández M, Cañamero M, Roncador G, Martinez-Torrecuadrada JL, Grivas D, de la Pompa JL, Valencia A, Paramio JM, Real FX, Serrano M.

J Clin Invest. 2015 Feb;125(2):824-30. doi: 10.1172/JCI78185. Epub 2015 Jan 9.

27.

Left ventricular noncompaction: a genetic cardiomyopathy looking for diagnostic criteria.

Garcia-Pavia P, de la Pompa JL.

J Am Coll Cardiol. 2014 Nov 11;64(19):1981-3. doi: 10.1016/j.jacc.2014.08.034. Epub 2014 Nov 3. No abstract available. Erratum in: J Am Coll Cardiol. 2015 Feb 10;65(5):519.

28.

How to make a heart valve: from embryonic development to bioengineering of living valve substitutes.

MacGrogan D, Luxán G, Driessen-Mol A, Bouten C, Baaijens F, de la Pompa JL.

Cold Spring Harb Perspect Med. 2014 Nov 3;4(11):a013912. doi: 10.1101/cshperspect.a013912. Review.

29.

Arid3b is essential for second heart field cell deployment and heart patterning.

Uribe V, Badía-Careaga C, Casanova JC, Domínguez JN, de la Pompa JL, Sanz-Ezquerro JJ.

Development. 2014 Nov;141(21):4168-81. doi: 10.1242/dev.109918.

30.

Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst.

Rayon T, Menchero S, Nieto A, Xenopoulos P, Crespo M, Cockburn K, Cañon S, Sasaki H, Hadjantonakis AK, de la Pompa JL, Rossant J, Manzanares M.

Dev Cell. 2014 Aug 25;30(4):410-22. doi: 10.1016/j.devcel.2014.06.019. Epub 2014 Aug 7.

31.

Notch1 regulates progenitor cell proliferation and differentiation during mouse yolk sac hematopoiesis.

Cortegano I, Melgar-Rojas P, Luna-Zurita L, Siguero-Álvarez M, Marcos MA, Gaspar ML, de la Pompa JL.

Cell Death Differ. 2014 Jul;21(7):1081-94. doi: 10.1038/cdd.2014.27. Epub 2014 Feb 28.

32.

Genetic and functional genomics approaches targeting the Notch pathway in cardiac development and congenital heart disease.

MacGrogan D, Luxán G, de la Pompa JL.

Brief Funct Genomics. 2014 Jan;13(1):15-27. doi: 10.1093/bfgp/elt036. Epub 2013 Oct 7. Review.

PMID:
24106100
33.

Notch activation stimulates migration of breast cancer cells and promotes tumor growth.

Bolós V, Mira E, Martínez-Poveda B, Luxán G, Cañamero M, Martínez-A C, Mañes S, de la Pompa JL.

Breast Cancer Res. 2013;15(4):R54.

34.

Epithelial to mesenchymal transition-the roles of cell morphology, labile adhesion and junctional coupling.

Abdulla T, Luna-Zurita L, de la Pompa JL, Schleich JM, Summers R.

Comput Methods Programs Biomed. 2013 Aug;111(2):435-46. doi: 10.1016/j.cmpb.2013.05.018. Epub 2013 Jun 18.

35.

Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration.

Münch J, González-Rajal A, de la Pompa JL.

Development. 2013 Apr;140(7):1402-11. doi: 10.1242/dev.087346. Epub 2013 Jan 23.

36.

Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy.

Luxán G, Casanova JC, Martínez-Poveda B, Prados B, D'Amato G, MacGrogan D, Gonzalez-Rajal A, Dobarro D, Torroja C, Martinez F, Izquierdo-García JL, Fernández-Friera L, Sabater-Molina M, Kong YY, Pizarro G, Ibañez B, Medrano C, García-Pavía P, Gimeno JR, Monserrat L, Jiménez-Borreguero LJ, de la Pompa JL.

Nat Med. 2013 Feb;19(2):193-201. doi: 10.1038/nm.3046. Epub 2013 Jan 13.

PMID:
23314057
37.

Epithelial-to-mesenchymal transition in epicardium is independent of Snail1.

Casanova JC, Travisano S, de la Pompa JL.

Genesis. 2013 Jan;51(1):32-40. doi: 10.1002/dvg.22353. Epub 2012 Nov 7.

PMID:
23097346
38.

Coordinating tissue interactions: Notch signaling in cardiac development and disease.

de la Pompa JL, Epstein JA.

Dev Cell. 2012 Feb 14;22(2):244-54. doi: 10.1016/j.devcel.2012.01.014. Review.

39.

Signaling during epicardium and coronary vessel development.

Pérez-Pomares JM, de la Pompa JL.

Circ Res. 2011 Dec 9;109(12):1429-42. doi: 10.1161/CIRCRESAHA.111.245589. Review.

PMID:
22158650
40.

The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis.

Rodríguez P, Higueras MA, González-Rajal A, Alfranca A, Fierro-Fernández M, García-Fernández RA, Ruiz-Hidalgo MJ, Monsalve M, Rodríguez-Pascual F, Redondo JM, de la Pompa JL, Laborda J, Lamas S.

Cardiovasc Res. 2012 Feb 1;93(2):232-41. doi: 10.1093/cvr/cvr296. Epub 2011 Nov 8.

41.

Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development.

Fütterer A, Raya A, Llorente M, Izpisúa-Belmonte JC, de la Pompa JL, Klatt P, Martínez-A C.

Cell Death Differ. 2012 Jan;19(1):132-43. doi: 10.1038/cdd.2011.62. Epub 2011 Jun 10.

42.

Notch signaling in cardiac valve development and disease.

MacGrogan D, Luna-Zurita L, de la Pompa JL.

Birth Defects Res A Clin Mol Teratol. 2011 Jun;91(6):449-59. doi: 10.1002/bdra.20815. Epub 2011 May 11. Review.

PMID:
21563298
43.

Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL.

Nus M, MacGrogan D, Martínez-Poveda B, Benito Y, Casanova JC, Fernández-Avilés F, Bermejo J, de la Pompa JL.

Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1580-8. doi: 10.1161/ATVBAHA.111.227561. Epub 2011 Apr 14.

PMID:
21493891
44.

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.

del Monte G, Casanova JC, Guadix JA, MacGrogan D, Burch JB, Pérez-Pomares JM, de la Pompa JL.

Circ Res. 2011 Apr 1;108(7):824-36. doi: 10.1161/CIRCRESAHA.110.229062. Epub 2011 Feb 10.

PMID:
21311046
45.

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

Luna-Zurita L, Prados B, Grego-Bessa J, Luxán G, del Monte G, Benguría A, Adams RH, Pérez-Pomares JM, de la Pompa JL.

J Clin Invest. 2010 Oct;120(10):3493-507. doi: 10.1172/JCI42666. Epub 2010 Sep 20.

46.

Notch signaling in cardiac development and disease.

MacGrogan D, Nus M, de la Pompa JL.

Curr Top Dev Biol. 2010;92:333-65. doi: 10.1016/S0070-2153(10)92011-5. Review.

PMID:
20816401
47.

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.

Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper B, del Monte G, de la Pompa JL, Maroto M.

PLoS Genet. 2009 Sep;5(9):e1000662. doi: 10.1371/journal.pgen.1000662. Epub 2009 Sep 25.

48.

CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia.

González-García S, García-Peydró M, Martín-Gayo E, Ballestar E, Esteller M, Bornstein R, de la Pompa JL, Ferrando AA, Toribio ML.

J Exp Med. 2009 Apr 13;206(4):779-91. doi: 10.1084/jem.20081922. Epub 2009 Apr 6. Erratum in: J Exp Med. 2009 Jul 6;206(7):1633.

49.

Notch signaling in cardiac development and disease.

de la Pompa JL.

Pediatr Cardiol. 2009 Jul;30(5):643-50. doi: 10.1007/s00246-008-9368-z. Epub 2009 Jan 31. Review.

PMID:
19184573
50.

The notch pathway positively regulates programmed cell death during erythroid differentiation.

Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A.

Leukemia. 2007 Jul;21(7):1496-503. Epub 2007 May 3.

PMID:
17476283

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