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Items: 49


Using pneumococcal carriage studies to monitor vaccine impact in low- and middle-income countries.

Chan J, Nguyen CD, Dunne EM, Kim Mulholland E, Mungun T, Pomat WS, Rafai E, Satzke C, Weinberger DM, Russell FM.

Vaccine. 2019 Oct 8;37(43):6299-6309. doi: 10.1016/j.vaccine.2019.08.073. Epub 2019 Sep 6. Review.


Microscopic and submicroscopic Plasmodium falciparum infection, maternal anaemia and adverse pregnancy outcomes in Papua New Guinea: a cohort study.

Unger HW, Rosanas-Urgell A, Robinson LJ, Ome-Kaius M, Jally S, Umbers AJ, Pomat W, Mueller I, Kattenberg E, Rogerson SJ.

Malar J. 2019 Sep 2;18(1):302. doi: 10.1186/s12936-019-2931-7.


Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.

Lee AH, Shannon CP, Amenyogbe N, Bennike TB, Diray-Arce J, Idoko OT, Gill EE, Ben-Othman R, Pomat WS, van Haren SD, Cao KL, Cox M, Darboe A, Falsafi R, Ferrari D, Harbeson DJ, He D, Bing C, Hinshaw SJ, Ndure J, Njie-Jobe J, Pettengill MA, Richmond PC, Ford R, Saleu G, Masiria G, Matlam JP, Kirarock W, Roberts E, Malek M, Sanchez-Schmitz G, Singh A, Angelidou A, Smolen KK; EPIC Consortium, Brinkman RR, Ozonoff A, Hancock REW, van den Biggelaar AHJ, Steen H, Tebbutt SJ, Kampmann B, Levy O, Kollmann TR.

Nat Commun. 2019 Mar 12;10(1):1092. doi: 10.1038/s41467-019-08794-x.


Molecular Evidence of Drug-Resistant Tuberculosis in the Balimo Region of Papua New Guinea.

Diefenbach-Elstob T, Guernier V, Burgess G, Pelowa D, Dowi R, Gula B, Puri M, Pomat W, McBryde E, Plummer D, Rush C, Warner J.

Trop Med Infect Dis. 2019 Feb 10;4(1). pii: E33. doi: 10.3390/tropicalmed4010033.


Immunogenicity and Immune Memory after a Pneumococcal Polysaccharide Vaccine Booster in a High-Risk Population Primed with 10-Valent or 13-Valent Pneumococcal Conjugate Vaccine: A Randomized Controlled Trial in Papua New Guinean Children.

van den Biggelaar AHJ, Pomat WS, Masiria G, Wana S, Nivio B, Francis J, Ford R, Passey M, Kirkham LA, Jacoby P, Lehmann D, Richmond P; 10v13v PCV Trial Team.

Vaccines (Basel). 2019 Feb 4;7(1). pii: E17. doi: 10.3390/vaccines7010017.


Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae, Mycoplasma genitalium, M. hominis, Ureaplasma urealyticum and U. parvum: a systematic review and meta-analysis protocol.

Vallely LM, Egli-Gany D, Pomat W, Homer CS, Guy R, Wand H, Silver B, Rumbold AR, Kaldor JM, Low N, Vallely AJ.

BMJ Open. 2018 Nov 28;8(11):e024175. doi: 10.1136/bmjopen-2018-024175.


Youth-centred research to help prevent and mitigate the adverse health and social impacts of pregnancy amongst young Papua New Guineans.

Bell S, Kennedy E, Black K, Vallely A, Vallely L, Mola G, Kaldor J, Bagita M, Ninnes C, Pomat W, Kelly-Hanku A.

Reprod Health Matters. 2018 Nov;26(54):5-12. doi: 10.1080/09688080.2018.1512297. Epub 2018 Sep 27.


Safety and Immunogenicity of Pneumococcal Conjugate Vaccines in a High-risk Population: A Randomized Controlled Trial of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccine in Papua New Guinean Infants.

Pomat WS, van den Biggelaar AHJ, Wana S, Francis JP, Solomon V, Greenhill AR, Ford R, Orami T, Passey M, Jacoby P, Kirkham LA, Lehmann D, Richmond PC; 10v13v PCV Trial Team .

Clin Infect Dis. 2019 Apr 24;68(9):1472-1481. doi: 10.1093/cid/ciy743.


The epidemiology of tuberculosis in the rural Balimo region of Papua New Guinea.

Diefenbach-Elstob T, Graves P, Dowi R, Gula B, Plummer D, McBryde E, Pelowa D, Siba P, Pomat W, Warner J.

Trop Med Int Health. 2018 Sep;23(9):1022-1032. doi: 10.1111/tmi.13118. Epub 2018 Jul 5.


Antimicrobial sensitivity trends and virulence genes in Shigella spp. from the Oceania region.

Malau E, Ford R, Valcanis M, Jennison AV, Mosse J, Bean D, Yoannes M, Pomat W, Horwood PF, Greenhill AR.

Infect Genet Evol. 2018 Oct;64:52-56. doi: 10.1016/j.meegid.2018.06.015. Epub 2018 Jun 12.


Determining the pneumococcal conjugate vaccine coverage required for indirect protection against vaccine-type pneumococcal carriage in low and middle-income countries: a protocol for a prospective observational study.

Chan J, Nguyen CD, Lai JYR, Dunne EM, Andrews R, Blyth CC, Datta S, Fox K, Ford R, Hinds J, La Vincente S, Lehmann D, Lim R, Mungun T, Newton PN, Phetsouvanh R, Pomat WS, Xeuatvongsa A, von Mollendorf C, Dance DAB, Satzke C, Muholland K, Russell FM; PneuCAPTIVE Protocol Group.

BMJ Open. 2018 May 18;8(5):e021512. doi: 10.1136/bmjopen-2018-021512.


Rationale and methods of a randomized controlled trial of immunogenicity, safety and impact on carriage of pneumococcal conjugate and polysaccharide vaccines in infants in Papua New Guinea.

Lehmann D, Kirarock W, van den Biggelaar AHJ, Passey M, Jacoby P, Saleu G, Masiria G, Nivio B, Greenhill A, Orami T, Francis J, Ford R, Kirkham LA, Solomon V, Richmond PC, Pomat WS; 10v13v PCV trial team.

Pneumonia (Nathan). 2017 Dec 25;9:20. doi: 10.1186/s41479-017-0044-z. eCollection 2017.


Pneumococcal responses are similar in Papua New Guinean children aged 3-5 years vaccinated in infancy with pneumococcal polysaccharide vaccine with or without prior pneumococcal conjugate vaccine, or without pneumococcal vaccination.

van den Biggelaar AHJ, Richmond PC, Fuery A, Anderson D, Opa C, Saleu G, Lai M, Francis JP, Alpers MP, Pomat WS, Lehmann D.

PLoS One. 2017 Oct 13;12(10):e0185877. doi: 10.1371/journal.pone.0185877. eCollection 2017.


A High Burden of Asymptomatic Gastrointestinal Infections in Traditional Communities in Papua New Guinea.

Horwood PF, Soli KW, Maure T, Naito YI, Morita A, Natsuhara K, Tadokoro K, Baba J, Odani S, Tomitsuka E, Igai K, Larkins JA, Siba PM, Pomat W, McBryde ES, Umezaki M, Greenhill AR.

Am J Trop Med Hyg. 2017 Dec;97(6):1872-1875. doi: 10.4269/ajtmh.17-0282. Epub 2017 Sep 21.


A Neolithic expansion, but strong genetic structure, in the independent history of New Guinea.

Bergström A, Oppenheimer SJ, Mentzer AJ, Auckland K, Robson K, Attenborough R, Alpers MP, Koki G, Pomat W, Siba P, Xue Y, Sandhu MS, Tyler-Smith C.

Science. 2017 Sep 15;357(6356):1160-1163. doi: 10.1126/science.aan3842.


Childhood pneumonia and meningitis in the Eastern Highlands Province, Papua New Guinea in the era of conjugate vaccines: study methods and challenges.

Blyth CC, Ford R, Sapura J, Kumani T, Masiria G, Kave J, Yuasi L, Greenhill A, Hwaihwanje I, Lang A, Lehmann D, Pomat W; Papua New Guinea Pneumonia and Meningitis Etiology Study Team.

Pneumonia (Nathan). 2017 Mar 5;9:5. doi: 10.1186/s41479-017-0029-y. eCollection 2017.


A longitudinal study of natural antibody development to pneumococcal surface protein A families 1 and 2 in Papua New Guinean Highland children: a cohort study.

Francis JP, Richmond PC, Michael A, Siba PM, Jacoby P, Hales BJ, Thomas WR, Lehmann D, Pomat WS, van den Biggelaar AHJ.

Pneumonia (Nathan). 2016 Aug 15;8:12. doi: 10.1186/s41479-016-0014-x. eCollection 2016.


Limited impact of neonatal or early infant schedules of 7-valent pneumococcal conjugate vaccination on nasopharyngeal carriage of Streptococcus pneumoniae in Papua New Guinean children: A randomized controlled trial.

Aho C, Michael A, Yoannes M, Greenhill A, Jacoby P, Reeder J, Pomat W, Saleu G, Namuigi P, Phuanukoonnon S, Smith-Vaughan H, Leach AJ, Richmond P, Lehmann D; Neonatal Pneumococcal Conjugate Vaccine Trial Study Team.

Vaccine Rep. 2016 Dec;6:36-43. doi: 10.1016/j.vacrep.2016.08.002.


Cord blood Streptococcus pneumoniae-specific cellular immune responses predict early pneumococcal carriage in high-risk infants in Papua New Guinea.

Francis JP, Richmond PC, Strickland D, Prescott SL, Pomat WS, Michael A, Nadal-Sims MA, Edwards-Devitt CJ, Holt PG, Lehmann D, van den Biggelaar AH.

Clin Exp Immunol. 2017 Mar;187(3):408-417. doi: 10.1111/cei.12902. Epub 2016 Dec 18.


A genomic history of Aboriginal Australia.

Malaspinas AS, Westaway MC, Muller C, Sousa VC, Lao O, Alves I, Bergström A, Athanasiadis G, Cheng JY, Crawford JE, Heupink TH, Macholdt E, Peischl S, Rasmussen S, Schiffels S, Subramanian S, Wright JL, Albrechtsen A, Barbieri C, Dupanloup I, Eriksson A, Margaryan A, Moltke I, Pugach I, Korneliussen TS, Levkivskyi IP, Moreno-Mayar JV, Ni S, Racimo F, Sikora M, Xue Y, Aghakhanian FA, Brucato N, Brunak S, Campos PF, Clark W, Ellingvåg S, Fourmile G, Gerbault P, Injie D, Koki G, Leavesley M, Logan B, Lynch A, Matisoo-Smith EA, McAllister PJ, Mentzer AJ, Metspalu M, Migliano AB, Murgha L, Phipps ME, Pomat W, Reynolds D, Ricaut FX, Siba P, Thomas MG, Wales T, Wall CM, Oppenheimer SJ, Tyler-Smith C, Durbin R, Dortch J, Manica A, Schierup MH, Foley RA, Lahr MM, Bowern C, Wall JD, Mailund T, Stoneking M, Nielsen R, Sandhu MS, Excoffier L, Lambert DM, Willerslev E.

Nature. 2016 Oct 13;538(7624):207-214. doi: 10.1038/nature18299. Epub 2016 Sep 21.


A novel point-of-care testing strategy for sexually transmitted infections among pregnant women in high-burden settings: results of a feasibility study in Papua New Guinea.

Badman SG, Vallely LM, Toliman P, Kariwiga G, Lote B, Pomat W, Holmer C, Guy R, Luchters S, Morgan C, Garland SM, Tabrizi S, Whiley D, Rogerson SJ, Mola G, Wand H, Donovan B, Causer L, Kaldor J, Vallely A.

BMC Infect Dis. 2016 Jun 6;16:250. doi: 10.1186/s12879-016-1573-4.


Streptococcus pneumoniae and Haemophilus influenzae in paediatric meningitis patients at Goroka General Hospital, Papua New Guinea: serotype distribution and antimicrobial susceptibility in the pre-vaccine era.

Greenhill AR, Phuanukoonnon S, Michael A, Yoannes M, Orami T, Smith H, Murphy D, Blyth C, Reeder J, Siba P, Pomat W, Lehmann D.

BMC Infect Dis. 2015 Oct 27;15:485. doi: 10.1186/s12879-015-1197-0.


Intestinal parasitic infections and anaemia among pregnant women in the highlands of Papua New Guinea.

Phuanukoonnon S, Michael A, Kirarock WS, Pomat WS, van den Biggelaar AH.

P N G Med J. 2013 Sep-Dec;56(3-4):119-25.


Ethical challenges in integrating patient-care with clinical research in a resource-limited setting: perspectives from Papua New Guinea.

Laman M, Pomat W, Siba P, Betuela I.

BMC Med Ethics. 2013 Jul 26;14:29. doi: 10.1186/1472-6939-14-29.


Safety and immunogenicity of neonatal pneumococcal conjugate vaccination in Papua New Guinean children: a randomised controlled trial.

Pomat WS, van den Biggelaar AH, Phuanukoonnon S, Francis J, Jacoby P, Siba PM, Alpers MP, Reeder JC, Holt PG, Richmond PC, Lehmann D; Neonatal Pneumococcal Conjugate Vaccine Trial Study Team.

PLoS One. 2013;8(2):e56698. doi: 10.1371/journal.pone.0056698. Epub 2013 Feb 22.


Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions.

Lisciandro JG, Prescott SL, Nadal-Sims MG, Devitt CJ, Richmond PC, Pomat W, Siba PM, Holt PG, Strickland DH, van den Biggelaar AH.

J Allergy Clin Immunol. 2012 Nov;130(5):1167-1174.e10. doi: 10.1016/j.jaci.2012.06.005. Epub 2012 Jul 19.


Immunization of newborns with bacterial conjugate vaccines.

van den Biggelaar AH, Pomat WS.

Vaccine. 2013 May 17;31(21):2525-30. doi: 10.1016/j.vaccine.2012.06.019. Epub 2012 Jun 19. Review.


Ontogeny of Toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants.

Lisciandro JG, Prescott SL, Nadal-Sims MG, Devitt CJ, Pomat W, Siba PM, Tulic MC, Holt PG, Strickland D, van den Biggelaar AH.

PLoS One. 2012;7(5):e36793. doi: 10.1371/journal.pone.0036793. Epub 2012 May 23.


Respiratory viral pathogens associated with lower respiratory tract disease among young children in the highlands of Papua New Guinea.

Chidlow GR, Laing IA, Harnett GB, Greenhill AR, Phuanukoonnon S, Siba PM, Pomat WS, Shellam GR, Smith DW, Lehmann D.

J Clin Virol. 2012 Jul;54(3):235-9. doi: 10.1016/j.jcv.2012.04.008. Epub 2012 May 16.


Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns.

Lisciandro JG, Prescott SL, Nadal-Sims MG, Devitt CJ, Pomat W, Siba PM, Holt PG, Strickland D, van den Biggelaar AH.

Pediatr Allergy Immunol. 2012 Mar;23(2):173-80. doi: 10.1111/j.1399-3038.2011.01242.x. Epub 2011 Dec 23.


Effect of early carriage of Streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancy.

van den Biggelaar AH, Pomat WS, Phuanukoonnon S, Michael A, Aho C, Nadal-Sims MA, Devitt CJ, Jacoby PA, Hales BJ, Smith WA, Mitchell T, Wiertsema S, Richmond P, Siba P, Holt PG, Lehmann D.

Pediatr Infect Dis J. 2012 Mar;31(3):243-8. doi: 10.1097/INF.0b013e318245a5a8.


Divergent human populations show extensive shared IGK rearrangements in peripheral blood B cells.

Jackson KJ, Wang Y, Gaeta BA, Pomat W, Siba P, Rimmer J, Sewell WA, Collins AM.

Immunogenetics. 2012 Jan;64(1):3-14. doi: 10.1007/s00251-011-0559-z. Epub 2011 Jul 26.


Pneumococcal conjugate vaccination at birth in a high-risk setting: no evidence for neonatal T-cell tolerance.

van den Biggelaar AH, Pomat W, Bosco A, Phuanukoonnon S, Devitt CJ, Nadal-Sims MA, Siba PM, Richmond PC, Lehmann D, Holt PG.

Vaccine. 2011 Jul 26;29(33):5414-20. doi: 10.1016/j.vaccine.2011.05.065. Epub 2011 Jun 7.


IgE sequences in individuals living in an area of endemic parasitism show little mutational evidence of antigen selection.

Wang Y, Jackson KJ, Chen Z, Gaëta BA, Siba PM, Pomat W, Walpole E, Rimmer J, Sewell WA, Collins AM.

Scand J Immunol. 2011 May;73(5):496-504. doi: 10.1111/j.1365-3083.2011.02525.x.


Genomic screening by 454 pyrosequencing identifies a new human IGHV gene and sixteen other new IGHV allelic variants.

Wang Y, Jackson KJ, Gäeta B, Pomat W, Siba P, Sewell WA, Collins AM.

Immunogenetics. 2011 May;63(5):259-65. doi: 10.1007/s00251-010-0510-8. Epub 2011 Jan 20.


A neonatal pneumococcal conjugate vaccine trial in Papua New guinea: study population, methods and operational challenges.

Phuanukoonnon S, Reeder JC, Pomat WS, Van den Biggelaar AH, Holt PG, Saleu G, Opa C, Michael A, Aho C, Yoannes M, Francis J, Orami T, Namuigi P, Siba PM, Richmond PC, Lehmann D; Neonatal Pneumococcal Conjugate Vaccine Trial Study Team.

P N G Med J. 2010 Sep-Dec;53(3-4):191-206.


Pneumonia in Papua New Guinea: lessons learnt for the way forward.

Pomat WS, Greenhill AR, Lehmann D.

P N G Med J. 2010 Sep-Dec;53(3-4):89-93. No abstract available.


The role of biomedical research in the fight against pneumonia in Papua New Guinea.

Greenhill A, Pomat W, Duke T, Lagani W, Mokela D, Lehmann D.

P N G Med J. 2010 Mar-Jun;53(1-2):1-4. No abstract available.


Maternal antibodies to pneumolysin but not to pneumococcal surface protein A delay early pneumococcal carriage in high-risk Papua New Guinean infants.

Francis JP, Richmond PC, Pomat WS, Michael A, Keno H, Phuanukoonnon S, Nelson JB, Whinnen M, Heinrich T, Smith WA, Prescott SL, Holt PG, Siba PM, Lehmann D, van den Biggelaar AH.

Clin Vaccine Immunol. 2009 Nov;16(11):1633-8. doi: 10.1128/CVI.00247-09. Epub 2009 Sep 23.


Neonatal innate cytokine responses to BCG controlling T-cell development vary between populations.

van den Biggelaar AH, Prescott SL, Roponen M, Nadal-Sims MA, Devitt CJ, Phuanukoonnon S, Pomat W, Tulic MK, Lehmann D, Siba PM, Richmond PC, Holt PG.

J Allergy Clin Immunol. 2009 Sep;124(3):544-50, 550.e1-2. doi: 10.1016/j.jaci.2009.03.040. Epub 2009 Jun 4.


Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: a randomized controlled trial in Papua New Guinea.

van den Biggelaar AH, Richmond PC, Pomat WS, Phuanukoonnon S, Nadal-Sims MA, Devitt CJ, Siba PM, Lehmann D, Holt PG.

Vaccine. 2009 Feb 25;27(9):1340-7. doi: 10.1016/j.vaccine.2008.12.046. Epub 2009 Jan 14.


Studies of maternal immunisation with pneumococcal polysaccharide vaccine in Papua New Guinea.

Lehmann D, Pomat WS, Riley ID, Alpers MP.

Vaccine. 2003 Jul 28;21(24):3446-50. Review.


Maternal immunization with pneumococcal polysaccharide vaccine in the highlands of Papua New Guinea.

Lehmann D, Pomat WS, Combs B, Dyke T, Alpers MP.

Vaccine. 2002 Mar 15;20(13-14):1837-45.


Immunoglobulin G antibody responses to polyvalent pneumococcal vaccine in children in the highlands of Papua New Guinea.

Pomat WS, Lehmann D, Sanders RC, Lewis DJ, Wilson J, Rogers S, Dyke T, Alpers MP.

Infect Immun. 1994 May;62(5):1848-53.


Levels of anti-pneumococcal antibodies in young children in Papua New Guinea.

Pomat WS, Smith TA, Sanders RC, Witt CS, Montgomery J, Lehmann D, Alpers MP.

Epidemiol Infect. 1993 Aug;111(1):109-19.


Immune function risk factors for acute lower respiratory tract infections.

Witt CS, Pomat W.

P N G Med J. 1991 Sep;34(3):211-4.


Pneumococcal antibody concentrations in young Papua New Guinean Highland children with pneumonia.

Witt CS, Pomat W, Alpers MP.

Pediatr Infect Dis J. 1989 Aug;8(8):533-4. No abstract available.


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