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The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate.

Yamashita M, Ing CE, Yeung PS, Maneshi MM, Pomès R, Prakriya M.

J Gen Physiol. 2020 Jan 6;152(1). pii: e201912397. doi: 10.1085/jgp.201912397.


Hydrophobic gasket mutation produces gating pore currents in closed human voltage-gated proton channels.

Banh R, Cherny VV, Morgan D, Musset B, Thomas S, Kulleperuma K, Smith SME, Pomès R, DeCoursey TE.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18951-18961. doi: 10.1073/pnas.1905462116. Epub 2019 Aug 28.


Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.

Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D.

Nat Commun. 2019 Aug 6;10(1):3521. doi: 10.1038/s41467-019-11425-0.


Substrate-Based Allosteric Regulation of a Homodimeric Enzyme.

Mehrabi P, Di Pietrantonio C, Kim TH, Sljoka A, Taverner K, Ing C, Kruglyak N, Pomès R, Pai EF, Prosser RS.

J Am Chem Soc. 2019 Jul 24;141(29):11540-11556. doi: 10.1021/jacs.9b03703. Epub 2019 Jun 26.


Role of Liquid-Liquid Phase Separation in Assembly of Elastin and Other Extracellular Matrix Proteins.

Muiznieks LD, Sharpe S, Pomès R, Keeley FW.

J Mol Biol. 2018 Nov 2;430(23):4741-4753. doi: 10.1016/j.jmb.2018.06.010. Epub 2018 Jun 8. Review.


Structural basis for gating pore current in periodic paralysis.

Jiang D, Gamal El-Din TM, Ing C, Lu P, Pomès R, Zheng N, Catterall WA.

Nature. 2018 May;557(7706):590-594. doi: 10.1038/s41586-018-0120-4. Epub 2018 May 16.


Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating.

Yeung PS, Yamashita M, Ing CE, Pomès R, Freymann DM, Prakriya M.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5193-E5202. doi: 10.1073/pnas.1718373115. Epub 2018 May 14.


Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations.

Ye L, Neale C, Sljoka A, Lyda B, Pichugin D, Tsuchimura N, Larda ST, Pomès R, García AE, Ernst OP, Sunahara RK, Prosser RS.

Nat Commun. 2018 Apr 10;9(1):1372. doi: 10.1038/s41467-018-03314-9.


Solution NMR structure of yeast Rcf1, a protein involved in respiratory supercomplex formation.

Zhou S, Pettersson P, Huang J, Sjöholm J, Sjöstrand D, Pomès R, Högbom M, Brzezinski P, Mäler L, Ädelroth P.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3048-3053. doi: 10.1073/pnas.1712061115. Epub 2018 Mar 5.


Molecular recognition and packing frustration in a helical protein.

Huynh L, Neale C, Pomès R, Chan HS.

PLoS Comput Biol. 2017 Dec 19;13(12):e1005909. doi: 10.1371/journal.pcbi.1005909. eCollection 2017 Dec.


The liquid structure of elastin.

Rauscher S, Pomès R.

Elife. 2017 Nov 9;6. pii: e26526. doi: 10.7554/eLife.26526.


Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue.

Molinski SV, Ahmadi S, Ip W, Ouyang H, Villella A, Miller JP, Lee PS, Kulleperuma K, Du K, Di Paola M, Eckford PD, Laselva O, Huan LJ, Wellhauser L, Li E, Ray PN, Pomès R, Moraes TJ, Gonska T, Ratjen F, Bear CE.

EMBO Mol Med. 2017 Sep;9(9):1224-1243. doi: 10.15252/emmm.201607137.


Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.

Wang H, Muiznieks LD, Ghosh P, Williams D, Solarski M, Fang A, Ruiz-Riquelme A, Pomès R, Watts JC, Chakrabartty A, Wille H, Sharpe S, Schmitt-Ulms G.

Elife. 2017 Jun 26;6. pii: e28401. doi: 10.7554/eLife.28401.


Structures of closed and open states of a voltage-gated sodium channel.

Lenaeus MJ, Gamal El-Din TM, Ing C, Ramanadane K, Pomès R, Zheng N, Catterall WA.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3051-E3060. doi: 10.1073/pnas.1700761114. Epub 2017 Mar 27.


STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.

Yamashita M, Yeung PS, Ing CE, McNally BA, Pomès R, Prakriya M.

Nat Commun. 2017 Feb 21;8:14512. doi: 10.1038/ncomms14512.


The role of dimer asymmetry and protomer dynamics in enzyme catalysis.

Kim TH, Mehrabi P, Ren Z, Sljoka A, Ing C, Bezginov A, Ye L, Pomès R, Prosser RS, Pai EF.

Science. 2017 Jan 20;355(6322). pii: eaag2355. doi: 10.1126/science.aag2355.


Simulation Studies of Ion Permeation and Selectivity in Voltage-Gated Sodium Channels.

Ing C, Pomès R.

Curr Top Membr. 2016;78:215-60. doi: 10.1016/bs.ctm.2016.07.005. Epub 2016 Aug 3. Review.


Structure and Dynamics of Extracellular Loops in Human Aquaporin-1 from Solid-State NMR and Molecular Dynamics.

Wang S, Ing C, Emami S, Jiang Y, Liang H, Pomès R, Brown LS, Ladizhansky V.

J Phys Chem B. 2016 Sep 22;120(37):9887-902. doi: 10.1021/acs.jpcb.6b06731. Epub 2016 Sep 13.


Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis.

Xiong ZJ, Huang J, Poda G, Pomès R, Privé GG.

J Mol Biol. 2016 Jul 31;428(15):3026-42. doi: 10.1016/j.jmb.2016.06.012. Epub 2016 Jun 24.


Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone.

Chan SW, Yau J, Ing C, Liu K, Farber P, Won A, Bhandari V, Kara-Yacoubian N, Seraphim TV, Chakrabarti N, Kay LE, Yip CM, Pomès R, Sharpe S, Houry WA.

Structure. 2016 Jul 6;24(7):1095-109. doi: 10.1016/j.str.2016.05.002. Epub 2016 Jun 2.

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