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Items: 1 to 50 of 135

1.

Revisiting the History of the 1997 Alpha-Synuclein Discovery in Parkinson's Disease.

Polymeropoulos MH.

J Parkinsons Dis. 2019;9(2):443-444. doi: 10.3233/JPD-191569. No abstract available.

PMID:
31127734
2.

Tasimelteon for non-24-hour sleep-wake disorder in totally blind people (SET and RESET): two multicentre, randomised, double-masked, placebo-controlled phase 3 trials.

Lockley SW, Dressman MA, Licamele L, Xiao C, Fisher DM, Flynn-Evans EE, Hull JT, Torres R, Lavedan C, Polymeropoulos MH.

Lancet. 2015 Oct 31;386(10005):1754-64. doi: 10.1016/S0140-6736(15)60031-9. Epub 2015 Aug 4.

PMID:
26466871
3.

Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis in schizophrenia.

Polymeropoulos MH, Licamele L, Volpi S, Mack K, Mitkus SN, Carstea ED, Getoor L, Thompson A, Lavedan C.

Schizophr Res. 2009 Mar;108(1-3):134-42. doi: 10.1016/j.schres.2008.11.025. Epub 2009 Jan 15.

PMID:
19150222
4.

Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials.

Rajaratnam SM, Polymeropoulos MH, Fisher DM, Roth T, Scott C, Birznieks G, Klerman EB.

Lancet. 2009 Feb 7;373(9662):482-91. doi: 10.1016/S0140-6736(08)61812-7. Epub 2008 Dec 4. Erratum in: Lancet. 2009 Apr 11;373(9671):1252.

PMID:
19054552
5.

Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.

Volpi S, Heaton C, Mack K, Hamilton JB, Lannan R, Wolfgang CD, Licamele L, Polymeropoulos MH, Lavedan C.

Mol Psychiatry. 2009 Nov;14(11):1024-31. doi: 10.1038/mp.2008.52. Epub 2008 Jun 3.

PMID:
18521091
6.

Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.

Lavedan C, Licamele L, Volpi S, Hamilton J, Heaton C, Mack K, Lannan R, Thompson A, Wolfgang CD, Polymeropoulos MH.

Mol Psychiatry. 2009 Aug;14(8):804-19. doi: 10.1038/mp.2008.56. Epub 2008 Jun 3.

PMID:
18521090
7.

Safety profile of iloperidone: a pooled analysis of 6-week acute-phase pivotal trials.

Weiden PJ, Cutler AJ, Polymeropoulos MH, Wolfgang CD.

J Clin Psychopharmacol. 2008 Apr;28(2 Suppl 1):S12-9. doi: 10.1097/JCP.0b013e3181694f5a.

PMID:
18334908
8.

Effect of a ciliary neurotrophic factor polymorphism on schizophrenia symptom improvement in an iloperidone clinical trial.

Lavedan C, Volpi S, Polymeropoulos MH, Wolfgang CD.

Pharmacogenomics. 2008 Mar;9(3):289-301. doi: 10.2217/14622416.9.3.289.

PMID:
18303965
9.

Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene.

Yamaguchi K, Cochran EJ, Murrell JR, Polymeropoulos MH, Shannon KM, Crowther RA, Goedert M, Ghetti B.

Acta Neuropathol. 2005 Sep;110(3):298-305. Epub 2005 Jun 25.

PMID:
15981014
10.

Correlation of major cytogenetic response with a pharmacogenetic marker in chronic myeloid leukemia patients treated with imatinib (STI571).

Dressman MA, Malinowski R, McLean LA, Gathmann I, Capdeville R, Hensley M, Polymeropoulos MH; International Randomized Study of Interferon-alpha versus ST1571 Study Group.

Clin Cancer Res. 2004 Apr 1;10(7):2265-71.

11.

Pharmacogenomic analysis of cytogenetic response in chronic myeloid leukemia patients treated with imatinib.

McLean LA, Gathmann I, Capdeville R, Polymeropoulos MH, Dressman M.

Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):155-65.

12.

Gene expression profiling detects gene amplification and differentiates tumor types in breast cancer.

Dressman MA, Baras A, Malinowski R, Alvis LB, Kwon I, Walz TM, Polymeropoulos MH.

Cancer Res. 2003 May 1;63(9):2194-9.

13.

A mutation in the human neurofilament M gene in Parkinson's disease that suggests a role for the cytoskeleton in neuronal degeneration.

Lavedan C, Buchholtz S, Nussbaum RL, Albin RL, Polymeropoulos MH.

Neurosci Lett. 2002 Mar 29;322(1):57-61.

PMID:
11958843
14.

Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies.

Dressman MA, Walz TM, Lavedan C, Barnes L, Buchholtz S, Kwon I, Ellis MJ, Polymeropoulos MH.

Pharmacogenomics J. 2001;1(2):135-41.

PMID:
11911440
15.

The G209A mutation in the alpha-synuclein gene in Brazilian families with Parkinson's disease.

Teive HA, Raskin S, Iwamoto FM, Germiniani FM, Baran MH, Werneck LC, Allan N, Quagliato E, Leroy E, Ide SE, Polymeropoulos MH.

Arq Neuropsiquiatr. 2001 Sep;59(3-B):722-4.

16.

Clinical phenotype in patients with alpha-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease.

Papapetropoulos S, Paschalis C, Athanassiadou A, Papadimitriou A, Ellul J, Polymeropoulos MH, Papapetropoulos T.

J Neurol Neurosurg Psychiatry. 2001 May;70(5):662-5.

17.

Mutation screening of the Wolfram syndrome gene in psychiatric patients.

Torres R, Leroy E, Hu X, Katrivanou A, Gourzis P, Papachatzopoulou A, Athanassiadou A, Beratis S, Collier D, Polymeropoulos MH.

Mol Psychiatry. 2001 Jan;6(1):39-43.

PMID:
11244483
18.

Genetics of Parkinson's disease.

Polymeropoulos MH.

Ann N Y Acad Sci. 2000;920:28-32. Review.

PMID:
11193165
19.

Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element.

Touchman JW, Dehejia A, Chiba-Falek O, Cabin DE, Schwartz JR, Orrison BM, Polymeropoulos MH, Nussbaum RL.

Genome Res. 2001 Jan;11(1):78-86.

20.

Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease.

Zhang J, Hattori N, Leroy E, Morris HR, Kubo S, Kobayashi T, Wood NW, Polymeropoulos MH, Mizuno Y.

Parkinsonism Relat Disord. 2000 Oct 1;6(4):195-197.

PMID:
10900392
21.

Alpha-synuclein immunoreactivity of huntingtin polyglutamine aggregates in striatum and cortex of Huntington's disease patients and transgenic mouse models.

Charles V, Mezey E, Reddy PH, Dehejia A, Young TA, Polymeropoulos MH, Brownstein MJ, Tagle DA.

Neurosci Lett. 2000 Jul 28;289(1):29-32.

PMID:
10899401
22.

Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis.

Ruiz-Perez VL, Ide SE, Strom TM, Lorenz B, Wilson D, Woods K, King L, Francomano C, Freisinger P, Spranger S, Marino B, Dallapiccola B, Wright M, Meitinger T, Polymeropoulos MH, Goodship J.

Nat Genet. 2000 Mar;24(3):283-6. Erratum in: Nat Genet 2000 May;25(1):125.

PMID:
10700184
23.

The genexpress IMAGE knowledge base of the human muscle transcriptome: a resource of structural, functional, and positional candidate genes for muscle physiology and pathologies.

Piétu G, Eveno E, Soury-Segurens B, Fayein NA, Mariage-Samson R, Matingou C, Leroy E, Dechesne C, Krieger S, Ansorge W, Reguigne-Arnould I, Cox D, Dehejia A, Polymeropoulos MH, Devignes MD, Auffray C.

Genome Res. 1999 Dec;9(12):1313-20.

24.

Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit.

Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH.

DNA Res. 1999 Oct 29;6(5):323-7.

PMID:
10574460
25.

Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein.

Athanassiadou A, Voutsinas G, Psiouri L, Leroy E, Polymeropoulos MH, Ilias A, Maniatis GM, Papapetropoulos T.

Am J Hum Genet. 1999 Aug;65(2):555-8. No abstract available.

26.

Absence of mutation in the beta- and gamma-synuclein genes in familial autosomal dominant Parkinson's disease.

Lavedan C, Buchholtz S, Auburger G, Albin RL, Athanassiadou A, Blancato J, Burguera JA, Ferrell RE, Kostic V, Leroy E, Leube B, Mota-Vieira L, Papapetropoulos T, Pericak-Vance MA, Pinkus J, Scott WK, Ulm G, Vasconcelos J, Vilchez JJ, Nussbaum RL, Polymeropoulos MH.

DNA Res. 1998 Dec 31;5(6):401-2. No abstract available.

PMID:
10048491
27.

Intron-exon structure of ubiquitin c-terminal hydrolase-L1.

Leroy E, Boyer R, Polymeropoulos MH.

DNA Res. 1998 Dec 31;5(6):397-400. No abstract available.

PMID:
10048490
28.

Genomic organization and localization of the human CRMP-1 gene.

Torres R, Polymeropoulos MH.

DNA Res. 1998 Dec 31;5(6):393-5.

PMID:
10048489
29.

Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease.

Mezey E, Dehejia AM, Harta G, Tresser N, Suchy SF, Nussbaum RL, Brownstein MJ, Polymeropoulos MH.

Mol Psychiatry. 1998 Nov;3(6):493-9. Erratum in: Mol Psychiatry 1999 Mar;4(2):197.

PMID:
9857974
30.

Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson's disease.

Leroy E, Anastasopoulos D, Konitsiotis S, Lavedan C, Polymeropoulos MH.

Hum Genet. 1998 Oct;103(4):424-7.

PMID:
9856485
31.

Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.

Gruber SB, Entius MM, Petersen GM, Laken SJ, Longo PA, Boyer R, Levin AM, Mujumdar UJ, Trent JM, Kinzler KW, Vogelstein B, Hamilton SR, Polymeropoulos MH, Offerhaus GJ, Giardiello FM.

Cancer Res. 1998 Dec 1;58(23):5267-70.

32.

Autosomal dominant Parkinson's disease.

Polymeropoulos MH.

J Neurol. 1998 Nov;245(11 Suppl 3):P1-3.

PMID:
9808333
33.

Genomic organization and expression of the human beta-synuclein gene (SNCB).

Lavedan C, Leroy E, Torres R, Dehejia A, Dutra A, Buchholtz S, Nussbaum RL, Polymeropoulos MH.

Genomics. 1998 Nov 15;54(1):173-5.

PMID:
9806846
34.

A physical map of 30,000 human genes.

Deloukas P, Schuler GD, Gyapay G, Beasley EM, Soderlund C, Rodriguez-Tomé P, Hui L, Matise TC, McKusick KB, Beckmann JS, Bentolila S, Bihoreau M, Birren BB, Browne J, Butler A, Castle AB, Chiannilkulchai N, Clee C, Day PJ, Dehejia A, Dibling T, Drouot N, Duprat S, Fizames C, Fox S, Gelling S, Green L, Harrison P, Hocking R, Holloway E, Hunt S, Keil S, Lijnzaad P, Louis-Dit-Sully C, Ma J, Mendis A, Miller J, Morissette J, Muselet D, Nusbaum HC, Peck A, Rozen S, Simon D, Slonim DK, Staples R, Stein LD, Stewart EA, Suchard MA, Thangarajah T, Vega-Czarny N, Webber C, Wu X, Hudson J, Auffray C, Nomura N, Sikela JM, Polymeropoulos MH, James MR, Lander ES, Hudson TJ, Myers RM, Cox DR, Weissenbach J, Boguski MS, Bentley DR.

Science. 1998 Oct 23;282(5389):744-6.

35.

The ubiquitin pathway in Parkinson's disease.

Leroy E, Boyer R, Auburger G, Leube B, Ulm G, Mezey E, Harta G, Brownstein MJ, Jonnalagada S, Chernova T, Dehejia A, Lavedan C, Gasser T, Steinbach PJ, Wilkinson KD, Polymeropoulos MH.

Nature. 1998 Oct 1;395(6701):451-2. No abstract available.

PMID:
9774100
36.

Autosomal dominant Parkinson's disease and alpha-synuclein.

Polymeropoulos MH.

Ann Neurol. 1998 Sep;44(3 Suppl 1):S63-4. Review.

PMID:
9749575
37.

Identification, localization and characterization of the human gamma-synuclein gene.

Lavedan C, Leroy E, Dehejia A, Buchholtz S, Dutra A, Nussbaum RL, Polymeropoulos MH.

Hum Genet. 1998 Jul;103(1):106-12.

PMID:
9737786
38.

Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21.

Patel SB, Salen G, Hidaka H, Kwiterovich PO, Stalenhoef AF, Miettinen TA, Grundy SM, Lee MH, Rubenstein JS, Polymeropoulos MH, Brownstein MJ.

J Clin Invest. 1998 Sep 1;102(5):1041-4.

39.

Alpha synuclein in neurodegenerative disorders: murderer or accomplice?

Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos MH, Brownstein MJ.

Nat Med. 1998 Jul;4(7):755-7. Review. No abstract available.

PMID:
9662355
40.

Contig map of the Parkinson's disease region on 4q21-q23.

Lavedan C, Dehejia A, Pike B, Dutra A, Leroy E, Ide SE, Root H, Rubenstein J, Boyer RL, Chandrasekharappa S, Makalowska I, Nussbaum RL, Polymeropoulos MH.

DNA Res. 1998 Feb 28;5(1):19-23.

PMID:
9628579
41.

C2H2-171: a novel human cDNA representing a developmentally regulated POZ domain/zinc finger protein preferentially expressed in brain.

Becker KG, Lee IJ, Nagle JW, Canning RD, Gado AM, Torres R, Polymeropoulos MH, Massa PT, Biddison WE, Drew PD.

Int J Dev Neurosci. 1997 Nov;15(7):891-9.

PMID:
9568537
42.

The gene for glycogen-storage disease type 1b maps to chromosome 11q23.

Annabi B, Hiraiwa H, Mansfield BC, Lei KJ, Ubagai T, Polymeropoulos MH, Moses SW, Parvari R, Hershkovitz E, Mandel H, Fryman M, Chou JY.

Am J Hum Genet. 1998 Feb;62(2):400-5.

43.

Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21.

Johnson MR, Wilkin DJ, Vos HL, Ortiz de Luna RI, Dehejia AM, Polymeropoulos MH, Francomano CA.

Matrix Biol. 1997 Nov;16(5):289-92.

PMID:
9501329
44.

Predisposition of Wolfram syndrome heterozygotes to psychiatric illness.

Swift RG, Polymeropoulos MH, Torres R, Swift M.

Mol Psychiatry. 1998 Jan;3(1):86-91.

PMID:
9491819
45.

C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells.

Drew PD, Gado AM, Canning RD, Nagle JW, Dehejia AM, Polymeropoulos MH, Biddison WE, Jacobson S, Becker KG.

J Neurovirol. 1997 Dec;3(6):455-9.

PMID:
9475118
46.

Mapping of the gene (NRAP) encoding N-RAP in the mouse and human genomes.

Luo G, Leroy E, Kozak CA, Polymeropoulos MH, Horowits R.

Genomics. 1997 Oct 1;45(1):229-32.

PMID:
9339382
47.

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.

Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C, Gu J, Rosenfeld MA, Pavan WJ, Krizman DB, Nagle J, Polymeropoulos MH, Sturley SL, Ioannou YA, Higgins ME, Comly M, Cooney A, Brown A, Kaneski CR, Blanchette-Mackie EJ, Dwyer NK, Neufeld EB, Chang TY, Liscum L, Strauss JF 3rd, Ohno K, Zeigler M, Carmi R, Sokol J, Markie D, O'Neill RR, van Diggelen OP, Elleder M, Patterson MC, Brady RO, Vanier MT, Pentchev PG, Tagle DA.

Science. 1997 Jul 11;277(5323):228-31.

48.

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.

Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL.

Science. 1997 Jun 27;276(5321):2045-7.

49.

Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1.

Becker KG, Nagle JW, Canning RD, Dehejia AM, Polymeropoulos MH, Gado AM, Biddison WE, Drew PD.

Genomics. 1997 May 1;41(3):502-4. No abstract available.

PMID:
9169157
50.

Evidence for a new spinocerebellar ataxia locus.

Higgins JJ, Pho LT, Ide SE, Nee LE, Polymeropoulos MH.

Mov Disord. 1997 May;12(3):412-7.

PMID:
9159738

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