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Items: 1 to 50 of 91

1.

Postpartum metabolic syndrome after gestational hypertension and preeclampsia, a prospective cohort study.

Osoti AO, Page ST, Richardson BA, Guthrie BL, Kinuthia J, Polyak SJ, Farquhar C.

Pregnancy Hypertens. 2019 Aug 19;18:35-41. doi: 10.1016/j.preghy.2019.08.088. [Epub ahead of print]

PMID:
31493627
2.

The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication.

Herod MR, Adeyemi OO, Ward J, Bentley K, Harris M, Stonehouse NJ, Polyak SJ.

J Gen Virol. 2019 Sep;100(9):1293-1302. doi: 10.1099/jgv.0.001283. Epub 2019 Jun 4.

3.

Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses.

Hulseberg CE, Fénéant L, Szymańska-de Wijs KM, Kessler NP, Nelson EA, Shoemaker CJ, Schmaljohn CS, Polyak SJ, White JM.

J Virol. 2019 Apr 3;93(8). pii: e02185-18. doi: 10.1128/JVI.02185-18. Print 2019 Apr 15.

PMID:
30700611
4.

1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles.

Pilkington LI, Wagoner J, Kline T, Polyak SJ, Barker D.

J Nat Prod. 2018 Dec 28;81(12):2630-2637. doi: 10.1021/acs.jnatprod.8b00416. Epub 2018 Nov 28.

PMID:
30485098
5.

The Antiviral Drug Arbidol Inhibits Zika Virus.

Fink SL, Vojtech L, Wagoner J, Slivinski NSJ, Jackson KJ, Wang R, Khadka S, Luthra P, Basler CF, Polyak SJ.

Sci Rep. 2018 Jun 12;8(1):8989. doi: 10.1038/s41598-018-27224-4.

6.

Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites.

Paguigan ND, Al-Huniti MH, Raja HA, Czarnecki A, Burdette JE, González-Medina M, Medina-Franco JL, Polyak SJ, Pearce CJ, Croatt MP, Oberlies NH.

Bioorg Med Chem. 2017 Oct 15;25(20):5238-5246. doi: 10.1016/j.bmc.2017.07.041. Epub 2017 Jul 28.

7.

Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells.

Lovelace ES, Maurice NJ, Miller HW, Slichter CK, Harrington R, Magaret A, Prlic M, De Rosa S, Polyak SJ.

PLoS One. 2017 Feb 3;12(2):e0171139. doi: 10.1371/journal.pone.0171139. eCollection 2017.

8.

[The synthetic antiviral drug arbidol inhibits globally prevalent pathogenic viruses].

Pécheur ÈI, Polyak SJ.

Med Sci (Paris). 2016 Dec;32(12):1056-1059. doi: 10.1051/medsci/20163212004. Epub 2017 Jan 3. French. No abstract available.

9.

A validated UHPLC-tandem mass spectrometry method for quantitative analysis of flavonolignans in milk thistle (Silybum marianum) extracts.

Graf TN, Cech NB, Polyak SJ, Oberlies NH.

J Pharm Biomed Anal. 2016 Jul 15;126:26-33. doi: 10.1016/j.jpba.2016.04.028. Epub 2016 Apr 22.

10.

The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses.

Pécheur EI, Borisevich V, Halfmann P, Morrey JD, Smee DF, Prichard M, Mire CE, Kawaoka Y, Geisbert TW, Polyak SJ.

J Virol. 2016 Jan 6;90(6):3086-92. doi: 10.1128/JVI.02077-15.

11.

Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry.

Kyle JE, Zhang X, Weitz KK, Monroe ME, Ibrahim YM, Moore RJ, Cha J, Sun X, Lovelace ES, Wagoner J, Polyak SJ, Metz TO, Dey SK, Smith RD, Burnum-Johnson KE, Baker ES.

Analyst. 2016 Mar 7;141(5):1649-59. doi: 10.1039/c5an02062j.

12.
13.

Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling.

Lovelace ES, Wagoner J, MacDonald J, Bammler T, Bruckner J, Brownell J, Beyer RP, Zink EM, Kim YM, Kyle JE, Webb-Robertson BJ, Waters KM, Metz TO, Farin F, Oberlies NH, Polyak SJ.

J Nat Prod. 2015 Aug 28;78(8):1990-2000. doi: 10.1021/acs.jnatprod.5b00288. Epub 2015 Jul 17.

14.

Human Cytokinome Analysis for Interferon Response.

Al-Yahya S, Mahmoud L, Al-Zoghaibi F, Al-Tuhami A, Amer H, Almajhdi FN, Polyak SJ, Khabar KS.

J Virol. 2015 Jul;89(14):7108-19. doi: 10.1128/JVI.03729-14. Epub 2015 Apr 29.

15.

Enantioselective synthesis, stereochemical correction, and biological investigation of the rodgersinine family of 1,4-benzodioxane neolignans.

Pilkington LI, Wagoner J, Polyak SJ, Barker D.

Org Lett. 2015 Feb 20;17(4):1046-9. doi: 10.1021/acs.orglett.5b00189. Epub 2015 Feb 11.

PMID:
25671292
16.

Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression.

Stone AE, Mitchell A, Brownell J, Miklin DJ, Golden-Mason L, Polyak SJ, Gale MJ Jr, Rosen HR.

PLoS One. 2014 May 1;9(5):e95627. doi: 10.1371/journal.pone.0095627. eCollection 2014.

17.

Arbidol as a broad-spectrum antiviral: an update.

Blaising J, Polyak SJ, Pécheur EI.

Antiviral Res. 2014 Jul;107:84-94. doi: 10.1016/j.antiviral.2014.04.006. Epub 2014 Apr 24. Review.

PMID:
24769245
18.

Inhibition of HIV by Legalon-SIL is independent of its effect on cellular metabolism.

McClure J, Margineantu DH, Sweet IR, Polyak SJ.

Virology. 2014 Jan 20;449:96-103. doi: 10.1016/j.virol.2013.11.003. Epub 2013 Nov 27.

19.

Direct, interferon-independent activation of the CXCL10 promoter by NF-κB and interferon regulatory factor 3 during hepatitis C virus infection.

Brownell J, Bruckner J, Wagoner J, Thomas E, Loo YM, Gale M Jr, Liang TJ, Polyak SJ.

J Virol. 2014 Feb;88(3):1582-90. doi: 10.1128/JVI.02007-13. Epub 2013 Nov 20.

20.

Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking.

Blaising J, Lévy PL, Polyak SJ, Stanifer M, Boulant S, Pécheur EI.

Antiviral Res. 2013 Oct;100(1):215-9. doi: 10.1016/j.antiviral.2013.08.008. Epub 2013 Aug 25.

PMID:
23981392
21.

Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes.

Brownell J, Wagoner J, Lovelace ES, Thirstrup D, Mohar I, Smith W, Giugliano S, Li K, Crispe IN, Rosen HR, Polyak SJ.

J Hepatol. 2013 Oct;59(4):701-8. doi: 10.1016/j.jhep.2013.06.001. Epub 2013 Jun 12.

22.

The circulatory orbit of micro-RNAs in hepatitis C.

Polyak SJ.

Hepatology. 2013 Sep;58(3):847-9. doi: 10.1002/hep.26508. Epub 2013 Jul 29. No abstract available.

PMID:
23712324
23.

Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking.

Blaising J, Lévy PL, Gondeau C, Phelip C, Varbanov M, Teissier E, Ruggiero F, Polyak SJ, Oberlies NH, Ivanovic T, Boulant S, Pécheur EI.

Cell Microbiol. 2013 Nov;15(11):1866-82. doi: 10.1111/cmi.12155. Epub 2013 Jun 14.

PMID:
23701235
24.

Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.

Althagafy HS, Graf TN, Sy-Cordero AA, Gufford BT, Paine MF, Wagoner J, Polyak SJ, Croatt MP, Oberlies NH.

Bioorg Med Chem. 2013 Jul 1;21(13):3919-26. doi: 10.1016/j.bmc.2013.04.017. Epub 2013 Apr 16.

25.

Molecular pathways: hepatitis C virus, CXCL10, and the inflammatory road to liver cancer.

Brownell J, Polyak SJ.

Clin Cancer Res. 2013 Mar 15;19(6):1347-52. doi: 10.1158/1078-0432.CCR-12-0928. Epub 2013 Jan 15. Review.

26.

Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.

Esser-Nobis K, Romero-Brey I, Ganten TM, Gouttenoire J, Harak C, Klein R, Schemmer P, Binder M, Schnitzler P, Moradpour D, Bartenschlager R, Polyak SJ, Stremmel W, Penin F, Eisenbach C, Lohmann V.

Hepatology. 2013 Mar;57(3):953-63. doi: 10.1002/hep.26260. Epub 2013 Feb 7.

27.

Enhanced bioactivity of silybin B methylation products.

Sy-Cordero AA, Graf TN, Runyon SP, Wani MC, Kroll DJ, Agarwal R, Brantley SJ, Paine MF, Polyak SJ, Oberlies NH.

Bioorg Med Chem. 2013 Feb 1;21(3):742-7. doi: 10.1016/j.bmc.2012.11.035. Epub 2012 Dec 5.

28.

Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection.

Polyak SJ, Ferenci P, Pawlotsky JM.

Hepatology. 2013 Mar;57(3):1262-71. doi: 10.1002/hep.26179. Review. No abstract available.

29.

In vitro toxicity assessment of amphiphillic polymer-coated CdSe/ZnS quantum dots in two human liver cell models.

Smith WE, Brownell J, White CC, Afsharinejad Z, Tsai J, Hu X, Polyak SJ, Gao X, Kavanagh TJ, Eaton DL.

ACS Nano. 2012 Nov 27;6(11):9475-84. doi: 10.1021/nn302288r. Epub 2012 Oct 18.

30.

Silymarin for HCV infection.

Polyak SJ, Oberlies NH, Pécheur EI, Dahari H, Ferenci P, Pawlotsky JM.

Antivir Ther. 2013;18(2):141-7. doi: 10.3851/IMP2402. Epub 2012 Sep 25. Review.

31.

Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation.

McClure J, Lovelace ES, Elahi S, Maurice NJ, Wagoner J, Dragavon J, Mittler JE, Kraft Z, Stamatatos L, Horton H, De Rosa SC, Coombs RW, Polyak SJ.

PLoS One. 2012;7(7):e41832. doi: 10.1371/journal.pone.0041832. Epub 2012 Jul 25. Erratum in: PLoS One. 2012;7(10). doi: 10.1371/annotation/78ba072a-6b7a-430a-8fcd-ef020e4fc458. Stamatatos, Leonidis [corrected to Stamatatos, Leonidas].

32.

A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses.

Polyak SJ, Morishima C, Scott JD, Gastaminza P, Cox A, de Araújo ES, Higgs MR, Loo YM, Golden-Mason L, Lindenbach BD, Baumert TF, Randall G, Gale M Jr.

Gastroenterology. 2012 Jan;142(1):e1-5. doi: 10.1053/j.gastro.2011.11.002. No abstract available. Erratum in: Gastroenterology. 2012 Feb;142(2):411. Gastaminza, Pablo [added].

PMID:
22185796
33.

Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species.

Tacke RS, Lee HC, Goh C, Courtney J, Polyak SJ, Rosen HR, Hahn YS.

Hepatology. 2012 Feb;55(2):343-53. doi: 10.1002/hep.24700.

34.

Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism.

Goldwasser J, Cohen PY, Lin W, Kitsberg D, Balaguer P, Polyak SJ, Chung RT, Yarmush ML, Nahmias Y.

J Hepatol. 2011 Nov;55(5):963-71. doi: 10.1016/j.jhep.2011.02.011. Epub 2011 Feb 24.

35.

Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation.

Wagoner J, Morishima C, Graf TN, Oberlies NH, Teissier E, Pécheur EI, Tavis JE, Polyak SJ.

PLoS One. 2011 Jan 28;6(1):e16464. doi: 10.1371/journal.pone.0016464.

36.

Assemble and Interact: Pleiotropic Functions of the HCV Core Protein.

Polyak SJ, Klein KC, Shoji I, Miyamura T, Lingappa JR.

In: Tan SL, editor. Hepatitis C Viruses: Genomes and Molecular Biology. Norfolk (UK): Horizon Bioscience; 2006. Chapter 3.

37.

Multiple effects of silymarin on the hepatitis C virus lifecycle.

Wagoner J, Negash A, Kane OJ, Martinez LE, Nahmias Y, Bourne N, Owen DM, Grove J, Brimacombe C, McKeating JA, Pécheur EI, Graf TN, Oberlies NH, Lohmann V, Cao F, Tavis JE, Polyak SJ.

Hepatology. 2010 Jun;51(6):1912-21. doi: 10.1002/hep.23587.

38.

A versatile ribosomal protein promoter-based reporter system for selective assessment of RNA stability and post-transcriptional control.

Hitti E, Al-Yahya S, Al-Saif M, Mohideen P, Mahmoud L, Polyak SJ, Khabar KS.

RNA. 2010 Jun;16(6):1245-55. doi: 10.1261/rna.2026310. Epub 2010 Apr 23.

39.

Identification of hepatoprotective flavonolignans from silymarin.

Polyak SJ, Morishima C, Lohmann V, Pal S, Lee DY, Liu Y, Graf TN, Oberlies NH.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5995-9. doi: 10.1073/pnas.0914009107. Epub 2010 Mar 15.

40.

A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.

Mengshol JA, Golden-Mason L, Arikawa T, Smith M, Niki T, McWilliams R, Randall JA, McMahan R, Zimmerman MA, Rangachari M, Dobrinskikh E, Busson P, Polyak SJ, Hirashima M, Rosen HR.

PLoS One. 2010 Mar 4;5(3):e9504. doi: 10.1371/journal.pone.0009504. Erratum in: PLoS One. 2010;5(3). doi: 10.1371/annotation/d15b793c-85c7-4529-bc80-aabcb088a8cf.

41.

Functional characterization of core genes from patients with acute hepatitis C virus infection.

Tang X, Wagoner J, Negash A, Austin M, McLauchlan J, Hahn YS, Rosen HR, Polyak SJ.

J Infect Dis. 2010 Mar 15;201(6):912-22. doi: 10.1086/650699.

42.

Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1.

Pal S, Polyak SJ, Bano N, Qiu WC, Carithers RL, Shuhart M, Gretch DR, Das A.

J Gastroenterol Hepatol. 2010 Mar;25(3):627-34. doi: 10.1111/j.1440-1746.2009.06128.x. Epub 2010 Jan 14.

43.

HCV research 20 years after discovery: a summary of the 16th international symposium on hepatitis C virus and related viruses.

Pawlotsky JM, Cocquerel L, Durantel D, Lavillette D, Lerat H, Pécheur EI, Polyak SJ, Tautz N, Thimme R.

Gastroenterology. 2010 Jan;138(1):6-12.e1-2. doi: 10.1053/j.gastro.2009.11.018. Epub 2009 Nov 18. No abstract available.

PMID:
19931267
44.

Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection.

Morishima C, Shuhart MC, Wang CC, Paschal DM, Apodaca MC, Liu Y, Sloan DD, Graf TN, Oberlies NH, Lee DY, Jerome KR, Polyak SJ.

Gastroenterology. 2010 Feb;138(2):671-81, 681.e1-2. doi: 10.1053/j.gastro.2009.09.021. Epub 2009 Sep 24.

45.

Antiviral effects of silymarin against hepatitis C: the jury is still out.

Polyak SJ, Morishima C, Hawke R.

Hepatology. 2008 Jul;48(1):345-6. doi: 10.1002/hep.22235. No abstract available.

PMID:
18509876
46.

Arbidol: a broad-spectrum antiviral compound that blocks viral fusion.

Boriskin YS, Leneva IA, Pécheur EI, Polyak SJ.

Curr Med Chem. 2008;15(10):997-1005. Review.

PMID:
18393857
47.

Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop.

Chung RT, Gale M Jr, Polyak SJ, Lemon SM, Liang TJ, Hoofnagle JH.

Hepatology. 2008 Jan;47(1):306-20. No abstract available.

48.

Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells.

Wertheimer AM, Polyak SJ, Leistikow R, Rosen HR.

Hepatology. 2007 Jun;45(6):1422-32. Erratum in: Hepatology. 2007 Aug;46(2):610.

PMID:
17538964
49.

Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin.

Polyak SJ, Morishima C, Shuhart MC, Wang CC, Liu Y, Lee DY.

Gastroenterology. 2007 May;132(5):1925-36. Epub 2007 Feb 21.

PMID:
17484885
50.

Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol.

Pécheur EI, Lavillette D, Alcaras F, Molle J, Boriskin YS, Roberts M, Cosset FL, Polyak SJ.

Biochemistry. 2007 May 22;46(20):6050-9. Epub 2007 Apr 25.

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