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Items: 1 to 50 of 53

1.

Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop.

Akkina R, Barber DL, Bility MT, Bissig KD, Burwitz BJ, Eichelberg K, Endsley JJ, Garcia JV, Hafner R, Karakousis PC, Korba BE, Koshy R, Lambros C, Menne S, Nuermberger EL, Ploss A, Podell BK, Poluektova LY, Sanders-Beer BE, Subbian S, Wahl A.

Curr HIV Res. 2019 Dec 22. doi: 10.2174/1570162X18666191223114019. [Epub ahead of print]

PMID:
31870268
2.

Alcohol Metabolism Potentiates HIV-Induced Hepatotoxicity: Contribution to End-Stage Liver Disease.

Ganesan M, New-Aaron M, Dagur RS, Makarov E, Wang W, Kharbanda KK, Kidambi S, Poluektova LY, Osna NA.

Biomolecules. 2019 Dec 10;9(12). pii: E851. doi: 10.3390/biom9120851.

3.

miR-15a-5p, miR-15b-5p, and miR-16-5p inhibit tumor progression by directly targeting MYCN in neuroblastoma.

Chava S, Reynolds CP, Pathania AS, Gorantla S, Poluektova LY, Coulter DW, Gupta SC, Pandey MK, Challagundla KB.

Mol Oncol. 2020 Jan;14(1):180-196. doi: 10.1002/1878-0261.12588. Epub 2019 Nov 29.

4.

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis.

Dagur RS, Wang W, Makarov E, Sun Y, Poluektova LY.

J Vis Exp. 2019 Sep 11;(151). doi: 10.3791/58645.

5.

Eluted 25-hydroxyvitamin D3 from radially aligned nanofiber scaffolds enhances cathelicidin production while reducing inflammatory response in human immune system-engrafted mice.

Chen S, Ge L, Wang H, Cheng Y, Gorantla S, Poluektova LY, Gombart AF, Xie J.

Acta Biomater. 2019 Oct 1;97:187-199. doi: 10.1016/j.actbio.2019.08.005. Epub 2019 Aug 3.

PMID:
31386930
6.

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice.

Dash PK, Kaminski R, Bella R, Su H, Mathews S, Ahooyi TM, Chen C, Mancuso P, Sariyer R, Ferrante P, Donadoni M, Robinson JA, Sillman B, Lin Z, Hilaire JR, Banoub M, Elango M, Gautam N, Mosley RL, Poluektova LY, McMillan J, Bade AN, Gorantla S, Sariyer IK, Burdo TH, Young WB, Amini S, Gordon J, Jacobson JM, Edagwa B, Khalili K, Gendelman HE.

Nat Commun. 2019 Jul 2;10(1):2753. doi: 10.1038/s41467-019-10366-y.

7.

Small molecule ONC201 inhibits HIV-1 replication in macrophages via FOXO3a and TRAIL.

Zhao R, Li Y, Gorantla S, Poluektova LY, Lin H, Gao F, Wang H, Zhao J, Zheng JC, Huang Y.

Antiviral Res. 2019 Aug;168:134-145. doi: 10.1016/j.antiviral.2019.05.015. Epub 2019 May 31.

8.

Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes.

Ganesan M, Krutik VM, Makarov E, Mathews S, Kharbanda KK, Poluektova LY, Casey CA, Osna NA.

Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G127-G140. doi: 10.1152/ajpgi.00064.2019. Epub 2019 May 29.

PMID:
31141391
9.

Immune Activations and Viral Tissue Compartmentalization During Progressive HIV-1 Infection of Humanized Mice.

Su H, Cheng Y, Sravanam S, Mathews S, Gorantla S, Poluektova LY, Dash PK, Gendelman HE.

Front Immunol. 2019 Feb 28;10:340. doi: 10.3389/fimmu.2019.00340. eCollection 2019.

10.

Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice.

Mathews S, Branch Woods A, Katano I, Makarov E, Thomas MB, Gendelman HE, Poluektova LY, Ito M, Gorantla S.

Mol Neurodegener. 2019 Mar 5;14(1):12. doi: 10.1186/s13024-019-0311-y.

11.

Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression.

Ganesan M, Poluektova LY, Kharbanda KK, Osna NA.

World J Gastroenterol. 2019 Jan 28;25(4):398-410. doi: 10.3748/wjg.v25.i4.398. Review.

12.

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection.

Dagur RS, Branch-Woods A, Mathews S, Joshi PS, Quadros RM, Harms DW, Cheng Y, Miles SM, Pirruccello SJ, Gurumurthy CB, Gorantla S, Poluektova LY.

BMC Immunol. 2019 Jan 7;20(1):2. doi: 10.1186/s12865-018-0279-3.

13.

Liver as a target of human immunodeficiency virus infection.

Ganesan M, Poluektova LY, Kharbanda KK, Osna NA.

World J Gastroenterol. 2018 Nov 14;24(42):4728-4737. doi: 10.3748/wjg.v24.i42.4728. Review.

14.

Hepatitis C Virus-Infected Apoptotic Hepatocytes Program Macrophages and Hepatic Stellate Cells for Liver Inflammation and Fibrosis Development: Role of Ethanol as a Second Hit.

Ganesan M, Poluektova LY, Enweluzo C, Kharbanda KK, Osna NA.

Biomolecules. 2018 Oct 13;8(4). pii: E113. doi: 10.3390/biom8040113.

15.

Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice.

Olson KE, Bade AN, Namminga KL, Potash MJ, Mosley RL, Poluektova LY, Volsky DJ, Gendelman HE.

J Neurovirol. 2018 Aug;24(4):398-410. doi: 10.1007/s13365-018-0629-1. Epub 2018 Mar 28.

16.

Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice.

McMillan JM, Cobb DA, Lin Z, Banoub MG, Dagur RS, Branch Woods AA, Wang W, Makarov E, Kocher T, Joshi PS, Quadros RM, Harms DW, Cohen SM, Gendelman HE, Gurumurthy CB, Gorantla S, Poluektova LY.

J Pharmacol Exp Ther. 2018 May;365(2):272-280. doi: 10.1124/jpet.117.247288. Epub 2018 Feb 23.

17.

Creation of a long-acting nanoformulated dolutegravir.

Sillman B, Bade AN, Dash PK, Bhargavan B, Kocher T, Mathews S, Su H, Kanmogne GD, Poluektova LY, Gorantla S, McMillan J, Gautam N, Alnouti Y, Edagwa B, Gendelman HE.

Nat Commun. 2018 Feb 6;9(1):443. doi: 10.1038/s41467-018-02885-x.

18.

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice.

Dagur RS, Wang W, Cheng Y, Makarov E, Ganesan M, Suemizu H, Gebhart CL, Gorantla S, Osna N, Poluektova LY.

Biol Open. 2018 Feb 13;7(2). pii: bio029785. doi: 10.1242/bio.029785.

19.

Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains.

Li W, Gorantla S, Gendelman HE, Poluektova LY.

Dis Model Mech. 2017 Dec 19;10(12):1489-1502. doi: 10.1242/dmm.031773.

20.

Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection.

Singh VB, Singh MV, Piekna-Przybylska D, Gorantla S, Poluektova LY, Maggirwar SB.

Sci Rep. 2017 Aug 29;7(1):9578. doi: 10.1038/s41598-017-10241-0.

21.

A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy.

Araínga M, Edagwa B, Mosley RL, Poluektova LY, Gorantla S, Gendelman HE.

Retrovirology. 2017 Mar 9;14(1):17. doi: 10.1186/s12977-017-0344-7.

22.

Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18.

Ganesan M, Poluektova LY, Tuma DJ, Kharbanda KK, Osna NA.

Alcohol Clin Exp Res. 2016 Nov;40(11):2329-2338. doi: 10.1111/acer.13226. Epub 2016 Sep 26.

23.

Neuropharmacologic Approaches to Restore the Brain's Microenvironment.

Li W, Tong HI, Gorantla S, Poluektova LY, Gendelman HE, Lu Y.

J Neuroimmune Pharmacol. 2016 Sep;11(3):484-94. doi: 10.1007/s11481-016-9686-5. Epub 2016 Jun 28. Review.

24.

Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice.

Singh VB, Singh MV, Gorantla S, Poluektova LY, Maggirwar SB.

Sci Rep. 2016 May 31;6:26876. doi: 10.1038/srep26876.

25.

HIV-1 cellular and tissue replication patterns in infected humanized mice.

Araínga M, Su H, Poluektova LY, Gorantla S, Gendelman HE.

Sci Rep. 2016 Mar 21;6:23513. doi: 10.1038/srep23513.

26.

Simple and reliable genotyping protocol for mouse Prkdc(SCID) mutation.

Quadros RM, Poluektova LY, Gurumurthy CB.

J Immunol Methods. 2016 Apr;431:60-2. doi: 10.1016/j.jim.2016.02.002. Epub 2016 Feb 3.

27.

Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.

Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA.

AIDS Res Hum Retroviruses. 2016 Feb;32(2):109-19. doi: 10.1089/AID.2015.0258.

28.

The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy.

Zhang G, Guo D, Dash PK, Araínga M, Wiederin JL, Haverland NA, Knibbe-Hollinger J, Martinez-Skinner A, Ciborowski P, Goodfellow VS, Wysocki TA, Wysocki BJ, Poluektova LY, Liu XM, McMillan JM, Gorantla S, Gelbard HA, Gendelman HE.

Nanomedicine. 2016 Jan;12(1):109-22. doi: 10.1016/j.nano.2015.09.009. Epub 2015 Oct 22.

29.

Influence of age, irradiation and humanization on NSG mouse phenotypes.

Knibbe-Hollinger JS, Fields NR, Chaudoin TR, Epstein AA, Makarov E, Akhter SP, Gorantla S, Bonasera SJ, Gendelman HE, Poluektova LY.

Biol Open. 2015 Sep 9;4(10):1243-52. doi: 10.1242/bio.013201.

30.

Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics.

Zhang J, Garrison JC, Poluektova LY, Bronich TK, Osna NA.

Biomaterials. 2015 Nov;70:37-47. doi: 10.1016/j.biomaterials.2015.08.014. Epub 2015 Aug 8.

31.

Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice.

Bade AN, Gorantla S, Dash PK, Makarov E, Sajja BR, Poluektova LY, Luo J, Gendelman HE, Boska MD, Liu Y.

Mol Neurobiol. 2016 Jul;53(5):3286-3297. doi: 10.1007/s12035-015-9258-3. Epub 2015 Jun 11.

32.

Amphiphilic cationic nanogels as brain-targeted carriers for activated nucleoside reverse transcriptase inhibitors.

Warren G, Makarov E, Lu Y, Senanayake T, Rivera K, Gorantla S, Poluektova LY, Vinogradov SV.

J Neuroimmune Pharmacol. 2015 Mar;10(1):88-101. doi: 10.1007/s11481-014-9576-7. Epub 2015 Jan 6.

33.

Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice.

Boska MD, Dash PK, Knibbe J, Epstein AA, Akhter SP, Fields N, High R, Makarov E, Bonasera S, Gelbard HA, Poluektova LY, Gendelman HE, Gorantla S.

Mol Neurodegener. 2014 Dec 18;9:58. doi: 10.1186/1750-1326-9-58.

34.

Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations.

Puligujja P, Balkundi SS, Kendrick LM, Baldridge HM, Hilaire JR, Bade AN, Dash PK, Zhang G, Poluektova LY, Gorantla S, Liu XM, Ying T, Feng Y, Wang Y, Dimitrov DS, McMillan JM, Gendelman HE.

Biomaterials. 2015 Feb;41:141-50. doi: 10.1016/j.biomaterials.2014.11.012. Epub 2014 Dec 9.

35.

Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice.

Gutti TL, Knibbe JS, Makarov E, Zhang J, Yannam GR, Gorantla S, Sun Y, Mercer DF, Suemizu H, Wisecarver JL, Osna NA, Bronich TK, Poluektova LY.

Am J Pathol. 2014 Jan;184(1):101-9. doi: 10.1016/j.ajpath.2013.09.008. Epub 2013 Nov 6.

36.

Nano-NRTIs demonstrate low neurotoxicity and high antiviral activity against HIV infection in the brain.

Gerson T, Makarov E, Senanayake TH, Gorantla S, Poluektova LY, Vinogradov SV.

Nanomedicine. 2014 Jan;10(1):177-85. doi: 10.1016/j.nano.2013.06.012. Epub 2013 Jul 9.

37.

Improved visualization of neuronal injury following glial activation by manganese enhanced MRI.

Bade AN, Zhou B, Epstein AA, Gorantla S, Poluektova LY, Luo J, Gendelman HE, Boska MD, Liu Y.

J Neuroimmune Pharmacol. 2013 Sep;8(4):1027-36. doi: 10.1007/s11481-013-9475-3. Epub 2013 Jun 1.

38.

Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection.

Epstein AA, Narayanasamy P, Dash PK, High R, Bathena SP, Gorantla S, Poluektova LY, Alnouti Y, Gendelman HE, Boska MD.

J Neuroimmune Pharmacol. 2013 Dec;8(5):1224-38. doi: 10.1007/s11481-013-9461-9. Epub 2013 May 24.

39.

Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection.

Zhang J, Mulvenon A, Makarov E, Wagoner J, Knibbe J, Kim JO, Osna N, Bronich TK, Poluektova LY.

Biomaterials. 2013 May;34(15):3846-57. doi: 10.1016/j.biomaterials.2013.01.026. Epub 2013 Feb 10.

40.

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice.

Dash PK, Gendelman HE, Roy U, Balkundi S, Alnouti Y, Mosley RL, Gelbard HA, McMillan J, Gorantla S, Poluektova LY.

AIDS. 2012 Nov 13;26(17):2135-44. doi: 10.1097/QAD.0b013e328357f5ad.

41.

Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice.

Oberoi HS, Nukolova NV, Laquer FC, Poluektova LY, Huang J, Alnouti Y, Yokohira M, Arnold LL, Kabanov AV, Cohen SM, Bronich TK.

Int J Nanomedicine. 2012;7:2557-71. doi: 10.2147/IJN.S29145. Epub 2012 Jun 8.

42.

Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders?

Gorantla S, Gendelman HE, Poluektova LY.

J Neuroimmune Pharmacol. 2012 Jun;7(2):352-62. doi: 10.1007/s11481-011-9335-y. Epub 2012 Jan 7. Review.

43.

IL-23 in infections, inflammation, autoimmunity and cancer: possible role in HIV-1 and AIDS.

Yannam GR, Gutti T, Poluektova LY.

J Neuroimmune Pharmacol. 2012 Mar;7(1):95-112. doi: 10.1007/s11481-011-9315-2. Epub 2011 Sep 24. Review.

44.

Loss of neuronal integrity during progressive HIV-1 infection of humanized mice.

Dash PK, Gorantla S, Gendelman HE, Knibbe J, Casale GP, Makarov E, Epstein AA, Gelbard HA, Boska MD, Poluektova LY.

J Neurosci. 2011 Mar 2;31(9):3148-57. doi: 10.1523/JNEUROSCI.5473-10.2011.

45.

Nano-NRTIs: efficient inhibitors of HIV type-1 in macrophages with a reduced mitochondrial toxicity.

Vinogradov SV, Poluektova LY, Makarov E, Gerson T, Senanayake MT.

Antivir Chem Chemother. 2010 Oct 28;21(1):1-14. doi: 10.3851/IMP1680.

46.

CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.

Gorantla S, Makarov E, Finke-Dwyer J, Gebhart CL, Domm W, Dewhurst S, Gendelman HE, Poluektova LY.

J Immunol. 2010 Jun 15;184(12):7082-91. doi: 10.4049/jimmunol.1000438. Epub 2010 May 21.

47.

Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase.

Li B, Duysen EG, Poluektova LY, Murrin LC, Lockridge O.

Toxicol Appl Pharmacol. 2006 Jul 15;214(2):152-65. Epub 2006 Jan 26.

PMID:
16443250
48.

Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis.

Dou H, Ellison B, Bradley J, Kasiyanov A, Poluektova LY, Xiong H, Maggirwar S, Dewhurst S, Gelbard HA, Gendelman HE.

J Neurosci. 2005 Sep 14;25(37):8375-85.

49.

OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis.

Carlson KA, Limoges J, Pohlman GD, Poluektova LY, Langford D, Masliah E, Ikezu T, Gendelman HE.

J Neuroimmunol. 2004 May;150(1-2):186-98.

PMID:
15081264
50.

Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis.

Dou H, Birusingh K, Faraci J, Gorantla S, Poluektova LY, Maggirwar SB, Dewhurst S, Gelbard HA, Gendelman HE.

J Neurosci. 2003 Oct 8;23(27):9162-70.

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