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Items: 24

1.

Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.

Casale E, Amboldi N, Brasca MG, Caronni D, Colombo N, Dalvit C, Felder ER, Fogliatto G, Galvani A, Isacchi A, Polucci P, Riceputi L, Sola F, Visco C, Zuccotto F, Casuscelli F.

Bioorg Med Chem. 2014 Aug 1;22(15):4135-50. doi: 10.1016/j.bmc.2014.05.056. Epub 2014 Jun 14.

PMID:
24980703
2.

Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90).

Brasca MG, Mantegani S, Amboldi N, Bindi S, Caronni D, Casale E, Ceccarelli W, Colombo N, De Ponti A, Donati D, Ermoli A, Fachin G, Felder ER, Ferguson RD, Fiorelli C, Guanci M, Isacchi A, Pesenti E, Polucci P, Riceputi L, Sola F, Visco C, Zuccotto F, Fogliatto G.

Bioorg Med Chem. 2013 Nov 15;21(22):7047-63. doi: 10.1016/j.bmc.2013.09.018. Epub 2013 Sep 19. Erratum in: Bioorg Med Chem. 2014 Jan 1;22(1):662.

PMID:
24100158
3.

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.

Magnaghi P, D'Alessio R, Valsasina B, Avanzi N, Rizzi S, Asa D, Gasparri F, Cozzi L, Cucchi U, Orrenius C, Polucci P, Ballinari D, Perrera C, Leone A, Cervi G, Casale E, Xiao Y, Wong C, Anderson DJ, Galvani A, Donati D, O'Brien T, Jackson PK, Isacchi A.

Nat Chem Biol. 2013 Sep;9(9):548-56. doi: 10.1038/nchembio.1313. Epub 2013 Jul 28.

PMID:
23892893
4.

NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases.

Fogliatto G, Gianellini L, Brasca MG, Casale E, Ballinari D, Ciomei M, Degrassi A, De Ponti A, Germani M, Guanci M, Paolucci M, Polucci P, Russo M, Sola F, Valsasina B, Visco C, Zuccotto F, Donati D, Felder E, Pesenti E, Galvani A, Mantegani S, Isacchi A.

Clin Cancer Res. 2013 Jul 1;19(13):3520-32. doi: 10.1158/1078-0432.CCR-12-3512. Epub 2013 May 14.

5.

Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.

Polucci P, Magnaghi P, Angiolini M, Asa D, Avanzi N, Badari A, Bertrand J, Casale E, Cauteruccio S, Cirla A, Cozzi L, Galvani A, Jackson PK, Liu Y, Magnuson S, Malgesini B, Nuvoloni S, Orrenius C, Sirtori FR, Riceputi L, Rizzi S, Trucchi B, O'Brien T, Isacchi A, Donati D, D'Alessio R.

J Med Chem. 2013 Jan 24;56(2):437-50. doi: 10.1021/jm3013213. Epub 2013 Jan 4.

PMID:
23245311
6.

Benzodipyrazoles: a new class of potent CDK2 inhibitors.

D'Alessio R, Bargiotti A, Metz S, Brasca MG, Cameron A, Ermoli A, Marsiglio A, Polucci P, Roletto F, Tibolla M, Vazquez ML, Vulpetti A, Pevarello P.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1315-9.

PMID:
15713378
7.

Catecholic flavonoids acting as telomerase inhibitors.

Menichincheri M, Ballinari D, Bargiotti A, Bonomini L, Ceccarelli W, D'Alessio R, Fretta A, Moll J, Polucci P, Soncini C, Tibolla M, Trosset JY, Vanotti E.

J Med Chem. 2004 Dec 16;47(26):6466-75.

PMID:
15588081
8.
9.

Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agents.

Antonini I, Polucci P, Magnano A, Gatto B, Palumbo M, Menta E, Pescalli N, Martelli S.

J Med Chem. 2003 Jul 3;46(14):3109-15.

PMID:
12825949
10.

Rational design, synthesis and biological evaluation of thiadiazinoacridines: a new class of antitumor agents.

Antonini I, Polucci P, Magnano A, Cacciamani D, Konieczny MT, Paradziej-Ɓukowicz J, Martelli S.

Bioorg Med Chem. 2003 Feb 6;11(3):399-405.

PMID:
12517435
11.

Binding free energy of selected anticancer compounds to DNA--theoretical calculations.

Baginski M, Polucci P, Antonini I, Martelli S.

J Mol Model. 2002 Jan;8(1):24-32.

PMID:
12111399
12.

2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: novel, potent, cytotoxic, and DNA-binding agents.

Antonini I, Polucci P, Magnano A, Gatto B, Palumbo M, Menta E, Pescalli N, Martelli S.

J Med Chem. 2002 Jan 31;45(3):696-702.

PMID:
11806721
13.
14.

N4-(omega-Aminoalkyl)-1-[(omega-aminoalkyl)amino]-4- acridinecarboxamides: novel, potent, cytotoxic, and DNA-binding agents.

Antonini I, Polucci P, Kelland LR, Spinelli S, Pescalli N, Martelli S.

J Med Chem. 2000 Dec 14;43(25):4801-5.

PMID:
11123989
15.

Pyrimido[4,5,6-kl]acridines. Synthesis, in vitro cytotoxicity and structure-activity relationships.

Antonini I, Polucci P, Martelli S.

Anticancer Drug Des. 1999 Oct;14(5):451-9.

PMID:
10766300
17.

1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.

Perry PJ, Gowan SM, Reszka AP, Polucci P, Jenkins TC, Kelland LR, Neidle S.

J Med Chem. 1998 Aug 13;41(17):3253-60.

PMID:
9703471
18.

1-[(omega-aminoalkyl)amino]-4-[N-(omega-aminoalkyl)carbamoyl]-9-oxo-9, 10-dihydroacridines as intercalating cytotoxic agents: synthesis, DNA binding, and biological evaluation.

Antonini I, Polucci P, Jenkins TC, Kelland LR, Menta E, Pescalli N, Stefanska B, Mazerski J, Martelli S.

J Med Chem. 1997 Nov 7;40(23):3749-55.

PMID:
9371240
19.

Pyrimido [4,5,6-kl] acridines, a new class of potential anticancer agents. Synthesis and biological evaluation.

Antonini I, Polucci P, Cola D, Bontemps-Gracz M, Pescalli N, Menta E, Martelli S.

Anticancer Drug Des. 1996 Jun;11(4):339-49.

PMID:
8679056
20.
21.

Synthesis of (dialkylamino)alkyl-disubstituted pyrimido[5,6,1- de]acridines, a novel group of anticancer agents active on a multidrug resistant cell line.

Antonini I, Cola D, Polucci P, Bontemps-Gracz M, Borowski E, Martelli S.

J Med Chem. 1995 Aug 18;38(17):3282-6.

PMID:
7650682
22.

A molecular anchor for stabilizing triple-helical DNA.

Fox KR, Polucci P, Jenkins TC, Neidle S.

Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7887-91.

23.

Synthesis of 9,10-anthraquinone monoalkylaminoalkylhydrazones as potential antitumor drugs.

Antonini I, Polucci P, Cola D, Palmieri G, Martelli S, Bontemps-Gracz M.

Farmaco. 1993 Dec;48(12):1641-8.

PMID:
8135988
24.

Synthesis of 7-oxo-7H-benzo[e]perimidine-4-carboxamides as potential antitumor drugs.

Antonini I, Polucci P, Cola D, Filippo Palmieri G, Martelli S.

Farmaco. 1992 Nov;47(11):1385-93.

PMID:
1492902

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