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Items: 46

1.

A Novel Angiotensin-(1-7)-glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation Related Memory Dysfunction.

Hay M, Polt R, Heien ML, Vanderah TW, Largen-Milnes TM, Rodgers KE, Falk T, Bartlett MJ, Doyle K, Konhilas J.

J Pharmacol Exp Ther. 2019 Feb 1. pii: jpet.118.254854. doi: 10.1124/jpet.118.254854. [Epub ahead of print]

2.

An update on sphingosine-1-phosphate receptor 1 modulators.

Marciniak A, Camp SM, Garcia JGN, Polt R.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3585-3591. doi: 10.1016/j.bmcl.2018.10.042. Epub 2018 Oct 26. Review.

PMID:
30409535
3.

Biodegradability and toxicity of monorhamnolipid biosurfactant diastereomers.

Hogan DE, Tian F, Malm SW, Olivares C, Palos Pacheco R, Simonich MT, Hunjan AS, Tanguay RL, Klimecki WT, Polt R, Pemberton JE, Curry JE, Maier RM.

J Hazard Mater. 2019 Feb 15;364:600-607. doi: 10.1016/j.jhazmat.2018.10.050. Epub 2018 Nov 1.

PMID:
30390580
4.

The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia.

Flores AJ, Bartlett MJ, Root BK, Parent KL, Heien ML, Porreca F, Polt R, Sherman SJ, Falk T.

Neuropharmacology. 2018 Oct;141:260-271. doi: 10.1016/j.neuropharm.2018.09.005. Epub 2018 Sep 7.

PMID:
30201210
5.

Synthesis and Characterization of Four Diastereomers of Monorhamnolipids.

Palos Pacheco R, Eismin RJ, Coss CS, Wang H, Maier RM, Polt R, Pemberton JE.

J Am Chem Soc. 2017 Apr 3. doi: 10.1021/jacs.7b00427. [Epub ahead of print]

PMID:
28301722
6.

Preparation of S-glycoside surfactants and cysteine thioglycosides using minimally competent Lewis acid catalysis.

Szabó LZ, Hanrahan DJ, Jones EM, Martin E, Pemberton JE, Polt R.

Carbohydr Res. 2016 Mar 3;422:1-4. doi: 10.1016/j.carres.2015.12.008. Epub 2016 Jan 6.

PMID:
26795078
7.

CNS active O-linked glycopeptides.

Jones EM, Polt R.

Front Chem. 2015 Jun 24;3:40. doi: 10.3389/fchem.2015.00040. eCollection 2015. Review.

8.

Structural Requirements for CNS Active Opioid Glycopeptides.

Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R.

J Med Chem. 2015 Aug 13;58(15):5728-41. doi: 10.1021/acs.jmedchem.5b00014. Epub 2015 Jul 23.

PMID:
26125201
9.

The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence.

Stevenson GW, Luginbuhl A, Dunbar C, LaVigne J, Dutra J, Atherton P, Bell B, Cone K, Giuvelis D, Polt R, Streicher JM, Bilsky EJ.

Pharmacol Biochem Behav. 2015 May;132:49-55. doi: 10.1016/j.pbb.2015.02.022. Epub 2015 Feb 28.

10.

Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin?

Li Y, St Louis L, Knapp BI, Muthu D, Anglin B, Giuvelis D, Bidlack JM, Bilsky EJ, Polt R.

J Med Chem. 2014 Mar 27;57(6):2237-46. doi: 10.1021/jm400879w. Epub 2014 Mar 7.

11.

A PM-IRRAS investigation of monorhamnolipid orientation at the air-water interface.

Wang H, Coss CS, Mudalige A, Polt RL, Pemberton JE.

Langmuir. 2013 Apr 9;29(14):4441-50. doi: 10.1021/la3051725. Epub 2013 Mar 26.

PMID:
23406083
12.

CNS penetration of the opioid glycopeptide MMP-2200: a microdialysis study.

Mabrouk OS, Falk T, Sherman SJ, Kennedy RT, Polt R.

Neurosci Lett. 2012 Dec 7;531(2):99-103. doi: 10.1016/j.neulet.2012.10.029. Epub 2012 Nov 2.

13.

Glycosylation of α-amino acids by sugar acetate donors with InBr3. Minimally competent Lewis acids.

Lefever MR, Szabò LZ, Anglin B, Ferracane M, Hogan J, Cooney L, Polt R.

Carbohydr Res. 2012 Apr 1;351:121-5. doi: 10.1016/j.carres.2012.01.008. Epub 2012 Jan 28.

14.

Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins.

Li Y, Lefever MR, Muthu D, Bidlack JM, Bilsky EJ, Polt R.

Future Med Chem. 2012 Feb;4(2):205-26. doi: 10.4155/fmc.11.195. Review.

15.

Effects of the novel glycopeptide opioid agonist MMP-2200 in preclinical models of Parkinson's disease.

Yue X, Falk T, Zuniga LA, Szabò L, Porreca F, Polt R, Sherman SJ.

Brain Res. 2011 Sep 21;1413:72-83. doi: 10.1016/j.brainres.2011.07.038. Epub 2011 Jul 23.

16.

Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments.

Yeomans L, Muthu D, Lowery JJ, Martinez HN, Abrell L, Lin G, Strom K, Knapp BI, Bidlack JM, Bilsky EJ, Polt R.

Chem Biol Drug Des. 2011 Nov;78(5):749-56. doi: 10.1111/j.1747-0285.2011.01203.x. Epub 2011 Sep 26.

17.

In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice.

Lowery JJ, Raymond TJ, Giuvelis D, Bidlack JM, Polt R, Bilsky EJ.

J Pharmacol Exp Ther. 2011 Mar;336(3):767-78. doi: 10.1124/jpet.110.172866. Epub 2010 Nov 30.

18.

(S)-Methyl 2-{(S)-2-[bis-(4-meth-oxy-phen-yl)methyl-idene-amino]-3-hy-droxy-propanamido}-3-methyl-butano-ate.

Keyari CM, Polt R, Nichol GS.

Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 4;67(Pt 1):o13-4. doi: 10.1107/S1600536810049032.

19.

Glycosyl-enkephalins: synthesis and binding at the mu, delta & kappa opioid receptors. Antinociception in mice.

Keyari CM, Knapp BI, Bidlack JM, Lowey J, Bilsky EJ, Polt R.

Adv Exp Med Biol. 2009;611:495-6. No abstract available.

PMID:
19400281
20.

Behavioral pharmacology of the mu/delta opioid glycopeptide MMP2200 in rhesus monkeys.

Do Carmo GP, Polt R, Bilsky EJ, Rice KC, Negus SS.

J Pharmacol Exp Ther. 2008 Sep;326(3):939-48. doi: 10.1124/jpet.108.138180. Epub 2008 May 29.

21.

Structural studies on the neutral glycosphingolipids of Manduca sexta.

Abeytunga DT, Oland L, Somogyi A, Polt R.

Bioorg Chem. 2008 Apr;36(2):70-6. Epub 2007 Nov 19.

22.

Sugar synthesis from a gas-phase formose reaction.

Jalbout AF, Abrell L, Adamowicz L, Polt R, Apponi AJ, Ziurys LM.

Astrobiology. 2007 Jun;7(3):433-42.

PMID:
17630839
23.

Glycosylation improves the central effects of DAMGO.

Lowery JJ, Yeomans L, Keyari CM, Davis P, Porreca F, Knapp BI, Bidlack JM, Bilsky EJ, Polt R.

Chem Biol Drug Des. 2007 Jan;69(1):41-7.

PMID:
17313456
24.

New prospects for glycopeptide based analgesia: glycoside-induced penetration of the blood-brain barrier.

Dhanasekaran M, Polt R.

Curr Drug Deliv. 2005 Jan;2(1):59-73. Review.

PMID:
16305409
25.

Glycosylated neuropeptides: a new vista for neuropsychopharmacology?

Polt R, Dhanasekaran M, Keyari CM.

Med Res Rev. 2005 Sep;25(5):557-85. Review.

PMID:
16075406
26.

Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers.

Dhanasekaran M, Palian MM, Alves I, Yeomans L, Keyari CM, Davis P, Bilsky EJ, Egleton RD, Yamamura HI, Jacobsen NE, Tollin G, Hruby VJ, Porreca F, Polt R.

J Am Chem Soc. 2005 Apr 20;127(15):5435-48.

PMID:
15826181
27.

Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides.

Elmagbari NO, Egleton RD, Palian MM, Lowery JJ, Schmid WR, Davis P, Navratilova E, Dhanasekaran M, Keyari CM, Yamamura HI, Porreca F, Hruby VJ, Polt R, Bilsky EJ.

J Pharmacol Exp Ther. 2004 Oct;311(1):290-7. Epub 2004 May 27.

PMID:
15166257
28.

Presence of unsaturated sphingomyelins and changes in their composition during the life cycle of the moth Manduca sexta.

Abeytunga DT, Glick JJ, Gibson NJ, Oland LA, Somogyi A, Wysocki VH, Polt R.

J Lipid Res. 2004 Jul;45(7):1221-31. Epub 2004 Apr 21.

29.

New PDMP analogues inhibit process outgrowth in an insect cell line.

Slavish JP, Friel DK, Oland LA, Polt R.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1487-90.

PMID:
15006387
30.

Glycopeptide-membrane interactions: glycosyl enkephalin analogues adopt turn conformations by NMR and CD in amphipathic media.

Palian MM, Boguslavsky VI, O'Brien DF, Polt R.

J Am Chem Soc. 2003 May 14;125(19):5823-31.

PMID:
12733923
31.

Optically active 4- and 5-coordinate transition metal complexes of bifurcated dipeptide Schiff bases.

Polt R, Kelly BD, Dangel BD, Tadikonda UB, Ross RE, Raitsimring AM, Astashkin AV.

Inorg Chem. 2003 Jan 27;42(2):566-74.

PMID:
12693240
32.

Improved blood-brain barrier penetration and enhanced analgesia of an opioid peptide by glycosylation.

Egleton RD, Mitchell SA, Huber JD, Palian MM, Polt R, Davis TP.

J Pharmacol Exp Ther. 2001 Dec;299(3):967-72.

PMID:
11714884
33.

Lipo alpha-amino-beta-hydroxy acids and O-linked glycosides: building blocks for ceramyl and glycosphingoyl peptides.

Palian MM, Polt R.

J Org Chem. 2001 Oct 19;66(21):7178-83. No abstract available.

PMID:
11597248
34.

O-Linked glycopeptides retain helicity in water.

Palian MM, Jacobsen NE, Polt R.

J Pept Res. 2001 Aug;58(2):180-9.

PMID:
11532077
35.

Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin.

Mitchell SA, Pratt MR, Hruby VJ, Polt R.

J Org Chem. 2001 Apr 6;66(7):2327-42.

PMID:
11281773
36.

Improved bioavailability to the brain of glycosylated Met-enkephalin analogs.

Egleton RD, Mitchell SA, Huber JD, Janders J, Stropova D, Polt R, Yamamura HI, Hruby VJ, Davis TP.

Brain Res. 2000 Oct 20;881(1):37-46.

PMID:
11033091
39.

Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.

Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R.

J Med Chem. 2000 Jun 29;43(13):2586-90.

PMID:
10891118
40.

[New chemical method for synthesis of O-linked glycopeptides].

Polt RL, Szabo L, Ramza J.

Postepy Hig Med Dosw. 1996;50(5):493-503. Polish.

PMID:
9072765
41.

Antibodies to Campylobacter jejuni react with myelin proteins of the central nervous system.

Polt RJ, Moran AP, Bernheimer H, Schwerer B.

J Infect. 1995 Nov;31(3):249-50. No abstract available.

PMID:
8586851
42.

Stereoselective synthesis of O-serinyl/threoninyl-2-acetamido-2-deoxy-alpha- or beta-glycosides.

Szabó L, Ramza J, Langdon C, Polt R.

Carbohydr Res. 1995 Sep 8;274:11-28.

PMID:
7585702
43.

Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

Polt R, Porreca F, Szabò LZ, Bilsky EJ, Davis P, Abbruscato TJ, Davis TP, Harvath R, Yamamura HI, Hruby VJ.

Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7114-8.

44.

Stereoselective synthesis of beta-D-glycopyranosyl-L-serinate or -threoninate derivatives with an unusual migration.

Szabó L, Polt R.

Carbohydr Res. 1994 May 20;258:293-7. No abstract available.

PMID:
8039183
46.

Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs.

Weber SJ, Abbruscato TJ, Brownson EA, Lipkowski AW, Polt R, Misicka A, Haaseth RC, Bartosz H, Hruby VJ, Davis TP.

J Pharmacol Exp Ther. 1993 Sep;266(3):1649-55.

PMID:
8371162

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