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Items: 50

1.

Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.

Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, Barrezueta N, Polson C, Wes P, Rangan VS, Cacace A, Albright CF, Meredith J Jr, Trojanowski JQ, Lee VM, Brunden KR, Ahlijanian M.

PLoS One. 2015 May 1;10(5):e0125614. doi: 10.1371/journal.pone.0125614. eCollection 2015.

2.

Stable isotope labeling by amino acids in cell culture-based liquid chromatography-mass spectrometry assay to measure microtubule dynamics in neuronal cell cultures.

Polson C, Cantone JL, Wei C, Drexler DM, Meredith JE Jr.

Anal Biochem. 2014 Dec 1;466:65-71. doi: 10.1016/j.ab.2014.08.011. Epub 2014 Aug 28.

PMID:
25175011
3.

Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease.

Wes PD, Easton A, Corradi J, Barten DM, Devidze N, DeCarr LB, Truong A, He A, Barrezueta NX, Polson C, Bourin C, Flynn ME, Keenan S, Lidge R, Meredith J, Natale J, Sankaranarayanan S, Cadelina GW, Albright CF, Cacace AM.

PLoS One. 2014 Aug 25;9(8):e106050. doi: 10.1371/journal.pone.0106050. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0121509.

4.

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.

Toyn JH, Thompson LA, Lentz KA, Meredith JE Jr, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, Denton RR, Grace JE, Morrison J, Raybon J, Zhuo X, Snow K, Padmanabha R, Agler M, Esposito K, Harden D, Prack M, Varma S, Wong V, Zhu Y, Zvyaga T, Gerritz S, Marcin LR, Higgins MA, Shi J, Wei C, Cantone JL, Drexler DM, Macor JE, Olson RE, Ahlijanian MK, Albright CF.

Int J Alzheimers Dis. 2014;2014:431858. doi: 10.1155/2014/431858. Epub 2014 Jul 8.

5.

Thermal latency studies in opiate-treated mice.

Schildhaus N, Trink E, Polson C, Detolla L, Tyler BM, Jallo GI, Tok S, Guarnieri M.

J Pharm Bioallied Sci. 2014 Jan;6(1):43-7. doi: 10.4103/0975-7406.124316.

6.

Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.

Albright CF, Dockens RC, Meredith JE Jr, Olson RE, Slemmon R, Lentz KA, Wang JS, Denton RR, Pilcher G, Rhyne PW, Raybon JJ, Barten DM, Burton C, Toyn JH, Sankaranarayanan S, Polson C, Guss V, White R, Simutis F, Sanderson T, Gillman KW, Starrett JE Jr, Bronson J, Sverdlov O, Huang SP, Castaneda L, Feldman H, Coric V, Zaczek R, Macor JE, Houston J, Berman RM, Tong G.

J Pharmacol Exp Ther. 2013 Mar;344(3):686-95. doi: 10.1124/jpet.112.199356. Epub 2012 Dec 28.

PMID:
23275065
7.

2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors.

Parker MF, Barten DM, Bergstrom CP, Bronson JJ, Corsa JA, Dee MF, Gai Y, Guss VL, Higgins MA, Keavy DJ, Loo A, Mate RA, Marcin LR, McElhone KE, Polson CT, Roberts SB, Macor JE.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6828-31. doi: 10.1016/j.bmcl.2012.09.057. Epub 2012 Sep 24.

PMID:
23046960
8.

Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.

Barten DM, Fanara P, Andorfer C, Hoque N, Wong PY, Husted KH, Cadelina GW, Decarr LB, Yang L, Liu V, Fessler C, Protassio J, Riff T, Turner H, Janus CG, Sankaranarayanan S, Polson C, Meredith JE, Gray G, Hanna A, Olson RE, Kim SH, Vite GD, Lee FY, Albright CF.

J Neurosci. 2012 May 23;32(21):7137-45. doi: 10.1523/JNEUROSCI.0188-12.2012.

9.

The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.

Burton CR, Meredith JE, Barten DM, Goldstein ME, Krause CM, Kieras CJ, Sisk L, Iben LG, Polson C, Thompson MW, Lin XA, Corsa J, Fiedler T, Pierdomenico M, Cao Y, Roach AH, Cantone JL, Ford MJ, Drexler DM, Olson RE, Yang MG, Bergstrom CP, McElhone KE, Bronson JJ, Macor JE, Blat Y, Grafstrom RH, Stern AM, Seiffert DA, Zaczek R, Albright CF, Toyn JH.

J Biol Chem. 2008 Aug 22;283(34):22992-3003. doi: 10.1074/jbc.M804175200. Epub 2008 Jun 23.

10.

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

Meredith JE Jr, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE Jr, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF.

J Pharmacol Exp Ther. 2008 Aug;326(2):502-13. doi: 10.1124/jpet.108.138974. Epub 2008 May 22.

PMID:
18499745
11.

Qualitative and quantitative characterization of the amyloid beta peptide (Abeta) population in biological matrices using an immunoprecipitation-LC/MS assay.

Ford MJ, Cantone JL, Polson C, Toyn JH, Meredith JE, Drexler DM.

J Neurosci Methods. 2008 Mar 15;168(2):465-74. doi: 10.1016/j.jneumeth.2007.11.019. Epub 2007 Nov 29.

PMID:
18187205
12.

Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase.

Bergstrom CP, Sloan CP, Lau WY, Smith DW, Zheng M, Hansel SB, Polson CT, Corsa JA, Barten DM, Felsenstein KM, Roberts SB.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):464-8. doi: 10.1016/j.bmcl.2007.11.102. Epub 2007 Dec 3.

PMID:
18178084
13.

Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase.

Bergstrom CP, Sloan CP, Wang HH, Parker MF, Smith DW, Zheng M, Hansel SB, Polson CT, Barber LE, Bursuker I, Guss VL, Corsa JA, Barten DM, Felsenstein KM, Roberts SB.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):175-8. Epub 2007 Nov 1.

PMID:
18023581
14.

Amino-caprolactam derivatives as gamma-secretase inhibitors.

Parker MF, Bronson JJ, Barten DM, Corsa JA, Du W, Felsenstein KM, Guss VL, Izzarelli D, Loo A, McElhone KE, Marcin LR, Padmanabha R, Pak R, Polson CT, Toyn JH, Varma S, Wang J, Wong V, Zheng M, Roberts SB.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5790-5. Epub 2007 Aug 26.

PMID:
17869509
15.

Macrophyte zonation in stormwater wetlands: getting it right! A case study from subtropical Australia.

Greenway M, Jenkins G, Polson C.

Water Sci Technol. 2007;56(3):223-31.

PMID:
17802859
16.

N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors.

Parker MF, Barten DM, Bergstrom CP, Bronson JJ, Corsa JA, Deshpande MS, Felsenstein KM, Guss VL, Hansel SB, Johnson G, Keavy DJ, Lau WY, Mock J, Prasad CV, Polson CT, Sloan CP, Smith DW, Wallace OB, Wang HH, Williams A, Zheng M.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4432-6. Epub 2007 Jun 10.

PMID:
17606371
17.

Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease.

Prasad CV, Zheng M, Vig S, Bergstrom C, Smith DW, Gao Q, Yeola S, Polson CT, Corsa JA, Guss VL, Loo A, Wang J, Sleczka BG, Dangler C, Robertson BJ, Hendrick JP, Roberts SB, Barten DM.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):4006-11. Epub 2007 Apr 30.

PMID:
17502137
18.

In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor.

Zhang D, Hanson R, Roongta V, Dischino DD, Gao Q, Sloan CP, Polson C, Keavy D, Zheng M, Mitroka J, Yeola S.

Curr Drug Metab. 2006 Dec;7(8):883-96.

PMID:
17168689
19.

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.

Barten DM, Guss VL, Corsa JA, Loo A, Hansel SB, Zheng M, Munoz B, Srinivasan K, Wang B, Robertson BJ, Polson CT, Wang J, Roberts SB, Hendrick JP, Anderson JJ, Loy JK, Denton R, Verdoorn TA, Smith DW, Felsenstein KM.

J Pharmacol Exp Ther. 2005 Feb;312(2):635-43. Epub 2004 Sep 27.

PMID:
15452193
20.

2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of gamma-secretase.

Prasad CV, Vig S, Smith DW, Gao Q, Polson CT, Corsa JA, Guss VL, Loo A, Barten DM, Zheng M, Felsenstein KM, Roberts SB.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3535-8.

PMID:
15177468
21.

Hydroxytriamides as potent gamma-secretase inhibitors.

Prasad CV, Wallace OB, Noonan JW, Sloan CP, Lau W, Vig S, Parker MF, Smith DW, Hansel SB, Polson CT, Barten DM, Felsenstein KM, Roberts SB.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1917-21. Erratum in: Bioorg Med Chem Lett. 2004 Jun 21;14(12):3361.

PMID:
15050627
22.

An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning.

Lindner MD, Hodges DB Jr, Hogan JB, Orie AF, Corsa JA, Barten DM, Polson C, Robertson BJ, Guss VL, Gillman KW, Starrett JE Jr, Gribkoff VK.

J Pharmacol Exp Ther. 2003 Nov;307(2):682-91. Epub 2003 Sep 15.

PMID:
12975483
23.

Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition.

Wu YJ, Davis CD, Dworetzky S, Fitzpatrick WC, Harden D, He H, Knox RJ, Newton AE, Philip T, Polson C, Sivarao DV, Sun LQ, Tertyshnikova S, Weaver D, Yeola S, Zoeckler M, Sinz MW.

J Med Chem. 2003 Aug 28;46(18):3778-81.

PMID:
12930139
24.

Inhibitors of Abeta production: solid-phase synthesis and SAR of alpha-hydroxycarbonyl derivatives.

Wallace OB, Smith DW, Deshpande MS, Polson C, Felsenstein KM.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1203-6.

PMID:
12643944
25.

Optimization of protein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography-tandem mass spectrometry.

Polson C, Sarkar P, Incledon B, Raguvaran V, Grant R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Mar 5;785(2):263-75.

PMID:
12554139
26.

Effect of a marriage and family therapy practicum upon students' self-perceived strengths and weaknesses.

Jurich AP, Polson CJ.

Psychol Rep. 1986 Apr;58(2):527-33. No abstract available.

PMID:
3704053
27.

Nonverbal assessment of anxiety as a function of intimacy of sexual attitude questions.

Jurich AP, Polson CJ.

Psychol Rep. 1985 Dec;57(3 Pt 2):1247-53. No abstract available.

PMID:
4095237
28.

Family factors in the lives of drug users and abusers.

Jurich AP, Polson CJ, Jurich JA, Bates RA.

Adolescence. 1985 Spring;20(77):143-59.

PMID:
3984801
29.

Reasons for drug use: comparison of drug users and abusers.

Jurich AP, Polson CJ.

Psychol Rep. 1984 Oct;55(2):371-8. No abstract available.

PMID:
6514916
31.

Cytological effects of phenothiazine tranquilizing agents on barley meristems.

Polson CD, Adams JD.

Pharmacology. 1978;16(2):83-8.

PMID:
22881
32.

Let us remember there are also simple tests.

Polson CJ.

Med Sci Law. 1976 Jan;16(1):2-8. No abstract available.

PMID:
1250097
33.

Plastic bag suffocation.

Polson CJ, Gee DJ.

Z Rechtsmed. 1972;70(3):184-90. No abstract available.

PMID:
5047585
34.
35.

The role of the pathologist in the investigation of fatal poisoning.

Polson CJ.

Med Sci Law. 1965 Oct;5(4):203-10. No abstract available.

PMID:
5849642
36.

Advances in clinical toxicology.

POLSON CJ, TATTERSALL RN.

Practitioner. 1961 Oct;187:549-56. No abstract available.

PMID:
14487692
37.

[Bilateral fatal pneumothorax as sequel to a laryngotracheal lesion].

POLSON CJ, HORNBAK H.

Ugeskr Laeger. 1960 Aug 4;122:1041-3. Danish. No abstract available.

PMID:
13736912
38.

Subcutaneous rupture of the larynx and trachea: complicated by bilateral pneumothorax.

POLSON CJ, HORNBAK H.

Med Leg J. 1960;28:88-91. No abstract available.

PMID:
14433912
39.

Electrocution.

POLSON CJ.

Med Leg J. 1959;27:121-35. No abstract available.

PMID:
13856254
40.

Historical facets of the disposal of the dead.

POLSON CJ.

Med Leg J. 1958;26(4):135-47. No abstract available.

PMID:
13656182
41.

Strangulation; manslaughter or murder.

POLSON C.

Med Leg J. 1957;25(3):101-8; discussion 108-10. No abstract available.

PMID:
13492897
42.

Amniotic embolism; a report of two fatalities.

DENNISS RG, GOLDIE W, POLSON CJ.

J Obstet Gynaecol Br Emp. 1954 Oct;61(5):620-2. No abstract available.

PMID:
13212491
43.

The general medical council; disciplinary powers and procedure.

POLSON CJ.

Practitioner. 1952 Dec;169(1014):650-9. No abstract available.

PMID:
13003798
44.

The general medical council its constitution and duties.

POLSON CJ.

Practitioner. 1952 Oct;169(1012):441-9. No abstract available.

PMID:
13003773
45.

Modification of a fingerprint by a skin graft.

POLSON CJ.

Nature. 1950 Jul 15;166(4211):115. No abstract available.

PMID:
15439168
46.

Suffocation by milk feeds.

POLSON CJ, PRICE DE.

Lancet. 1948 Feb 28;1(6496):343. No abstract available.

PMID:
18905400
47.

Tattooing.

POLSON CJ.

Med Leg J. 1948;16(Pt.3):96-102. No abstract available.

PMID:
18098790
48.

Congenital choanal atresia.

DURWARD A, LORD OC, POLSON CJ.

J Laryngol Otol. 1945 Dec;60:461-500. No abstract available.

PMID:
20994680
49.

Chronic Ulcer in Myelogenous Reticulosis.

Polson CJ.

Br Med J. 1942 Oct 24;2(4268):481-2. No abstract available.

50.

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