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Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak.

Sun J, Mao LQ, Polonsky KS, Ren DC.

J Biol Chem. 2016 Jun 24;291(26):13529-34. doi: 10.1074/jbc.M115.705293. Epub 2016 May 2.


Research in academic medical centers: two threats to sustainable support.

Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM.

Sci Transl Med. 2015 May 27;7(289):289fs22. doi: 10.1126/scitranslmed.aac5200.


Donald F. Steiner, MD, 1930-2014: pioneering diabetes researcher.

Polonsky KS, Rubenstein AH.

Diabetologia. 2015 Mar;58(3):419-21. doi: 10.1007/s00125-015-3495-x. No abstract available.


Donald F. Steiner MD, 1930-2014: discoverer of proinsulin.

Philipson LH, Bell G, Polonsky KS.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):940-1. doi: 10.1073/pnas.1423774112. Epub 2015 Jan 5. No abstract available.


β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.

Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC.

Diabetes Care. 2014 Jun;37(6):1751-8. doi: 10.2337/dc14-0396. Epub 2014 May 8. Review.


BH3-only molecule Bim mediates β-cell death in IRS2 deficiency.

Ren D, Sun J, Mao L, Ye H, Polonsky KS.

Diabetes. 2014 Oct;63(10):3378-87. doi: 10.2337/db13-1814. Epub 2014 Apr 23.


β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.

Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC.

J Clin Endocrinol Metab. 2014 Jun;99(6):1983-92. doi: 10.1210/jc.2014-1425. Epub 2014 Apr 8.


Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency.

Ren D, Sun J, Wang C, Ye H, Mao L, Cheng EH, Bell GI, Polonsky KS.

Diabetes. 2014 Aug;63(8):2744-50. doi: 10.2337/db13-1513. Epub 2014 Mar 21.


Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes.

Chowdhury S, Reeds DN, Crimmins DL, Patterson BW, Laciny E, Wang S, Tran HD, Griest TA, Rometo DA, Dunai J, Wallendorf MJ, Ladenson JH, Polonsky KS, Wice BM.

Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G301-9. doi: 10.1152/ajpgi.00383.2013. Epub 2013 Dec 19.


Complex patterns of metabolic and Ca²⁺ entrainment in pancreatic islets by oscillatory glucose.

Pedersen MG, Mosekilde E, Polonsky KS, Luciani DS.

Biophys J. 2013 Jul 2;105(1):29-39. doi: 10.1016/j.bpj.2013.05.036.


Introduction of Arthur H. Rubenstein.

Polonsky KS.

J Clin Invest. 2012 Nov;122(11):4283-8. doi: 10.1172/JCI66849. Epub 2012 Nov 1. No abstract available.


The past 200 years in diabetes.

Polonsky KS.

N Engl J Med. 2012 Oct 4;367(14):1332-40. doi: 10.1056/NEJMra1110560. No abstract available.


Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats.

Han DH, Kim SH, Higashida K, Jung SR, Polonsky KS, Klein S, Holloszy JO.

Metabolism. 2012 Nov;61(11):1615-21. doi: 10.1016/j.metabol.2012.04.008. Epub 2012 May 8.


Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes.

Wice BM, Reeds DN, Tran HD, Crimmins DL, Patterson BW, Dunai J, Wallendorf MJ, Ladenson JH, Villareal DT, Polonsky KS.

Diabetes. 2012 Jul;61(7):1793-800. doi: 10.2337/db11-1451. Epub 2012 Apr 20.


Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes.

Klein S, Fabbrini E, Patterson BW, Polonsky KS, Schiavon CA, Correa JL, Salles JE, Wajchenberg BL, Cohen R.

Obesity (Silver Spring). 2012 Jun;20(6):1266-72. doi: 10.1038/oby.2011.377. Epub 2012 Jan 19.


Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes.

Reeds DN, Patterson BW, Okunade A, Holloszy JO, Polonsky KS, Klein S.

Diabetes Care. 2011 May;34(5):1071-6. doi: 10.2337/dc10-2299. Epub 2011 Mar 16.


Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic β-cells.

Johnson JD, Otani K, Bell GI, Polonsky KS.

Islets. 2009 Nov-Dec;1(3):242-8. doi: 10.4161/isl.1.3.9780.


Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes.

Fujimoto K, Ford EL, Tran H, Wice BM, Crosby SD, Dorn GW 2nd, Polonsky KS.

J Clin Invest. 2010 Nov;120(11):4031-9. doi: 10.1172/JCI44011. Epub 2010 Oct 11.


Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency.

Fujimoto K, Chen Y, Polonsky KS, Dorn GW 2nd.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10214-9. doi: 10.1073/pnas.0914209107. Epub 2010 May 17.


Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism.

Wice BM, Wang S, Crimmins DL, Diggs-Andrews KA, Althage MC, Ford EL, Tran H, Ohlendorf M, Griest TA, Wang Q, Fisher SJ, Ladenson JH, Polonsky KS.

J Biol Chem. 2010 Jun 25;285(26):19842-53. doi: 10.1074/jbc.M110.129304. Epub 2010 Apr 26.


Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.

Cheverud JM, Fawcett GL, Jarvis JP, Norgard EA, Pavlicev M, Pletscher LS, Polonsky KS, Ye H, Bell GI, Semenkovich CF.

J Lipid Res. 2010 May;51(5):907-13. doi: 10.1194/jlr.M900128.


TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

Villareal DT, Robertson H, Bell GI, Patterson BW, Tran H, Wice B, Polonsky KS.

Diabetes. 2010 Feb;59(2):479-85. doi: 10.2337/db09-1169. Epub 2009 Nov 23.


Pdx1 and other factors that regulate pancreatic beta-cell survival.

Fujimoto K, Polonsky KS.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:30-7. doi: 10.1111/j.1463-1326.2009.01121.x. Review.


Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.

Kawai T, Ng MC, Hayes MG, Yoshiuchi I, Tsuchiya T, Robertson H, Cox NJ, Polonsky KS, Bell GI, Ehrmann DA.

Diabetes Res Clin Pract. 2009 Dec;86(3):186-92. doi: 10.1016/j.diabres.2009.09.002. Epub 2009 Sep 25.


Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.

Fujimoto K, Hanson PT, Tran H, Ford EL, Han Z, Johnson JD, Schmidt RE, Green KG, Wice BM, Polonsky KS.

J Biol Chem. 2009 Oct 2;284(40):27664-73. doi: 10.1074/jbc.M109.041616. Epub 2009 Aug 4.


Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.

Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS.

Diabetes. 2009 Aug;58(8):1869-78. doi: 10.2337/db09-0025. Epub 2009 Jun 2.


To nap or not to nap? Residents' work hours revisited.

Blanchard MS, Meltzer D, Polonsky KS.

N Engl J Med. 2009 May 21;360(21):2242-4. doi: 10.1056/NEJMe0901226. No abstract available.


Serum leptin levels in obese males during over- and underfeeding.

Cooper JA, Polonsky KS, Schoeller DA.

Obesity (Silver Spring). 2009 Dec;17(12):2149-54. doi: 10.1038/oby.2009.149. Epub 2009 May 14.


Insulin signaling in alpha cells modulates glucagon secretion in vivo.

Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN.

Cell Metab. 2009 Apr;9(4):350-61. doi: 10.1016/j.cmet.2009.02.007.


The physician scientist training program in internal medicine at Washington University School of Medicine.

Muslin AJ, Kornfeld S, Polonsky KS.

Acad Med. 2009 Apr;84(4):468-71. doi: 10.1097/ACM.0b013e31819a8158.


Role of HNF-1alpha in regulating the expression of genes involved in cellular growth and proliferation in pancreatic beta-cells.

Uchizono Y, Baldwin AC, Sakuma H, Pugh W, Polonsky KS, Hara M.

Diabetes Res Clin Pract. 2009 Apr;84(1):19-26. doi: 10.1016/j.diabres.2008.12.014. Epub 2009 Jan 31.


Gastric banding to treat obesity: band-aid or breakthrough?

Polonsky KS, Klein S.

Nat Clin Pract Endocrinol Metab. 2008 Aug;4(8):421. doi: 10.1038/ncpendmet0889. No abstract available.


Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.

Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, Lin Y, Townsend RR, Polonsky KS, Johnson JD.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8452-7. doi: 10.1073/pnas.0711232105. Epub 2008 Jun 11.


Standardization of C-peptide measurements.

Little RR, Rohlfing CL, Tennill AL, Madsen RW, Polonsky KS, Myers GL, Greenbaum CJ, Palmer JP, Rogatsky E, Stein DT.

Clin Chem. 2008 Jun;54(6):1023-6. doi: 10.1373/clinchem.2007.101287. Epub 2008 Apr 17.


Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet.

Althage MC, Ford EL, Wang S, Tso P, Polonsky KS, Wice BM.

J Biol Chem. 2008 Jun 27;283(26):18365-76. doi: 10.1074/jbc.M710466200. Epub 2008 Apr 17.


Weight loss therapy improves pancreatic endocrine function in obese older adults.

Villareal DT, Banks MR, Patterson BW, Polonsky KS, Klein S.

Obesity (Silver Spring). 2008 Jun;16(6):1349-54. doi: 10.1038/oby.2008.226. Epub 2008 Apr 3.


Sustained expression of hepatocyte nuclear factor-6 leads to loss of pancreatic beta-cells by apoptosis.

Hara M, Shen J, Pugh W, Polonsky KS, Le Beau MM, Bell GI.

Exp Clin Endocrinol Diabetes. 2007 Nov;115(10):654-61.


International comparison of C-peptide measurements.

Wiedmeyer HM, Polonsky KS, Myers GL, Little RR, Greenbaum CJ, Goldstein DE, Palmer JP.

Clin Chem. 2007 Apr;53(4):784-7. Epub 2007 Mar 1.


Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.

Johnson JD, Bernal-Mizrachi E, Alejandro EU, Han Z, Kalynyak TB, Li H, Beith JL, Gross J, Warnock GL, Townsend RR, Permutt MA, Polonsky KS.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19575-80. Epub 2006 Dec 8.


International trial of the Edmonton protocol for islet transplantation.

Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR.

N Engl J Med. 2006 Sep 28;355(13):1318-30.


Suppressed insulin signaling and increased apoptosis in CD38-null islets.

Johnson JD, Ford EL, Bernal-Mizrachi E, Kusser KL, Luciani DS, Han Z, Tran H, Randall TD, Lund FE, Polonsky KS.

Diabetes. 2006 Oct;55(10):2737-46.


A significant role for histocompatibility in human islet transplantation.

Mohanakumar T, Narayanan K, Desai N, Ramachandran S, Shenoy S, Jendrisak M, Susskind BM, Olack B, Benshoff N, Phelan DL, Brennan DC, Fernandez LA, Odorico JS, Polonsky KS.

Transplantation. 2006 Jul 27;82(2):180-7.


Retinol-binding protein 4, insulin resistance, and type 2 diabetes.

Polonsky KS.

N Engl J Med. 2006 Jun 15;354(24):2596-8. No abstract available.


Inhibition of calpain results in impaired contraction-stimulated GLUT4 translocation in skeletal muscle.

Otani K, Polonsky KS, Holloszy JO, Han DH.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E544-8. Epub 2006 May 16.


Ca2+ controls slow NAD(P)H oscillations in glucose-stimulated mouse pancreatic islets.

Luciani DS, Misler S, Polonsky KS.

J Physiol. 2006 Apr 15;572(Pt 2):379-92. Epub 2006 Feb 2.


Diabetic pancreatic beta cells ARNT all they should be.

Levisetti MG, Polonsky KS.

Cell Metab. 2005 Aug;2(2):78-80.


Rosiglitazone reduces glucose-stimulated insulin secretion rate and increases insulin clearance in nondiabetic, insulin-resistant individuals.

Kim SH, Abbasi F, Chu JW, McLaughlin TL, Lamendola C, Polonsky KS, Reaven GM.

Diabetes. 2005 Aug;54(8):2447-52.


Insulin sensitivity by oral glucose minimal models: validation against clamp.

Dalla Man C, Yarasheski KE, Caumo A, Robertson H, Toffolo G, Polonsky KS, Cobelli C.

Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E954-9. Epub 2005 Jul 12.


Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.

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