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Items: 20

1.

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.

Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG.

Clin Pharmacol Ther. 2019 Nov 10. doi: 10.1002/cpt.1647. [Epub ahead of print]

PMID:
31709525
2.

Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence.

Lei CL, Clerx M, Beattie KA, Melgari D, Hancox JC, Gavaghan DJ, Polonchuk L, Wang K, Mirams GR.

Biophys J. 2019 Jul 25. pii: S0006-3495(19)30598-3. doi: 10.1016/j.bpj.2019.07.030. [Epub ahead of print]

3.

Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System.

Lei CL, Clerx M, Gavaghan DJ, Polonchuk L, Mirams GR, Wang K.

Biophys J. 2019 Jul 25. pii: S0006-3495(19)30597-1. doi: 10.1016/j.bpj.2019.07.029. [Epub ahead of print]

4.

Stem Cell-Derived Cardiac Spheroids as 3D In Vitro Models of the Human Heart Microenvironment.

Campbell M, Chabria M, Figtree GA, Polonchuk L, Gentile C.

Methods Mol Biol. 2019;2002:51-59. doi: 10.1007/7651_2018_187.

PMID:
30159827
5.

Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes.

Bot CT, Juhasz K, Haeusermann F, Polonchuk L, Traebert M, Stoelzle-Feix S.

J Pharmacol Toxicol Methods. 2018 Sep - Oct;93:46-58. doi: 10.1016/j.vascn.2018.06.006. Epub 2018 Jun 22.

6.

Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology.

Lei CL, Wang K, Clerx M, Johnstone RH, Hortigon-Vinagre MP, Zamora V, Allan A, Smith GL, Gavaghan DJ, Mirams GR, Polonchuk L.

Front Physiol. 2017 Dec 12;8:986. doi: 10.3389/fphys.2017.00986. eCollection 2017.

7.

Cardiac spheroids as promising in vitro models to study the human heart microenvironment.

Polonchuk L, Chabria M, Badi L, Hoflack JC, Figtree G, Davies MJ, Gentile C.

Sci Rep. 2017 Aug 1;7(1):7005. doi: 10.1038/s41598-017-06385-8.

8.

Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research.

Kroll K, Chabria M, Wang K, Häusermann F, Schuler F, Polonchuk L.

Prog Biophys Mol Biol. 2017 Nov;130(Pt B):212-222. doi: 10.1016/j.pbiomolbio.2017.07.003. Epub 2017 Jul 6.

PMID:
28688751
9.

Human ex-vivo action potential model for pro-arrhythmia risk assessment.

Page G, Ratchada P, Miron Y, Steiner G, Ghetti A, Miller PE, Reynolds JA, Wang K, Greiter-Wilke A, Polonchuk L, Traebert M, Gintant GA, Abi-Gerges N.

J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:183-95. doi: 10.1016/j.vascn.2016.05.016. Epub 2016 May 25.

10.

Recent developments in using mechanistic cardiac modelling for drug safety evaluation.

Davies MR, Wang K, Mirams GR, Caruso A, Noble D, Walz A, Lavé T, Schuler F, Singer T, Polonchuk L.

Drug Discov Today. 2016 Jun;21(6):924-38. doi: 10.1016/j.drudis.2016.02.003. Epub 2016 Feb 15. Review.

11.

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, Kilduff TS, Vieira E, Kolczewski S, Wichmann J, Hartung T, Honer M, Borroni E, Moreau JL, Prinssen E, Spooren W, Wettstein JG, Jaeschke G.

J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. doi: 10.1124/jpet.114.222463. Epub 2015 Feb 9.

PMID:
25665805
12.

Industrializing electrophysiology: HT automated patch clamp on SyncroPatch® 96 using instant frozen cells.

Polonchuk L.

Methods Mol Biol. 2014;1183:81-92. doi: 10.1007/978-1-4939-1096-0_5.

PMID:
25023303
13.

Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors.

Lucas MC, Bhagirath N, Chiao E, Goldstein DM, Hermann JC, Hsu PY, Kirchner S, Kennedy-Smith JJ, Kuglstatter A, Lukacs C, Menke J, Niu L, Padilla F, Peng Y, Polonchuk L, Railkar A, Slade M, Soth M, Xu D, Yadava P, Yee C, Zhou M, Liao C.

J Med Chem. 2014 Mar 27;57(6):2683-91. doi: 10.1021/jm401982j. Epub 2014 Feb 26.

PMID:
24520947
14.

Toward a New Gold Standard for Early Safety: Automated Temperature-Controlled hERG Test on the PatchLiner.

Polonchuk L.

Front Pharmacol. 2012 Jan 26;3:3. doi: 10.3389/fphar.2012.00003. eCollection 2012.

15.

A pharmacokinetic-pharmacodynamic model for cardiovascular safety assessment of R1551.

Fleury A, Lavé T, Jonsson F, Schmitt M, Hirkaler G, Polonchuk L, Breidenbach A.

J Pharmacol Toxicol Methods. 2011 Jan-Feb;63(1):123-33. doi: 10.1016/j.vascn.2010.08.003. Epub 2010 Aug 21.

PMID:
20732434
16.

Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists.

Martin RE, Mohr P, Maerki HP, Guba W, Kuratli C, Gavelle O, Binggeli A, Bendels S, Alvarez-Sánchez R, Alker A, Polonchuk L, Christ AD.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6106-13. doi: 10.1016/j.bmcl.2009.09.024. Epub 2009 Sep 12.

PMID:
19786348
17.

Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics.

Vargas HM, Bass AS, Breidenbach A, Feldman HS, Gintant GA, Harmer AR, Heath B, Hoffmann P, Lagrutta A, Leishman D, McMahon N, Mittelstadt S, Polonchuk L, Pugsley MK, Salata JJ, Valentin JP.

J Pharmacol Toxicol Methods. 2008 Sep-Oct;58(2):72-6. doi: 10.1016/j.vascn.2008.04.001. Epub 2008 Apr 18.

PMID:
18508287
18.

Oxetanes as promising modules in drug discovery.

Wuitschik G, Rogers-Evans M, Müller K, Fischer H, Wagner B, Schuler F, Polonchuk L, Carreira EM.

Angew Chem Int Ed Engl. 2006 Nov 27;45(46):7736-9. No abstract available.

PMID:
17013952
19.

Titanium dioxide ceramics control the differentiated phenotype of cardiac muscle cells in culture.

Polonchuk L, Elbel J, Eckert L, Blum J, Wintermantel E, Eppenberger HM.

Biomaterials. 2000 Mar;21(6):539-50.

PMID:
10701455
20.

The effect of arachidonic acid on junctional conductance in isolated murine hepatocytes.

Polonchuk LO, Frolov VA, Yuskovich AK, Dunina-Barkovskaya AYa.

Membr Cell Biol. 1997;11(2):225-42.

PMID:
9354401

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