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Items: 36

1.

Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.

Berg EL, Polokoff MA, O'Mahony A, Nguyen D, Li X.

Int J Mol Sci. 2015 Jan 5;16(1):1008-29. doi: 10.3390/ijms16011008.

2.

Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies.

Haselmayer P, Camps M, Muzerelle M, El Bawab S, Waltzinger C, Bruns L, Abla N, Polokoff MA, Jond-Necand C, Gaudet M, Benoit A, Bertschy Meier D, Martin C, Gretener D, Lombardi MS, Grenningloh R, Ladel C, Petersen JS, Gaillard P, Ji H.

Front Immunol. 2014 May 22;5:233. doi: 10.3389/fimmu.2014.00233. eCollection 2014.

3.

Building predictive models for mechanism-of-action classification from phenotypic assay data sets.

Berg EL, Yang J, Polokoff MA.

J Biomol Screen. 2013 Dec;18(10):1260-9. doi: 10.1177/1087057113505324. Epub 2013 Oct 2.

PMID:
24088371
4.

Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation.

Melton AC, Melrose J, Alajoki L, Privat S, Cho H, Brown N, Plavec AM, Nguyen D, Johnston ED, Yang J, Polokoff MA, Plavec I, Berg EL, O'Mahony A.

PLoS One. 2013;8(3):e58966. doi: 10.1371/journal.pone.0058966. Epub 2013 Mar 7.

5.

Potent triazolothione inhibitor of heat-shock protein-90.

Feldman RI, Mintzer B, Zhu D, Wu JM, Biroc SL, Yuan S, Emayan K, Chang Z, Chen D, Arnaiz DO, Bryant J, Ge XS, Whitlow M, Adler M, Polokoff MA, Li WW, Ferrer M, Sato T, Gu JM, Shen J, Tseng JL, Dinter H, Buckman B.

Chem Biol Drug Des. 2009 Jul;74(1):43-50. doi: 10.1111/j.1747-0285.2009.00833.x.

PMID:
19519743
6.

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.

Islam I, Brown G, Bryant J, Hrvatin P, Kochanny MJ, Phillips GB, Yuan S, Adler M, Whitlow M, Lentz D, Polokoff MA, Wu J, Shen J, Walters J, Ho E, Subramanyam B, Zhu D, Feldman RI, Arnaiz DO.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25. Epub 2007 May 23.

PMID:
17544272
7.

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.

Islam I, Bryant J, Chou YL, Kochanny MJ, Lee W, Phillips GB, Yu H, Adler M, Whitlow M, Ho E, Lentz D, Polokoff MA, Subramanyam B, Wu JM, Zhu D, Feldman RI, Arnaiz DO.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. Epub 2007 Apr 27.

PMID:
17531483
8.

A novel high-throughput screening format to identify inhibitors of secreted acid sphingomyelinase.

Mintzer RJ, Appell KC, Cole A, Johns A, Pagila R, Polokoff MA, Tabas I, Snider RM, Meurer-Ogden JA.

J Biomol Screen. 2005 Apr;10(3):225-34.

PMID:
15809318
9.

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

Feldman RI, Wu JM, Polokoff MA, Kochanny MJ, Dinter H, Zhu D, Biroc SL, Alicke B, Bryant J, Yuan S, Buckman BO, Lentz D, Ferrer M, Whitlow M, Adler M, Finster S, Chang Z, Arnaiz DO.

J Biol Chem. 2005 May 20;280(20):19867-74. Epub 2005 Mar 16.

10.

Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors.

Blasko E, Glaser CB, Devlin JJ, Xia W, Feldman RI, Polokoff MA, Phillips GB, Whitlow M, Auld DS, McMillan K, Ghosh S, Stuehr DJ, Parkinson JF.

J Biol Chem. 2002 Jan 4;277(1):295-302. Epub 2001 Oct 31.

11.

Changes of endothelial nitric oxide synthase level and activity during endothelial cell proliferation.

Zöllner S, Aberle S, Harvey SE, Polokoff MA, Rubanyi GM.

Endothelium. 2000;7(3):169-84.

PMID:
10912911
12.

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry.

McMillan K, Adler M, Auld DS, Baldwin JJ, Blasko E, Browne LJ, Chelsky D, Davey D, Dolle RE, Eagen KA, Erickson S, Feldman RI, Glaser CB, Mallari C, Morrissey MM, Ohlmeyer MH, Pan G, Parkinson JF, Phillips GB, Polokoff MA, Sigal NH, Vergona R, Whitlow M, Young TA, Devlin JJ.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1506-11.

13.

Hydroxamic acids as potent inhibitors of endothelin-converting enzyme from human bronchiolar smooth muscle.

Bihovsky R, Levinson BL, Loewi RC, Erhardt PW, Polokoff MA.

J Med Chem. 1995 Jun 9;38(12):2119-29.

PMID:
7783143
14.

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.

Rubanyi GM, Polokoff MA.

Pharmacol Rev. 1994 Sep;46(3):325-415. Review. No abstract available.

PMID:
7831383
15.

Evidence of glycosylated sites on the endothelin-1 receptor in Swiss 3T3 cells.

Devesly P, Cade C, Polokoff MA, Botelho LH.

J Cardiovasc Pharmacol. 1991;17 Suppl 7:S134-6.

PMID:
1725309
16.

Disintegrins: a family of integrin inhibitory proteins from viper venoms.

Gould RJ, Polokoff MA, Friedman PA, Huang TF, Holt JC, Cook JJ, Niewiarowski S.

Proc Soc Exp Biol Med. 1990 Nov;195(2):168-71. Review.

PMID:
2236100
17.

Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 does not elicit protective immunity in chimpanzees.

Emini EA, Schleif WA, Quintero JC, Conard PG, Eichberg JW, Vlasuk GP, Lehman ED, Polokoff MA, Schaeffer TF, Schultz LD, et al.

AIDS Res Hum Retroviruses. 1990 Nov;6(11):1247-50.

PMID:
2127681
18.

Yeast thioltransferase--the active site cysteines display differential reactivity.

Gan ZR, Sardana MK, Jacobs JW, Polokoff MA.

Arch Biochem Biophys. 1990 Oct;282(1):110-5.

PMID:
2221913
19.

Complete amino acid sequence of yeast thioltransferase (glutaredoxin).

Gan ZR, Polokoff MA, Jacobs JW, Sardana MK.

Biochem Biophys Res Commun. 1990 May 16;168(3):944-51.

PMID:
2189409
21.

High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28]echistatin.

Gan ZR, Condra JH, Gould RJ, Zivin RA, Bennett CD, Jacobs JW, Friedman PA, Polokoff MA.

Gene. 1989 Jun 30;79(1):159-66.

PMID:
2673933
22.

Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus.

Gan ZR, Gould RJ, Jacobs JW, Friedman PA, Polokoff MA.

J Biol Chem. 1988 Dec 25;263(36):19827-32.

23.

Metabolism of synthetic inositol trisphosphate analogs.

Polokoff MA, Bencen GH, Vacca JP, deSolms SJ, Young SD, Huff JR.

J Biol Chem. 1988 Aug 25;263(24):11922-7.

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Chronic ethanol increases liver plasma membrane fluidity.

Polokoff MA, Simon TJ, Harris RA, Simon FR, Iwahashi M.

Biochemistry. 1985 Jun 18;24(13):3114-20.

PMID:
4027234
28.
29.

Isolation of somatic cell mutants defective in the biosynthesis of phosphatidylethanolamine.

Polokoff MA, Wing DC, Raetz CR.

J Biol Chem. 1981 Aug 10;256(15):7687-90.

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Hypertriacylglycerolemia in the chick: effect of estrogen on hepatic microsomal enzymes of triacylglycerol and phospholipid synthesis.

Coleman R, Polokoff MA, Bell RM.

Metabolism. 1977 Oct;26(10):1123-30. No abstract available.

PMID:
895527
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