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Items: 1 to 50 of 137

1.

CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1.

Nepravishta R, Ferrentino F, Mandaliti W, Mattioni A, Weber J, Polo S, Castagnoli L, Cesareni G, Paci M, Santonico E.

Biomolecules. 2019 Jul 17;9(7). pii: E284. doi: 10.3390/biom9070284.

2.

Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.

Wagner W, Lippmann K, Heisler FF, Gromova KV, Lombino FL, Roesler MK, Pechmann Y, Hornig S, Schweizer M, Polo S, Schwarz JR, Eilers J, Kneussel M.

Cell Rep. 2019 Jul 2;28(1):11-20.e9. doi: 10.1016/j.celrep.2019.06.005.

3.

Analgesic and Antidepressant Effects of Oltipraz on Neuropathic Pain in Mice by Modulating Microglial Activation.

Díaz AF, Polo S, Gallardo N, Leánez S, Pol O.

J Clin Med. 2019 Jun 21;8(6). pii: E890. doi: 10.3390/jcm8060890.

4.

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S.

Cell Rep. 2019 Jun 4;27(10):3049-3061.e6. doi: 10.1016/j.celrep.2019.05.017.

5.

The Effects of Cobalt Protoporphyrin IX and Tricarbonyldichlororuthenium (II) Dimer Treatments and Its Interaction with Nitric Oxide in the Locus Coeruleus of Mice with Peripheral Inflammation.

Moreno P, Cazuza RA, Mendes-Gomes J, Díaz AF, Polo S, Leánez S, Leite-Panissi CRA, Pol O.

Int J Mol Sci. 2019 May 5;20(9). pii: E2211. doi: 10.3390/ijms20092211.

6.

HECT E3 Ligases: A Tale With Multiple Facets.

Weber J, Polo S, Maspero E.

Front Physiol. 2019 Apr 3;10:370. doi: 10.3389/fphys.2019.00370. eCollection 2019. Review.

7.

A Highly Luminescent Tetrahydrocurcumin IrIII Complex with Remarkable Photoactivated Anticancer Activity.

Colombo A, Fontani M, Dragonetti C, Roberto D, Williams JAG, Scotto di Perrotolo R, Casagrande F, Barozzi S, Polo S.

Chemistry. 2019 Jun 12;25(33):7948-7952. doi: 10.1002/chem.201901527. Epub 2019 May 13.

PMID:
30985041
8.

Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated.

Polo S, Díaz AF, Gallardo N, Leánez S, Balboni G, Pol O.

Front Pharmacol. 2019 Mar 26;10:283. doi: 10.3389/fphar.2019.00283. eCollection 2019.

9.

Detection of ubiquitinated targets in mammalian and Drosophila models.

Maspero E, Fajner V, Weber J, Polo S.

Methods Enzymol. 2019;619:293-318. doi: 10.1016/bs.mie.2018.12.030. Epub 2019 Feb 11.

PMID:
30910026
10.

Selectivity of the CUBAN domain in the recognition of ubiquitin and NEDD8.

Castagnoli L, Mandaliti W, Nepravishta R, Valentini E, Mattioni A, Procopio R, Iannuccelli M, Polo S, Paci M, Cesareni G, Santonico E.

FEBS J. 2019 Feb;286(4):653-677. doi: 10.1111/febs.14752. Epub 2019 Feb 5.

11.

When ubiquitin meets E-cadherin: Plasticity of the epithelial cellular barrier.

Niño CA, Sala S, Polo S.

Semin Cell Dev Biol. 2018 Dec 19. pii: S1084-9521(18)30081-8. doi: 10.1016/j.semcdb.2018.12.005. [Epub ahead of print] Review.

PMID:
30566893
12.

Inotuzumab ozogamicin is effective in relapsed/refractory extramedullary B acute lymphoblastic leukemia.

Bertamini L, Nanni J, Marconi G, Abbenante M, Robustelli V, Bacci F, Matti A, Paolini S, Sartor C, Monaco SL, Fontana MC, De Polo S, Cavo M, Curti A, Martinelli G, Papayannidis C.

BMC Cancer. 2018 Nov 15;18(1):1117. doi: 10.1186/s12885-018-5026-x.

13.

The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage.

Piquet S, Le Parc F, Bai SK, Chevallier O, Adam S, Polo SE.

Mol Cell. 2018 Dec 6;72(5):888-901.e7. doi: 10.1016/j.molcel.2018.09.010. Epub 2018 Oct 18.

14.

Live Imaging of Parental Histone Variant Dynamics in UVC-Damaged Chromatin.

Dabin J, Fortuny A, Piquet S, Polo SE.

Methods Mol Biol. 2018;1832:243-253. doi: 10.1007/978-1-4939-8663-7_13.

PMID:
30073531
15.

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.

Rambau PF, Vierkant RA, Intermaggio MP, Kelemen LE, Goodman MT, Herpel E, Pharoah PD, Kommoss S, Jimenez-Linan M, Karlan BY, Gentry-Maharaj A, Menon U, Polo SH, Candido Dos Reis FJ, Doherty JA, Gayther SA, Sharma R, Larson MC, Harnett PR, Hatfield E, de Andrade JM, Nelson GS, Steed H, Schildkraut JM, Carney ME, Høgdall E, Whittemore AS, Widschwendter M, Kennedy CJ, Wang F, Wang Q, Wang C, Armasu SM, Daley F, Coulson P, Jones ME, Anglesio MS, Chow C, de Fazio A, García-Closas M, Brucker SY, Cybulski C, Harris HR, Hartkopf AD, Huzarski T, Jensen A, Lubiński J, Oszurek O, Benitez J, Mina F, Staebler A, Taran FA, Pasternak J, Talhouk A, Rossing MA, Hendley J; AOCS Group, Edwards RP, Fereday S, Modugno F, Ness RB, Sieh W, El-Bahrawy MA, Winham SJ, Lester J, Kjaer SK, Gronwald J, Sinn P, Fasching PA, Chang-Claude J, Moysich KB, Bowtell DD, Hernandez BY, Luk H, Behrens S, Shah M, Jung A, Ghatage P, Alsop J, Alsop K, García-Donas J, Thompson PJ, Swerdlow AJ, Karpinskyj C, Cazorla-Jiménez A, García MJ, Deen S, Wilkens LR, Palacios J, Berchuck A, Koziak JM, Brenton JD, Cook LS, Goode EL, Huntsman DG, Ramus SJ, Köbel M.

J Pathol Clin Res. 2018 Oct;4(4):250-261. doi: 10.1002/cjp2.109. Epub 2018 Sep 21.

16.

β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.

Jäckl M, Stollmaier C, Strohäker T, Hyz K, Maspero E, Polo S, Wiesner S.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3218-3233. doi: 10.1016/j.jmb.2018.06.044. Epub 2018 Jun 28.

PMID:
29964046
17.

Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.

Kam CY, Dubash AD, Magistrati E, Polo S, Satchell KJF, Sheikh F, Lampe PD, Green KJ.

J Cell Biol. 2018 Sep 3;217(9):3219-3235. doi: 10.1083/jcb.201710161. Epub 2018 Jun 29.

18.

Design, facile synthesis, and evaluation of novel spiro- and pyrazolo[1,5-c]quinazolines as cholinesterase inhibitors: Molecular docking and MM/GBSA studies.

Gálvez J, Polo S, Insuasty B, Gutiérrez M, Cáceres D, Alzate-Morales JH, De-la-Torre P, Quiroga J.

Comput Biol Chem. 2018 Jun;74:218-229. doi: 10.1016/j.compbiolchem.2018.03.001. Epub 2018 Mar 7.

PMID:
29655025
19.

The response to DNA damage in heterochromatin domains.

Fortuny A, Polo SE.

Chromosoma. 2018 Sep;127(3):291-300. doi: 10.1007/s00412-018-0669-6. Epub 2018 Mar 29. Review.

20.

Effect of sludge features and extraction-esterification technology on the synthesis of biodiesel from secondary wastewater treatment sludges.

Patiño Y, Mantecón LG, Polo S, Faba L, Díaz E, Ordóñez S.

Bioresour Technol. 2018 Jan;247:209-216. doi: 10.1016/j.biortech.2017.09.058. Epub 2017 Sep 10.

PMID:
28950128
21.

Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors.

Fajner V, Maspero E, Polo S.

FEBS Lett. 2017 Sep;591(17):2636-2647. doi: 10.1002/1873-3468.12775. Epub 2017 Aug 20. Review.

22.

Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.

Caldieri G, Barbieri E, Nappo G, Raimondi A, Bonora M, Conte A, Verhoef LGGC, Confalonieri S, Malabarba MG, Bianchi F, Cuomo A, Bonaldi T, Martini E, Mazza D, Pinton P, Tacchetti C, Polo S, Di Fiore PP, Sigismund S.

Science. 2017 May 12;356(6338):617-624. doi: 10.1126/science.aah6152.

23.

Choreography of parental histones in damaged chromatin.

Dabin J, Polo SE.

Nucleus. 2017 May 4;8(3):255-260. doi: 10.1080/19491034.2017.1292192. Epub 2017 Feb 23. Review.

24.

Genome and Epigenome Maintenance by Keeping Histone Turnover in Check.

Fortuny A, Polo SE.

Mol Cell. 2017 Apr 6;66(1):3-4. doi: 10.1016/j.molcel.2017.03.015.

25.

Switching genes to silent mode near DNA double-strand breaks.

Polo SE.

EMBO Rep. 2017 May;18(5):659-660. doi: 10.15252/embr.201744052. Epub 2017 Mar 23. No abstract available.

26.

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.

Myant KB, Cammareri P, Hodder MC, Wills J, Von Kriegsheim A, Győrffy B, Rashid M, Polo S, Maspero E, Vaughan L, Gurung B, Barry E, Malliri A, Camargo F, Adams DJ, Iavarone A, Lasorella A, Sansom OJ.

EMBO Mol Med. 2017 Feb;9(2):181-197. doi: 10.15252/emmm.201606684.

27.

Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage.

Adam S, Dabin J, Chevallier O, Leroy O, Baldeyron C, Corpet A, Lomonte P, Renaud O, Almouzni G, Polo SE.

Mol Cell. 2016 Oct 6;64(1):65-78. doi: 10.1016/j.molcel.2016.08.019. Epub 2016 Sep 15.

28.

In Vitro Ubiquitination: Self-Ubiquitination, Chain Formation, and Substrate Ubiquitination Assays.

Maspero E, Polo S.

Methods Mol Biol. 2016;1449:153-60. doi: 10.1007/978-1-4939-3756-1_7.

PMID:
27613033
29.

Strategies to Detect Endogenous Ubiquitination of a Target Mammalian Protein.

Sigismund S, Polo S.

Methods Mol Biol. 2016;1449:143-51. doi: 10.1007/978-1-4939-3756-1_6. Review.

PMID:
27613032
30.

Epigenome Maintenance in Response to DNA Damage.

Dabin J, Fortuny A, Polo SE.

Mol Cell. 2016 Jun 2;62(5):712-27. doi: 10.1016/j.molcel.2016.04.006. Review.

31.

Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.

He F, Wollscheid HP, Nowicka U, Biancospino M, Valentini E, Ehlinger A, Acconcia F, Magistrati E, Polo S, Walters KJ.

Cell Rep. 2016 Mar 22;14(11):2683-94. doi: 10.1016/j.celrep.2016.01.079. Epub 2016 Mar 10.

32.

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.

Wollscheid HP, Biancospino M, He F, Magistrati E, Molteni E, Lupia M, Soffientini P, Rottner K, Cavallaro U, Pozzoli U, Mapelli M, Walters KJ, Polo S.

Nat Struct Mol Biol. 2016 Apr;23(4):300-308. doi: 10.1038/nsmb.3187. Epub 2016 Mar 7.

33.

USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15.

Savio MG, Wollscheid N, Cavallaro E, Algisi V, Di Fiore PP, Sigismund S, Maspero E, Polo S.

Curr Biol. 2016 Jan 25;26(2):173-183. doi: 10.1016/j.cub.2015.11.050. Epub 2015 Dec 31.

34.

Chromatin dynamics after DNA damage: The legacy of the access-repair-restore model.

Polo SE, Almouzni G.

DNA Repair (Amst). 2015 Dec;36:114-121. doi: 10.1016/j.dnarep.2015.09.014. Epub 2015 Sep 15. Review.

35.

Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells.

Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, Di Fiore PP, Sigismund S, Ciliberto A.

Nat Commun. 2015 Aug 12;6:7999. doi: 10.1038/ncomms8999.

36.

Clostridium amazonense sp. nov. an obliqately anaerobic bacterium isolated from a remote Amazonian community in Peru.

O'Neal L, Obregón-Tito AJ, Tito RY, Ozga AT, Polo SI, Lewis CM Jr, Lawson PA.

Anaerobe. 2015 Oct;35(Pt B):33-7. doi: 10.1016/j.anaerobe.2015.06.005. Epub 2015 Jun 26.

37.

Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway.

Lou H, Villagran G, Boland JF, Im KM, Polo S, Zhou W, Odey U, Juárez-Torres E, Medina-Martínez I, Roman-Basaure E, Mitchell J, Roberson D, Sawitzke J, Garland L, Rodríguez-Herrera M, Wells D, Troyer J, Pinto FC, Bass S, Zhang X, Castillo M, Gold B, Morales H, Yeager M, Berumen J, Alvirez E, Gharzouzi E, Dean M.

Clin Cancer Res. 2015 Dec 1;21(23):5360-70. doi: 10.1158/1078-0432.CCR-14-1837. Epub 2015 Jun 16.

38.

Chromatin plasticity in response to DNA damage: The shape of things to come.

Adam S, Dabin J, Polo SE.

DNA Repair (Amst). 2015 Aug;32:120-126. doi: 10.1016/j.dnarep.2015.04.022. Epub 2015 May 1. Review.

39.

Imaging local deposition of newly synthesized histones in UVC-damaged chromatin.

Adam S, Dabin J, Bai SK, Polo SE.

Methods Mol Biol. 2015;1288:337-47. doi: 10.1007/978-1-4939-2474-5_19.

PMID:
25827889
40.

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

Mari S, Ruetalo N, Maspero E, Stoffregen MC, Pasqualato S, Polo S, Wiesner S.

Structure. 2014 Nov 4;22(11):1639-49. doi: 10.1016/j.str.2014.09.006. Epub 2014 Oct 30.

41.

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.

Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, Safi F, Moran MF, Polo S, Rotin D.

Sci Signal. 2014 Oct 7;7(346):ra95. doi: 10.1126/scisignal.2005290.

PMID:
25292214
42.

Blurring the line between the DNA damage response and transcription: the importance of chromatin dynamics.

Adam S, Polo SE.

Exp Cell Res. 2014 Nov 15;329(1):148-53. doi: 10.1016/j.yexcr.2014.07.017. Epub 2014 Jul 22. Review.

43.

Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.

Boissan M, Montagnac G, Shen Q, Griparic L, Guitton J, Romao M, Sauvonnet N, Lagache T, Lascu I, Raposo G, Desbourdes C, Schlattner U, Lacombe ML, Polo S, van der Bliek AM, Roux A, Chavrier P.

Science. 2014 Jun 27;344(6191):1510-5. doi: 10.1126/science.1253768.

44.

Reshaping chromatin after DNA damage: the choreography of histone proteins.

Polo SE.

J Mol Biol. 2015 Feb 13;427(3):626-36. doi: 10.1016/j.jmb.2014.05.025. Epub 2014 Jun 2. Review.

45.
46.

Keeping EGFR signaling in check: ubiquitin is the guardian.

Polo S, Di Fiore PP, Sigismund S.

Cell Cycle. 2014;13(5):681-2. doi: 10.4161/cc.27855. Epub 2014 Jan 21. No abstract available.

47.

Expression of c-erbB-2 in breast cancer cell lines as experimental receptor of magnetic nanoparticles.

Silva JG, Sánchez V, Polo SM, González CA.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:4498-501. doi: 10.1109/EMBC.2013.6610546.

PMID:
24110733
48.

Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA.

Adam S, Polo SE, Almouzni G.

Cell. 2013 Sep 26;155(1):94-106. doi: 10.1016/j.cell.2013.08.029.

49.

Threshold-controlled ubiquitination of the EGFR directs receptor fate.

Sigismund S, Algisi V, Nappo G, Conte A, Pascolutti R, Cuomo A, Bonaldi T, Argenzio E, Verhoef LG, Maspero E, Bianchi F, Capuani F, Ciliberto A, Polo S, Di Fiore PP.

EMBO J. 2013 Jul 31;32(15):2140-57. doi: 10.1038/emboj.2013.149. Epub 2013 Jun 25.

50.

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.

Sorrentino V, Nelson JK, Maspero E, Marques AR, Scheer L, Polo S, Zelcer N.

J Lipid Res. 2013 Aug;54(8):2174-84. doi: 10.1194/jlr.M037713. Epub 2013 Jun 3.

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