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Items: 10


Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.

Pollizzi KN, Sun IH, Patel CH, Lo YC, Oh MH, Waickman AT, Tam AJ, Blosser RL, Wen J, Delgoffe GM, Powell JD.

Nat Immunol. 2016 Jun;17(6):704-11. doi: 10.1038/ni.3438. Epub 2016 Apr 11.


mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation.

Pollizzi KN, Patel CH, Sun IH, Oh MH, Waickman AT, Wen J, Delgoffe GM, Powell JD.

J Clin Invest. 2015 May;125(5):2090-108. doi: 10.1172/JCI77746. Epub 2015 Apr 20.


Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition.

Pollizzi KN, Waickman AT, Patel CH, Sun IH, Powell JD.

PLoS One. 2015 Apr 7;10(4):e0121710. doi: 10.1371/journal.pone.0121710. eCollection 2015.


Regulation of T cells by mTOR: the known knowns and the known unknowns.

Pollizzi KN, Powell JD.

Trends Immunol. 2015 Jan;36(1):13-20. doi: 10.1016/ Epub 2014 Dec 16. Review.


Integrating canonical and metabolic signalling programmes in the regulation of T cell responses.

Pollizzi KN, Powell JD.

Nat Rev Immunol. 2014 Jul;14(7):435-46. doi: 10.1038/nri3701. Review.


A modified model of T-cell differentiation based on mTOR activity and metabolism.

Powell JD, Heikamp EB, Pollizzi KN, Waickman AT.

Cold Spring Harb Symp Quant Biol. 2013;78:125-30. doi: 10.1101/sqb.2013.78.020214. Epub 2013 Oct 7.


Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.

Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, Koretzky GA.

Nat Immunol. 2013 Jun;14(6):611-8. doi: 10.1038/ni.2607. Epub 2013 May 5. Retraction in: Nat Immunol. 2014 Oct;15(10):996.


Regulation of immune responses by mTOR.

Powell JD, Pollizzi KN, Heikamp EB, Horton MR.

Annu Rev Immunol. 2012;30:39-68. doi: 10.1146/annurev-immunol-020711-075024. Epub 2011 Nov 29. Review.


Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.

Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18348-53. doi: 10.1073/pnas.1108856108. Epub 2011 Oct 31.


The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD.

Nat Immunol. 2011 Apr;12(4):295-303. doi: 10.1038/ni.2005. Epub 2011 Feb 27.

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