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Items: 27


Low dose Btk inhibitors selectively block platelet activation by CLEC-2.

Nicolson PLR, Nock SH, Hinds J, Garcia-Quintanilla L, Smith CW, Campos J, Brill A, Pike JA, Khan AO, Poulter NS, Kavanagh DM, Watson S, Watson CN, Clifford H, Huissoon AP, Pollitt AY, Eble JA, Pratt G, Watson SP, Hughes CE.

Haematologica. 2020 Jan 16. pii: haematol.2019.218545. doi: 10.3324/haematol.2019.218545. [Epub ahead of print]


Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation.

Dunster JL, Unsworth AJ, Bye AP, Haining EJ, Sowa MA, Di Y, Sage T, Pallini C, Pike JA, Hardy AT, Nieswandt B, García Á, Watson SP, Poulter NS, Gibbins JM, Pollitt AY.

J Thromb Haemost. 2020 Feb;18(2):485-496. doi: 10.1111/jth.14673. Epub 2019 Dec 6.


The Study of Platelet Receptors Using Artificial Lipid Bilayers.

Dustin ML, Pollitt AY.

Methods Mol Biol. 2018;1812:127-137. doi: 10.1007/978-1-4939-8585-2_8.


Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI.

Nicolson PLR, Hughes CE, Watson S, Nock SH, Hardy AT, Watson CN, Montague SJ, Clifford H, Huissoon AP, Malcor JD, Thomas MR, Pollitt AY, Tomlinson MG, Pratt G, Watson SP.

Haematologica. 2018 Dec;103(12):2097-2108. doi: 10.3324/haematol.2018.193391. Epub 2018 Jul 19.


Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis.

Lombard SE, Pollitt AY, Hughes CE, Di Y, Mckinnon T, O'callaghan CA, Watson SP.

Platelets. 2018 Nov;29(7):716-722. doi: 10.1080/09537104.2017.1356919. Epub 2017 Nov 1.


Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets.

Poulter NS, Pollitt AY, Owen DM, Gardiner EE, Andrews RK, Shimizu H, Ishikawa D, Bihan D, Farndale RW, Moroi M, Watson SP, Jung SM.

J Thromb Haemost. 2017 Mar;15(3):549-564. doi: 10.1111/jth.13613. Epub 2017 Feb 16.


Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.

Poulter NS, Pollitt AY, Davies A, Malinova D, Nash GB, Hannon MJ, Pikramenou Z, Rappoport JZ, Hartwig JH, Owen DM, Thrasher AJ, Watson SP, Thomas SG.

Nat Commun. 2015 Jun 1;6:7254. doi: 10.1038/ncomms8254.


Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.

Alshehri OM, Montague S, Watson S, Carter P, Sarker N, Manne BK, Miller JL, Herr AB, Pollitt AY, O'Callaghan CA, Kunapuli S, Arman M, Hughes CE, Watson SP.

Biochem J. 2015 Jun 15;468(3):459-73. doi: 10.1042/BJ20150192. Epub 2015 Apr 7.


Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling.

Navarro-Núñez L, Pollitt AY, Lowe K, Latif A, Nash GB, Watson SP.

Thromb Haemost. 2015 May;113(5):1109-20. doi: 10.1160/TH14-09-0762. Epub 2015 Feb 19.


Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.

Flierl U, Nero TL, Lim B, Arthur JF, Yao Y, Jung SM, Gitz E, Pollitt AY, Zaldivia MT, Jandrot-Perrus M, Schäfer A, Nieswandt B, Andrews RK, Parker MW, Gardiner EE, Peter K.

J Exp Med. 2015 Feb 9;212(2):129-37. doi: 10.1084/jem.20140391. Epub 2015 Feb 2.


Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.

Pollitt AY, Poulter NS, Gitz E, Navarro-Nuñez L, Wang YJ, Hughes CE, Thomas SG, Nieswandt B, Douglas MR, Owen DM, Jackson DG, Dustin ML, Watson SP.

J Biol Chem. 2014 Dec 26;289(52):35695-710. doi: 10.1074/jbc.M114.584284. Epub 2014 Nov 3.


CLEC-2 expression is maintained on activated platelets and on platelet microparticles.

Gitz E, Pollitt AY, Gitz-Francois JJ, Alshehri O, Mori J, Montague S, Nash GB, Douglas MR, Gardiner EE, Andrews RK, Buckley CD, Harrison P, Watson SP.

Blood. 2014 Oct 2;124(14):2262-70. doi: 10.1182/blood-2014-05-572818. Epub 2014 Aug 22.


CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP.

Borgognone A, Navarro-Núñez L, Correia JN, Pollitt AY, Thomas SG, Eble JA, Pulcinelli FM, Madhani M, Watson SP.

J Thromb Haemost. 2014 Apr;12(4):550-9. doi: 10.1111/jth.12514.


Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation.

Ura S, Pollitt AY, Veltman DM, Morrice NA, Machesky LM, Insall RH.

Curr Biol. 2012 Apr 10;22(7):553-61. doi: 10.1016/j.cub.2012.02.020. Epub 2012 Mar 1.


CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

Finney BA, Schweighoffer E, Navarro-Núñez L, Bénézech C, Barone F, Hughes CE, Langan SA, Lowe KL, Pollitt AY, Mourao-Sa D, Sheardown S, Nash GB, Smithers N, Reis e Sousa C, Tybulewicz VL, Watson SP.

Blood. 2012 Feb 16;119(7):1747-56. doi: 10.1182/blood-2011-09-380709. Epub 2011 Dec 20.


Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling.

Séverin S, Pollitt AY, Navarro-Nuñez L, Nash CA, Mourão-Sá D, Eble JA, Senis YA, Watson SP.

J Biol Chem. 2011 Feb 11;286(6):4107-16. doi: 10.1074/jbc.M110.167502. Epub 2010 Nov 22.


A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.

Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH.

J Exp Med. 2010 Aug 30;207(9):1967-79. doi: 10.1084/jem.20100222. Epub 2010 Aug 16.


CLEC-2 is not required for platelet aggregation at arteriolar shear.

Hughes CE, Navarro-Núñez L, Finney BA, Mourão-Sá D, Pollitt AY, Watson SP.

J Thromb Haemost. 2010 Oct;8(10):2328-2332. doi: 10.1111/j.1538-7836.2010.04006.x. No abstract available.


GPVI and CLEC-2 in hemostasis and vascular integrity.

Watson SP, Herbert JM, Pollitt AY.

J Thromb Haemost. 2010 Jul;8(7):1456-67. doi: 10.1111/j.1538-7836.2010.03875.x. Epub 2010 Mar 25. Review.


CLEC-2 activates Syk through dimerization.

Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP.

Blood. 2010 Apr 8;115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12.


Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.

Pollitt AY, Grygielska B, Leblond B, Désiré L, Eble JA, Watson SP.

Blood. 2010 Apr 8;115(14):2938-46. doi: 10.1182/blood-2009-12-257212. Epub 2010 Feb 12.


WASP and SCAR/WAVE proteins: the drivers of actin assembly.

Pollitt AY, Insall RH.

J Cell Sci. 2009 Aug 1;122(Pt 15):2575-8. doi: 10.1242/jcs.023879. Review. No abstract available.


The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.

Spalton JC, Mori J, Pollitt AY, Hughes CE, Eble JA, Watson SP.

J Thromb Haemost. 2009 Jul;7(7):1192-9. doi: 10.1111/j.1538-7836.2009.03451.x. Epub 2009 Apr 24.


Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein.

Pollitt AY, Insall RH.

BMC Cell Biol. 2009 Feb 19;10:13. doi: 10.1186/1471-2121-10-13.


Abi mutants in Dictyostelium reveal specific roles for the SCAR/WAVE complex in cytokinesis.

Pollitt AY, Insall RH.

Curr Biol. 2008 Feb 12;18(3):203-10. doi: 10.1016/j.cub.2008.01.026.


Renal cells activate the platelet receptor CLEC-2 through podoplanin.

Christou CM, Pearce AC, Watson AA, Mistry AR, Pollitt AY, Fenton-May AE, Johnson LA, Jackson DG, Watson SP, O'Callaghan CA.

Biochem J. 2008 Apr 1;411(1):133-40. doi: 10.1042/BJ20071216.


Cell motility and SCAR localisation in axenically growing Dictyostelium cells.

Pollitt AY, Blagg SL, Ibarra N, Insall RH.

Eur J Cell Biol. 2006 Sep;85(9-10):1091-8. Epub 2006 Jul 5.


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