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Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.

Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, Carvalho DD, Lupien M, Arrowsmith CH, O'Brien CA.

Nat Commun. 2019 Mar 29;10(1):1436. doi: 10.1038/s41467-019-09309-4.


Interobserver Agreement for Mismatch Repair Protein Immunohistochemistry in Endometrial and Nonserous, Nonmucinous Ovarian Carcinomas.

Sari A, Pollett A, Eiriksson LR, Lumsden-Johanson B, Van de Laar E, Kazerouni H, Salehi A, Sur M, Lytwyn A, Ferguson SE.

Am J Surg Pathol. 2019 May;43(5):591-600. doi: 10.1097/PAS.0000000000001220.


Learning by Example: An International Perspective on Reflex-Testing for Lynch Syndrome.

Palter VN, Baker NA, Pollett A, Daly C, Facey M, Rotenberg C, Rabeneck L, Baxter NN.

Ann Surg Oncol. 2019 Feb;26(2):425-436. doi: 10.1245/s10434-018-6809-7. Epub 2018 Oct 1.


Familial PDGFRA-mutation syndrome: somatic and gastrointestinal phenotype.

Manley PN, Abu-Abed S, Kirsch R, Hawrysh A, Perrier N, Feilotter H, Pollett A, Riddell RH, Hookey L, Walia JS.

Hum Pathol. 2018 Jun;76:52-57. doi: 10.1016/j.humpath.2018.02.014. Epub 2018 Feb 25.


The impact of knowledge transfer on the detection of venous invasion in colorectal cancer.

Kirsch R, Assarzadegan N, Messenger DE, Juda A, Riddell RH, Pollett A, Streutker CJ, Divaris DX, Newell KJ, Price RG, Smith S, Al-Haddad S, Parfitt JR, Driman DK.

Hum Pathol. 2017 Sep;67:45-53. doi: 10.1016/j.humpath.2017.07.004. Epub 2017 Jul 15.


Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.

Connor AA, Denroche RE, Jang GH, Timms L, Kalimuthu SN, Selander I, McPherson T, Wilson GW, Chan-Seng-Yue MA, Borozan I, Ferretti V, Grant RC, Lungu IM, Costello E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos JP, Buchler M, Petersen G, Thayer S, Hollingsworth MA, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl MHA, Bavi P, Bartlett JMS, Cleary S, Wilson JM, Alexandrov LB, Moore M, Wouters BG, McPherson JD, Notta F, Stein LD, Gallinger S.

JAMA Oncol. 2017 Jun 1;3(6):774-783. doi: 10.1001/jamaoncol.2016.3916.


Prophylactic Total Gastrectomy: a Prospective Cohort Study of Long-Term Impact on Quality of Life.

Muir J, Aronson M, Esplen MJ, Pollett A, Swallow CJ.

J Gastrointest Surg. 2016 Dec;20(12):1950-1958. Epub 2016 Oct 17.


High prevalence of adenomatous colorectal polyps in young cancer survivors treated with abdominal radiation therapy: results of a prospective trial.

Daly PE, Samiee S, Cino M, Gryfe R, Pollett A, Ng A, Constine LS, Hodgson DC.

Gut. 2017 Oct;66(10):1797-1801. doi: 10.1136/gutjnl-2016-311501. Epub 2016 Jul 13.


Ileal "carcinoid" tumors-small size belies deadly intent: high rate of nodal metastasis in tumors ≤1 cm in size.

Walsh JC, Schaeffer DF, Kirsch R, Pollett A, Manzoni M, Riddell RH, Albarello L.

Hum Pathol. 2016 Oct;56:123-7. doi: 10.1016/j.humpath.2016.05.023. Epub 2016 Jun 18.


Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.

Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio IIC, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW.

Cell Stem Cell. 2016 Aug 4;19(2):205-216. doi: 10.1016/j.stem.2016.04.002. Epub 2016 May 12.


Genetic testing for Lynch syndrome in the province of Ontario.

Wang M, Aldubayan S, Connor AA, Wong B, Mcnamara K, Khan T, Semotiuk K, Khalouei S, Holter S, Aronson M, Cohen Z, Gallinger S, Charames G, Pollett A, Lerner-Ellis J.

Cancer. 2016 Jun 1;122(11):1672-9. doi: 10.1002/cncr.29950. Epub 2016 Mar 28.


A Method for Catchment Scale Mapping of Groundwater-Dependent Ecosystems to Support Natural Resource Management (Queensland, Australia).

Glanville K, Ryan T, Tomlinson M, Muriuki G, Ronan M, Pollett A.

Environ Manage. 2016 Feb;57(2):432-49. doi: 10.1007/s00267-015-0612-z. Epub 2015 Sep 24.


DNA Mismatch Repair Status Predicts Need for Future Colorectal Surgery for Metachronous Neoplasms in Young Individuals Undergoing Colorectal Cancer Resection.

Aronson M, Holter S, Semotiuk K, Winter L, Pollett A, Gallinger S, Cohen Z, Gryfe R.

Dis Colon Rectum. 2015 Jul;58(7):645-52. doi: 10.1097/DCR.0000000000000391.


Phenotypic and genotypic characterisation of biallelic mismatch repair deficiency (BMMR-D) syndrome.

Durno CA, Sherman PM, Aronson M, Malkin D, Hawkins C, Bakry D, Bouffet E, Gallinger S, Pollett A, Campbell B, Tabori U; International BMMRD Consortium.

Eur J Cancer. 2015 May;51(8):977-83. doi: 10.1016/j.ejca.2015.02.008. Epub 2015 Apr 13. Review.


Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S, Pollett A, Lipman T, Heidari A, Deshmukh S, Avitzur N, Meier B, Gerstung M, Hong Y, Merino DM, Ramakrishna M, Remke M, Arnold R, Panigrahi GB, Thakkar NP, Hodel KP, Henninger EE, Göksenin AY, Bakry D, Charames GS, Druker H, Lerner-Ellis J, Mistry M, Dvir R, Grant R, Elhasid R, Farah R, Taylor GP, Nathan PC, Alexander S, Ben-Shachar S, Ling SC, Gallinger S, Constantini S, Dirks P, Huang A, Scherer SW, Grundy RG, Durno C, Aronson M, Gartner A, Meyn MS, Taylor MD, Pursell ZF, Pearson CE, Malkin D, Futreal PA, Stratton MR, Bouffet E, Hawkins C, Campbell PJ, Tabori U; Biallelic Mismatch Repair Deficiency Consortium.

Nat Genet. 2015 Mar;47(3):257-62. doi: 10.1038/ng.3202. Epub 2015 Feb 2.


Personalized medicine: CCO's vision, accomplishments and future plans.

Guo J, Kamel-Reid S, Rutherford M, Hart J, Melamed S, Pollett A.

Healthc Q. 2015;17 Spec No:41-3.


Performance characteristics of a brief Family History Questionnaire to screen for Lynch syndrome in women with newly diagnosed endometrial cancer.

Eiriksson L, Aronson M, Clarke B, Mojtahedi G, Massey C, Oza AM, Gallinger S, Pollett A, Mackay H, Bernardini MQ, Ferguson SE.

Gynecol Oncol. 2015 Feb;136(2):311-6. doi: 10.1016/j.ygyno.2014.12.023. Epub 2014 Dec 19.


Identification of a novel MSH6 germline variant in a family with multiple gastro-intestinal malignancies by next generation sequencing.

Connor AA, Katzov-Eckert H, Whelan T, Aronson M, Lau L, Marshall C, Charames GS, Pollett A, Gallinger S, Lerner-Ellis J.

Fam Cancer. 2015 Mar;14(1):69-75. doi: 10.1007/s10689-014-9765-9.


High prevalence of mismatch repair deficiency in prostate cancers diagnosed in mismatch repair gene mutation carriers from the colon cancer family registry.

Rosty C, Walsh MD, Lindor NM, Thibodeau SN, Mundt E, Gallinger S, Aronson M, Pollett A, Baron JA, Pearson S, Clendenning M, Walters RJ, Nagler BN, Crawford WJ, Young JP, Winship I, Win AK, Hopper JL, Jenkins MA, Buchanan DD.

Fam Cancer. 2014 Dec;13(4):573-82. doi: 10.1007/s10689-014-9744-1.


Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing.

Ferguson SE, Aronson M, Pollett A, Eiriksson LR, Oza AM, Gallinger S, Lerner-Ellis J, Alvandi Z, Bernardini MQ, MacKay HJ, Mojtahedi G, Tone AA, Massey C, Clarke BA.

Cancer. 2014 Dec 15;120(24):3932-9. doi: 10.1002/cncr.28933. Epub 2014 Jul 31.


The histomorphology of Lynch syndrome-associated ovarian carcinomas: toward a subtype-specific screening strategy.

Chui MH, Ryan P, Radigan J, Ferguson SE, Pollett A, Aronson M, Semotiuk K, Holter S, Sy K, Kwon JS, Soma A, Singh N, Gallinger S, Shaw P, Arseneau J, Foulkes WD, Gilks CB, Clarke BA.

Am J Surg Pathol. 2014 Sep;38(9):1173-81. doi: 10.1097/PAS.0000000000000298.


Progression and Management of Duodenal Neoplasia in Familial Adenomatous Polyposis: A Cohort Study.

Serrano PE, Grant RC, Berk TC, Kim D, Al-Ali H, Cohen Z, Pollett A, Riddell R, Silverberg MS, Kortan P, May GR, Gallinger S.

Ann Surg. 2015 Jun;261(6):1138-44. doi: 10.1097/SLA.0000000000000734.


Review of findings in prophylactic gynaecological specimens in Lynch syndrome with literature review and recommendations for grossing.

Downes MR, Allo G, McCluggage WG, Sy K, Ferguson SE, Aronson M, Pollett A, Gallinger S, Bilbily E, Shaw P, Clarke BA.

Histopathology. 2014 Aug;65(2):228-39. doi: 10.1111/his.12386. Epub 2014 Apr 16. Review.


Genetic and clinical determinants of constitutional mismatch repair deficiency syndrome: report from the constitutional mismatch repair deficiency consortium.

Bakry D, Aronson M, Durno C, Rimawi H, Farah R, Alharbi QK, Alharbi M, Shamvil A, Ben-Shachar S, Mistry M, Constantini S, Dvir R, Qaddoumi I, Gallinger S, Lerner-Ellis J, Pollett A, Stephens D, Kelies S, Chao E, Malkin D, Bouffet E, Hawkins C, Tabori U.

Eur J Cancer. 2014 Mar;50(5):987-96. doi: 10.1016/j.ejca.2013.12.005. Epub 2014 Jan 15.


The microenvironment-specific transformation of adult stem cells models malignant triton tumors.

Lavasani M, Pollett JB, Usas A, Thompson SD, Pollett AF, Huard J.

PLoS One. 2013 Dec 9;8(12):e82173. doi: 10.1371/journal.pone.0082173. eCollection 2013.


Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.

Peltekova VD, Lemire M, Qazi AM, Zaidi SH, Trinh QM, Bielecki R, Rogers M, Hodgson L, Wang M, D'Souza DJ, Zandi S, Chong T, Kwan JY, Kozak K, De Borja R, Timms L, Rangrej J, Volar M, Chan-Seng-Yue M, Beck T, Ash C, Lee S, Wang J, Boutros PC, Stein LD, Dick JE, Gryfe R, McPherson JD, Zanke BW, Pollett A, Gallinger S, Hudson TJ.

Int J Cancer. 2014 May 15;134(10):2330-41. doi: 10.1002/ijc.28557. Epub 2013 Nov 13.


Mucinous tumor of the appendix with limited peritoneal spread: is there a role for expectant observation?

Zih FS, Wong-Chong N, Hummel C, Petronis J, Panzarella T, Pollett A, McCart JA, Swallow CJ.

Ann Surg Oncol. 2014 Jan;21(1):225-31. doi: 10.1245/s10434-013-3283-0. Epub 2013 Oct 8. Erratum in: Ann Surg Oncol. 2014 Dec;21 Suppl 4:S777. McCart, Andrea J [corrected to McCart, J Andrea].


Unifying diagnosis for adenomatous polyps, café-au-lait macules, and a brain mass?

Durno C, Pollett A, Gallinger S.

Gastroenterology. 2013 Nov;145(5):e3-4. doi: 10.1053/j.gastro.2013.06.044. Epub 2013 Sep 24. No abstract available.


ARID1A loss correlates with mismatch repair deficiency and intact p53 expression in high-grade endometrial carcinomas.

Allo G, Bernardini MQ, Wu RC, Shih IeM, Kalloger S, Pollett A, Gilks CB, Clarke BA.

Mod Pathol. 2014 Feb;27(2):255-61. doi: 10.1038/modpathol.2013.144. Epub 2013 Jul 26.


The Fatty Liver Index has limited utility for the detection and quantification of hepatic steatosis in obese patients.

Borman MA, Ladak F, Crotty P, Pollett A, Kirsch R, Pomier-Layrargues G, Beaton M, Duarte-Rojo A, Elkashab M, Myers RP.

Hepatol Int. 2013 Jun;7(2):592-9. doi: 10.1007/s12072-012-9401-4. Epub 2012 Sep 29.


Digital pathology: Attitudes and practices in the Canadian pathology community.

Bellis M, Metias S, Naugler C, Pollett A, Jothy S, Yousef GM.

J Pathol Inform. 2013 Mar 14;4:3. doi: 10.4103/2153-3539.108540. Print 2013.


Retroperitoneal pelvic cyst: a diagnostic and therapeutic challenge.

Vilos AG, Vilos GA, Marks J, Pollett A.

J Obstet Gynaecol Can. 2013 Feb;35(2):164-167. doi: 10.1016/S1701-2163(15)31022-7.


Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer.

Kreso A, O'Brien CA, van Galen P, Gan OI, Notta F, Brown AM, Ng K, Ma J, Wienholds E, Dunant C, Pollett A, Gallinger S, McPherson J, Mullighan CG, Shibata D, Dick JE.

Science. 2013 Feb 1;339(6119):543-8. doi: 10.1126/science.1227670. Epub 2012 Dec 13.


Venous invasion in colorectal cancer: impact of an elastin stain on detection and interobserver agreement among gastrointestinal and nongastrointestinal pathologists.

Kirsch R, Messenger DE, Riddell RH, Pollett A, Cook M, Al-Haddad S, Streutker CJ, Divaris DX, Pandit R, Newell KJ, Liu J, Price RG, Smith S, Parfitt JR, Driman DK.

Am J Surg Pathol. 2013 Feb;37(2):200-10. doi: 10.1097/PAS.0b013e31826a92cd.


Prevalence of loss of expression of DNA mismatch repair proteins in primary epithelial ovarian tumors.

Lu FI, Gilks CB, Mulligan AM, Ryan P, Allo G, Sy K, Shaw PA, Pollett A, Clarke BA.

Int J Gynecol Pathol. 2012 Nov;31(6):524-31. doi: 10.1097/PGP.0b013e31824fe2aa.


Patients with Lynch syndrome mismatch repair gene mutations are at higher risk for not only upper tract urothelial cancer but also bladder cancer.

Skeldon SC, Semotiuk K, Aronson M, Holter S, Gallinger S, Pollett A, Kuk C, van Rhijn B, Bostrom P, Cohen Z, Fleshner NE, Jewett MA, Hanna S, Shariat SF, Van Der Kwast TH, Evans A, Catto J, Bapat B, Zlotta AR.

Eur Urol. 2013 Feb;63(2):379-85. doi: 10.1016/j.eururo.2012.07.047. Epub 2012 Aug 2.


Lynch syndrome in a predominantly Afrocentric population: a clinicopathological and genetic study.

Plummer JM, Chin SN, Aronson M, Graham RP, Williams NP, Bapat B, Wharfe G, Pollett A, Gallinger S.

Can J Surg. 2012 Oct;55(5):294-300.


Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography.

Myers RP, Pollett A, Kirsch R, Pomier-Layrargues G, Beaton M, Levstik M, Duarte-Rojo A, Wong D, Crotty P, Elkashab M.

Liver Int. 2012 Jul;32(6):902-10. doi: 10.1111/j.1478-3231.2012.02781.x. Epub 2012 Mar 21.


Juvenile polyposis, hereditary hemorrhagic telangiectasia, and early onset colorectal cancer in patients with SMAD4 mutation.

Schwenter F, Faughnan ME, Gradinger AB, Berk T, Gryfe R, Pollett A, Cohen Z, Gallinger S, Durno C.

J Gastroenterol. 2012 Jul;47(7):795-804. doi: 10.1007/s00535-012-0545-8. Epub 2012 Feb 14.


Use of mismatch repair immunohistochemistry and microsatellite instability testing: exploring Canadian practices.

Kalloger SE, Allo G, Mulligan AM, Pollett A, Aronson M, Gallinger S, Torlakovic EE, Clarke BA.

Am J Surg Pathol. 2012 Apr;36(4):560-9. doi: 10.1097/PAS.0b013e31823f3b28.


Discordance in fibrosis staging between liver biopsy and transient elastography using the FibroScan XL probe.

Myers RP, Pomier-Layrargues G, Kirsch R, Pollett A, Beaton M, Levstik M, Duarte-Rojo A, Wong D, Crotty P, Elkashab M.

J Hepatol. 2012 Mar;56(3):564-70. doi: 10.1016/j.jhep.2011.10.007. Epub 2011 Oct 23.


Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients.

Myers RP, Pomier-Layrargues G, Kirsch R, Pollett A, Duarte-Rojo A, Wong D, Beaton M, Levstik M, Crotty P, Elkashab M.

Hepatology. 2012 Jan;55(1):199-208. doi: 10.1002/hep.24624. Epub 2011 Nov 18.


Canadian Expert Group consensus recommendations: KRAS testing in colorectal cancer.

Aubin F, Gill S, Burkes R, Colwell B, Kamel-Reid S, Koski S, Pollett A, Samson B, Tehfe M, Wong R, Young S, Soulières D.

Curr Oncol. 2011 Aug;18(4):e180-4.


Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation-positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registries.

Ryan P, Mulligan AM, Aronson M, Ferguson SE, Bapat B, Semotiuk K, Holter S, Kwon J, Kalloger SE, Gilks CB, Gallinger S, Pollett A, Clarke BA.

Cancer. 2012 Feb 1;118(3):681-8. doi: 10.1002/cncr.26323. Epub 2011 Jun 30.


Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients.

Rawson JB, Mrkonjic M, Daftary D, Dicks E, Buchanan DD, Younghusband HB, Parfrey PS, Young JP, Pollett A, Green RC, Gallinger S, McLaughlin JR, Knight JA, Bapat B.

Br J Cancer. 2011 Jun 7;104(12):1906-12. doi: 10.1038/bjc.2011.165. Epub 2011 May 17.


A descriptive analysis of gastric cancer specimen processing techniques.

Mahar AL, Qureshi AP, Ottensmeyer CA, Pollett A, Wright FC, Coburn NG, Chetty R.

J Surg Oncol. 2011 Mar 1;103(3):248-56. doi: 10.1002/jso.21827.


Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients.

Rawson JB, Manno M, Mrkonjic M, Daftary D, Dicks E, Buchanan DD, Younghusband HB, Parfrey PS, Young JP, Pollett A, Green RC, Gallinger S, McLaughlin JR, Knight JA, Bapat B.

Carcinogenesis. 2011 May;32(5):741-7. doi: 10.1093/carcin/bgr020. Epub 2011 Feb 8.


Hepatic adenomas caused by somatic HNF1A mutations in children with biallelic mismatch repair gene mutations.

Holter S, Pollett A, Zogopoulos G, Kim H, Schwenter F, Asai K, Gallinger S, Clendenning M, Steinbach G, Jacobson A, Boycott KM.

Gastroenterology. 2011 Feb;140(2):735-6. doi: 10.1053/j.gastro.2010.11.051. Epub 2010 Dec 21. No abstract available.


A histology-based model for predicting microsatellite instability in colorectal cancers.

Hyde A, Fontaine D, Stuckless S, Green R, Pollett A, Simms M, Sipahimalani P, Parfrey P, Younghusband B.

Am J Surg Pathol. 2010 Dec;34(12):1820-9. doi: 10.1097/PAS.0b013e3181f6a912.


Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.

Mrkonjic M, Roslin NM, Greenwood CM, Raptis S, Pollett A, Laird PW, Pethe VV, Chiang T, Daftary D, Dicks E, Thibodeau SN, Gallinger S, Parfrey PS, Younghusband HB, Potter JD, Hudson TJ, McLaughlin JR, Green RC, Zanke BW, Newcomb PA, Paterson AD, Bapat B.

PLoS One. 2010 Oct 13;5(10):e13314. doi: 10.1371/journal.pone.0013314.

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