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Two centuries of immunisation in the UK (part II).

Lang S, Loving S, McCarthy ND, Ramsay ME, Salisbury D, Pollard AJ.

Arch Dis Child. 2019 Jul 13. pii: archdischild-2019-317707. doi: 10.1136/archdischild-2019-317707. [Epub ahead of print]


Epigenetics in Sepsis: Understanding Its Role in Endothelial Dysfunction, Immunosuppression, and Potential Therapeutics.

Cross D, Drury R, Hill J, Pollard AJ.

Front Immunol. 2019 Jun 18;10:1363. doi: 10.3389/fimmu.2019.01363. eCollection 2019. Review.


Two centuries of immunisation in the UK (part 1).

Lang S, Loving S, McCarthy ND, Ramsay ME, Salisbury D, Pollard AJ.

Arch Dis Child. 2019 Jul 4. pii: archdischild-2019-317314. doi: 10.1136/archdischild-2019-317314. [Epub ahead of print]


Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.

Gibani MM, Jones E, Barton A, Jin C, Meek J, Camara S, Galal U, Heinz E, Rosenberg-Hasson Y, Obermoser G, Jones C, Campbell D, Black C, Thomaides-Brears H, Darlow C, Dold C, Silva-Reyes L, Blackwell L, Lara-Tejero M, Jiao X, Stack G, Blohmke CJ, Hill J, Angus B, Dougan G, Galán J, Pollard AJ.

Nat Med. 2019 Jul;25(7):1082-1088. doi: 10.1038/s41591-019-0505-4. Epub 2019 Jul 3.


Classical and Non-classical Presentations of Complement Factor I Deficiency: Two Contrasting Cases Diagnosed via Genetic and Genomic Methods.

Shields AM, Pagnamenta AT, Pollard AJ; OxClinWGS, Taylor JC, Allroggen H, Patel SY.

Front Immunol. 2019 Jun 7;10:1150. doi: 10.3389/fimmu.2019.01150. eCollection 2019.


A systematic review of antimicrobial resistance of typhoidal Salmonella in India.

Britto CD, John J, Verghese VP, Pollard AJ.

Indian J Med Res. 2019 Feb;149(2):151-163. doi: 10.4103/ijmr.IJMR_830_18. Review.


Characterization and immunogenicity of a Shigella flexneri 2a O-antigen bioconjugate vaccine candidate.

Ravenscroft N, Braun M, Schneider J, Dreyer AM, Wetter M, Haeuptle MA, Kemmler S, Steffen M, Sirena D, Herwig S, Carranza P, Jones C, Pollard AJ, Wacker M, Kowarik M.

Glycobiology. 2019 Jun 17. pii: cwz044. doi: 10.1093/glycob/cwz044. [Epub ahead of print]



Curtis N, Finn A, Warris A, Pollard AJ, van Rossum A, Ramilo O.

Pediatr Infect Dis J. 2019 Jun;38(6S Suppl 1):S1. doi: 10.1097/INF.0000000000002316. No abstract available.


Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization.

O'Connor D, Png E, Khor CC, Snape MD, Hill AVS, van der Klis F, Hoggart C, Levin M, Hibberd ML, Pollard AJ.

Cell Rep. 2019 Jun 11;27(11):3241-3253.e4. doi: 10.1016/j.celrep.2019.05.053.


OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines.

Cotugno N, Ruggiero A, Santilli V, Manno EC, Rocca S, Zicari S, Amodio D, Colucci M, Rossi P, Levy O, Martinon-Torres F, Pollard AJ, Palma P.

J Immunol Res. 2019 Apr 28;2019:8732191. doi: 10.1155/2019/8732191. eCollection 2019. Review.


Cost-effectiveness of routine and campaign use of typhoid Vi-conjugate vaccine in Gavi-eligible countries: a modelling study.

Bilcke J, Antillón M, Pieters Z, Kuylen E, Abboud L, Neuzil KM, Pollard AJ, Paltiel AD, Pitzer VE.

Lancet Infect Dis. 2019 Jul;19(7):728-739. doi: 10.1016/S1473-3099(18)30804-1. Epub 2019 May 23.


Airway response to respiratory syncytial virus has incidental antibacterial effects.

Sande CJ, Njunge JM, Mwongeli Ngoi J, Mutunga MN, Chege T, Gicheru ET, Gardiner EM, Gwela A, Green CA, Drysdale SB, Berkley JA, Nokes J, Pollard AJ.

Nat Commun. 2019 May 17;10(1):2218. doi: 10.1038/s41467-019-10222-z.


Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study.

Osowicki J, Azzopardi KI, Baker C, Waddington CS, Pandey M, Schuster T, Grobler A, Cheng AC, Pollard AJ, McCarthy JS, Good MF, Walker MJ, Dale JB, Batzloff MR, Carapetis JR, Smeesters PR, Steer AC.

Vaccine. 2019 Jun 6;37(26):3485-3494. doi: 10.1016/j.vaccine.2019.03.059. Epub 2019 May 14.


Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.

Borghini L, Png E, Binder A, Wright VJ, Pinnock E, de Groot R, Hazelzet J, Emonts M, Van der Flier M, Schlapbach LJ, Anderson S, Secka F, Salas A, Fink C, Carrol ED, Pollard AJ, Coin LJ, Kuijpers TW, Martinon-Torres F, Zenz W, Levin M, Hibberd ML, Davila S; EUCLIDS consortium.

Sci Rep. 2019 May 6;9(1):6966. doi: 10.1038/s41598-019-43292-6.


Immunogenicity profiling of protein antigens from capsular group B Neisseria meningitidis.

Awanye AM, Chang CM, Wheeler JX, Chan H, Marsay L, Dold C, Rollier CS, Bird LE, Nettleship JE, Owens RJ, Pollard AJ, Derrick JP.

Sci Rep. 2019 May 2;9(1):6843. doi: 10.1038/s41598-019-43139-0.


The role of immune correlates of protection on the pathway to licensure, policy decision and use of group B Streptococcus vaccines for maternal immunization: considerations from World Health Organization consultations.

Vekemans J, Crofts J, Baker CJ, Goldblatt D, Heath PT, Madhi SA, Le Doare K, Andrews N, Pollard AJ, Saha SK, Schrag SJ, Smith PG, Kaslow DC.

Vaccine. 2019 May 27;37(24):3190-3198. doi: 10.1016/j.vaccine.2019.04.039. Epub 2019 Apr 25. Review.


Persistent circulation of vaccine serotypes and serotype replacement after five years of UK infant immunisation with PCV13.

Kandasamy R, Voysey M, Collins S, Berbers G, Robinson H, Noel I, Hughes H, Ndimah S, Gould K, Fry N, Sheppard C, Ladhani S, Snape MD, Hinds J, Pollard AJ.

J Infect Dis. 2019 Apr 20. pii: jiz178. doi: 10.1093/infdis/jiz178. [Epub ahead of print]


Nanoscale chemical imaging using tip-enhanced Raman spectroscopy.

Kumar N, Weckhuysen BM, Wain AJ, Pollard AJ.

Nat Protoc. 2019 Apr;14(4):1169-1193. doi: 10.1038/s41596-019-0132-z. Epub 2019 Mar 25.


X-Ray Fluorescence Ionomics of Herbarium Collections.

van der Ent A, Echevarria G, Pollard AJ, Erskine PD.

Sci Rep. 2019 Mar 18;9(1):4746. doi: 10.1038/s41598-019-40050-6.


Publisher Correction: Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.

Napolitani G, Kurupati P, Teng KWW, Gibani MM, Rei M, Aulicino A, Preciado-Llanes L, Wong MT, Becht E, Howson L, de Haas P, Salio M, Blohmke CJ, Olsen LR, Pinto DMS, Scifo L, Jones C, Dobinson H, Campbell D, Juel HB, Thomaides-Brears H, Pickard D, Bumann D, Baker S, Dougan G, Simmons A, Gordon MA, Newell EW, Pollard AJ, Cerundolo V.

Nat Immunol. 2019 Apr;20(4):514. doi: 10.1038/s41590-019-0357-6.


Logistics of Implementing a Large-scale Typhoid Vaccine Trial in Kathmandu, Nepal.

Colin-Jones R, Shakya M, Voysey M, Theiss-Nyland K, Smith N, Pant D, Liu X, Tonks S, Mazur O, Farooq YG, Kelly S, Adhikari A, Dongol S, Karkey A, Shrestha S, Basnyat B, Pollard AJ.

Clin Infect Dis. 2019 Mar 7;68(Supplement_2):S138-S145. doi: 10.1093/cid/ciy1125.


Assessing the Impact of a Vi-polysaccharide Conjugate Vaccine in Preventing Typhoid Infection Among Bangladeshi Children: A Protocol for a Phase IIIb Trial.

Theiss-Nyland K, Qadri F, Colin-Jones R, Zaman K, Khanam F, Liu X, Voysey M, Khan A, Hasan N, Ashher F, Farooq YG, Pollard AJ, Clemens JD.

Clin Infect Dis. 2019 Mar 7;68(Supplement_2):S74-S82. doi: 10.1093/cid/ciy1107.


Assessing the Impact of a Vi-polysaccharide Conjugate Vaccine in Preventing Typhoid Infections Among Nepalese Children: A Protocol for a Phase III, Randomized Control Trial.

Theiss-Nyland K, Shakya M, Colin-Jones R, Voysey M, Smith N, Karkey A, Dongol S, Pant D, Farooq YG, Neuzil KM, Shrestha S, Basnyat B, Pollard AJ.

Clin Infect Dis. 2019 Mar 7;68(Supplement_2):S67-S73. doi: 10.1093/cid/ciy1106.


Accelerating Typhoid Conjugate Vaccine Introduction: What Can Be Learned From Prior New Vaccine Introduction Initiatives?

Jamka LP, Simiyu KW, Bentsi-Enchill AD, Mwisongo AJ, Matzger H, Marfin AA, Pollard AJ, Neuzil KM.

Clin Infect Dis. 2019 Mar 7;68(Supplement_2):S171-S176. doi: 10.1093/cid/ciy1118.


The Time is Now to Control Typhoid.

Pollard AJ, Marfin AA, Neuzil KM.

Clin Infect Dis. 2019 Mar 7;68(Supplement_2):S47-S49. doi: 10.1093/cid/ciy1115. No abstract available.


The Design and Analysis of Seroefficacy Studies for Typhoid Conjugate Vaccines.

Liu X, Pitzer VE, Pollard AJ, Voysey M.

Clin Infect Dis. 2019 Mar 7;68(Supplement_2):S183-S190. doi: 10.1093/cid/ciy1119.


Introduction of Typhoid Conjugate Vaccines in Africa and Asia.

Neuzil KM, Pollard AJ, Marfin AA.

Clin Infect Dis. 2019 Feb 15;68(Supplement_1):S27-S30. doi: 10.1093/cid/ciy878.


Novel genetically-modified chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine safely boosts humoral and cellular immunity in healthy older adults.

Green CA, Sande CJ, Scarselli E, Capone S, Vitelli A, Nicosia A, Silva-Reyes L, Thompson AJ, de Lara CM, Taylor KS, Haworth K, Hutchings CL, Cargill T, Angus B, Klenerman P, Pollard AJ.

J Infect. 2019 May;78(5):382-392. doi: 10.1016/j.jinf.2019.02.003. Epub 2019 Feb 8.


A Population-based Observational Study of Childhood Encephalitis in Children Admitted to Pediatric Intensive Care Units in England and Wales.

Iro MA, Sadarangani M, Nickless A, Kelly DF, Pollard AJ.

Pediatr Infect Dis J. 2019 Jul;38(7):673-677. doi: 10.1097/INF.0000000000002280.


Comparison of two schedules of two-dose priming with the ten-valent pneumococcal conjugate vaccine in Nepalese children: an open-label, randomised non-inferiority controlled trial.

Kandasamy R, Gurung M, Thorson S, Yu LM, Galal U, Voysey M, Kelly S, Wahl B, Berbers G, Finnegan K, Ansari I, Paudel K, Murdoch DR, O'Brien KL, Kelly DF, Goldblatt D, Shrestha S, Pollard AJ.

Lancet Infect Dis. 2019 Feb;19(2):156-164. doi: 10.1016/S1473-3099(18)30568-1. Epub 2019 Jan 8.


PERISCOPE: road towards effective control of pertussis.

PERISCOPE Consortium.

Lancet Infect Dis. 2019 May;19(5):e179-e186. doi: 10.1016/S1473-3099(18)30646-7. Epub 2018 Nov 28. Review.


Prevention of enteric fever in travellers with typhoid conjugate vaccines.

Britto C, Jin C, Theiss-Nyland K, Pollard AJ.

J Travel Med. 2018 Jan 1;25(1). doi: 10.1093/jtm/tay120. No abstract available.


Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci.

Azarian T, Mitchell PK, Georgieva M, Thompson CM, Ghouila A, Pollard AJ, von Gottberg A, du Plessis M, Antonio M, Kwambana-Adams BA, Clarke SC, Everett D, Cornick J, Sadowy E, Hryniewicz W, Skoczynska A, Moïsi JC, McGee L, Beall B, Metcalf BJ, Breiman RF, Ho PL, Reid R, O'Brien KL, Gladstone RA, Bentley SD, Hanage WP.

PLoS Pathog. 2018 Nov 26;14(11):e1007438. doi: 10.1371/journal.ppat.1007438. eCollection 2018 Nov.


Anamnestic Immune Response and Safety of an Inactivated Quadrivalent Influenza Vaccine in Primed Versus Vaccine-Naïve Children.

Claeys C, Chandrasekaran V, García-Sicilia J, Prymula R, Díez-Domingo J, Brzostek J, Marès-Bermúdez J, Martinón-Torres F, Pollard AJ, Růžková R, Carmona Martinez A, Ulied A, Miranda Valdivieso M, Faust SN, Snape MD, Friel D, Ollinger T, Soni J, Schuind A, Li P, Innis BL, Jain VK.

Pediatr Infect Dis J. 2019 Feb;38(2):203-210. doi: 10.1097/INF.0000000000002217.


Strategies to improve detection and management of human parechovirus infection in young infants.

Kadambari S, Harvala H, Simmonds P, Pollard AJ, Sadarangani M.

Lancet Infect Dis. 2019 Feb;19(2):e51-e58. doi: 10.1016/S1473-3099(18)30288-3. Epub 2018 Oct 12. Review.


Epidemiology and Immune Pathogenesis of Viral Sepsis.

Lin GL, McGinley JP, Drysdale SB, Pollard AJ.

Front Immunol. 2018 Sep 27;9:2147. doi: 10.3389/fimmu.2018.02147. eCollection 2018. Review.


Antibodies in lymphocyte supernatants can distinguish between neutralising antibodies induced by RSV vaccination and pre-existing antibodies induced by natural infection.

Gerretsen HE, Capone S, Vitelli A, Reyes LS, Thompson A, Jones C, Green CA, Pollard AJ, Sande CJ.

Vaccine. 2018 Nov 12;36(46):6988-6994. doi: 10.1016/j.vaccine.2018.09.070. Epub 2018 Oct 11.


A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.

Britto CD, Wong VK, Dougan G, Pollard AJ.

PLoS Negl Trop Dis. 2018 Oct 11;12(10):e0006779. doi: 10.1371/journal.pntd.0006779. eCollection 2018 Oct.


The Relationship Between Blood Sample Volume and Diagnostic Sensitivity of Blood Culture for Typhoid and Paratyphoid Fever: A Systematic Review and Meta-Analysis.

Antillon M, Saad NJ, Baker S, Pollard AJ, Pitzer VE.

J Infect Dis. 2018 Nov 10;218(suppl_4):S255-S267. doi: 10.1093/infdis/jiy471.


The Impact of Vaccination and Prior Exposure on Stool Shedding of Salmonella Typhi and Salmonella Paratyphi in 6 Controlled Human Infection Studies.

Gibani MM, Voysey M, Jin C, Jones C, Thomaides-Brears H, Jones E, Baker P, Morgan M, Simmons A, Gordon MA, Cerundolo V, Pitzer VE, Angus B, Levine MM, Darton TC, Pollard AJ.

Clin Infect Dis. 2019 Apr 8;68(8):1265-1273. doi: 10.1093/cid/ciy670.


A naturally protective epitope of limited variability as an influenza vaccine target.

Thompson CP, Lourenço J, Walters AA, Obolski U, Edmans M, Palmer DS, Kooblall K, Carnell GW, O'Connor D, Bowden TA, Pybus OG, Pollard AJ, Temperton NJ, Lambe T, Gilbert SC, Gupta S.

Nat Commun. 2018 Sep 21;9(1):3859. doi: 10.1038/s41467-018-06228-8.


Establishment of the first International Standard for human anti-typhoid capsular Vi polysaccharide IgG.

Rijpkema S, Hockley J, Logan A, Rigsby P, Atkinson E, Jin C, Goldblatt D, Liang H, Bachtiar NS, Yang JS, Goel A, Ramasamy V, Pasetti MF, Pollard AJ; anti-Vi IgG working group.

Biologicals. 2018 Nov;56:29-38. doi: 10.1016/j.biologicals.2018.09.001. Epub 2018 Sep 7.


Computing threshold antibody levels of protection in vaccine clinical trials: An assessment of methodological bias.

Voysey M, Sadarangani M, Pollard AJ, Fanshawe TR.

PLoS One. 2018 Sep 7;13(9):e0202517. doi: 10.1371/journal.pone.0202517. eCollection 2018.


A Turning Point in Typhoid Control.

Bentsi-Enchill AD, Pollard AJ.

J Infect Dis. 2018 Nov 10;218(suppl_4):S185-S187. doi: 10.1093/infdis/jiy417. No abstract available.


Humoral and cellular immunity to RSV in infants, children and adults.

Green CA, Sande CJ, de Lara C, Thompson AJ, Silva-Reyes L, Napolitano F, Pierantoni A, Capone S, Vitelli A, Klenerman P, Pollard AJ.

Vaccine. 2018 Oct 1;36(41):6183-6190. doi: 10.1016/j.vaccine.2018.08.056. Epub 2018 Aug 31.


Corrigendum: SeroBA: rapid high-throughput serotyping of Streptococcus pneumoniae from whole genome sequence data.

Epping L, van Tonder AJ, Gladstone RA, Bentley SD, Page AJ, Keane JA; The Global Pneumococcal Sequencing Consortium.

Microb Genom. 2018 Aug;4(8). doi: 10.1099/mgen.0.000204. No abstract available.


Typhoid and paratyphoid fever: a call to action.

Gibani MM, Britto C, Pollard AJ.

Curr Opin Infect Dis. 2018 Oct;31(5):440-448. doi: 10.1097/QCO.0000000000000479. Erratum in: Curr Opin Infect Dis. 2019 Jun;32(3):293.


Influenza Vaccination Strategies Should Target Children.

Bambery B, Douglas T, Selgelid MJ, Maslen H, Giubilini A, Pollard AJ, Savulescu J.

Public Health Ethics. 2017 Dec 8;11(2):221-234. doi: 10.1093/phe/phx021. eCollection 2018 Jul.


Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons.

Bolze A, Boisson B, Bosch B, Antipenko A, Bouaziz M, Sackstein P, Chaker-Margot M, Barlogis V, Briggs T, Colino E, Elmore AC, Fischer A, Genel F, Hewlett A, Jedidi M, Kelecic J, Krüger R, Ku CL, Kumararatne D, Lefevre-Utile A, Loughlin S, Mahlaoui N, Markus S, Garcia JM, Nizon M, Oleastro M, Pac M, Picard C, Pollard AJ, Rodriguez-Gallego C, Thomas C, Von Bernuth H, Worth A, Meyts I, Risolino M, Selleri L, Puel A, Klinge S, Abel L, Casanova JL.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8007-E8016. doi: 10.1073/pnas.1805437115. Epub 2018 Aug 2.


The relative invasive disease potential of Streptococcus pneumoniae among children after PCV introduction: A systematic review and meta-analysis.

Balsells E, Dagan R, Yildirim I, Gounder PP, Steens A, Muñoz-Almagro C, Mameli C, Kandasamy R, Givon Lavi N, Daprai L, van der Ende A, Trzciński K, Nzenze SA, Meiring S, Foster D, Bulkow LR, Rudolph K, Valero-Rello A, Ducker S, Vestrheim DF, von Gottberg A, Pelton SI, Zuccotti G, Pollard AJ, Sanders EAM, Campbell H, Madhi SA, Nair H, Kyaw MH.

J Infect. 2018 Nov;77(5):368-378. doi: 10.1016/j.jinf.2018.06.004. Epub 2018 Jun 30.


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