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The prevalence and associated mortality of non-anaemic iron deficiency in older adults: a 14 years observational cohort study.

Philip KEJ, Sadaka AS, Polkey MI, Hopkinson NS, Steptoe A, Fancourt D.

Br J Haematol. 2020 Feb 18. doi: 10.1111/bjh.16409. [Epub ahead of print]


Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study.

Fermont JM, Bolton CE, Fisk M, Mohan D, Macnee W, Cockcroft JR, McEniery C, Fuld J, Cheriyan J, Tal-Singer R, Wilkinson IB, Wood AM, Polkey MI, Müllerova H.

PLoS One. 2020 Feb 10;15(2):e0228940. doi: 10.1371/journal.pone.0228940. eCollection 2020.


Short Physical Performance Battery: What Does Each Sub-Test Measure in Patients with Chronic Obstructive Pulmonary Disease?

Mohan D, Benson VS, Allinder M, Galwey N, Bolton CE, Cockcroft JR, MacNee W, Wilkinson IB, Tal-Singer R, Polkey MI; ERICA Consortium.

Chronic Obstr Pulm Dis. 2020 Jan;7(1):13-25. doi: 10.15326/jcopdf.7.1.2019.0144.


Absence of dynamic hyperinflation during exhaustive exercise in severe COPD reflects submaximal IC maneuvers rather than a nonhyperinflator phenotype.

Luo YM, Qiu ZH, Wang Y, He BT, Qin H, Xiao SC, Luo YM, Steier J, Moxham J, Polkey MI.

J Appl Physiol (1985). 2020 Mar 1;128(3):586-595. doi: 10.1152/japplphysiol.00695.2018. Epub 2020 Jan 16.


Progression of physical inactivity in COPD patients: the effect of time and climate conditions - a multicenter prospective cohort study.

Boutou AK, Raste Y, Demeyer H, Troosters T, Polkey MI, Vogiatzis I, Louvaris Z, Rabinovich RA, van der Molen T, Garcia-Aymerich J, Hopkinson NS.

Int J Chron Obstruct Pulmon Dis. 2019 Sep 3;14:1979-1992. doi: 10.2147/COPD.S208826. eCollection 2019. Erratum in: Int J Chron Obstruct Pulmon Dis. 2019 Oct 18;14:2375.


Anaemia and iron dysregulation: untapped therapeutic targets in chronic lung disease?

Patel MS, McKie E, Steiner MC, Pascoe SJ, Polkey MI.

BMJ Open Respir Res. 2019 Aug 30;6(1):e000454. doi: 10.1136/bmjresp-2019-000454. eCollection 2019.


EGF receptor (EGFR) inhibition promotes a slow-twitch oxidative, over a fast-twitch, muscle phenotype.

Ciano M, Mantellato G, Connolly M, Paul-Clark M, Willis-Owen S, Moffatt MF, Cookson WOCM, Mitchell JA, Polkey MI, Hughes SM, Kemp PR, Natanek SA.

Sci Rep. 2019 Jun 25;9(1):9218. doi: 10.1038/s41598-019-45567-4.


The prognostic significance of weight loss in chronic obstructive pulmonary disease-related cachexia: a prospective cohort study.

Kwan HY, Maddocks M, Nolan CM, Jones SE, Patel S, Barker RE, Kon SSC, Polkey MI, Cullinan P, Man WD.

J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1330-1338. doi: 10.1002/jcsm.12463. Epub 2019 Jun 17.


Platypnoea-orthodeoxia syndrome: beware of investigations undertaken supine.

Liew F, Gargoum F, Potter R, Rosen SD, Ward S, Hind M, Polkey MI.

Thorax. 2019 Sep;74(9):917-919. doi: 10.1136/thoraxjnl-2019-213258. Epub 2019 May 30.


Sex differences in COPD-related quadriceps muscle dysfunction and fibre abnormalities.

Sharanya A, Ciano M, Withana S, Kemp PR, Polkey MI, Sathyapala SA.

Chron Respir Dis. 2019 Jan-Dec;16:1479973119843650. doi: 10.1177/1479973119843650.


Respiratory Muscle Assessment in Clinical Practice.

Polkey MI.

Clin Chest Med. 2019 Jun;40(2):307-315. doi: 10.1016/j.ccm.2019.02.015. Review.


Patterns of breathlessness and associated consulting behaviour: results of an online survey.

Elbehairy AF, Quint JK, Rogers J, Laffan M, Polkey MI, Hopkinson NS.

Thorax. 2019 Aug;74(8):814-817. doi: 10.1136/thoraxjnl-2018-212950. Epub 2019 Apr 8.


ERS statement on respiratory muscle testing at rest and during exercise.

Laveneziana P, Albuquerque A, Aliverti A, Babb T, Barreiro E, Dres M, Dubé BP, Fauroux B, Gea J, Guenette JA, Hudson AL, Kabitz HJ, Laghi F, Langer D, Luo YM, Neder JA, O'Donnell D, Polkey MI, Rabinovich RA, Rossi A, Series F, Similowski T, Spengler CM, Vogiatzis I, Verges S.

Eur Respir J. 2019 Jun 13;53(6). pii: 1801214. doi: 10.1183/13993003.01214-2018. Print 2019 Jun.


Quadriceps miR-542-3p and -5p are elevated in COPD and reduce function by inhibiting ribosomal and protein synthesis.

Farre-Garros R, Lee JY, Natanek SA, Connolly M, Sayer AA, Patel H, Cooper C, Polkey MI, Kemp PR.

J Appl Physiol (1985). 2019 Jun 1;126(6):1514-1524. doi: 10.1152/japplphysiol.00882.2018. Epub 2019 Jan 24.


Biomarkers and clinical outcomes in COPD: a systematic review and meta-analysis.

Fermont JM, Masconi KL, Jensen MT, Ferrari R, Di Lorenzo VAP, Marott JM, Schuetz P, Watz H, Waschki B, Müllerova H, Polkey MI, Wilkinson IB, Wood AM.

Thorax. 2019 May;74(5):439-446. doi: 10.1136/thoraxjnl-2018-211855. Epub 2019 Jan 7.


Muscle wasting in the presence of disease, why is it so variable?

Kemp PR, Griffiths M, Polkey MI.

Biol Rev Camb Philos Soc. 2019 Jun;94(3):1038-1055. doi: 10.1111/brv.12489. Epub 2018 Dec 26. Review.


Smartphone-Based Physical Activity Telecoaching in Chronic Obstructive Pulmonary Disease: Mixed-Methods Study on Patient Experiences and Lessons for Implementation.

Loeckx M, Rabinovich RA, Demeyer H, Louvaris Z, Tanner R, Rubio N, Frei A, De Jong C, Gimeno-Santos E, Rodrigues FM, Buttery SC, Hopkinson NS, Büsching G, Strassmann A, Serra I, Vogiatzis I, Garcia-Aymerich J, Polkey MI, Troosters T.

JMIR Mhealth Uhealth. 2018 Dec 21;6(12):e200. doi: 10.2196/mhealth.9774.


Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension.

Garfield BE, Crosby A, Shao D, Yang P, Read C, Sawiak S, Moore S, Parfitt L, Harries C, Rice M, Paul R, Ormiston ML, Morrell NW, Polkey MI, Wort SJ, Kemp PR.

Thorax. 2019 Feb;74(2):164-176. doi: 10.1136/thoraxjnl-2017-211440. Epub 2018 Dec 15.


A novel in-ear sensor to determine sleep latency during the Multiple Sleep Latency Test in healthy adults with and without sleep restriction.

Alqurashi YD, Nakamura T, Goverdovsky V, Moss J, Polkey MI, Mandic DP, Morrell MJ.

Nat Sci Sleep. 2018 Nov 19;10:385-396. doi: 10.2147/NSS.S175998. eCollection 2018.



Polkey MI, Zhong NS, Luo YM.

Chest. 2018 Sep;154(3):733-734. doi: 10.1016/j.chest.2018.07.008. No abstract available.



Polkey MI, Zhong NS, Luo YM.

Chest. 2018 Sep;154(3):731-732. doi: 10.1016/j.chest.2018.05.033. No abstract available.


COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix.

Willis-Owen SAG, Thompson A, Kemp PR, Polkey MI, Cookson WOCM, Moffatt MF, Natanek SA.

Sci Rep. 2018 Aug 15;8(1):12165. doi: 10.1038/s41598-018-29789-6.


Activin Type II Receptor Blockade for Treatment of Muscle Depletion in Chronic Obstructive Pulmonary Disease. A Randomized Trial.

Polkey MI, Praestgaard J, Berwick A, Franssen FME, Singh D, Steiner MC, Casaburi R, Tillmann HC, Lach-Trifilieff E, Roubenoff R, Rooks DS.

Am J Respir Crit Care Med. 2019 Feb 1;199(3):313-320. doi: 10.1164/rccm.201802-0286OC.


Inspiratory muscle training in COPD: can data finally beat emotion?

Polkey MI, Ambrosino N.

Thorax. 2018 Oct;73(10):900-901. doi: 10.1136/thoraxjnl-2018-212070. Epub 2018 Jun 26. No abstract available.


Restrictive lung defects: parenchymal, chest wall and neuromuscular.

Shanks AM, Desai SR, Rice A, Thomas SR, Polkey MI, George PM.

Thorax. 2018 Oct;73(10):989-991. doi: 10.1136/thoraxjnl-2018-211895. Epub 2018 Jun 7.


Exercise response to oxygen supplementation is not associated with survival in hypoxemic patients with obstructive lung disease.

Sadaka AS, Montgomery AJ, Mourad SM, Polkey MI, Hopkinson NS.

Int J Chron Obstruct Pulmon Dis. 2018 May 17;13:1607-1612. doi: 10.2147/COPD.S163119. eCollection 2018.


Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease.

Fisk M, Cheriyan J, Mohan D, McEniery CM, Forman J, Cockcroft JR, Rudd JHF, Tal-Singer R, Hopkinson NS, Polkey MI, Wilkinson IB.

Respir Res. 2018 May 24;19(1):100. doi: 10.1186/s12931-018-0792-1.


Exercise ventilatory irregularity can be quantified by approximate entropy to detect breathing pattern disorder.

Bansal T, Haji GS, Rossiter HB, Polkey MI, Hull JH.

Respir Physiol Neurobiol. 2018 Sep;255:1-6. doi: 10.1016/j.resp.2018.05.002. Epub 2018 May 3.


Tai Chi and Pulmonary Rehabilitation Compared for Treatment-Naive Patients With COPD: A Randomized Controlled Trial.

Polkey MI, Qiu ZH, Zhou L, Zhu MD, Wu YX, Chen YY, Ye SP, He YS, Jiang M, He BT, Mehta B, Zhong NS, Luo YM.

Chest. 2018 May;153(5):1116-1124. doi: 10.1016/j.chest.2018.01.053. Epub 2018 Apr 3.


Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.

Mohan D, Forman JR, Allinder M, McEniery CM, Bolton CE, Cockcroft JR, MacNee W, Fuld J, Marchong M, Gale NS, Fisk M, Nagarajan S, Cheriyan J, Lomas DA, Calverley PMA, Miller BE, Tal-Singer R, Wilkinson IB, Polkey MI; ERICA Consortium.

Thorax. 2018 Dec;73(12):1182-1185. doi: 10.1136/thoraxjnl-2018-211556. Epub 2018 Apr 4.


The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial.

Fisk M, Cheriyan J, Mohan D, Forman J, Mäki-Petäjä KM, McEniery CM, Fuld J, Rudd JHF, Hopkinson NS, Lomas DA, Cockcroft JR, Tal-Singer R, Polkey MI, Wilkinson IB.

PLoS One. 2018 Mar 22;13(3):e0194197. doi: 10.1371/journal.pone.0194197. eCollection 2018.


Is Peer Review Still Anonymous?

Ritchie AI, Polkey MI, Donaldson GC, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):278-280. doi: 10.1164/rccm.201711-2257LE. No abstract available.


The acute effect of continuous positive airway pressure titration on blood pressure in awake overweight/obese patients with obstructive sleep apnoea.

Ratneswaran C, Pengo MF, Xiao S, Luo Y, Rossi GP, Polkey MI, Moxham J, Steier J.

Blood Press. 2018 Aug;27(4):206-214. doi: 10.1080/08037051.2018.1443391. Epub 2018 Feb 23.


Both moderate and severe exacerbations accelerate physical activity decline in COPD patients.

Demeyer H, Costilla-Frias M, Louvaris Z, Gimeno-Santos E, Tabberer M, Rabinovich RA, de Jong C, Polkey MI, Hopkinson NS, Karlsson N, Serra I, Vogiatzis I, Troosters T, Garcia-Aymerich J; PROactive Consortium.

Eur Respir J. 2018 Jan 25;51(1). pii: 1702110. doi: 10.1183/13993003.02110-2017. Print 2018 Jan. No abstract available.


Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease: A Large Case-Controlled Study.

Fisk M, McEniery CM, Gale N, Mäki-Petäjä K, Forman JR, Munnery M, Woodcock-Smith J, Cheriyan J, Mohan D, Fuld J, Tal-Singer R, Polkey MI, Cockcroft JR, Wilkinson IB; ERICA Consortium and ACCT Investigators.

Hypertension. 2018 Mar;71(3):499-506. doi: 10.1161/HYPERTENSIONAHA.117.10151. Epub 2018 Jan 22. Erratum in: Hypertension. 2018 Sep;72(3):e30.


London ambulance source data on choking incidence for the calendar year 2016: an observational study.

Pavitt MJ, Nevett J, Swanton LL, Hind MD, Polkey MI, Green M, Hopkinson NS.

BMJ Open Respir Res. 2017 Dec 10;4(1):e000215. doi: 10.1136/bmjresp-2017-000215. eCollection 2017.


miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting.

Connolly M, Paul R, Farre-Garros R, Natanek SA, Bloch S, Lee J, Lorenzo JP, Patel H, Cooper C, Sayer AA, Wort SJ, Griffiths M, Polkey MI, Kemp PR.

J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):400-416. doi: 10.1002/jcsm.12266. Epub 2017 Dec 7.


Reply to Rodrigues et al.: Increasing Physical Activity in Daily Life in Chronic Obstructive Pulmonary Disease: To Solve the Puzzle, Every Piece Counts.

Nolan CM, Maddocks M, Canavan JL, Jones SE, Delogu V, Kaliaraju D, Banya W, Kon SSC, Polkey MI, Man WD.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):1089-1090. doi: 10.1164/rccm.201711-2213LE. No abstract available.


Poor cough flow in acute stroke patients is associated with reduced functional residual capacity and low cough inspired volume.

Ward K, Rao P, Reilly CC, Rafferty GF, Polkey MI, Kalra L, Moxham J.

BMJ Open Respir Res. 2017 Oct 26;4(1):e000230. doi: 10.1136/bmjresp-2017-000230. eCollection 2017.


Increased respiratory neural drive and work of breathing in exercise-induced laryngeal obstruction.

Walsted ES, Faisal A, Jolley CJ, Swanton LL, Pavitt MJ, Luo YM, Backer V, Polkey MI, Hull JH.

J Appl Physiol (1985). 2018 Feb 1;124(2):356-363. doi: 10.1152/japplphysiol.00691.2017. Epub 2017 Nov 2.


Deterioration of Limb Muscle Function during Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Abdulai RM, Jensen TJ, Patel NR, Polkey MI, Jansson P, Celli BR, Rennard SI.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):433-449. doi: 10.1164/rccm.201703-0615CI. Review.


miR-422a suppresses SMAD4 protein expression and promotes resistance to muscle loss.

Paul R, Lee J, Donaldson AV, Connolly M, Sharif M, Natanek SA, Rosendahl U, Polkey MI, Griffiths M, Kemp PR.

J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):119-128. doi: 10.1002/jcsm.12236. Epub 2017 Oct 6.


Nutrition and Exercise Rehabilitation in Obesity hypoventilation syndrome (NERO): a pilot randomised controlled trial.

Mandal S, Suh ES, Harding R, Vaughan-France A, Ramsay M, Connolly B, Bear DE, MacLaughlin H, Greenwood SA, Polkey MI, Elliott M, Chen T, Douiri A, Moxham J, Murphy PB, Hart N.

Thorax. 2018 Jan;73(1):62-69. doi: 10.1136/thoraxjnl-2016-209826. Epub 2017 Sep 29.


MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit-acquired Weakness.

Garros RF, Paul R, Connolly M, Lewis A, Garfield BE, Natanek SA, Bloch S, Mouly V, Griffiths MJ, Polkey MI, Kemp PR.

Am J Respir Crit Care Med. 2017 Dec 1;196(11):1422-1433. doi: 10.1164/rccm.201701-0101OC.


Longitudinal follow-up of quadriceps strength and function in a COPD cohort after 3 years.

Buttery SC, Mohan D, Fisk M, Hopkinson NS, Tal-Singer R, Wilkinson IB, Polkey MI.

Eur Respir J. 2017 Aug 10;50(2). pii: 1700707. doi: 10.1183/13993003.00707-2017. Print 2017 Aug. No abstract available.


Reply to Sasso et al.: Are All Steps Created Equal? Revisiting Pedometer Use during Pulmonary Rehabilitation for Individuals Living with Chronic Obstructive Pulmonary Disease.

Nolan CM, Maddocks M, Canavan JL, Jones SE, Delogu V, Kaliaraju D, Banya W, Kon SSC, Polkey MI, Man WD.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):406-409. doi: 10.1164/rccm.201707-1513LE. No abstract available.


Physical activity patterns and clusters in 1001 patients with COPD.

Mesquita R, Spina G, Pitta F, Donaire-Gonzalez D, Deering BM, Patel MS, Mitchell KE, Alison J, van Gestel AJ, Zogg S, Gagnon P, Abascal-Bolado B, Vagaggini B, Garcia-Aymerich J, Jenkins SC, Romme EA, Kon SS, Albert PS, Waschki B, Shrikrishna D, Singh SJ, Hopkinson NS, Miedinger D, Benzo RP, Maltais F, Paggiaro P, McKeough ZJ, Polkey MI, Hill K, Man WD, Clarenbach CF, Hernandes NA, Savi D, Wootton S, Furlanetto KC, Cindy Ng LW, Vaes AW, Jenkins C, Eastwood PR, Jarreta D, Kirsten A, Brooks D, Hillman DR, Sant'Anna T, Meijer K, Dürr S, Rutten EP, Kohler M, Probst VS, Tal-Singer R, Gil EG, den Brinker AC, Leuppi JD, Calverley PM, Smeenk FW, Costello RW, Gramm M, Goldstein R, Groenen MT, Magnussen H, Wouters EF, ZuWallack RL, Amft O, Watz H, Spruit MA.

Chron Respir Dis. 2017 Aug;14(3):256-269. doi: 10.1177/1479972316687207. Epub 2017 Feb 24.


Should We Get Sniffy About Maximal Inspiratory Pressure?

Polkey MI, Man WD.

Chest. 2017 Jul;152(1):6-7. doi: 10.1016/j.chest.2017.01.015. No abstract available.


Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation.

Coello C, Fisk M, Mohan D, Wilson FJ, Brown AP, Polkey MI, Wilkinson I, Tal-Singer R, Murphy PS, Cheriyan J, Gunn RN.

EJNMMI Res. 2017 Dec;7(1):47. doi: 10.1186/s13550-017-0291-2. Epub 2017 May 25.


Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial.

Murphy PB, Rehal S, Arbane G, Bourke S, Calverley PMA, Crook AM, Dowson L, Duffy N, Gibson GJ, Hughes PD, Hurst JR, Lewis KE, Mukherjee R, Nickol A, Oscroft N, Patout M, Pepperell J, Smith I, Stradling JR, Wedzicha JA, Polkey MI, Elliott MW, Hart N.

JAMA. 2017 Jun 6;317(21):2177-2186. doi: 10.1001/jama.2017.4451.

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