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Inspiratory muscle training in COPD: can data finally beat emotion?

Polkey MI, Ambrosino N.

Thorax. 2018 Jun 26. pii: thoraxjnl-2018-212070. doi: 10.1136/thoraxjnl-2018-212070. [Epub ahead of print] No abstract available.


Restrictive lung defects: parenchymal, chest wall and neuromuscular.

Shanks AM, Desai SR, Rice A, Thomas SR, Polkey MI, George PM.

Thorax. 2018 Jun 7. pii: thoraxjnl-2018-211895. doi: 10.1136/thoraxjnl-2018-211895. [Epub ahead of print]


Exercise response to oxygen supplementation is not associated with survival in hypoxemic patients with obstructive lung disease.

Sadaka AS, Montgomery AJ, Mourad SM, Polkey MI, Hopkinson NS.

Int J Chron Obstruct Pulmon Dis. 2018 May 17;13:1607-1612. doi: 10.2147/COPD.S163119. eCollection 2018.


Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease.

Fisk M, Cheriyan J, Mohan D, McEniery CM, Forman J, Cockcroft JR, Rudd JHF, Tal-Singer R, Hopkinson NS, Polkey MI, Wilkinson IB.

Respir Res. 2018 May 24;19(1):100. doi: 10.1186/s12931-018-0792-1.


Exercise ventilatory irregularity can be quantified by approximate entropy to detect breathing pattern disorder.

Bansal T, Haji GS, Rossiter HB, Polkey MI, Hull JH.

Respir Physiol Neurobiol. 2018 Sep;255:1-6. doi: 10.1016/j.resp.2018.05.002. Epub 2018 May 3.


Tai Chi and Pulmonary Rehabilitation Compared for Treatment-Naive Patients With COPD: A Randomized Controlled Trial.

Polkey MI, Qiu ZH, Zhou L, Zhu MD, Wu YX, Chen YY, Ye SP, He YS, Jiang M, He BT, Mehta B, Zhong NS, Luo YM.

Chest. 2018 May;153(5):1116-1124. doi: 10.1016/j.chest.2018.01.053. Epub 2018 Apr 3.


Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.

Mohan D, Forman JR, Allinder M, McEniery CM, Bolton CE, Cockcroft JR, MacNee W, Fuld J, Marchong M, Gale NS, Fisk M, Nagarajan S, Cheriyan J, Lomas DA, Calverley PMA, Miller BE, Tal-Singer R, Wilkinson IB, Polkey MI; ERICA Consortium.

Thorax. 2018 Apr 4. pii: thoraxjnl-2018-211556. doi: 10.1136/thoraxjnl-2018-211556. [Epub ahead of print]


The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial.

Fisk M, Cheriyan J, Mohan D, Forman J, Mäki-Petäjä KM, McEniery CM, Fuld J, Rudd JHF, Hopkinson NS, Lomas DA, Cockcroft JR, Tal-Singer R, Polkey MI, Wilkinson IB.

PLoS One. 2018 Mar 22;13(3):e0194197. doi: 10.1371/journal.pone.0194197. eCollection 2018.


Is Peer Review Still Anonymous?

Ritchie AI, Polkey MI, Donaldson GC, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):278-280. doi: 10.1164/rccm.201711-2257LE. No abstract available.


The acute effect of continuous positive airway pressure titration on blood pressure in awake overweight/obese patients with obstructive sleep apnoea.

Ratneswaran C, Pengo MF, Xiao S, Luo Y, Rossi GP, Polkey MI, Moxham J, Steier J.

Blood Press. 2018 Aug;27(4):206-214. doi: 10.1080/08037051.2018.1443391. Epub 2018 Feb 23.


Both moderate and severe exacerbations accelerate physical activity decline in COPD patients.

Demeyer H, Costilla-Frias M, Louvaris Z, Gimeno-Santos E, Tabberer M, Rabinovich RA, de Jong C, Polkey MI, Hopkinson NS, Karlsson N, Serra I, Vogiatzis I, Troosters T, Garcia-Aymerich J; PROactive Consortium.

Eur Respir J. 2018 Jan 25;51(1). pii: 1702110. doi: 10.1183/13993003.02110-2017. Print 2018 Jan. No abstract available.


Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease: A Large Case-Controlled Study.

Fisk M, McEniery CM, Gale N, Mäki-Petäjä K, Forman JR, Munnery M, Woodcock-Smith J, Cheriyan J, Mohan D, Fuld J, Tal-Singer R, Polkey MI, Cockcroft JR, Wilkinson IB; ERICA Consortium and ACCT Investigators.

Hypertension. 2018 Mar;71(3):499-506. doi: 10.1161/HYPERTENSIONAHA.117.10151. Epub 2018 Jan 22.


London ambulance source data on choking incidence for the calendar year 2016: an observational study.

Pavitt MJ, Nevett J, Swanton LL, Hind MD, Polkey MI, Green M, Hopkinson NS.

BMJ Open Respir Res. 2017 Dec 10;4(1):e000215. doi: 10.1136/bmjresp-2017-000215. eCollection 2017.


miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting.

Connolly M, Paul R, Farre-Garros R, Natanek SA, Bloch S, Lee J, Lorenzo JP, Patel H, Cooper C, Sayer AA, Wort SJ, Griffiths M, Polkey MI, Kemp PR.

J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):400-416. doi: 10.1002/jcsm.12266. Epub 2017 Dec 7.


Reply to Rodrigues et al.: Increasing Physical Activity in Daily Life in Chronic Obstructive Pulmonary Disease: To Solve the Puzzle, Every Piece Counts.

Nolan CM, Maddocks M, Canavan JL, Jones SE, Delogu V, Kaliaraju D, Banya W, Kon SSC, Polkey MI, Man WD.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):1089-1090. doi: 10.1164/rccm.201711-2213LE. No abstract available.


Poor cough flow in acute stroke patients is associated with reduced functional residual capacity and low cough inspired volume.

Ward K, Rao P, Reilly CC, Rafferty GF, Polkey MI, Kalra L, Moxham J.

BMJ Open Respir Res. 2017 Oct 26;4(1):e000230. doi: 10.1136/bmjresp-2017-000230. eCollection 2017.


Increased respiratory neural drive and work of breathing in exercise-induced laryngeal obstruction.

Walsted ES, Faisal A, Jolley CJ, Swanton LL, Pavitt MJ, Luo YM, Backer V, Polkey MI, Hull JH.

J Appl Physiol (1985). 2018 Feb 1;124(2):356-363. doi: 10.1152/japplphysiol.00691.2017. Epub 2017 Nov 2.


Deterioration of Limb Muscle Function during Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Abdulai RM, Jensen TJ, Patel NR, Polkey MI, Jansson P, Celli BR, Rennard SI.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):433-449. doi: 10.1164/rccm.201703-0615CI.


miR-422a suppresses SMAD4 protein expression and promotes resistance to muscle loss.

Paul R, Lee J, Donaldson AV, Connolly M, Sharif M, Natanek SA, Rosendahl U, Polkey MI, Griffiths M, Kemp PR.

J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):119-128. doi: 10.1002/jcsm.12236. Epub 2017 Oct 6.


Nutrition and Exercise Rehabilitation in Obesity hypoventilation syndrome (NERO): a pilot randomised controlled trial.

Mandal S, Suh ES, Harding R, Vaughan-France A, Ramsay M, Connolly B, Bear DE, MacLaughlin H, Greenwood SA, Polkey MI, Elliott M, Chen T, Douiri A, Moxham J, Murphy PB, Hart N.

Thorax. 2018 Jan;73(1):62-69. doi: 10.1136/thoraxjnl-2016-209826. Epub 2017 Sep 29.


MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit-acquired Weakness.

Garros RF, Paul R, Connolly M, Lewis A, Garfield BE, Natanek SA, Bloch S, Mouly V, Griffiths MJ, Polkey MI, Kemp PR.

Am J Respir Crit Care Med. 2017 Dec 1;196(11):1422-1433. doi: 10.1164/rccm.201701-0101OC.


Longitudinal follow-up of quadriceps strength and function in a COPD cohort after 3 years.

Buttery SC, Mohan D, Fisk M, Hopkinson NS, Tal-Singer R, Wilkinson IB, Polkey MI.

Eur Respir J. 2017 Aug 10;50(2). pii: 1700707. doi: 10.1183/13993003.00707-2017. Print 2017 Aug. No abstract available.


Reply to Sasso et al.: Are All Steps Created Equal? Revisiting Pedometer Use during Pulmonary Rehabilitation for Individuals Living with Chronic Obstructive Pulmonary Disease.

Nolan CM, Maddocks M, Canavan JL, Jones SE, Delogu V, Kaliaraju D, Banya W, Kon SSC, Polkey MI, Man WD.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):406-409. doi: 10.1164/rccm.201707-1513LE. No abstract available.


Physical activity patterns and clusters in 1001 patients with COPD.

Mesquita R, Spina G, Pitta F, Donaire-Gonzalez D, Deering BM, Patel MS, Mitchell KE, Alison J, van Gestel AJ, Zogg S, Gagnon P, Abascal-Bolado B, Vagaggini B, Garcia-Aymerich J, Jenkins SC, Romme EA, Kon SS, Albert PS, Waschki B, Shrikrishna D, Singh SJ, Hopkinson NS, Miedinger D, Benzo RP, Maltais F, Paggiaro P, McKeough ZJ, Polkey MI, Hill K, Man WD, Clarenbach CF, Hernandes NA, Savi D, Wootton S, Furlanetto KC, Cindy Ng LW, Vaes AW, Jenkins C, Eastwood PR, Jarreta D, Kirsten A, Brooks D, Hillman DR, Sant'Anna T, Meijer K, Dürr S, Rutten EP, Kohler M, Probst VS, Tal-Singer R, Gil EG, den Brinker AC, Leuppi JD, Calverley PM, Smeenk FW, Costello RW, Gramm M, Goldstein R, Groenen MT, Magnussen H, Wouters EF, ZuWallack RL, Amft O, Watz H, Spruit MA.

Chron Respir Dis. 2017 Aug;14(3):256-269. doi: 10.1177/1479972316687207. Epub 2017 Feb 24.


Should We Get Sniffy About Maximal Inspiratory Pressure?

Polkey MI, Man WD.

Chest. 2017 Jul;152(1):6-7. doi: 10.1016/j.chest.2017.01.015. No abstract available.


Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation.

Coello C, Fisk M, Mohan D, Wilson FJ, Brown AP, Polkey MI, Wilkinson I, Tal-Singer R, Murphy PS, Cheriyan J, Gunn RN.

EJNMMI Res. 2017 Dec;7(1):47. doi: 10.1186/s13550-017-0291-2. Epub 2017 May 25.


Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial.

Murphy PB, Rehal S, Arbane G, Bourke S, Calverley PMA, Crook AM, Dowson L, Duffy N, Gibson GJ, Hughes PD, Hurst JR, Lewis KE, Mukherjee R, Nickol A, Oscroft N, Patout M, Pepperell J, Smith I, Stradling JR, Wedzicha JA, Polkey MI, Elliott MW, Hart N.

JAMA. 2017 Jun 6;317(21):2177-2186. doi: 10.1001/jama.2017.4451.


Reduced HDAC2 in skeletal muscle of COPD patients.

To M, Swallow EB, Akashi K, Haruki K, Natanek SA, Polkey MI, Ito K, Barnes PJ.

Respir Res. 2017 May 19;18(1):99. doi: 10.1186/s12931-017-0588-8.


Exercise Training Versus Neuromuscular Stimulation in Severe Chronic Obstructive Pulmonary Disease.

Maddocks M, Delogu V, Jones SE, Polkey MI, Man WD.

Arch Bronconeumol. 2017 Jul;53(7):357-359. doi: 10.1016/j.arbres.2016.11.022. Epub 2017 May 4. English, Spanish. No abstract available.


Gait speed and pedestrian crossings in COPD.

Nolan CM, Kon SSC, Patel S, Jones SE, Barker RE, Polkey MI, Maddocks M, Man WD.

Thorax. 2018 Feb;73(2):191-192. doi: 10.1136/thoraxjnl-2017-210173. Epub 2017 May 5.


A man with progressive type II respiratory failure.

Hind M, Jordan S, Hansell DM, Nicholson AG, Neild G, Polkey MI.

Lancet Respir Med. 2017 May;5(5):456. doi: 10.1016/S2213-2600(17)30139-X. Epub 2017 Apr 24. No abstract available.


AJRCCM: 100-Year Anniversary. Homeward Bound: A Centenary of Home Mechanical Ventilation.

Hind M, Polkey MI, Simonds AK.

Am J Respir Crit Care Med. 2017 May 1;195(9):1140-1149. doi: 10.1164/rccm.201702-0285CI. Review.


Circulating miRNAs from imprinted genomic regions are associated with peripheral muscle strength in COPD patients.

Lee JY, Donaldson AV, Lewis A, Natanek SA, Polkey MI, Kemp PR.

Eur Respir J. 2017 Apr 26;49(4). pii: 1601881. doi: 10.1183/13993003.01881-2016. Print 2017 Apr. No abstract available.


Choking on a foreign body: a physiological study of the effectiveness of abdominal thrust manoeuvres to increase thoracic pressure.

Pavitt MJ, Swanton LL, Hind M, Apps M, Polkey MI, Green M, Hopkinson NS.

Thorax. 2017 Jun;72(6):576-578. doi: 10.1136/thoraxjnl-2016-209540. Epub 2017 Apr 12.


ACE and response to pulmonary rehabilitation in COPD: two observational studies.

Kon SS, Jolley CJ, Shrikrishna D, Montgomery HE, Skipworth JR, Puthucheary Z, Moxham J, Polkey MI, Man WD, Hopkinson NS.

BMJ Open Respir Res. 2017 Mar 8;4(1):e000165. doi: 10.1136/bmjresp-2016-000165. eCollection 2017.


Maximum inspiratory pressure as a clinically meaningful trial endpoint for neuromuscular diseases: a comprehensive review of the literature.

Schoser B, Fong E, Geberhiwot T, Hughes D, Kissel JT, Madathil SC, Orlikowski D, Polkey MI, Roberts M, Tiddens HA, Young P.

Orphanet J Rare Dis. 2017 Mar 16;12(1):52. doi: 10.1186/s13023-017-0598-0. Review.


Exercise-induced changes in QT interval are smaller in COPD patients and have no impact on mortality.

Boutou AK, Franks R, Mohan D, Mantziari L, Wong T, Hopkinson NS, Polkey MI.

Eur Respir J. 2017 Mar 15;49(3). pii: 1602394. doi: 10.1183/13993003.02394-2016. Print 2017 Mar. No abstract available.


Physical activity is increased by a 12-week semiautomated telecoaching programme in patients with COPD: a multicentre randomised controlled trial.

Demeyer H, Louvaris Z, Frei A, Rabinovich RA, de Jong C, Gimeno-Santos E, Loeckx M, Buttery SC, Rubio N, Van der Molen T, Hopkinson NS, Vogiatzis I, Puhan MA, Garcia-Aymerich J, Polkey MI, Troosters T; Mr Papp PROactive study group and the PROactive consortium.

Thorax. 2017 May;72(5):415-423. doi: 10.1136/thoraxjnl-2016-209026. Epub 2017 Jan 30.


Endobronchial valves for patients with heterogeneous emphysema and without interlobar collateral ventilation: open label treatment following the BeLieVeR-HIFi study.

Zoumot Z, Davey C, Jordan S, McNulty WH, Carr DH, Hind MD, Polkey MI, Shah PL, Hopkinson NS.

Thorax. 2017 Mar;72(3):277-279. doi: 10.1136/thoraxjnl-2016-208865. Epub 2016 Dec 20.


Pedometer Step Count Targets during Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease. A Randomized Controlled Trial.

Nolan CM, Maddocks M, Canavan JL, Jones SE, Delogu V, Kaliaraju D, Banya W, Kon SSC, Polkey MI, Man WD.

Am J Respir Crit Care Med. 2017 May 15;195(10):1344-1352. doi: 10.1164/rccm.201607-1372OC.


Coexistence of OSA may compensate for sleep related reduction in neural respiratory drive in patients with COPD.

He BT, Lu G, Xiao SC, Chen R, Steier J, Moxham J, Polkey MI, Luo YM.

Thorax. 2017 Mar;72(3):256-262. doi: 10.1136/thoraxjnl-2016-208467. Epub 2016 Nov 2.


Muscle Regeneration after Critical Illness: Are Satellite Cells the Answer?

Polkey MI, Griffiths MJ, Kemp PR.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):780-782. No abstract available.


Using laser capture microdissection to study fiber specific signaling in locomotor muscle in COPD: A pilot study.

Mohan D, Lewis A, Patel MS, Curtis KJ, Lee JY, Hopkinson NS, Wilkinson IB, Kemp PR, Polkey MI.

Muscle Nerve. 2017 Jun;55(6):902-912. doi: 10.1002/mus.25423. Epub 2017 Feb 3.


Survival after Endobronchial Valve Placement for Emphysema: A 10-Year Follow-up Study.

Garner J, Kemp SV, Toma TP, Hansell DM, Polkey MI, Shah PL, Hopkinson NS.

Am J Respir Crit Care Med. 2016 Aug 15;194(4):519-21. doi: 10.1164/rccm.201604-0852LE. No abstract available.


Respiratory Muscle Strength as a Predictive Biomarker for Survival in Amyotrophic Lateral Sclerosis.

Polkey MI, Lyall RA, Yang K, Johnson E, Leigh PN, Moxham J.

Am J Respir Crit Care Med. 2017 Jan 1;195(1):86-95. doi: 10.1164/rccm.201604-0848OC.


Randomised sham-controlled trial of transcutaneous electrical stimulation in obstructive sleep apnoea.

Pengo MF, Xiao S, Ratneswaran C, Reed K, Shah N, Chen T, Douiri A, Hart N, Luo Y, Rafferty GF, Rossi GP, Williams A, Polkey MI, Moxham J, Steier J.

Thorax. 2016 Oct;71(10):923-31. doi: 10.1136/thoraxjnl-2016-208691. Epub 2016 Jul 19.


Depression symptoms reduce physical activity in COPD patients: a prospective multicenter study.

Dueñas-Espín I, Demeyer H, Gimeno-Santos E, Polkey MI, Hopkinson NS, Rabinovich RA, Dobbels F, Karlsson N, Troosters T, Garcia-Aymerich J.

Int J Chron Obstruct Pulmon Dis. 2016 Jun 10;11:1287-95. doi: 10.2147/COPD.S101459. eCollection 2016.


The 6-Minute-Walk Distance Test as a Chronic Obstructive Pulmonary Disease Stratification Tool. Insights from the COPD Biomarker Qualification Consortium.

Celli B, Tetzlaff K, Criner G, Polkey MI, Sciurba F, Casaburi R, Tal-Singer R, Kawata A, Merrill D, Rennard S; COPD Biomarker Qualification Consortium.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1483-1493.


Neuromuscular electrical stimulation to improve exercise capacity in patients with severe COPD - Authors' reply.

Maddocks M, Nolan C, Man WD, Polkey M, Hart N, Gao W, Rafferty GF, Moxham J, Higginson IJ.

Lancet Respir Med. 2016 Apr;4(4):e16. doi: 10.1016/S2213-2600(16)00093-X. Epub 2016 Apr 4. No abstract available.


Physical frailty and pulmonary rehabilitation in COPD: a prospective cohort study.

Maddocks M, Kon SS, Canavan JL, Jones SE, Nolan CM, Labey A, Polkey MI, Man WD.

Thorax. 2016 Nov;71(11):988-995. doi: 10.1136/thoraxjnl-2016-208460. Epub 2016 Jun 12.

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