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Items: 3


NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.

James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V.

Mol Cell Biol. 2009 Aug;29(15):4250-61. doi: 10.1128/MCB.01581-08. Epub 2009 May 18.


Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas.

Han S, Polizzano C, Nielsen GP, Hornicek FJ, Rosenberg AE, Ramesh V.

Clin Cancer Res. 2009 Mar 15;15(6):1940-6. doi: 10.1158/1078-0432.CCR-08-2364. Epub 2009 Mar 10.


Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling.

Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V.

Cell Signal. 2008 Jun;20(6):1084-91. doi: 10.1016/j.cellsig.2008.01.020. Epub 2008 Feb 1.

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