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Items: 15


Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer.

Singh K, Pruski MA, Polireddy K, Jones NC, Chen Q, Yao J, Dar WA, McAllister F, Ju C, Eltzschig HK, Younes M, Moran C, Karmouty-Quintana H, Ying H, Bailey JM.

Oncogene. 2019 Sep 30. doi: 10.1038/s41388-019-1031-z. [Epub ahead of print]


Mutant p53R175H promotes cancer initiation in the pancreas by stabilizing HSP70.

Polireddy K, Singh K, Pruski M, Jones NC, Manisundaram NV, Ponnela P, Ouellette M, Van Buren G, Younes M, Bynon JS, Dar WA, Bailey JM.

Cancer Lett. 2019 Jul 1;453:122-130. doi: 10.1016/j.canlet.2019.03.047. Epub 2019 Apr 1.


Knockout of l-Histidine Decarboxylase Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling.

Kennedy L, Hargrove L, Demieville J, Bailey JM, Dar W, Polireddy K, Chen Q, Nevah Rubin MI, Sybenga A, DeMorrow S, Meng F, Stockton L, Alpini G, Francis H.

Am J Pathol. 2018 Mar;188(3):600-615. doi: 10.1016/j.ajpath.2017.11.016. Epub 2017 Dec 15.


High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study.

Polireddy K, Dong R, Reed G, Yu J, Chen P, Williamson S, Violet PC, Pessetto Z, Godwin AK, Fan F, Levine M, Drisko JA, Chen Q.

Sci Rep. 2017 Dec 7;7(1):17188. doi: 10.1038/s41598-017-17568-8.


Targeting Epithelial-Mesenchymal Transition for Identification of Inhibitors for Pancreatic Cancer Cell Invasion and Tumor Spheres Formation.

Polireddy K, Dong R, McDonald PR, Wang T, Luke B, Chen P, Broward M, Roy A, Chen Q.

PLoS One. 2016 Oct 20;11(10):e0164811. doi: 10.1371/journal.pone.0164811. eCollection 2016.


Cancer of the Pancreas: Molecular Pathways and Current Advancement in Treatment.

Polireddy K, Chen Q.

J Cancer. 2016 Jul 7;7(11):1497-514. doi: 10.7150/jca.14922. eCollection 2016. Review.


p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia.

Hendley AM, Wang YJ, Polireddy K, Alsina J, Ahmed I, Lafaro KJ, Zhang H, Roy N, Savidge SG, Cao Y, Hebrok M, Maitra A, Reynolds AB, Goggins M, Younes M, Iacobuzio-Donahue CA, Leach SD, Bailey JM.

Cancer Res. 2016 Jun 1;76(11):3351-63. doi: 10.1158/0008-5472.CAN-15-2268. Epub 2016 Mar 31.


The unpaved journey of vitamin C in cancer treatment.

Chen Q, Polireddy K, Chen P, Dong R.

Can J Physiol Pharmacol. 2015 Dec;93(12):1055-63. doi: 10.1139/cjpp-2014-0509. Epub 2015 May 27. Review.


Mechanism of Ascorbate-Induced Cell Death in Human Pancreatic Cancer Cells: Role of Bcl-2, Beclin 1 and Autophagy.

Fukui M, Yamabe N, Choi HJ, Polireddy K, Chen Q, Zhu BT.

Planta Med. 2015 Jul;81(10):838-46. doi: 10.1055/s-0035-1546132. Epub 2015 Jul 1.


The tumor-suppressing activity of the prenyl diphosphate synthase subunit 2 gene in lung cancer cells.

Chen P, Zhang Y, Polireddy K, Chen Q.

Anticancer Drugs. 2014 Aug;25(7):790-8. doi: 10.1097/CAD.0000000000000105.


High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy.

Ma Y, Chapman J, Levine M, Polireddy K, Drisko J, Chen Q.

Sci Transl Med. 2014 Feb 5;6(222):222ra18. doi: 10.1126/scitranslmed.3007154.


A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6.

Polireddy K, Khan MM, Chavan H, Young S, Ma X, Waller A, Garcia M, Perez D, Chavez S, Strouse JJ, Haynes MK, Bologa CG, Oprea TI, Tegos GP, Sklar LA, Krishnamurthy P.

PLoS One. 2012;7(7):e40005. doi: 10.1371/journal.pone.0040005. Epub 2012 Jul 10.


Identification of substituted [3, 2-a] pyrimidines as selective antiviral agents: molecular modeling study.

Ravendra Babu K, Rao VK, Nanda Kumar Y, Polireddy K, Venkata Subbaiah K, Bhaskar M, Lokanatha V, Naga Raju C.

Antiviral Res. 2012 Aug;95(2):118-27. doi: 10.1016/j.antiviral.2012.05.010. Epub 2012 May 29.


Synthesis and spectral characterization of new bis(2-(pyrimidin-2-yl)ethoxy)alkanes and their pharmacological activity.

Rani VJ, Aminedi R, Polireddy K, Jagadeeswarareddy K.

Arch Pharm (Weinheim). 2012 Aug;345(8):663-9. doi: 10.1002/ardp.201200021. Epub 2012 May 16.


Functional significance of the ATP-binding cassette transporter B6 in hepatocellular carcinoma.

Polireddy K, Chavan H, Abdulkarim BA, Krishnamurthy P.

Mol Oncol. 2011 Oct;5(5):410-25. doi: 10.1016/j.molonc.2011.07.005. Epub 2011 Jul 28.

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