Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 60


Antibodies elicited by the first non-viral prophylactic cancer vaccine show tumor-specificity and immunotherapeutic potential.

Lohmueller JJ, Sato S, Popova L, Chu IM, Tucker MA, Barberena R, Innocenti GM, Cudic M, Ham JD, Cheung WC, Polakiewicz RD, Finn OJ.

Sci Rep. 2016 Aug 22;6:31740. doi: 10.1038/srep31740.


Astrogliosis Induced by Brain Injury Is Regulated by Sema4B Phosphorylation

Ben-Gigi L, Sweetat S, Besser E, Fellig Y, Wiederhold T, Polakiewicz RD, Behar O.

eNeuro. 2015 May 25;2(3). pii: ENEURO.0078-14.2015. doi: 10.1523/ENEURO.0078-14.2015. eCollection 2015 May-Jun.


Antibodies: The solution is validation.

Polakiewicz RD.

Nature. 2015 Feb 26;518(7540):483. doi: 10.1038/518483b. No abstract available.


Quantitative profiling of DNA damage and apoptotic pathways in UV damaged cells using PTMScan Direct.

Stokes MP, Silva JC, Jia X, Lee KA, Polakiewicz RD, Comb MJ.

Int J Mol Sci. 2012 Dec 21;14(1):286-307. doi: 10.3390/ijms14010286.


Proteomics-directed cloning of circulating antiviral human monoclonal antibodies.

Sato S, Beausoleil SA, Popova L, Beaudet JG, Ramenani RK, Zhang X, Wieler JS, Schieferl SM, Cheung WC, Polakiewicz RD.

Nat Biotechnol. 2012 Nov;30(11):1039-43. doi: 10.1038/nbt.2406. No abstract available.


Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.

Zhang P, Guo A, Possemato A, Wang C, Beard L, Carlin C, Markowitz SD, Polakiewicz RD, Wang Z.

Oncogene. 2013 Apr 18;32(16):2087-95. doi: 10.1038/onc.2012.220. Epub 2012 Jun 18.


A proteomics approach for the identification and cloning of monoclonal antibodies from serum.

Cheung WC, Beausoleil SA, Zhang X, Sato S, Schieferl SM, Wieler JS, Beaudet JG, Ramenani RK, Popova L, Comb MJ, Rush J, Polakiewicz RD.

Nat Biotechnol. 2012 Mar 25;30(5):447-52. doi: 10.1038/nbt.2167.


PTMScan direct: identification and quantification of peptides from critical signaling proteins by immunoaffinity enrichment coupled with LC-MS/MS.

Stokes MP, Farnsworth CL, Moritz A, Silva JC, Jia X, Lee KA, Guo A, Polakiewicz RD, Comb MJ.

Mol Cell Proteomics. 2012 May;11(5):187-201. doi: 10.1074/mcp.M111.015883. Epub 2012 Feb 9.


Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.

Hitosugi T, Fan J, Chung TW, Lythgoe K, Wang X, Xie J, Ge Q, Gu TL, Polakiewicz RD, Roesel JL, Chen GZ, Boggon TJ, Lonial S, Fu H, Khuri FR, Kang S, Chen J.

Mol Cell. 2011 Dec 23;44(6):864-77. doi: 10.1016/j.molcel.2011.10.015.


Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.

Fan J, Hitosugi T, Chung TW, Xie J, Ge Q, Gu TL, Polakiewicz RD, Chen GZ, Boggon TJ, Lonial S, Khuri FR, Kang S, Chen J.

Mol Cell Biol. 2011 Dec;31(24):4938-50. doi: 10.1128/MCB.06120-11. Epub 2011 Oct 3.


Survey of activated FLT3 signaling in leukemia.

Gu TL, Nardone J, Wang Y, Loriaux M, Villén J, Beausoleil S, Tucker M, Kornhauser J, Ren J, MacNeill J, Gygi SP, Druker BJ, Heinrich MC, Rush J, Polakiewicz RD.

PLoS One. 2011 Apr 28;6(4):e19169. doi: 10.1371/journal.pone.0019169.


p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.

Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, Khuri FR, Shin DM, Chen J.

J Clin Invest. 2010 Apr;120(4):1165-77. doi: 10.1172/JCI40582. Epub 2010 Mar 15.


Identification of activated Tnk1 kinase in Hodgkin's lymphoma.

Gu TL, Cherry J, Tucker M, Wu J, Reeves C, Polakiewicz RD.

Leukemia. 2010 Apr;24(4):861-5. doi: 10.1038/leu.2009.293. Epub 2010 Jan 21. No abstract available.


Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.

Pecquet C, Staerk J, Chaligné R, Goss V, Lee KA, Zhang X, Rush J, Van Hees J, Poirel HA, Scheiff JM, Vainchenker W, Giraudier S, Polakiewicz RD, Constantinescu SN.

Blood. 2010 Feb 4;115(5):1037-48. doi: 10.1182/blood-2008-10-183558. Epub 2009 Dec 8.


Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.

Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J.

Sci Signal. 2009 Nov 17;2(97):ra73. doi: 10.1126/scisignal.2000431.


Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancer.

Yu J, Kane S, Wu J, Benedettini E, Li D, Reeves C, Innocenti G, Wetzel R, Crosby K, Becker A, Ferrante M, Cheung WC, Hong X, Chirieac LR, Sholl LM, Haack H, Smith BL, Polakiewicz RD, Tan Y, Gu TL, Loda M, Zhou X, Comb MJ.

Clin Cancer Res. 2009 May 1;15(9):3023-8. doi: 10.1158/1078-0432.CCR-08-2739. Epub 2009 Apr 14.


Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody.

Haack H, Johnson LA, Fry CJ, Crosby K, Polakiewicz RD, Stelow EB, Hong SM, Schwartz BE, Cameron MJ, Rubin MA, Chang MC, Aster JC, French CA.

Am J Surg Pathol. 2009 Jul;33(7):984-91. doi: 10.1097/PAS.0b013e318198d666.


The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.

Boccalatte FE, Voena C, Riganti C, Bosia A, D'Amico L, Riera L, Cheng M, Ruggeri B, Jensen ON, Goss VL, Lee K, Nardone J, Rush J, Polakiewicz RD, Comb MJ, Chiarle R, Inghirami G.

Blood. 2009 Mar 19;113(12):2776-90. doi: 10.1182/blood-2008-06-161018. Epub 2008 Oct 9.


Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs.

Rong L, Livingstone M, Sukarieh R, Petroulakis E, Gingras AC, Crosby K, Smith B, Polakiewicz RD, Pelletier J, Ferraiuolo MA, Sonenberg N.

RNA. 2008 Jul;14(7):1318-27. doi: 10.1261/rna.950608. Epub 2008 May 30.


HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization.

Li Y, Zhang X, Polakiewicz RD, Yao TP, Comb MJ.

J Biol Chem. 2008 May 9;283(19):12686-90. doi: 10.1074/jbc.C700185200. Epub 2008 Mar 20.


Signaling networks assembled by oncogenic EGFR and c-Met.

Guo A, Villén J, Kornhauser J, Lee KA, Stokes MP, Rikova K, Possemato A, Nardone J, Innocenti G, Wetzel R, Wang Y, MacNeill J, Mitchell J, Gygi SP, Rush J, Polakiewicz RD, Comb MJ.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):692-7. doi: 10.1073/pnas.0707270105. Epub 2008 Jan 7.


Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.

Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ.

Cell. 2007 Dec 14;131(6):1190-203.


Profiling of UV-induced ATM/ATR signaling pathways.

Stokes MP, Rush J, Macneill J, Ren JM, Sprott K, Nardone J, Yang V, Beausoleil SA, Gygi SP, Livingstone M, Zhang H, Polakiewicz RD, Comb MJ.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19855-60. Epub 2007 Dec 6.


FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.

Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J.

Cancer Cell. 2007 Sep;12(3):201-14.


Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance.

Tremblay F, Brûlé S, Hee Um S, Li Y, Masuda K, Roden M, Sun XJ, Krebs M, Polakiewicz RD, Thomas G, Marette A.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14056-61. Epub 2007 Aug 20.


A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.

Gu TL, Mercher T, Tyner JW, Goss VL, Walters DK, Cornejo MG, Reeves C, Popova L, Lee K, Heinrich MC, Rush J, Daibata M, Miyoshi I, Gilliland DG, Druker BJ, Polakiewicz RD.

Blood. 2007 Jul 1;110(1):323-33. Epub 2007 Mar 14.


Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.

Zhang X, Guo A, Yu J, Possemato A, Chen Y, Zheng W, Polakiewicz RD, Kinzler KW, Vogelstein B, Velculescu VE, Wang ZJ.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4060-4. Epub 2007 Feb 21.


Phosphoproteomic analysis identifies the M0-91 cell line as a cellular model for the study of TEL-TRKC fusion-associated leukemia.

Gu TL, Popova L, Reeves C, Nardone J, Macneill J, Rush J, Nimer SD, Polakiewicz RD.

Leukemia. 2007 Mar;21(3):563-6. Epub 2007 Jan 25. No abstract available.


Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2.

Zhande R, Zhang W, Zheng Y, Pendleton E, Li Y, Polakiewicz RD, Sun XJ.

J Biol Chem. 2006 Dec 22;281(51):39071-80. Epub 2006 Oct 26.


Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia.

Gu TL, Goss VL, Reeves C, Popova L, Nardone J, Macneill J, Walters DK, Wang Y, Rush J, Comb MJ, Druker BJ, Polakiewicz RD.

Blood. 2006 Dec 15;108(13):4202-4. Epub 2006 Aug 31.


Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib.

Griswold IJ, MacPartlin M, Bumm T, Goss VL, O'Hare T, Lee KA, Corbin AS, Stoffregen EP, Smith C, Johnson K, Moseson EM, Wood LJ, Polakiewicz RD, Druker BJ, Deininger MW.

Mol Cell Biol. 2006 Aug;26(16):6082-93.


Activating alleles of JAK3 in acute megakaryoblastic leukemia.

Walters DK, Mercher T, Gu TL, O'Hare T, Tyner JW, Loriaux M, Goss VL, Lee KA, Eide CA, Wong MJ, Stoffregen EP, McGreevey L, Nardone J, Moore SA, Crispino J, Boggon TJ, Heinrich MC, Deininger MW, Polakiewicz RD, Gilliland DG, Druker BJ.

Cancer Cell. 2006 Jul;10(1):65-75.


Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2.

Dorsch M, Wang A, Cheng H, Lu C, Bielecki A, Charron K, Clauser K, Ren H, Polakiewicz RD, Parsons T, Li P, Ocain T, Xu Y.

Cell Signal. 2006 Dec;18(12):2223-9. Epub 2006 May 22.


JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model.

Mercher T, Wernig G, Moore SA, Levine RL, Gu TL, Fröhling S, Cullen D, Polakiewicz RD, Bernard OA, Boggon TJ, Lee BH, Gilliland DG.

Blood. 2006 Oct 15;108(8):2770-9. Epub 2006 Jun 27.


A common phosphotyrosine signature for the Bcr-Abl kinase.

Goss VL, Lee KA, Moritz A, Nardone J, Spek EJ, MacNeill J, Rush J, Comb MJ, Polakiewicz RD.

Blood. 2006 Jun 15;107(12):4888-97. Epub 2006 Feb 23.


Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice.

Park SS, Kim JS, Tessarollo L, Owens JD, Peng L, Han SS, Tae Chung S, Torrey TA, Cheung WC, Polakiewicz RD, McNeil N, Ried T, Mushinski JF, Morse HC 3rd, Janz S.

Cancer Res. 2005 Feb 15;65(4):1306-15.


Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ.

Nat Biotechnol. 2005 Jan;23(1):94-101. Epub 2004 Dec 12.


Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).

Li Y, Soos TJ, Li X, Wu J, Degennaro M, Sun X, Littman DR, Birnbaum MJ, Polakiewicz RD.

J Biol Chem. 2004 Oct 29;279(44):45304-7. Epub 2004 Sep 10.


Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice.

Cheung WC, Kim JS, Linden M, Peng L, Van Ness B, Polakiewicz RD, Janz S.

J Clin Invest. 2004 Jun;113(12):1763-73.


Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.

Raught B, Peiretti F, Gingras AC, Livingstone M, Shahbazian D, Mayeur GL, Polakiewicz RD, Sonenberg N, Hershey JW.

EMBO J. 2004 Apr 21;23(8):1761-9. Epub 2004 Apr 8.


Morphine induces desensitization of insulin receptor signaling.

Li Y, Eitan S, Wu J, Evans CJ, Kieffer B, Sun X, Polakiewicz RD.

Mol Cell Biol. 2003 Sep;23(17):6255-66.


Lysophosphatidic acid-regulated mitogenic ERK signaling in androgen-insensitive prostate cancer PC-3 cells.

Kue PF, Taub JS, Harrington LB, Polakiewicz RD, Ullrich A, Daaka Y.

Int J Cancer. 2002 Dec 20;102(6):572-9.


Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs.

Zhang H, Zha X, Tan Y, Hornbeck PV, Mastrangelo AJ, Alessi DR, Polakiewicz RD, Comb MJ.

J Biol Chem. 2002 Oct 18;277(42):39379-87. Epub 2002 Jul 31.


Hierarchical phosphorylation of the translation inhibitor 4E-BP1.

Gingras AC, Raught B, Gygi SP, Niedzwiecka A, Miron M, Burley SK, Polakiewicz RD, Wyslouch-Cieszynska A, Aebersold R, Sonenberg N.

Genes Dev. 2001 Nov 1;15(21):2852-64.


Phosphatidylinositol 3-kinase-dependent extracellular calcium influx is essential for CX(3)CR1-mediated activation of the mitogen-activated protein kinase cascade.

Kansra V, Groves C, Gutierrez-Ramos JC, Polakiewicz RD.

J Biol Chem. 2001 Aug 24;276(34):31831-8. Epub 2001 Jun 29.


Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.

Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R, Sonenberg N.

Genes Dev. 1999 Jun 1;13(11):1422-37.


mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control.

Polakiewicz RD, Schieferl SM, Gingras AC, Sonenberg N, Comb MJ.

J Biol Chem. 1998 Sep 4;273(36):23534-41.


A mitogen-activated protein kinase pathway is required for mu-opioid receptor desensitization.

Polakiewicz RD, Schieferl SM, Dorner LF, Kansra V, Comb MJ.

J Biol Chem. 1998 May 15;273(20):12402-6.


Zfx mutation results in small animal size and reduced germ cell number in male and female mice.

Luoh SW, Bain PA, Polakiewicz RD, Goodheart ML, Gardner H, Jaenisch R, Page DC.

Development. 1997 Jun;124(11):2275-84.


Developmental regulation of proenkephalin gene expression in osteoblasts.

Rosen H, Krichevsky A, Polakiewicz RD, Benzakine S, Bar-Shavit Z.

Mol Endocrinol. 1995 Nov;9(11):1621-31.


Supplemental Content

Loading ...
Support Center