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Items: 23


Genomic programming of IRF4-expressing human Langerhans cells.

Sirvent S, Vallejo AF, Davies J, Clayton K, Wu Z, Woo J, Riddell J, Chaudhri VK, Stumpf P, Nazlamova LA, Wheway G, Rose-Zerilli M, West J, Pujato M, Chen X, Woelk CH, MacArthur B, Ardern-Jones M, Friedmann PS, Weirauch MT, Singh H, Polak ME.

Nat Commun. 2020 Jan 16;11(1):313. doi: 10.1038/s41467-019-14125-x.


Constitutive Activation of Natural Killer Cells in Primary Biliary Cholangitis.

Hydes TJ, Blunt MD, Naftel J, Vallejo AF, Seumois G, Wang A, Vijayanand P, Polak ME, Khakoo SI.

Front Immunol. 2019 Nov 15;10:2633. doi: 10.3389/fimmu.2019.02633. eCollection 2019.


Malaria systems immunology: Plasmodium vivax induces tolerance during primary infection through dysregulation of neutrophils and dendritic cells.

Vallejo AF, Read RC, Arevalo-Herrera M, Herrera S, Elliott T, Polak ME.

J Infect. 2018 Nov;77(5):440-447. doi: 10.1016/j.jinf.2018.09.005. Epub 2018 Sep 22.


A graphical and computational modeling platform for biological pathways.

Livigni A, O'Hara L, Polak ME, Angus T, Wright DW, Smith LB, Freeman TC.

Nat Protoc. 2018 Apr;13(4):705-722. doi: 10.1038/nprot.2017.144. Epub 2018 Mar 15.


Langerhans Cells-Programmed by the Epidermis.

Clayton K, Vallejo AF, Davies J, Sirvent S, Polak ME.

Front Immunol. 2017 Nov 29;8:1676. doi: 10.3389/fimmu.2017.01676. eCollection 2017. Review.


Gene Expression Signatures in Tuberculosis Have Greater Overlap with Autoimmune Diseases Than with Infectious Diseases.

Clayton K, Polak ME, Woelk CH, Elkington P.

Am J Respir Crit Care Med. 2017 Sep 1;196(5):655-656. doi: 10.1164/rccm.201706-1248LE. No abstract available.


Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation.

Polak ME, Ung CY, Masapust J, Freeman TC, Ardern-Jones MR.

Sci Rep. 2017 Apr 6;7(1):668. doi: 10.1038/s41598-017-00651-5.


Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells.

Hutton AJ, Polak ME, Spalluto CM, Wallington JC, Pickard C, Staples KJ, Warner JA, Wilkinson TM.

J Immunol. 2017 Jan 1;198(1):110-118. Epub 2016 Nov 28.


In vitro rapid diagnostic tests for severe drug hypersensitivity reactions in children.

Haw WY, Polak ME, McGuire C, Erlewyn-Lajeunesse M, Ardern-Jones MR.

Ann Allergy Asthma Immunol. 2016 Jul;117(1):61-6. doi: 10.1016/j.anai.2016.04.017. Epub 2016 May 21.


OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential.

Lai C, August S, Albibas A, Behar R, Cho SY, Polak ME, Theaker J, MacLeod AS, French RR, Glennie MJ, Al-Shamkhani A, Healy E.

Clin Cancer Res. 2016 Aug 15;22(16):4236-48. doi: 10.1158/1078-0432.CCR-15-2614. Epub 2016 Mar 31.


Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.

White AL, Chan HT, French RR, Willoughby J, Mockridge CI, Roghanian A, Penfold CA, Booth SG, Dodhy A, Polak ME, Potter EA, Ardern-Jones MR, Verbeek JS, Johnson PW, Al-Shamkhani A, Cragg MS, Beers SA, Glennie MJ.

Cancer Cell. 2015 Jan 12;27(1):138-48. doi: 10.1016/j.ccell.2014.11.001. Epub 2014 Dec 11.


Presence of the HLA-A*3101 allele in a familial case of drug reaction with eosinophilia and systemic symptoms, secondary to carbamazepine.

Anjum N, Polak ME, Ardern-Jones M, Cooper HL.

Clin Exp Dermatol. 2014 Apr;39(3):307-9. doi: 10.1111/ced.12275.


Distinct molecular signature of human skin Langerhans cells denotes critical differences in cutaneous dendritic cell immune regulation.

Polak ME, Thirdborough SM, Ung CY, Elliott T, Healy E, Freeman TC, Ardern-Jones MR.

J Invest Dermatol. 2014 Mar;134(3):695-703. doi: 10.1038/jid.2013.375. Epub 2013 Sep 4.


Sensitization via healthy skin programs Th2 responses in individuals with atopic dermatitis.

Newell L, Polak ME, Perera J, Owen C, Boyd P, Pickard C, Howarth PH, Healy E, Holloway JW, Friedmann PS, Ardern-Jones MR.

J Invest Dermatol. 2013 Oct;133(10):2372-2380. doi: 10.1038/jid.2013.148. Epub 2013 Mar 25.


In vitro diagnostic assays are effective during the acute phase of delayed-type drug hypersensitivity reactions.

Polak ME, Belgi G, McGuire C, Pickard C, Healy E, Friedmann PS, Ardern-Jones MR.

Br J Dermatol. 2013 Mar;168(3):539-49. doi: 10.1111/bjd.12109. Epub 2013 Jan 31.


CD70-CD27 interaction augments CD8+ T-cell activation by human epidermal Langerhans cells.

Polak ME, Newell L, Taraban VY, Pickard C, Healy E, Friedmann PS, Al-Shamkhani A, Ardern-Jones MR.

J Invest Dermatol. 2012 Jun;132(6):1636-44. doi: 10.1038/jid.2012.26. Epub 2012 Mar 1.


Isolation of inflammatory cells from human tumours.

Polak ME.

Methods Mol Biol. 2011;731:201-8. doi: 10.1007/978-1-61779-080-5_17.


Resistance gene expression determines the in vitro chemosensitivity of non-small cell lung cancer (NSCLC).

Glaysher S, Yiannakis D, Gabriel FG, Johnson P, Polak ME, Knight LA, Goldthorpe Z, Peregrin K, Gyi M, Modi P, Rahamim J, Smith ME, Amer K, Addis B, Poole M, Narayanan A, Gulliford TJ, Andreotti PE, Cree IA.

BMC Cancer. 2009 Aug 27;9:300. doi: 10.1186/1471-2407-9-300.


Melanoma vaccines: The problems of local immunosuppression.

Polak ME, Borthwick NJ, Jager MJ, Cree IA.

Hum Immunol. 2009 May;70(5):331-9.


Activation of tonsil dendritic cells with immuno-adjuvants.

Polak ME, Borthwick NJ, Gabriel FG, Jager MJ, Cree IA.

BMC Immunol. 2008 Mar 18;9:10. doi: 10.1186/1471-2172-9-10.


Mechanisms of local immunosuppression in cutaneous melanoma.

Polak ME, Borthwick NJ, Gabriel FG, Johnson P, Higgins B, Hurren J, McCormick D, Jager MJ, Cree IA.

Br J Cancer. 2007 Jun 18;96(12):1879-87. Epub 2007 Jun 12.


Presence and phenotype of dendritic cells in uveal melanoma.

Polak ME, Borthwick NJ, Johnson P, Hungerford JL, Higgins B, Di Palma S, Jager MJ, Cree IA.

Br J Ophthalmol. 2007 Jul;91(7):971-6. Epub 2007 Mar 8.


Presence and maturity of dendritic cells in melanoma lymph node metastases.

Polak ME, Johnson P, Di Palma S, Higgins B, Hurren J, Borthwick NJ, Jager MJ, Mccormick D, Cree IA.

J Pathol. 2005 Sep;207(1):83-90.


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