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Items: 43

1.

Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1).

Röhrig UF, Reynaud A, Majjigapu SR, Vogel P, Pojer F, Zoete V.

J Med Chem. 2019 Sep 17. doi: 10.1021/acs.jmedchem.9b00942. [Epub ahead of print]

PMID:
31525930
2.

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.

Reckel S, Gehin C, Tardivon D, Georgeon S, Kükenshöner T, Löhr F, Koide A, Buchner L, Panjkovich A, Reynaud A, Pinho S, Gerig B, Svergun D, Pojer F, Güntert P, Dötsch V, Koide S, Gavin AC, Hantschel O.

Nat Commun. 2017 Dec 13;8(1):2101. doi: 10.1038/s41467-017-02313-6.

PMID:
29235475
Free PMC Article
3.

Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.

Kükenshöner T, Schmit NE, Bouda E, Sha F, Pojer F, Koide A, Seeliger M, Koide S, Hantschel O.

J Mol Biol. 2017 May 5;429(9):1364-1380. doi: 10.1016/j.jmb.2017.03.023. Epub 2017 Mar 25.

4.

A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria.

Murima P, Zimmermann M, Chopra T, Pojer F, Fonti G, Dal Peraro M, Alonso S, Sauer U, Pethe K, McKinney JD.

Nat Commun. 2016 Aug 24;7:12527. doi: 10.1038/ncomms12527.

5.

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-D-ribose 2'-oxidase.

Landge S, Mullick AB, Nagalapur K, Neres J, Subbulakshmi V, Murugan K, Ghosh A, Sadler C, Fellows MD, Humnabadkar V, Mahadevaswamy J, Vachaspati P, Sharma S, Kaur P, Mallya M, Rudrapatna S, Awasthy D, Sambandamurthy VK, Pojer F, Cole ST, Balganesh TS, Ugarkar BG, Balasubramanian V, Bandodkar BS, Panda M, Ramachandran V.

Bioorg Med Chem. 2015 Dec 15;23(24):7694-710. doi: 10.1016/j.bmc.2015.11.017. Epub 2015 Nov 18.

PMID:
26643218
6.

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1.

Rybniker J, Vocat A, Sala C, Busso P, Pojer F, Benjak A, Cole ST.

Nat Commun. 2015 Jul 9;6:7659. doi: 10.1038/ncomms8659.

7.

Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis.

Korotkova N, Piton J, Wagner JM, Boy-Röttger S, Japaridze A, Evans TJ, Cole ST, Pojer F, Korotkov KV.

J Struct Biol. 2015 Aug;191(2):236-44. doi: 10.1016/j.jsb.2015.06.003. Epub 2015 Jun 4.

8.

Internalization and vacuolar targeting of the brassinosteroid hormone receptor BRI1 are regulated by ubiquitination.

Martins S, Dohmann EM, Cayrel A, Johnson A, Fischer W, Pojer F, Satiat-Jeunemaître B, Jaillais Y, Chory J, Geldner N, Vert G.

Nat Commun. 2015 Jan 21;6:6151. doi: 10.1038/ncomms7151.

9.

The crystal structures of apo and cAMP-bound GlxR from Corynebacterium glutamicum reveal structural and dynamic changes upon cAMP binding in CRP/FNR family transcription factors.

Townsend PD, Jungwirth B, Pojer F, Bußmann M, Money VA, Cole ST, Pühler A, Tauch A, Bott M, Cann MJ, Pohl E.

PLoS One. 2014 Dec 3;9(12):e113265. doi: 10.1371/journal.pone.0113265. eCollection 2014.

10.

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.

Neres J, Hartkoorn RC, Chiarelli LR, Gadupudi R, Pasca MR, Mori G, Venturelli A, Savina S, Makarov V, Kolly GS, Molteni E, Binda C, Dhar N, Ferrari S, Brodin P, Delorme V, Landry V, de Jesus Lopes Ribeiro AL, Farina D, Saxena P, Pojer F, Carta A, Luciani R, Porta A, Zanoni G, De Rossi E, Costi MP, Riccardi G, Cole ST.

ACS Chem Biol. 2015 Mar 20;10(3):705-14. doi: 10.1021/cb5007163. Epub 2014 Dec 9.

PMID:
25427196
11.

Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.

Chen S, Gopalakrishnan R, Schaer T, Marger F, Hovius R, Bertrand D, Pojer F, Heinis C.

Nat Chem. 2014 Nov;6(11):1009-16. doi: 10.1038/nchem.2043. Epub 2014 Aug 31.

PMID:
25343607
12.

Functional dissection of intersubunit interactions in the EspR virulence regulator of Mycobacterium tuberculosis.

Blasco B, Japaridze A, Stenta M, Wicky BI, Dietler G, Dal Peraro M, Pojer F, Cole ST.

J Bacteriol. 2014 May;196(10):1889-900. doi: 10.1128/JB.00039-14. Epub 2014 Mar 14.

13.

The cysteine desulfurase IscS of Mycobacterium tuberculosis is involved in iron-sulfur cluster biogenesis and oxidative stress defence.

Rybniker J, Pojer F, Marienhagen J, Kolly GS, Chen JM, van Gumpel E, Hartmann P, Cole ST.

Biochem J. 2014 May 1;459(3):467-78. doi: 10.1042/BJ20130732.

PMID:
24548275
14.

Towards a new combination therapy for tuberculosis with next generation benzothiazinones.

Makarov V, Lechartier B, Zhang M, Neres J, van der Sar AM, Raadsen SA, Hartkoorn RC, Ryabova OB, Vocat A, Decosterd LA, Widmer N, Buclin T, Bitter W, Andries K, Pojer F, Dyson PJ, Cole ST.

EMBO Mol Med. 2014 Mar;6(3):372-83. doi: 10.1002/emmm.201303575. Epub 2014 Feb 5.

15.

Peptide ligands stabilized by small molecules.

Chen S, Bertoldo D, Angelini A, Pojer F, Heinis C.

Angew Chem Int Ed Engl. 2014 Feb 3;53(6):1602-6. doi: 10.1002/anie.201309459. Epub 2014 Jan 22.

PMID:
24453110
16.

Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.

Hartkoorn RC, Pojer F, Read JA, Gingell H, Neres J, Horlacher OP, Altmann KH, Cole ST.

Nat Chem Biol. 2014 Feb;10(2):96-8. doi: 10.1038/nchembio.1405. Epub 2013 Dec 1.

PMID:
24292073
17.

Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence.

Chen JM, Zhang M, Rybniker J, Basterra L, Dhar N, Tischler AD, Pojer F, Cole ST.

J Bacteriol. 2013 Dec;195(24):5421-30. doi: 10.1128/JB.00967-13. Epub 2013 Sep 27.

18.

Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence.

Chen JM, Zhang M, Rybniker J, Boy-Röttger S, Dhar N, Pojer F, Cole ST.

Mol Microbiol. 2013 Sep;89(6):1154-66. doi: 10.1111/mmi.12336. Epub 2013 Aug 15.

19.

Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.

Haruki H, Pedersen MG, Gorska KI, Pojer F, Johnsson K.

Science. 2013 May 24;340(6135):987-91. doi: 10.1126/science.1232972.

20.

Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.

El-Turk F, Fauvet B, Ashrafi A, Ouertatani-Sakouhi H, Cho MK, Neri M, Cascella M, Rothlisberger U, Pojer F, Zweckstetter M, Lashuel H.

PLoS One. 2012;7(9):e45024. doi: 10.1371/journal.pone.0045024. Epub 2012 Sep 21.

21.

Towards a new tuberculosis drug: pyridomycin - nature's isoniazid.

Hartkoorn RC, Sala C, Neres J, Pojer F, Magnet S, Mukherjee R, Uplekar S, Boy-Röttger S, Altmann KH, Cole ST.

EMBO Mol Med. 2012 Oct;4(10):1032-42. doi: 10.1002/emmm.201201689. Epub 2012 Sep 17.

22.

Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis.

Neres J, Pojer F, Molteni E, Chiarelli LR, Dhar N, Boy-Röttger S, Buroni S, Fullam E, Degiacomi G, Lucarelli AP, Read RJ, Zanoni G, Edmondson DE, De Rossi E, Pasca MR, McKinney JD, Dyson PJ, Riccardi G, Mattevi A, Cole ST, Binda C.

Sci Transl Med. 2012 Sep 5;4(150):150ra121. doi: 10.1126/scitranslmed.3004395.

23.

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.

Fullam E, Pojer F, Bergfors T, Jones TA, Cole ST.

Open Biol. 2012 Jan;2(1):110026. doi: 10.1098/rsob.110026.

24.

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis.

Ngaki MN, Louie GV, Philippe RN, Manning G, Pojer F, Bowman ME, Li L, Larsen E, Wurtele ES, Noel JP.

Nature. 2012 May 13;485(7399):530-3. doi: 10.1038/nature11009.

25.

Virulence regulator EspR of Mycobacterium tuberculosis is a nucleoid-associated protein.

Blasco B, Chen JM, Hartkoorn R, Sala C, Uplekar S, Rougemont J, Pojer F, Cole ST.

PLoS Pathog. 2012;8(3):e1002621. doi: 10.1371/journal.ppat.1002621. Epub 2012 Mar 29.

26.

Directed evolution of the suicide protein O⁶-alkylguanine-DNA alkyltransferase for increased reactivity results in an alkylated protein with exceptional stability.

Mollwitz B, Brunk E, Schmitt S, Pojer F, Bannwarth M, Schiltz M, Rothlisberger U, Johnsson K.

Biochemistry. 2012 Feb 7;51(5):986-94. doi: 10.1021/bi2016537. Epub 2012 Jan 25.

PMID:
22280500
27.

Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1.

Trefzer C, Škovierová H, Buroni S, Bobovská A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikušová K, Johnsson K.

J Am Chem Soc. 2012 Jan 18;134(2):912-5. doi: 10.1021/ja211042r. Epub 2011 Dec 21.

PMID:
22188377
28.

EspD is critical for the virulence-mediating ESX-1 secretion system in Mycobacterium tuberculosis.

Chen JM, Boy-Röttger S, Dhar N, Sweeney N, Buxton RS, Pojer F, Rosenkrands I, Cole ST.

J Bacteriol. 2012 Feb;194(4):884-93. doi: 10.1128/JB.06417-11. Epub 2011 Dec 9.

29.

Atypical DNA recognition mechanism used by the EspR virulence regulator of Mycobacterium tuberculosis.

Blasco B, Stenta M, Alonso-Sarduy L, Dietler G, Peraro MD, Cole ST, Pojer F.

Mol Microbiol. 2011 Oct;82(1):251-64. doi: 10.1111/j.1365-2958.2011.07813.x. Epub 2011 Sep 12.

30.

Sigma factor F does not prevent rifampin inhibition of RNA polymerase or cause rifampin tolerance in Mycobacterium tuberculosis.

Hartkoorn RC, Sala C, Magnet SJ, Chen JM, Pojer F, Cole ST.

J Bacteriol. 2010 Oct;192(20):5472-9. doi: 10.1128/JB.00687-10. Epub 2010 Aug 20.

31.

New auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone delivery.

Savaldi-Goldstein S, Baiga TJ, Pojer F, Dabi T, Butterfield C, Parry G, Santner A, Dharmasiri N, Tao Y, Estelle M, Noel JP, Chory J.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15190-5. doi: 10.1073/pnas.0806324105. Epub 2008 Sep 25.

32.

Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants.

Tao Y, Ferrer JL, Ljung K, Pojer F, Hong F, Long JA, Li L, Moreno JE, Bowman ME, Ivans LJ, Cheng Y, Lim J, Zhao Y, Ballaré CL, Sandberg G, Noel JP, Chory J.

Cell. 2008 Apr 4;133(1):164-76. doi: 10.1016/j.cell.2008.01.049.

33.

Discovery and characterization of a marine bacterial SAM-dependent chlorinase.

Eustáquio AS, Pojer F, Noel JP, Moore BS.

Nat Chem Biol. 2008 Jan;4(1):69-74. Epub 2007 Dec 2.

34.

[Substance use and psychiatric symptoms in subjects referred to the drug addiction services by the prefecture].

Bizzarri JV, Rucci P, Casalboni D, Randi S, Girelli M, Pojer F, Sbrana A.

Epidemiol Psichiatr Soc. 2007 Jan-Mar;16(1):73-8. Italian. No abstract available.

PMID:
17427607
35.
36.

Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes.

Keller S, Pojer F, Heide L, Lawson DM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt 11):1153-5. Epub 2006 Oct 20.

37.

Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.

Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24.

38.
39.
40.

CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis.

Pojer F, Kahlich R, Kammerer B, Li SM, Heide L.

J Biol Chem. 2003 Aug 15;278(33):30661-8. Epub 2003 May 30.

41.

CloQ, a prenyltransferase involved in clorobiocin biosynthesis.

Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2316-21.

43.

Antiviral and anticoagulant activities of a water-soluble fraction of the marine diatom Haslea ostrearia.

Bergé JP, Bourgougnon N, Alban S, Pojer F, Billaudel S, Chermann JC, Robert JM, Franz G.

Planta Med. 1999 Oct;65(7):604-9.

PMID:
10575374

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