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The autonomic nervous system regulates pancreatic β-cell proliferation in adult male rats.

Moullé VS, Tremblay C, Castell AL, Vivot K, Ethier M, Fergusson G, Alquier T, Ghislain J, Poitout V.

Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E234-E243. doi: 10.1152/ajpendo.00385.2018. Epub 2019 Apr 23.


A Call for Improved Reporting of Human Islet Characteristics in Research Articles.

Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG Jr, Marshall SM.

Diabetes. 2019 Feb;68(2):239-240. doi: 10.2337/dbi18-0055. Epub 2018 Dec 14. No abstract available.


A call for improved reporting of human islet characteristics in research articles.

Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG Jr, Marshall SM.

Diabetologia. 2019 Feb;62(2):209-211. doi: 10.1007/s00125-018-4784-y. Epub 2018 Dec 14. No abstract available.


Fatty Acids and Insulin Secretion: From FFAR and Near?

Poitout V.

Diabetes. 2018 Oct;67(10):1932-1934. doi: 10.2337/dbi18-0027. No abstract available.


Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet.

Seferovic MD, Beamish CA, Mosser RE, Townsend SE, Pappan K, Poitout V, Aagaard KM, Gannon M.

Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1251-E1263. doi: 10.1152/ajpendo.00001.2018. Epub 2018 Aug 14.


Considerations and guidelines for mouse metabolic phenotyping in diabetes research.

Alquier T, Poitout V.

Diabetologia. 2018 Mar;61(3):526-538. doi: 10.1007/s00125-017-4495-9. Epub 2017 Nov 16. Review.


Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice.

Bergeron V, Ghislain J, Vivot K, Tamarina N, Philipson LH, Fielitz J, Poitout V.

Diabetes. 2018 Jan;67(1):71-77. doi: 10.2337/db17-0982. Epub 2017 Oct 16.


Nutrient regulation of pancreatic β-cell proliferation.

Moullé VS, Ghislain J, Poitout V.

Biochimie. 2017 Dec;143:10-17. doi: 10.1016/j.biochi.2017.09.017. Epub 2017 Oct 5. Review.


Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats.

Moullé VS, Vivot K, Tremblay C, Zarrouki B, Ghislain J, Poitout V.

Diabetologia. 2017 May;60(5):879-888. doi: 10.1007/s00125-016-4197-8. Epub 2017 Jan 11.


The Role and Future of FFA1 as a Therapeutic Target.

Ghislain J, Poitout V.

Handb Exp Pharmacol. 2017;236:159-180. doi: 10.1007/164_2016_51. Review.


The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.

Vivot K, Moullé VS, Zarrouki B, Tremblay C, Mancini AD, Maachi H, Ghislain J, Poitout V.

Mol Metab. 2016 Aug 26;5(10):988-996. doi: 10.1016/j.molmet.2016.08.010. eCollection 2016 Oct.


Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.

Koppe L, Nyam E, Vivot K, Manning Fox JE, Dai XQ, Nguyen BN, Trudel D, Attané C, Moullé VS, MacDonald PE, Ghislain J, Poitout V.

J Clin Invest. 2016 Sep 1;126(9):3598-612. doi: 10.1172/JCI86181. Epub 2016 Aug 15.


CMPF: A Biomarker for Type 2 Diabetes Mellitus Progression?

Koppe L, Poitout V.

Trends Endocrinol Metab. 2016 Jul;27(7):439-440. doi: 10.1016/j.tem.2016.04.010. Epub 2016 Apr 27.


Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice.

Auguste S, Fisette A, Fernandes MF, Hryhorczuk C, Poitout V, Alquier T, Fulton S.

Int J Neuropsychopharmacol. 2016 Jul 5;19(7). pii: pyw014. doi: 10.1093/ijnp/pyw014. Print 2016 Jul.


Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry.

Ghislain J, Fontés G, Tremblay C, Kebede MA, Poitout V.

Endocrinology. 2016 Mar;157(3):1299-306. doi: 10.1210/en.2015-1550. Epub 2015 Dec 15.


PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids.

Oropeza D, Jouvet N, Bouyakdan K, Perron G, Ringuette LJ, Philipson LH, Kiss RS, Poitout V, Alquier T, Estall JL.

Mol Metab. 2015 Aug 14;4(11):811-22. doi: 10.1016/j.molmet.2015.08.001. eCollection 2015 Nov.


The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice.

Fontés G, Ghislain J, Benterki I, Zarrouki B, Trudel D, Berthiaume Y, Poitout V.

Diabetes. 2015 Dec;64(12):4112-22. doi: 10.2337/db14-0810. Epub 2015 Aug 17.


β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.

Mancini AD, Bertrand G, Vivot K, Carpentier É, Tremblay C, Ghislain J, Bouvier M, Poitout V.

J Biol Chem. 2015 Aug 21;290(34):21131-40. doi: 10.1074/jbc.M115.644450. Epub 2015 Jul 8.


Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.

Oropeza D, Jouvet N, Budry L, Campbell JE, Bouyakdan K, Lacombe J, Perron G, Bergeron V, Neuman JC, Brar HK, Fenske RJ, Meunier C, Sczelecki S, Kimple ME, Drucker DJ, Screaton RA, Poitout V, Ferron M, Alquier T, Estall JL.

Diabetes. 2015 Nov;64(11):3798-807. doi: 10.2337/db15-0272. Epub 2015 Jul 7.


An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.

Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT.

Mol Endocrinol. 2015 Jul;29(7):1055-66. doi: 10.1210/me.2015-1007. Epub 2015 Jun 15. Erratum in: Mol Endocrinol. 2016 Jul;30(7):826.


High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice.

Mosser RE, Maulis MF, Moullé VS, Dunn JC, Carboneau BA, Arasi K, Pappan K, Poitout V, Gannon M.

Am J Physiol Endocrinol Metab. 2015 Apr 1;308(7):E573-82. doi: 10.1152/ajpendo.00460.2014. Epub 2015 Jan 27.


GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.

Mancini AD, Poitout V.

Diabetes Obes Metab. 2015 Jul;17(7):622-9. doi: 10.1111/dom.12442. Epub 2015 Feb 24. Review.


Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice.

Fergusson G, Ethier M, Guévremont M, Chrétien C, Attané C, Joly E, Fioramonti X, Prentki M, Poitout V, Alquier T.

Mol Metab. 2014 Sep 28;3(9):848-54. doi: 10.1016/j.molmet.2014.09.006. eCollection 2014 Dec.


Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines.

Semache M, Ghislain J, Zarrouki B, Tremblay C, Poitout V.

Islets. 2014;6(4):e982376. doi: 10.4161/19382014.2014.982376.


The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes.

Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CW, Alonso LC, Myers MG Jr, Jonas JC, Poitout V, Kulkarni RN, Mauvais-Jarvis F.

PLoS One. 2014 Feb 3;9(2):e87941. doi: 10.1371/journal.pone.0087941. eCollection 2014.


Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1.

Zarrouki B, Benterki I, Fontés G, Peyot ML, Seda O, Prentki M, Poitout V.

Diabetes. 2014 Mar;63(3):982-93. doi: 10.2337/db13-0425. Epub 2013 Nov 5.


Modulating GPR40: therapeutic promise and potential in diabetes.

Poitout V, Lin DC.

Drug Discov Today. 2013 Dec;18(23-24):1301-8. doi: 10.1016/j.drudis.2013.09.003. Epub 2013 Sep 16. Review.


Early detection of liver steatosis by magnetic resonance imaging in rats infused with glucose and intralipid solutions and correlation to insulin levels.

d'Assignies G, Fontés G, Kauffmann C, Latour M, Gaboury L, Boulanger Y, Van Beers BE, Soulez G, Poitout V, Tang A.

Metabolism. 2013 Dec;62(12):1850-7. doi: 10.1016/j.metabol.2013.08.003. Epub 2013 Sep 12.


[Membrane fatty acid receptors in the β-cell: novel therapeutic targets for type 2 diabetes].

Mancini AD, Poitout V.

Med Sci (Paris). 2013 Aug-Sep;29(8-9):715-21. doi: 10.1051/medsci/2013298009. Epub 2013 Sep 5. Review. French.


A model of chronic nutrient infusion in the rat.

Fergusson G, Ethier M, Zarrouki B, Fontés G, Poitout V.

J Vis Exp. 2013 Aug 14;(78). doi: 10.3791/50267.


Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells.

Semache M, Zarrouki B, Fontés G, Fogarty S, Kikani C, Chawki MB, Rutter J, Poitout V.

J Biol Chem. 2013 Aug 23;288(34):24825-33. doi: 10.1074/jbc.M113.495945. Epub 2013 Jul 12.


Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-cells.

Sabatini PV, Krentz NA, Zarrouki B, Westwell-Roper CY, Nian C, Uy RA, Shapiro AM, Poitout V, Lynn FC.

Diabetes. 2013 Aug;62(8):2808-20. doi: 10.2337/db12-1527. Epub 2013 May 8.


The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

Mancini AD, Poitout V.

Trends Endocrinol Metab. 2013 Aug;24(8):398-407. doi: 10.1016/j.tem.2013.03.003. Epub 2013 Apr 27. Review.


Fatty acid receptor Gpr40 mediates neuromicrovascular degeneration induced by transarachidonic acids in rodents.

Honoré JC, Kooli A, Hamel D, Alquier T, Rivera JC, Quiniou C, Hou X, Kermorvant-Duchemin E, Hardy P, Poitout V, Chemtob S.

Arterioscler Thromb Vasc Biol. 2013 May;33(5):954-61. doi: 10.1161/ATVBAHA.112.300943. Epub 2013 Mar 21.


Pioglitazone acutely reduces energy metabolism and insulin secretion in rats.

Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot ML, Ruderman NB, Nolan CJ, Joly E, Madiraju SR, Poitout V, Prentki M.

Diabetes. 2013 Jun;62(6):2122-9. doi: 10.2337/db12-0428. Epub 2013 Feb 1.


The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation.

Wauquier F, Philippe C, Léotoing L, Mercier S, Davicco MJ, Lebecque P, Guicheux J, Pilet P, Miot-Noirault E, Poitout V, Alquier T, Coxam V, Wittrant Y.

J Biol Chem. 2013 Mar 1;288(9):6542-51. doi: 10.1074/jbc.M112.429084. Epub 2013 Jan 18.


Lipotoxicity impairs incretin signalling.

Poitout V.

Diabetologia. 2013 Feb;56(2):231-3. doi: 10.1007/s00125-012-2788-6. Epub 2012 Nov 28.


G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.

Ferdaoussi M, Bergeron V, Zarrouki B, Kolic J, Cantley J, Fielitz J, Olson EN, Prentki M, Biden T, MacDonald PE, Poitout V.

Diabetologia. 2012 Oct;55(10):2682-2692. doi: 10.1007/s00125-012-2650-x. Epub 2012 Jul 22.


Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics.

Schrimpe-Rutledge AC, Fontès G, Gritsenko MA, Norbeck AD, Anderson DJ, Waters KM, Adkins JN, Smith RD, Poitout V, Metz TO.

J Proteome Res. 2012 Jul 6;11(7):3520-32. doi: 10.1021/pr3002996. Epub 2012 May 29.


Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.

Amyot J, Semache M, Ferdaoussi M, Fontés G, Poitout V.

PLoS One. 2012;7(4):e36200. doi: 10.1371/journal.pone.0036200. Epub 2012 Apr 27.


Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1.

Kebede M, Ferdaoussi M, Mancini A, Alquier T, Kulkarni RN, Walker MD, Poitout V.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2376-81. doi: 10.1073/pnas.1114350109. Epub 2012 Jan 30.


Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.

Semplici F, Vaxillaire M, Fogarty S, Semache M, Bonnefond A, Fontés G, Philippe J, Meur G, Diraison F, Sessions RB, Rutter J, Poitout V, Froguel P, Rutter GA.

J Biol Chem. 2011 Dec 23;286(51):44005-14. doi: 10.1074/jbc.M111.254995. Epub 2011 Nov 7.


Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.

Amyot J, Benterki I, Fontés G, Hagman DK, Ferdaoussi M, Teodoro T, Volchuk A, Joly É, Poitout V.

J Mol Endocrinol. 2011 Sep 30;47(3):273-83. doi: 10.1530/JME-11-0016. Print 2011 Dec.


Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.

Fontés G, Zarrouki B, Hagman DK, Latour MG, Semache M, Roskens V, Moore PC, Prentki M, Rhodes CJ, Jetton TL, Poitout V.

Diabetologia. 2010 Nov;53(11):2369-79. doi: 10.1007/s00125-010-1850-5. Epub 2010 Jul 14.


Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity.

Fontés G, Hagman DK, Latour MG, Semache M, Poitout V.

Diabetes Res Clin Pract. 2010 Mar;87(3):322-8. doi: 10.1016/j.diabres.2009.12.020. Epub 2010 Jan 25.


Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress.

Ntimbane T, Comte B, Mailhot G, Berthiaume Y, Poitout V, Prentki M, Rabasa-Lhoret R, Levy E.

Clin Biochem Rev. 2009 Nov;30(4):153-77.


Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.

Chen J, Fontes G, Saxena G, Poitout V, Shalev A.

Diabetes. 2010 Feb;59(2):440-7. doi: 10.2337/db09-0949. Epub 2009 Oct 29.


Lipid receptors and islet function: therapeutic implications?

Kebede MA, Alquier T, Latour MG, Poitout V.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:10-20. doi: 10.1111/j.1463-1326.2009.01114.x. Review.


Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.

Alquier T, Peyot ML, Latour MG, Kebede M, Sorensen CM, Gesta S, Ronald Kahn C, Smith RD, Jetton TL, Metz TO, Prentki M, Poitout V.

Diabetes. 2009 Nov;58(11):2607-15. doi: 10.2337/db09-0362. Epub 2009 Aug 31.

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