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Gut microbiota of obese subjects with Prader-Willi syndrome is linked to metabolic health.

Olsson LM, Poitou C, Tremaroli V, Coupaye M, Aron-Wisnewsky J, Bäckhed F, Clément K, Caesar R.

Gut. 2019 Oct 14. pii: gutjnl-2019-319322. doi: 10.1136/gutjnl-2019-319322. [Epub ahead of print]


Increasing physical activity in adult women with Prader-Willi syndrome: A transferability study.

Bellicha A, Coupaye M, Hocquaux L, Speter F, Oppert JM, Poitou C.

J Appl Res Intellect Disabil. 2019 Oct 2. doi: 10.1111/jar.12669. [Epub ahead of print]


Changes in Body Composition, Comorbidities, and Nutritional Status Associated with Lower Weight Loss After Bariatric Surgery in Older Subjects.

Faucher P, Aron-Wisnewsky J, Ciangura C, Genser L, Torcivia A, Bouillot JL, Poitou C, Oppert JM.

Obes Surg. 2019 Jun 25. doi: 10.1007/s11695-019-04037-6. [Epub ahead of print]


Resistance Training and Protein Supplementation Increase Strength After Bariatric Surgery: A Randomized Controlled Trial.

Oppert JM, Bellicha A, Roda C, Bouillot JL, Torcivia A, Clement K, Poitou C, Ciangura C.

Obesity (Silver Spring). 2018 Nov;26(11):1709-1720. doi: 10.1002/oby.22317.


Effectiveness of exercise training after bariatric surgery-a systematic literature review and meta-analysis.

Bellicha A, Ciangura C, Poitou C, Portero P, Oppert JM.

Obes Rev. 2018 Nov;19(11):1544-1556. doi: 10.1111/obr.12740. Epub 2018 Aug 28.


Long-term Relapse of Type 2 Diabetes After Roux-en-Y Gastric Bypass: Prediction and Clinical Relevance.

Debédat J, Sokolovska N, Coupaye M, Panunzi S, Chakaroun R, Genser L, de Turenne G, Bouillot JL, Poitou C, Oppert JM, Blüher M, Stumvoll M, Mingrone G, Ledoux S, Zucker JD, Clément K, Aron-Wisnewsky J.

Diabetes Care. 2018 Oct;41(10):2086-2095. doi: 10.2337/dc18-0567. Epub 2018 Aug 6.


Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes.

Genser L, Aguanno D, Soula HA, Dong L, Trystram L, Assmann K, Salem JE, Vaillant JC, Oppert JM, Laugerette F, Michalski MC, Wind P, Rousset M, Brot-Laroche E, Leturque A, Clément K, Thenet S, Poitou C.

J Pathol. 2018 Oct;246(2):217-230. doi: 10.1002/path.5134. Epub 2018 Aug 28.


Mucosal-associated invariant T (MAIT) cells are depleted and prone to apoptosis in cardiometabolic disorders.

Touch S, Assmann KE, Aron-Wisnewsky J, Marquet F, Rouault C, Fradet M, Mosbah H, Consortium M, Isnard R, Helft G, Lehuen A, Poitou C, Clément K, André S; MetaCardis Consortium.

FASEB J. 2018 Apr 27:fj201800052RR. doi: 10.1096/fj.201800052RR. [Epub ahead of print]


MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.

Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P.

Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7.


Fasting levels of glicentin are higher in Roux-en-Y gastric bypass patients exhibiting postprandial hypoglycemia during a meal test.

Poitou C, Bouaziz-Amar E, Genser L, Oppert JM, Lacorte JM, Le Beyec J.

Surg Obes Relat Dis. 2018 Jul;14(7):929-935. doi: 10.1016/j.soard.2018.03.014. Epub 2018 Mar 19.


Impact of transitional care on endocrine and anthropometric parameters in Prader-Willi syndrome.

Paepegaey AC, Coupaye M, Jaziri A, Ménesguen F, Dubern B, Polak M, Oppert JM, Tauber M, Pinto G, Poitou C.

Endocr Connect. 2018 May;7(5):663-672. doi: 10.1530/EC-18-0089. Epub 2018 Apr 17.


Human catalase gene promoter haplotype and cardiometabolic improvement after bariatric surgery.

Alili R, Nivet-Antoine V, Saldmann A, Golmard JL, Cottart CH, Laguillier C, Giral P, Beaudeux JL, Bouillot JL, Poitou C, Clément K, Hébert-Schuster M.

Gene. 2018 May 20;656:17-21. doi: 10.1016/j.gene.2018.02.064. Epub 2018 Feb 27.


Just the tip of the iceberg: difficulties in assessing and managing extreme obesity in routine clinical care.

Poitou C, Denis M, Chakhtoura Z, Uzan C, Nikpayam M, Oppert JM.

Eur J Clin Nutr. 2018 Mar;72(3):452-454. doi: 10.1038/s41430-017-0056-z. Epub 2018 Jan 29.


AZP-531, an unacylated ghrelin analog, improves food-related behavior in patients with Prader-Willi syndrome: A randomized placebo-controlled trial.

Allas S, Caixàs A, Poitou C, Coupaye M, Thuilleaux D, Lorenzini F, Diene G, Crinò A, Illouz F, Grugni G, Potvin D, Bocchini S, Delale T, Abribat T, Tauber M.

PLoS One. 2018 Jan 10;13(1):e0190849. doi: 10.1371/journal.pone.0190849. eCollection 2018.


Prevalence and Phenotype of Sleep Disorders in 60 Adults With Prader-Willi Syndrome.

Ghergan A, Coupaye M, Leu-Semenescu S, Attali V, Oppert JM, Arnulf I, Poitou C, Redolfi S.

Sleep. 2017 Dec 1;40(12). doi: 10.1093/sleep/zsx162.


Heat Shock Protein 60 in Obesity: Effect of Bariatric Surgery and its Relation to Inflammation and Cardiovascular Risk.

Sell H, Poitou C, Habich C, Bouillot JL, Eckel J, Clément K.

Obesity (Silver Spring). 2017 Dec;25(12):2108-2114. doi: 10.1002/oby.22014. Epub 2017 Oct 11.


Morphine and metabolites plasma levels after administration of sustained release morphine in Roux-en-Y gastric bypass subjects versus matched control subjects.

Hachon L, Reis R, Labat L, Poitou C, Jacob A, Declèves X, Lloret-Linares C.

Surg Obes Relat Dis. 2017 Nov;13(11):1869-1874. doi: 10.1016/j.soard.2017.07.030. Epub 2017 Aug 3.


The advanced-DiaRem score improves prediction of diabetes remission 1 year post-Roux-en-Y gastric bypass.

Aron-Wisnewsky J, Sokolovska N, Liu Y, Comaneshter DS, Vinker S, Pecht T, Poitou C, Oppert JM, Bouillot JL, Genser L, Dicker D, Zucker JD, Rudich A, Clément K.

Diabetologia. 2017 Oct;60(10):1892-1902. doi: 10.1007/s00125-017-4371-7. Epub 2017 Jul 21.


Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue.

Caër C, Rouault C, Le Roy T, Poitou C, Aron-Wisnewsky J, Torcivia A, Bichet JC, Clément K, Guerre-Millo M, André S.

Sci Rep. 2017 Jun 7;7(1):3000. doi: 10.1038/s41598-017-02660-w.


Decision-making in obesity without eating disorders: a systematic review and meta-analysis of Iowa gambling task performances.

Rotge JY, Poitou C, Fossati P, Aron-Wisnewsky J, Oppert JM.

Obes Rev. 2017 Aug;18(8):936-942. doi: 10.1111/obr.12549. Epub 2017 Apr 21. Review.


The FAT Score, a Fibrosis Score of Adipose Tissue: Predicting Weight-Loss Outcome After Gastric Bypass.

Bel Lassen P, Charlotte F, Liu Y, Bedossa P, Le Naour G, Tordjman J, Poitou C, Bouillot JL, Genser L, Zucker JD, Sokolovska N, Aron-Wisnewsky J, Clément K.

J Clin Endocrinol Metab. 2017 Jul 1;102(7):2443-2453. doi: 10.1210/jc.2017-00138.


Metabolic signatures in an adolescent with Silver-Russell syndrome and outcomes after bariatric surgery.

Mosbah H, Netchine I, Poitou C.

Surg Obes Relat Dis. 2017 Jul;13(7):1248-1250. doi: 10.1016/j.soard.2017.01.044. Epub 2017 Feb 2. No abstract available.


Diabetes remission after bariatric surgery in obese patients with haemochromatosis.

Phan F, Vatier C, Vauloup-Soupault C, Poitou C, Bouillot JL, Oppert JM, Aron-Wisnewsky J.

Diabetes Metab. 2018 Mar;44(2):185-187. doi: 10.1016/j.diabet.2017.02.005. Epub 2017 Mar 14. No abstract available.


A PDGFRα-Mediated Switch toward CD9high Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis.

Marcelin G, Ferreira A, Liu Y, Atlan M, Aron-Wisnewsky J, Pelloux V, Botbol Y, Ambrosini M, Fradet M, Rouault C, Hénégar C, Hulot JS, Poitou C, Torcivia A, Nail-Barthelemy R, Bichet JC, Gautier EL, Clément K.

Cell Metab. 2017 Mar 7;25(3):673-685. doi: 10.1016/j.cmet.2017.01.010. Epub 2017 Feb 16.


AA amyloidosis is an emerging cause of nephropathy in obese patients.

Stankovic Stojanovic K, Georgin-Lavialle S, Poitou C, Buob D, Amselem S, Grateau G; AMYLOB Study Group.

Eur J Intern Med. 2017 Apr;39:e18-e20. doi: 10.1016/j.ejim.2017.02.004. Epub 2017 Feb 14. No abstract available.


[Physiopathology, causes and complications of obesity].

Faucher P, Poitou C.

Soins. 2016 Dec;61(811):20-25. doi: 10.1016/j.soin.2016.10.003. French.


Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome.

Burnett LC, LeDuc CA, Sulsona CR, Paull D, Rausch R, Eddiry S, Carli JF, Morabito MV, Skowronski AA, Hubner G, Zimmer M, Wang L, Day R, Levy B, Fennoy I, Dubern B, Poitou C, Clement K, Butler MG, Rosenbaum M, Salles JP, Tauber M, Driscoll DJ, Egli D, Leibel RL.

J Clin Invest. 2017 Jan 3;127(1):293-305. doi: 10.1172/JCI88648. Epub 2016 Dec 12.


Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity.

Bedossa P, Tordjman J, Aron-Wisnewsky J, Poitou C, Oppert JM, Torcivia A, Bouillot JL, Paradis V, Ratziu V, Clément K.

Gut. 2017 Sep;66(9):1688-1696. doi: 10.1136/gutjnl-2016-312238. Epub 2016 Nov 24. Review.


Effect of Genotype and Previous GH Treatment on Adiposity in Adults With Prader-Willi Syndrome.

Coupaye M, Tauber M, Cuisset L, Laurier V, Bieth E, Lacorte JM, Oppert JM, Clément K, Poitou C.

J Clin Endocrinol Metab. 2016 Dec;101(12):4895-4903. Epub 2016 Sep 23.


The effect of morbid obesity on morphine glucuronidation.

Lloret-Linares C, Luo H, Rouquette A, Labat L, Poitou C, Tordjman J, Bouillot JL, Mouly S, Scherrmann JM, Bergmann JF, Declèves X.

Pharmacol Res. 2017 Apr;118:64-70. doi: 10.1016/j.phrs.2016.08.031. Epub 2016 Sep 5.


Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects.

Miyauchi E, Tachikawa M, Declèves X, Uchida Y, Bouillot JL, Poitou C, Oppert JM, Mouly S, Bergmann JF, Terasaki T, Scherrmann JM, Lloret-Linares C.

Mol Pharm. 2016 Aug 1;13(8):2631-40. doi: 10.1021/acs.molpharmaceut.6b00085. Epub 2016 Jul 19.


Effective radium concentration in topsoils contaminated by lead and zinc smelters.

Girault F, Perrier F, Poitou C, Isambert A, Théveniaut H, Laperche V, Clozel-Leloup B, Douay F.

Sci Total Environ. 2016 Oct 1;566-567:865-876. doi: 10.1016/j.scitotenv.2016.05.007. Epub 2016 Jun 1.


Rare Genetic Forms of Obesity: Clinical Approach and Current Treatments in 2016.

Huvenne H, Dubern B, Clément K, Poitou C.

Obes Facts. 2016;9(3):158-73. doi: 10.1159/000445061. Epub 2016 Jun 1.


[Alteration of intestinal permeability: the missing link between gut microbiota modifications and inflammation in obesity?].

Genser L, Poitou C, Brot-Laroche É, Rousset M, Vaillant JC, Clément K, Thenet S, Leturque A.

Med Sci (Paris). 2016 May;32(5):461-9. doi: 10.1051/medsci/20163205012. Epub 2016 May 25. Review. French.


Economic burden and health-related quality of life associated with Prader-Willi syndrome in France.

Chevreul K, Berg Brigham K, Clément MC, Poitou C, Tauber M; Members of the BURQOL-RD Research Network listed in the Online Appendix.

J Intellect Disabil Res. 2016 Sep;60(9):879-90. doi: 10.1111/jir.12288. Epub 2016 May 13.


Statins, antidiabetic medications and liver histology in patients with diabetes with non-alcoholic fatty liver disease.

Nascimbeni F, Aron-Wisnewsky J, Pais R, Tordjman J, Poitou C, Charlotte F, Bedossa P, Poynard T, Clément K, Ratziu V; LIDO study Group.

BMJ Open Gastroenterol. 2016 Mar 18;3(1):e000075. doi: 10.1136/bmjgast-2015-000075. eCollection 2016.


Increased Basement Membrane Components in Adipose Tissue During Obesity: Links With TGFβ and Metabolic Phenotypes.

Reggio S, Rouault C, Poitou C, Bichet JC, Prifti E, Bouillot JL, Rizkalla S, Lacasa D, Tordjman J, Clément K.

J Clin Endocrinol Metab. 2016 Jun;101(6):2578-87. doi: 10.1210/jc.2015-4304. Epub 2016 Apr 6.


Bariatric Surgery in Obese Patients with Type 1 Diabetes: Effects on Weight Loss and Metabolic Control.

Faucher P, Poitou C, Carette C, Tezenas du Montcel S, Barsamian C, Touati E, Bouillot JL, Torcivia A, Czernichow S, Oppert JM, Ciangura C.

Obes Surg. 2016 Oct;26(10):2370-8. doi: 10.1007/s11695-016-2106-3.


Weight Loss, Xanthine Oxidase, and Serum Urate Levels: A Prospective Longitudinal Study of Obese Patients.

Richette P, Poitou C, Manivet P, Denis J, Bouillot JL, Clément K, Oppert JM, Bardin T.

Arthritis Care Res (Hoboken). 2016 Jul;68(7):1036-42. doi: 10.1002/acr.22798.


Laparoscopic sleeve gastrectomy in children and adolescents with Prader-Willi Syndrome: a matched control study.

Coupaye M, Poitou C, Tauber M.

Surg Obes Relat Dis. 2016 Jan;12(1):213-4. doi: 10.1016/j.soard.2015.09.015. Epub 2015 Sep 26. No abstract available.


Oral Morphine Pharmacokinetic in Obesity: The Role of P-Glycoprotein, MRP2, MRP3, UGT2B7, and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers.

Lloret-Linares C, Miyauchi E, Luo H, Labat L, Bouillot JL, Poitou C, Oppert JM, Laplanche JL, Mouly S, Scherrmann JM, Uchida Y, Tachikawa M, Terasaki T, Bergmann JF, Declèves X.

Mol Pharm. 2016 Mar 7;13(3):766-73. doi: 10.1021/acs.molpharmaceut.5b00656. Epub 2016 Jan 22.


[Bariatric surgery in obese adolescents: When and how should the transition from pediatric to adult medical management be made?].

Paepegaey AC, Dubern B, Karsenty A, Chantereau H, Aron-Wisnewsky J, Oderda L, Hadoux M, Robert-Gary A, Bouillot JL, Oppert JM, Tounian P, Poitou C.

Arch Pediatr. 2015 Dec;22(12):1233-9. doi: 10.1016/j.arcped.2015.09.010. French.


Lipid-rich diet enhances L-cell density in obese subjects and in mice through improved L-cell differentiation.

Aranias T, Grosfeld A, Poitou C, Omar AA, Le Gall M, Miquel S, Garbin K, Ribeiro A, Bouillot JL, Bado A, Brot-Laroche E, Clément K, Leturque A, Guilmeau S, Serradas P.

J Nutr Sci. 2015 May 20;4:e22. doi: 10.1017/jns.2015.11. eCollection 2015.


Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling.

Monteiro-Sepulveda M, Touch S, Mendes-Sá C, André S, Poitou C, Allatif O, Cotillard A, Fohrer-Ting H, Hubert EL, Remark R, Genser L, Tordjman J, Garbin K, Osinski C, Sautès-Fridman C, Leturque A, Clément K, Brot-Laroche E.

Cell Metab. 2015 Jul 7;22(1):113-24. doi: 10.1016/j.cmet.2015.05.020. Epub 2015 Jun 18.


Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.

Dalmas E, Toubal A, Alzaid F, Blazek K, Eames HL, Lebozec K, Pini M, Hainault I, Montastier E, Denis RG, Ancel P, Lacombe A, Ling Y, Allatif O, Cruciani-Guglielmacci C, André S, Viguerie N, Poitou C, Stich V, Torcivia A, Foufelle F, Luquet S, Aron-Wisnewsky J, Langin D, Clément K, Udalova IA, Venteclef N.

Nat Med. 2015 Jun;21(6):610-8. doi: 10.1038/nm.3829. Epub 2015 May 4.


Bariatric Surgery Induces Disruption in Inflammatory Signaling Pathways Mediated by Immune Cells in Adipose Tissue: A RNA-Seq Study.

Poitou C, Perret C, Mathieu F, Truong V, Blum Y, Durand H, Alili R, Chelghoum N, Pelloux V, Aron-Wisnewsky J, Torcivia A, Bouillot JL, Parks BW, Ninio E, Clément K, Tiret L.

PLoS One. 2015 May 4;10(5):e0125718. doi: 10.1371/journal.pone.0125718. eCollection 2015.


Profiling of the three circulating monocyte subpopulations in human obesity.

Devêvre EF, Renovato-Martins M, Clément K, Sautès-Fridman C, Cremer I, Poitou C.

J Immunol. 2015 Apr 15;194(8):3917-23. doi: 10.4049/jimmunol.1402655. Epub 2015 Mar 18.


Macrophage activation marker soluble CD163 and non-alcoholic fatty liver disease in morbidly obese patients undergoing bariatric surgery.

Kazankov K, Tordjman J, Møller HJ, Vilstrup H, Poitou C, Bedossa P, Bouillot JL, Clement K, Grønbaek H.

J Gastroenterol Hepatol. 2015 Aug;30(8):1293-300. doi: 10.1111/jgh.12943.


Midterm outcomes of gastric bypass for elderly (aged ≥ 60 yr) patients: a comparative study.

Thereaux J, Poitou C, Barsamian C, Oppert JM, Czernichow S, Bouillot JL.

Surg Obes Relat Dis. 2015 Jul-Aug;11(4):836-41. doi: 10.1016/j.soard.2014.10.022. Epub 2014 Nov 4.


Comparison of results after one year between sleeve gastrectomy and gastric bypass in patients with BMI ≥ 50 kg/m².

Thereaux J, Corigliano N, Poitou C, Oppert JM, Czernichow S, Bouillot JL.

Surg Obes Relat Dis. 2015 Jul-Aug;11(4):785-90. doi: 10.1016/j.soard.2014.11.022. Epub 2014 Dec 4.


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