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Intestinal polycyclic aromatic hydrocarbon-DNA adducts in a population of beluga whales with high levels of gastrointestinal cancers.

Poirier MC, Lair S, Michaud R, Hernández-Ramon EE, Divi KV, Dwyer JE, Ester CD, Si NN, Ali M, Loseto LL, Raverty SA, St Leger JA, Van Bonn WG, Colegrove K, Burek-Huntington KA, Suydam R, Stimmelmayr R, Wise JP, Wise SS, Beauchamp G, Martineau D.

Environ Mol Mutagen. 2018 Oct 11. doi: 10.1002/em.22251. [Epub ahead of print]


Carcinogens and DNA damage.

Barnes JL, Zubair M, John K, Poirier MC, Martin FL.

Biochem Soc Trans. 2018 Oct 3. pii: BST20180519. doi: 10.1042/BST20180519. [Epub ahead of print] Review.


Modifiable Risk Factors for Delirium in Critically Ill Trauma Patients.

Duceppe MA, Williamson DR, Elliott A, Para M, Poirier MC, Delisle MS, Deckelbaum D, Razek T, Desjardins M, Bertrand JC, Bernard F, Rico P, Burry L, Frenette AJ, Perreault M.

J Intensive Care Med. 2017 Jan 1:885066617698646. doi: 10.1177/0885066617698646. [Epub ahead of print]


Mitochondrial compromise in 3-year old patas monkeys exposed in utero to human-equivalent antiretroviral therapies.

Liu Y, Shim Park E, Gibbons AT, Shide ED, Divi RL, Woodward RA, Poirier MC.

Environ Mol Mutagen. 2016 Aug;57(7):526-34. doi: 10.1002/em.22033. Epub 2016 Jul 25.


Linking DNA adduct formation and human cancer risk in chemical carcinogenesis.

Poirier MC.

Environ Mol Mutagen. 2016 Aug;57(7):499-507. doi: 10.1002/em.22030. Epub 2016 Jun 27. Review.


Use of Ciliogenesis to Detect Aneugens: The Role of Primary Cilia.

Divi KV, Ward Y, Poirier MC, Olivero OA.

Curr Protoc Toxicol. 2015 Nov 2;66:3.13.1-8. doi: 10.1002/0471140856.tx0313s66.


Fetal consequences of maternal antiretroviral nucleoside reverse transcriptase inhibitor use in human and nonhuman primate pregnancy.

Poirier MC, Gibbons AT, Rugeles MT, Andre-Schmutz I, Blanche S.

Curr Opin Pediatr. 2015 Apr;27(2):233-9. doi: 10.1097/MOP.0000000000000193. Review.


Cardiomyocytes are Protected from Antiretroviral Nucleoside Analog-Induced Mitochondrial Toxicity by Overexpression of PGC-1α.

Liu Y, Shim E, Crespo-Mejias Y, Nguyen P, Gibbons A, Liu D, Shide E, Poirier MC.

Cardiovasc Toxicol. 2015 Jul;15(3):224-31. doi: 10.1007/s12012-014-9288-5.


Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene.

Divi RL, Lindeman TL, Shockley ME, Keshava C, Weston A, Poirier MC.

Mutagenesis. 2014 Nov;29(6):409-17. doi: 10.1093/mutage/geu049. Epub 2014 Sep 22.


Role of nucleotide excision repair and p53 in zidovudine (AZT)-induced centrosomal deregulation.

Momot D, Nostrand TA, John K, Ward Y, Steinberg SM, Liewehr DJ, Poirier MC, Olivero OA.

Environ Mol Mutagen. 2014 Dec;55(9):719-26. doi: 10.1002/em.21889. Epub 2014 Jul 30.


Selective protection of zidovudine-induced DNA-damage by the antioxidants WR-1065 and tempol.

Olivero OA, Ongele MO, Braun HM, Marrogi A, Divi K, Mitchell JB, Poirier MC.

Environ Mol Mutagen. 2014 Aug;55(7):566-72. doi: 10.1002/em.21872. Epub 2014 May 16.


Achieving professional success in US government, academia, and industry: an EMGS commentary.

Poirier MC, Schwartz JL, Aardema MJ.

Environ Mol Mutagen. 2014 Aug;55(7):525-9. doi: 10.1002/em.21871. Epub 2014 May 2.


Exposure of Allium cepa root cells to zidovudine or nevirapine induces cytogenotoxic changes.

Onwuamah CK, Ekama SO, Audu RA, Ezechi OC, Poirier MC, Odeigah PG.

PLoS One. 2014 Mar 5;9(3):e90296. doi: 10.1371/journal.pone.0090296. eCollection 2014.


Tempol protects cardiomyocytes from nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity.

Liu Y, Shim E, Nguyen P, Gibbons AT, Mitchell JB, Poirier MC.

Toxicol Sci. 2014 May;139(1):133-41. doi: 10.1093/toxsci/kfu034. Epub 2014 Mar 3.


Tamoxifen-DNA adduct formation in monkey and human reproductive organs.

Hernandez-Ramon EE, Sandoval NA, John K, Cline JM, Wood CE, Woodward RA, Poirier MC.

Carcinogenesis. 2014 May;35(5):1172-6. doi: 10.1093/carcin/bgu029. Epub 2014 Feb 5.


The influence of age on serum concentrations of cardiac troponin I: results in rats, monkeys, and commercial sera.

Herman EH, Knapton A, Liu Y, Lipshultz SE, Estis J, Todd J, Woodward RA, Cochran T, Zhang J, Poirier MC.

Toxicol Pathol. 2014 Jul;42(5):888-96. doi: 10.1177/0192623313505154. Epub 2013 Oct 15.


Perinatal exposure of patas monkeys to antiretroviral nucleoside reverse-transcriptase inhibitors induces genotoxicity persistent for up to 3 years of age.

Olivero OA, Torres LR, Gorjifard S, Momot D, Marrogi E, Divi RL, Liu Y, Woodward RA, Sowers MJ, Poirier MC.

J Infect Dis. 2013 Jul 15;208(2):244-8. doi: 10.1093/infdis/jit146. Epub 2013 Apr 4.


Chemical-induced DNA damage and human cancer risk.

Poirier MC.

Discov Med. 2012 Oct;14(77):283-8. Review.


Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days.

John K, Pratt MM, Beland FA, Churchwell MI, McMullen G, Olivero OA, Pogribny IP, Poirier MC.

Carcinogenesis. 2012 Nov;33(11):2236-41. doi: 10.1093/carcin/bgs247. Epub 2012 Jul 24.


Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

Arlt VM, Poirier MC, Sykes SE, John K, Moserova M, Stiborova M, Wolf CR, Henderson CJ, Phillips DH.

Toxicol Lett. 2012 Sep 3;213(2):160-6. doi: 10.1016/j.toxlet.2012.06.016. Epub 2012 Jul 1.


Development and validation of a direct sandwich chemiluminescence immunoassay for measuring DNA adducts of benzo[a]pyrene and other polycyclic aromatic hydrocarbons.

Georgiadis P, Kovács K, Kaila S, Makedonopoulou P, Anna L, Poirier MC, Knudsen LE, Schoket B, Kyrtopoulos SA.

Mutagenesis. 2012 Sep;27(5):589-97. doi: 10.1093/mutage/ges024. Epub 2012 May 18.


Molecular analysis of mitochondrial compromise in rodent cardiomyocytes exposed long term to nucleoside reverse transcriptase inhibitors (NRTIs).

Liu Y, Nguyen P, Baris TZ, Poirier MC.

Cardiovasc Toxicol. 2012 Jun;12(2):123-34. doi: 10.1007/s12012-011-9148-5.


Polycyclic aromatic hydrocarbon (PAH) exposure and DNA adduct semi-quantitation in archived human tissues.

Pratt MM, John K, MacLean AB, Afework S, Phillips DH, Poirier MC.

Int J Environ Res Public Health. 2011 Jul;8(7):2675-91. doi: 10.3390/ijerph8072675. Epub 2011 Jun 29. Review.


Seasonal variations in the levels of PAH-DNA adducts in young adults living in Mexico City.

García-Suástegui WA, Huerta-Chagoya A, Carrasco-Colín KL, Pratt MM, John K, Petrosyan P, Rubio J, Poirier MC, Gonsebatt ME.

Mutagenesis. 2011 May;26(3):385-91. doi: 10.1093/mutage/geq104. Epub 2010 Dec 30.


Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic.

Pratt MM, King LC, Adams LD, John K, Sirajuddin P, Olivero OA, Manchester DK, Sram RJ, DeMarini DM, Poirier MC.

Environ Mol Mutagen. 2011 Jan;52(1):58-68. doi: 10.1002/em.20581.


Progressive mitochondrial compromise in brains and livers of primates exposed in utero to nucleoside reverse transcriptase inhibitors (NRTIs).

Divi RL, Einem TL, Fletcher SL, Shockley ME, Kuo MM, St Claire MC, Cook A, Nagashima K, Harbaugh SW, Harbaugh JW, Poirier MC.

Toxicol Sci. 2010 Nov;118(1):191-201. doi: 10.1093/toxsci/kfq235. Epub 2010 Aug 11.


Nuclear bud formation: a novel manifestation of Zidovudine genotoxicity.

Dutra A, Pak E, Wincovitch S, John K, Poirier MC, Olivero OA.

Cytogenet Genome Res. 2010;128(1-3):105-10. doi: 10.1159/000298794. Epub 2010 Apr 20.


Human placental glutathione S-transferase activity and polycyclic aromatic hydrocarbon DNA adducts as biomarkers for environmental oxidative stress in placentas from pregnant women living in radioactivity- and chemically-polluted regions.

Obolenskaya MY, Teplyuk NM, Divi RL, Poirier MC, Filimonova NB, Zadrozna M, Pasanen MJ.

Toxicol Lett. 2010 Jul 1;196(2):80-6. doi: 10.1016/j.toxlet.2010.03.1115. Epub 2010 Apr 7.


CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin.

John K, Divi RL, Keshava C, Orozco CC, Schockley ME, Richardson DL, Poirier MC, Nath J, Weston A.

Cancer Lett. 2010 Jun 28;292(2):254-60. doi: 10.1016/j.canlet.2009.12.008. Epub 2010 Feb 16.


In utero exposure of female CD-1 mice to AZT and/or 3TC: II. Persistence of functional alterations in cardiac tissue.

Torres SM, Divi RL, Walker DM, McCash CL, Carter MM, Campen MJ, Einem TL, Chu Y, Seilkop SK, Kang H, Poirier MC, Walker VE.

Cardiovasc Toxicol. 2010 Jun;10(2):87-99. doi: 10.1007/s12012-010-9065-z.


Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells.

Olivero OA, Vazquez IL, Cooch CC, Ming J, Keller E, Yu M, Borojerdi JP, Braun HM, McKee E, Poirier MC.

Toxicol Sci. 2010 May;115(1):109-17. doi: 10.1093/toxsci/kfq023. Epub 2010 Jan 27.


In utero exposure of female CD-1 Mice to AZT and/or 3TC: I. Persistence of microscopic lesions in cardiac tissue.

Torres SM, March TH, Carter MM, McCash CL, Seilkop SK, Poirier MC, Walker DM, Walker VE.

Cardiovasc Toxicol. 2010 Mar;10(1):37-50. doi: 10.1007/s12012-010-9061-3.


Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo.

Poirier MC, Olivero OA, Hardy AW, Franchini G, Borojerdi JP, Walker VE, Walker DM, Shearer GM.

AIDS Res Ther. 2009 Nov 6;6:24. doi: 10.1186/1742-6405-6-24.


Centrosome amplification induced by the antiretroviral nucleoside reverse transcriptase inhibitors lamivudine, stavudine, and didanosine.

Yu M, Ward Y, Poirier MC, Olivero OA.

Environ Mol Mutagen. 2009 Oct;50(8):718-24. doi: 10.1002/em.20509.


Centrosomal amplification and aneuploidy induced by the antiretroviral drug AZT in hamster and human cells.

Borojerdi JP, Ming J, Cooch C, Ward Y, Semino-Mora C, Yu M, Braun HM, Taylor BJ, Poirier MC, Olivero OA.

Mutat Res. 2009 Jun 1;665(1-2):67-74. doi: 10.1016/j.mrfmmm.2009.03.004. Epub 2009 Mar 24.


WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.

Walker DM, Kajon AE, Torres SM, Carter MM, McCash CL, Swenberg JA, Upton PB, Hardy AW, Olivero OA, Shearer GM, Poirier MC, Walker VE.

Environ Mol Mutagen. 2009 Jul;50(6):460-72. doi: 10.1002/em.20482.


Tamoxifen induces expression of immune response-related genes in cultured normal human mammary epithelial cells.

Schild-Hay LJ, Leil TA, Divi RL, Olivero OA, Weston A, Poirier MC.

Cancer Res. 2009 Feb 1;69(3):1150-5. doi: 10.1158/0008-5472.CAN-08-2806. Epub 2009 Jan 20.


Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells.

Keshava C, Divi RL, Einem TL, Richardson DL, Leonard SL, Keshava N, Poirier MC, Weston A.

Environ Mol Mutagen. 2009 Mar;50(2):134-44. doi: 10.1002/em.20449.


Quantification of phase I/II metabolizing enzyme gene expression and polycyclic aromatic hydrocarbon-DNA adduct levels in human prostate.

John K, Ragavan N, Pratt MM, Singh PB, Al-Buheissi S, Matanhelia SS, Phillips DH, Poirier MC, Martin FL.

Prostate. 2009 Apr 1;69(5):505-19. doi: 10.1002/pros.20898.


The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo.

Courter LA, Luch A, Musafia-Jeknic T, Arlt VM, Fischer K, Bildfell R, Pereira C, Phillips DH, Poirier MC, Baird WM.

Cancer Lett. 2008 Jun 28;265(1):135-47. doi: 10.1016/j.canlet.2008.02.017. Epub 2008 Mar 18.


Human inter-individual variability in metabolism and genotoxic response to zidovudine.

Olivero OA, Ming JM, Das S, Vazquez IL, Richardson DL, Weston A, Poirier MC.

Toxicol Appl Pharmacol. 2008 Apr 15;228(2):158-64. doi: 10.1016/j.taap.2007.12.005. Epub 2007 Dec 14.


Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis.

Divi RL, Doerge DR, Twaddle NC, Shockley ME, St Claire MC, Harbaugh JW, Harbaugh SW, Poirier MC.

Toxicol Appl Pharmacol. 2008 Jan 15;226(2):206-11. Epub 2007 Sep 18.


Polycyclic aromatic hydrocarbon-DNA adducts in cervix of women infected with carcinogenic human papillomavirus types: an immunohistochemistry study.

Pratt MM, Sirajuddin P, Poirier MC, Schiffman M, Glass AG, Scott DR, Rush BB, Olivero OA, Castle PE.

Mutat Res. 2007 Nov 1;624(1-2):114-23. Epub 2007 May 5.


Erythrocebus patas monkey offspring exposed perinatally to NRTIs sustain skeletal muscle mitochondrial compromise at birth and at 1 year of age.

Divi RL, Leonard SL, Walker BL, Kuo MM, Shockley ME, St Claire MC, Nagashima K, Harbaugh SW, Harbaugh JW, Poirier MC.

Toxicol Sci. 2007 Sep;99(1):203-13. Epub 2007 Jun 1.


Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations.

Torres SM, Walker DM, Carter MM, Cook DL Jr, McCash CL, Cordova EM, Olivero OA, Poirier MC, Walker VE.

Environ Mol Mutagen. 2007 Apr-May;48(3-4):224-38.


Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC.

Escobar PA, Olivero OA, Wade NA, Abrams EJ, Nesel CJ, Ness RB, Day RD, Day BW, Meng Q, O'Neill JP, Walker DM, Poirier MC, Walker VE, Bigbee WL.

Environ Mol Mutagen. 2007 Apr-May;48(3-4):330-43.


Special issue on health risks of perinatal exposure to nucleoside reverse transcriptase inhibitors.

Walker VE, Poirier MC.

Environ Mol Mutagen. 2007 Apr-May;48(3-4):159-65. No abstract available.


Plasma and cellular markers of 3'-azido-3'-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs.

Meng Q, Olivero OA, Fasco MJ, Bellisario R, Kaminsky L, Pass KA, Wade NA, Abrams EJ, Nesel CJ, Ness RB, Bigbee WL, O'Neill JP, Walker DM, Poirier MC, Walker VE.

Environ Mol Mutagen. 2007 Apr-May;48(3-4):307-21.


Leukocyte polycyclic aromatic hydrocarbon-DNA adduct formation and colorectal adenoma.

Gunter MJ, Divi RL, Kulldorff M, Vermeulen R, Haverkos KJ, Kuo MM, Strickland P, Poirier MC, Rothman N, Sinha R.

Carcinogenesis. 2007 Jul;28(7):1426-9. Epub 2007 Feb 2.


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