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Items: 1 to 50 of 825

1.

HER2-mediated internalization of cytotoxic agents in ERBB2 amplified or mutant lung cancers.

Li BT, Michelini F, Misale S, Cocco E, Baldino L, Cai Y, Shifman S, Tu HY, Myers ML, Xu C, Mattar M, Khodos I, Little M, Qeriqi B, Weitsman G, Wilhelm CJ, Lalani AS, Diala I, Freedman RA, Lin NU, Solit DB, Berger MF, Barber PR, Ng T, Offin M, Isbell JM, Jones DR, Yu HA, Thyparambil S, Liao WL, Bhalkikar A, Cecchi F, Hyman DM, Lewis JS, Buonocore DJ, Ho AL, Makker V, Reis-Filho JS, Razavi P, Arcila ME, Kris MG, Poirier JT, Shen R, Tsurutani J, Ulaner GA, de Stanchina E, Rosen N, Rudin CM, Scaltriti M.

Cancer Discov. 2020 Mar 25. pii: CD-20-0215. doi: 10.1158/2159-8290.CD-20-0215. [Epub ahead of print]

2.

Virus-Receptor Interactions and Virus Neutralization: Insights for Oncolytic Virus Development.

Jayawardena N, Poirier JT, Burga LN, Bostina M.

Oncolytic Virother. 2020 Mar 6;9:1-15. doi: 10.2147/OV.S186337. eCollection 2020. Review.

3.

Outcomes of Pregnancies Affected by Gestational Diabetes and Type 2 Diabetes in a Rural First Nations Obstetrical Program in Northwest Ontario.

Kattini R, Poirier JN, Kelly LF, Madden SN, Ockenden H, Dooley JP, Hummelen RB.

Can J Diabetes. 2020 Jan 12. pii: S1499-2671(20)30001-0. doi: 10.1016/j.jcjd.2020.01.001. [Epub ahead of print]

PMID:
32178973
4.

Cerebral white matter diffusion properties and free-water with obstructive sleep apnea severity in older adults.

Baril AA, Gagnon K, Descoteaux M, Bedetti C, Chami S, Sanchez E, Montplaisir J, De Beaumont L, Gilbert D, Poirier J, Pelleieux S, Osorio RS, Carrier J, Gosselin N.

Hum Brain Mapp. 2020 Mar 13. doi: 10.1002/hbm.24971. [Epub ahead of print]

PMID:
32166865
5.

Value of an interactive phone application in an established enhanced recovery program.

Schlund D, Poirier J, Bhama AR, Hayden D, Saclarides T, Orkin B, Favuzza J.

Int J Colorectal Dis. 2020 Mar 12. doi: 10.1007/s00384-020-03563-5. [Epub ahead of print]

PMID:
32166373
6.

Recovery of Adrenal Insufficiency Is Frequent After Adjuvant Mitotane Therapy in Patients with Adrenocortical Carcinoma.

Poirier J, Gagnon N, Terzolo M, Puglisi S, Ghorayeb NE, Calabrese A, Lacroix A, Bourdeau I.

Cancers (Basel). 2020 Mar 10;12(3). pii: E639. doi: 10.3390/cancers12030639.

7.

APOEε4 potentiates the relationship between amyloid-β and tau pathologies.

Therriault J, Benedet AL, Pascoal TA, Mathotaarachchi S, Savard M, Chamoun M, Thomas E, Kang MS, Lussier F, Tissot C, Soucy JP, Massarweh G, Rej S, Saha-Chaudhuri P, Poirier J, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative.

Mol Psychiatry. 2020 Mar 11. doi: 10.1038/s41380-020-0688-6. [Epub ahead of print]

PMID:
32161362
8.

Risk factors associated with positive resection margins in patients with adrenocortical carcinoma.

Skertich NJ, Tierney JF, Chivukula SV, Babazadeh NT, Hertl M, Poirier J, Keutgen XM.

Am J Surg. 2020 Feb 22. pii: S0002-9610(20)30121-5. doi: 10.1016/j.amjsurg.2020.02.043. [Epub ahead of print]

PMID:
32111342
9.

Regenerative lineages and immune-mediated pruning in lung cancer metastasis.

Laughney AM, Hu J, Campbell NR, Bakhoum SF, Setty M, Lavallée VP, Xie Y, Masilionis I, Carr AJ, Kottapalli S, Allaj V, Mattar M, Rekhtman N, Xavier JB, Mazutis L, Poirier JT, Rudin CM, Pe'er D, Massagué J.

Nat Med. 2020 Feb;26(2):259-269. doi: 10.1038/s41591-019-0750-6. Epub 2020 Feb 10.

PMID:
32042191
10.

Morphometric network differences in ageing versus Alzheimer's disease dementia.

Pichet Binette A, Gonneaud J, Vogel JW, La Joie R, Rosa-Neto P, Collins DL, Poirier J, Breitner JCS, Villeneuve S, Vachon-Presseau E; Alzheimer’s Disease Neuroimaging Initiative; PREVENT-AD Research Group.

Brain. 2020 Feb 1;143(2):635-649. doi: 10.1093/brain/awz414.

PMID:
32040564
11.

Association of Vascular Risk Factors With β-Amyloid Peptide and Tau Burdens in Cognitively Unimpaired Individuals and Its Interaction With Vascular Medication Use.

Köbe T, Gonneaud J, Pichet Binette A, Meyer PF, McSweeney M, Rosa-Neto P, Breitner JCS, Poirier J, Villeneuve S; Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer Disease (PREVENT-AD) Research Group.

JAMA Netw Open. 2020 Feb 5;3(2):e1920780. doi: 10.1001/jamanetworkopen.2019.20780.

12.

New Approaches to SCLC Therapy: From the Laboratory to the Clinic.

Poirier JT, George J, Owonikoko TK, Berns A, Brambilla E, Byers LA, Carbone D, Chen HJ, Christensen CL, Dive C, Farago AF, Govindan R, Hann C, Hellmann MD, Horn L, Johnson JE, Ju YS, Kang S, Krasnow M, Lee J, Lee SH, Lehman J, Lok B, Lovly C, MacPherson D, McFadden D, Minna J, Oser M, Park K, Park KS, Pommier Y, Quaranta V, Ready N, Sage J, Scagliotti G, Sos ML, Sutherland KD, Travis WD, Vakoc CR, Wait SJ, Wistuba I, Wong KK, Zhang H, Daigneault J, Wiens J, Rudin CM, Oliver TG.

J Thorac Oncol. 2020 Apr;15(4):520-540. doi: 10.1016/j.jtho.2020.01.016. Epub 2020 Feb 1. Review.

PMID:
32018053
13.

Intermediate flortaucipir uptake is associated with Aβ-PET and CSF tau in asymptomatic adults.

McSweeney M, Pichet Binette A, Meyer PF, Gonneaud J, Bedetti C, Ozlen H, Labonté A, Rosa-Neto P, Breitner J, Poirier J, Villeneuve S; PREVENT-AD Research Group.

Neurology. 2020 Mar 17;94(11):e1190-e1200. doi: 10.1212/WNL.0000000000008905. Epub 2020 Feb 3.

PMID:
32015176
14.

Longitudinal Basal Forebrain Degeneration Interacts with TREM2/C3 Biomarkers of Inflammation in Presymptomatic Alzheimer's Disease.

Schmitz TW, Soreq H, Poirier J, Spreng RN.

J Neurosci. 2020 Feb 26;40(9):1931-1942. doi: 10.1523/JNEUROSCI.1184-19.2019. Epub 2020 Jan 8.

PMID:
31915256
15.

Virus-Receptor Interactions: Structural Insights For Oncolytic Virus Development.

Jayawardena N, Burga LN, Poirier JT, Bostina M.

Oncolytic Virother. 2019 Oct 29;8:39-56. doi: 10.2147/OV.S218494. eCollection 2019. Review.

16.

Operative resection in early stage pancreatic neuroendocrine tumors in the United States: Are we over- or undertreating patients?

Chivukula SV, Tierney JF, Hertl M, Poirier J, Keutgen XM.

Surgery. 2020 Jan;167(1):180-186. doi: 10.1016/j.surg.2019.04.061. Epub 2019 Sep 16.

PMID:
31537303
17.

Association between BDNF Polymorphism and Hypothalamic-Pituitary-Adrenal Activity in Later Adulthood.

Fiocco AJ, D'Amico D, de Beaumont L, Poirier J, Lupien S.

Gerontology. 2020;66(2):131-137. doi: 10.1159/000502143. Epub 2019 Sep 5.

PMID:
31487728
18.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) in Alzheimer's disease: A genetic and proteomic multi-cohort study.

Picard C, Poirier A, Bélanger S, Labonté A, Auld D, Poirier J; PREVENT-AD Research Group.

PLoS One. 2019 Aug 22;14(8):e0220254. doi: 10.1371/journal.pone.0220254. eCollection 2019.

19.

Hypothesis: cerebrospinal fluid protein markers suggest a pathway toward symptomatic resilience to AD pathology.

Meyer PF, Savard M, Poirier J, Morgan D, Breitner J; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2019 Sep;15(9):1160-1171. doi: 10.1016/j.jalz.2019.05.007. Epub 2019 Aug 9.

20.

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.

Dammert MA, Brägelmann J, Olsen RR, Böhm S, Monhasery N, Whitney CP, Chalishazar MD, Tumbrink HL, Guthrie MR, Klein S, Ireland AS, Ryan J, Schmitt A, Marx A, Ozretić L, Castiglione R, Lorenz C, Jachimowicz RD, Wolf E, Thomas RK, Poirier JT, Büttner R, Sen T, Byers LA, Reinhardt HC, Letai A, Oliver TG, Sos ML.

Nat Commun. 2019 Aug 2;10(1):3485. doi: 10.1038/s41467-019-11371-x.

21.

National Treatment Practice for Adrenocortical Carcinoma: Have They Changed and Have We Made Any Progress?

Tierney JF, Chivukula SV, Poirier J, Pappas SG, Schadde E, Hertl M, Kebebew E, Keutgen X.

J Clin Endocrinol Metab. 2019 Dec 1;104(12):5948-5956. doi: 10.1210/jc.2019-00915.

PMID:
31361313
22.

Association of PPP2R1A with Alzheimer's disease and specific cognitive domains.

Miron J, Picard C, Labonté A, Auld D, Breitner J, Poirier J; United Kingdom Brain Expression Consortium; PREVENT-AD research group.

Neurobiol Aging. 2019 Sep;81:234-243. doi: 10.1016/j.neurobiolaging.2019.06.008. Epub 2019 Jul 2.

PMID:
31349112
23.

Effects of 6-month vitamin D supplementation on insulin sensitivity and secretion: a randomised, placebo-controlled trial.

Lemieux P, Weisnagel SJ, Caron AZ, Julien AS, Morisset AS, Carreau AM, Poirier J, Tchernof A, Robitaille J, Bergeron J, Marette A, Vohl MC, Gagnon C.

Eur J Endocrinol. 2019 Sep;181(3):287-299. doi: 10.1530/EJE-19-0156.

PMID:
31344685
24.

The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study.

Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsiung GR, Camicioli R, Smith EE, Fogarty J, Lindsay J, Best S, Evans A, Das S, Mohaddes Z, Pilon R, Poirier J, Phillips NA, MacNamara E, Dixon RA, Duchesne S, MacKenzie I, Rylett RJ.

Can J Neurol Sci. 2019 Sep;46(5):499-511. doi: 10.1017/cjn.2019.27. Epub 2019 Jul 16.

PMID:
31309917
25.

Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids.

Laddha SV, da Silva EM, Robzyk K, Untch BR, Ke H, Rekhtman N, Poirier JT, Travis WD, Tang LH, Chan CS.

Cancer Res. 2019 Sep 1;79(17):4339-4347. doi: 10.1158/0008-5472.CAN-19-0214. Epub 2019 Jul 12.

26.

Circulating Tumor DNA Profiling in Small-Cell Lung Cancer Identifies Potentially Targetable Alterations.

Devarakonda S, Sankararaman S, Herzog BH, Gold KA, Waqar SN, Ward JP, Raymond VM, Lanman RB, Chaudhuri AA, Owonikoko TK, Li BT, Poirier JT, Rudin CM, Govindan R, Morgensztern D.

Clin Cancer Res. 2019 Oct 15;25(20):6119-6126. doi: 10.1158/1078-0432.CCR-19-0879. Epub 2019 Jul 12.

PMID:
31300452
27.

Is sarcopenia a better predictor of complications than body mass index? Sarcopenia and surgical outcomes in patients with rectal cancer.

Jochum SB, Kistner M, Wood EH, Hoscheit M, Nowak L, Poirier J, Eberhardt JM, Saclarides TJ, Hayden DM.

Colorectal Dis. 2019 Dec;21(12):1372-1378. doi: 10.1111/codi.14751. Epub 2019 Jul 21.

PMID:
31276286
28.

No apparent effect of naproxen on CSF markers of innate immune activation.

Meyer PF, Labonté A, Rosa-Neto P, Poirier J, Breitner JCS; PREVENT‐AD Research Group.

Ann Clin Transl Neurol. 2019 Jun 6;6(6):1127-1133. doi: 10.1002/acn3.788. eCollection 2019 Jun.

29.

Enabling chiral separations in discovery chemistry with open-access chiral supercritical fluid chromatography.

Michaels P, Neef J, Galyan K, Ginsburg-Moraff C, Zhou X, Dunstan D, Poirier J, Reilly J.

Chirality. 2019 Aug;31(8):575-582. doi: 10.1002/chir.23081. Epub 2019 Jun 13.

PMID:
31197868
30.

Positron-Emission Tomographic Imaging of a Fluorine 18-Radiolabeled Poly(ADP-Ribose) Polymerase 1 Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in SCLC Patient-Derived Xenografts.

Laird J, Lok BH, Carney B, Kossatz S, de Stanchina E, Reiner T, Poirier JT, Rudin CM.

J Thorac Oncol. 2019 Oct;14(10):1743-1752. doi: 10.1016/j.jtho.2019.05.032. Epub 2019 Jun 11.

PMID:
31195178
31.

Author Correction: Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.

Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF.

Nat Rev Cancer. 2019 Jul;19(7):415. doi: 10.1038/s41568-019-0164-2.

PMID:
31175338
32.

Association of TLR4 with Alzheimer's disease risk and presymptomatic biomarkers of inflammation.

Miron J, Picard C, Lafaille-Magnan MÉ, Savard M, Labonté A, Breitner J, Rosa-Neto P, Auld D, Poirier J; PREVENT-AD research group.

Alzheimers Dement. 2019 Jul;15(7):951-960. doi: 10.1016/j.jalz.2019.03.012. Epub 2019 Jun 4.

PMID:
31175027
33.

Evolution of the Surgical Technique for "Breast in a Day" Direct-to-Implant Breast Reconstruction: Transitioning from Dual-Plane to Prepectoral Implant Placement.

Antony AK, Poirier J, Madrigrano A, Kopkash KA, Robinson EC.

Plast Reconstr Surg. 2019 Jun;143(6):1547-1556. doi: 10.1097/PRS.0000000000005627.

PMID:
31136464
34.

A rapid bead-based radioligand binding assay for the determination of target-binding fraction and quality control of radiopharmaceuticals.

Sharma SK, Lyashchenko SK, Park HA, Pillarsetty N, Roux Y, Wu J, Poty S, Tully KM, Poirier JT, Lewis JS.

Nucl Med Biol. 2019 Apr;71:32-38. doi: 10.1016/j.nucmedbio.2019.04.005. Epub 2019 May 3.

PMID:
31128476
35.

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.

Liebsch F, Kulic L, Teunissen C, Shobo A, Ulku I, Engelschalt V, Hancock MA, van der Flier WM, Kunach P, Rosa-Neto P, Scheltens P, Poirier J, Saftig P, Bateman RJ, Breitner J, Hock C, Multhaup G.

Nat Commun. 2019 May 20;10(1):2240. doi: 10.1038/s41467-019-10152-w.

36.

The seminal acrosin-inhibitor ClTI1/SPINK2 is a fertility-associated marker in the chicken.

Thélie A, Rehault-Godbert S, Poirier JC, Govoroun M, Fouchécourt S, Blesbois E.

Mol Reprod Dev. 2019 Jul;86(7):762-775. doi: 10.1002/mrd.23153. Epub 2019 Apr 29.

37.

Primary Tumor Site Affects Survival in Patients with Gastroenteropancreatic and Neuroendocrine Liver Metastases.

Tierney JF, Poirier J, Chivukula S, Pappas SG, Hertl M, Schadde E, Keutgen X.

Int J Endocrinol. 2019 Mar 12;2019:9871319. doi: 10.1155/2019/9871319. eCollection 2019.

38.

Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study.

Lleó A, Alcolea D, Martínez-Lage P, Scheltens P, Parnetti L, Poirier J, Simonsen AH, Verbeek MM, Rosa-Neto P, Slot RER, Tainta M, Izaguirre A, Reijs BLR, Farotti L, Tsolaki M, Vandenbergue R, Freund-Levi Y, Verhey FRJ, Clarimón J, Fortea J, Frolich L, Santana I, Molinuevo JL, Lehmann S, Visser PJ, Teunissen CE, Zetterberg H, Blennow K.

Alzheimers Dement. 2019 Jun;15(6):742-753. doi: 10.1016/j.jalz.2019.01.015. Epub 2019 Apr 6.

PMID:
30967340
39.

INTREPAD: A randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease.

Meyer PF, Tremblay-Mercier J, Leoutsakos J, Madjar C, Lafaille-Maignan MÉ, Savard M, Rosa-Neto P, Poirier J, Etienne P, Breitner J; PREVENT-AD Research Group.

Neurology. 2019 Apr 30;92(18):e2070-e2080. doi: 10.1212/WNL.0000000000007232. Epub 2019 Apr 5. Erratum in: Neurology. 2019 Aug 20;93(8):371.

40.

Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.

Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF.

Nat Rev Cancer. 2019 May;19(5):289-297. doi: 10.1038/s41568-019-0133-9. Review. Erratum in: Nat Rev Cancer. 2019 Jun 7;:.

PMID:
30926931
41.

Disconnection Between Self-Reported and Objective Cognitive Impairment in Obstructive Sleep Apnea.

Gagnon K, Baril AA, Montplaisir J, Carrier J, De Beaumont L, D'Aragon C, Chami S, Pelleieux S, Poirier J, Gauthier S, Lafond C, Gagnon JF, Gosselin N.

J Clin Sleep Med. 2019 Mar 15;15(3):409-415. doi: 10.5664/jcsm.7664.

42.

Acquired BRAF Rearrangements Induce Secondary Resistance to EGFR therapy in EGFR-Mutated Lung Cancers.

Vojnic M, Kubota D, Kurzatkowski C, Offin M, Suzawa K, Benayed R, Schoenfeld AJ, Plodkowski AJ, Poirier JT, Rudin CM, Kris MG, Rosen NX, Yu HA, Riely GJ, Arcila ME, Somwar R, Ladanyi M.

J Thorac Oncol. 2019 May;14(5):802-815. doi: 10.1016/j.jtho.2018.12.038. Epub 2019 Mar 1.

PMID:
30831205
43.

Obesity Does Not Influence Management of Advanced Breast Cancer in the Elderly.

Tangalakis LL, Cortina CS, Son JD, Poirier J, Madrigrano A.

Clin Breast Cancer. 2019 Jun;19(3):197-199. doi: 10.1016/j.clbc.2018.12.020. Epub 2019 Jan 12.

PMID:
30827764
44.

Longer Operative Time and Intraoperative Blood Transfusion Are Associated with Postoperative Anastomotic Leak after Lower Gastrointestinal Surgery.

Cortina CS, Alex GC, Vercillo KN, Fleetwood VA, Smolevitz JB, Poirier J, Myers JA, Orkin BA, Singer MA.

Am Surg. 2019 Feb 1;85(2):136-141.

PMID:
30819288
45.

Laparoscopic Parenchymal-Sparing Hepatectomy: the New Maximally Minimal Invasive Surgery of the Liver-a Systematic Review and Meta-Analysis.

Kalil JA, Poirier J, Becker B, Van Dam R, Keutgen X, Schadde E.

J Gastrointest Surg. 2019 Apr;23(4):860-869. doi: 10.1007/s11605-019-04128-w. Epub 2019 Feb 12.

PMID:
30756316
46.

Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.

Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D.

Sci Signal. 2019 Feb 5;12(567). pii: eaau2922. doi: 10.1126/scisignal.aau2922.

47.

Do All Abdominal Neuroendocrine Tumors Require Extended Postoperative VTE Prophylaxis? A NSQIP Analysis.

Skertich NJ, Gerard J, Poirier J, Hertl M, Pappas SG, Schadde E, Keutgen XM.

J Gastrointest Surg. 2019 Apr;23(4):788-793. doi: 10.1007/s11605-018-04075-y. Epub 2019 Jan 22.

PMID:
30671795
48.

ONECUT2 is a driver of neuroendocrine prostate cancer.

Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A, Beltran H, Wang Y, He HH.

Nat Commun. 2019 Jan 17;10(1):278. doi: 10.1038/s41467-018-08133-6.

49.

CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis.

Dhaeze T, Tremblay L, Lachance C, Peelen E, Zandee S, Grasmuck C, Bourbonnière L, Larouche S, Ayrignac X, Rébillard RM, Poirier J, Lahav B, Duquette P, Girard M, Moumdjian R, Bouthillier A, Larochelle C, Prat A.

Cell Mol Immunol. 2019 Jul;16(7):652-665. doi: 10.1038/s41423-018-0198-5. Epub 2019 Jan 11.

PMID:
30635649
50.

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination.

Ruscetti M, Leibold J, Bott MJ, Fennell M, Kulick A, Salgado NR, Chen CC, Ho YJ, Sanchez-Rivera FJ, Feucht J, Baslan T, Tian S, Chen HA, Romesser PB, Poirier JT, Rudin CM, de Stanchina E, Manchado E, Sherr CJ, Lowe SW.

Science. 2018 Dec 21;362(6421):1416-1422. doi: 10.1126/science.aas9090.

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