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Items: 1 to 50 of 263

1.

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.

Caron MC, Sharma AK, O'Sullivan J, Myler LR, Ferreira MT, Rodrigue A, Coulombe Y, Ethier C, Gagné JP, Langelier MF, Pascal JM, Finkelstein IJ, Hendzel MJ, Poirier GG, Masson JY.

Nat Commun. 2019 Jul 4;10(1):2954. doi: 10.1038/s41467-019-10741-9.

2.

SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.

Hossain MI, Marcus JM, Lee JH, Garcia PL, Gagné JP, Poirier GG, Falany CN, Andrabi SA.

Drug Metab Dispos. 2019 Sep;47(9):949-953. doi: 10.1124/dmd.119.088047. Epub 2019 Jul 2.

PMID:
31266751
3.

Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation.

O'Sullivan J, Tedim Ferreira M, Gagné JP, Sharma AK, Hendzel MJ, Masson JY, Poirier GG.

Nat Commun. 2019 Mar 12;10(1):1182. doi: 10.1038/s41467-019-08859-x. Review.

4.

Erratum: Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination.

Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L.

Genes Dev. 2019 Feb 1;33(3-4):253. doi: 10.1101/gad.324053.119. No abstract available.

5.

A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in Drosophila.

Wang Z, Tacchelly-Benites O, Noble GP, Johnson MK, Gagné JP, Poirier GG, Ahmed Y.

Genetics. 2019 Mar;211(3):913-923. doi: 10.1534/genetics.118.301393. Epub 2018 Dec 28.

PMID:
30593492
6.

Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination.

Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L.

Genes Dev. 2019 Jan 1;33(1-2):75-89. doi: 10.1101/gad.315978.118. Epub 2018 Dec 19. Erratum in: Genes Dev. 2019 Feb 1;33(3-4):253.

7.

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.

Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL.

Science. 2018 Nov 2;362(6414). pii: eaat8407. doi: 10.1126/science.aat8407.

8.

Aurora kinase A localises to mitochondria to control organelle dynamics and energy production.

Bertolin G, Bulteau AL, Alves-Guerra MC, Burel A, Lavault MT, Gavard O, Le Bras S, Gagné JP, Poirier GG, Le Borgne R, Prigent C, Tramier M.

Elife. 2018 Aug 2;7. pii: e38111. doi: 10.7554/eLife.38111.

9.

Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks.

Dionne U, Chartier FJM, López de Los Santos Y, Lavoie N, Bernard DN, Banerjee SL, Otis F, Jacquet K, Tremblay MG, Jain M, Bourassa S, Gish GD, Gagné JP, Poirier GG, Laprise P, Voyer N, Landry CR, Doucet N, Bisson N.

Mol Cell. 2018 Jun 21;70(6):995-1007.e11. doi: 10.1016/j.molcel.2018.05.013. Epub 2018 Jun 18.

10.

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions.

Perreault M, Wunsch E, Białek A, Trottier J, Verreault M, Caron P, Poirier GG, Milkiewicz P, Barbier O.

Can J Gastroenterol Hepatol. 2018 Apr 11;2018:8096314. doi: 10.1155/2018/8096314. eCollection 2018.

11.

Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS.

Gagné JP, Langelier MF, Pascal JM, Poirier GG.

J Proteome Res. 2018 Jul 6;17(7):2542-2551. doi: 10.1021/acs.jproteome.8b00146. Epub 2018 Jun 11.

PMID:
29812941
12.

Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities.

Gagné JP, Lachapelle S, Garand C, Tsofack SP, Coulombe Y, Caron MC, Poirier GG, Masson JY, Lebel M.

Oncotarget. 2016 Dec 27;7(52):85680-85696. doi: 10.18632/oncotarget.13341.

13.

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer.

Velic D, Couturier AM, Ferreira MT, Rodrigue A, Poirier GG, Fleury F, Masson JY.

Biomolecules. 2015 Nov 20;5(4):3204-59. doi: 10.3390/biom5043204. Review.

14.

Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation.

Strickfaden H, McDonald D, Kruhlak MJ, Haince JF, Th'ng JP, Rouleau M, Ishibashi T, Corry GN, Ausio J, Underhill DA, Poirier GG, Hendzel MJ.

J Biol Chem. 2016 Jan 22;291(4):1789-802. doi: 10.1074/jbc.M115.694992. Epub 2015 Nov 11.

15.

The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice.

Ismail IH, Gagné JP, Genois MM, Strickfaden H, McDonald D, Xu Z, Poirier GG, Masson JY, Hendzel MJ.

Nat Cell Biol. 2015 Nov;17(11):1446-57. doi: 10.1038/ncb3259. Epub 2015 Oct 26.

PMID:
26502055
16.

The von Hippel-Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform.

Chesnel F, Hascoet P, Gagné JP, Couturier A, Jouan F, Poirier GG, Le Goff C, Vigneau C, Danger Y, Verite F, Le Goff X, Arlot-Bonnemains Y.

Br J Cancer. 2015 Jul 14;113(2):336-44. doi: 10.1038/bjc.2015.189. Epub 2015 Jun 2.

17.

Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs.

Gagné JP, Ethier C, Defoy D, Bourassa S, Langelier MF, Riccio AA, Pascal JM, Moon KM, Foster LJ, Ning Z, Figeys D, Droit A, Poirier GG.

DNA Repair (Amst). 2015 Jun;30:68-79. doi: 10.1016/j.dnarep.2015.02.004. Epub 2015 Feb 19.

PMID:
25800440
18.

Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum.

Genois MM, Plourde M, Éthier C, Roy G, Poirier GG, Ouellette M, Masson JY.

Nucleic Acids Res. 2015 Mar 11;43(5):2701-15. doi: 10.1093/nar/gkv118. Epub 2015 Feb 24.

19.

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair.

Abdou I, Poirier GG, Hendzel MJ, Weinfeld M.

Nucleic Acids Res. 2015 Jan;43(2):875-92. doi: 10.1093/nar/gku1307. Epub 2014 Dec 24.

20.

ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion.

Fouquerel E, Goellner EM, Yu Z, Gagné JP, Barbi de Moura M, Feinstein T, Wheeler D, Redpath P, Li J, Romero G, Migaud M, Van Houten B, Poirier GG, Sobol RW.

Cell Rep. 2014 Sep 25;8(6):1819-1831. doi: 10.1016/j.celrep.2014.08.036. Epub 2014 Sep 15.

21.

Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum.

Brotherton MC, Bourassa S, Légaré D, Poirier GG, Droit A, Ouellette M.

Int J Parasitol Drugs Drug Resist. 2014 May 16;4(2):126-32. doi: 10.1016/j.ijpddr.2014.05.002. eCollection 2014 Aug.

22.

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis.

Andrabi SA, Umanah GK, Chang C, Stevens DA, Karuppagounder SS, Gagné JP, Poirier GG, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10209-14. doi: 10.1073/pnas.1405158111. Epub 2014 Jul 1.

23.

Germline mutations in BAP1 impair its function in DNA double-strand break repair.

Ismail IH, Davidson R, Gagné JP, Xu ZZ, Poirier GG, Hendzel MJ.

Cancer Res. 2014 Aug 15;74(16):4282-94. doi: 10.1158/0008-5472.CAN-13-3109. Epub 2014 Jun 3.

24.

Ensconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells.

Gallaud E, Caous R, Pascal A, Bazile F, Gagné JP, Huet S, Poirier GG, Chrétien D, Richard-Parpaillon L, Giet R.

J Cell Biol. 2014 Mar 31;204(7):1111-21. doi: 10.1083/jcb.201311094.

25.

Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase.

Wang Z, Gagné JP, Poirier GG, Xu W.

PLoS One. 2014 Jan 21;9(1):e86010. doi: 10.1371/journal.pone.0086010. eCollection 2014.

26.

Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant.

Brotherton MC, Bourassa S, Leprohon P, Légaré D, Poirier GG, Droit A, Ouellette M.

PLoS One. 2013 Nov 27;8(11):e81899. doi: 10.1371/journal.pone.0081899. eCollection 2013.

27.

Polycomb repressive complex 2 contributes to DNA double-strand break repair.

Campbell S, Ismail IH, Young LC, Poirier GG, Hendzel MJ.

Cell Cycle. 2013 Aug 15;12(16):2675-83. doi: 10.4161/cc.25795. Epub 2013 Jul 29.

28.

Mapping PARP-1 auto-ADP-ribosylation sites by liquid chromatography-tandem mass spectrometry.

Chapman JD, Gagné JP, Poirier GG, Goodlett DR.

J Proteome Res. 2013 Apr 5;12(4):1868-80. doi: 10.1021/pr301219h. Epub 2013 Mar 18.

PMID:
23438649
29.

Reprogramming cellular events by poly(ADP-ribose)-binding proteins.

Krietsch J, Rouleau M, Pic É, Ethier C, Dawson TM, Dawson VL, Masson JY, Poirier GG, Gagné JP.

Mol Aspects Med. 2013 Dec;34(6):1066-87. doi: 10.1016/j.mam.2012.12.005. Epub 2012 Dec 23. Review.

30.

PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent.

Ethier C, Tardif M, Arul L, Poirier GG.

PLoS One. 2012;7(10):e47978. doi: 10.1371/journal.pone.0047978. Epub 2012 Oct 24.

31.

PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks.

Krietsch J, Caron MC, Gagné JP, Ethier C, Vignard J, Vincent M, Rouleau M, Hendzel MJ, Poirier GG, Masson JY.

Nucleic Acids Res. 2012 Nov 1;40(20):10287-301. doi: 10.1093/nar/gks798. Epub 2012 Aug 31.

32.

Quantitative proteomics and dynamic imaging reveal that G3BP-mediated stress granule assembly is poly(ADP-ribose)-dependent following exposure to MNNG-induced DNA alkylation.

Isabelle M, Gagné JP, Gallouzi IE, Poirier GG.

J Cell Sci. 2012 Oct 1;125(Pt 19):4555-66. doi: 10.1242/jcs.106963. Epub 2012 Jul 5.

33.

Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress.

Gagné JP, Pic E, Isabelle M, Krietsch J, Ethier C, Paquet E, Kelly I, Boutin M, Moon KM, Foster LJ, Poirier GG.

Nucleic Acids Res. 2012 Sep;40(16):7788-805. doi: 10.1093/nar/gks486. Epub 2012 Jun 4.

34.

Structural biology. PARP-1 activation--bringing the pieces together.

Gagné JP, Rouleau M, Poirier GG.

Science. 2012 May 11;336(6082):678-9. doi: 10.1126/science.1221870. No abstract available.

PMID:
22582250
35.

PARP1 parylation promotes silent locus transmission in the nucleolus: the suspicion confirmed.

Isabelle M, Gallouzi IE, Poirier GG.

Mol Cell. 2012 Mar 30;45(6):706-7. doi: 10.1016/j.molcel.2012.03.012.

36.

CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage.

Ismail IH, Gagné JP, Caron MC, McDonald D, Xu Z, Masson JY, Poirier GG, Hendzel MJ.

Nucleic Acids Res. 2012 Jul;40(12):5497-510. doi: 10.1093/nar/gks222. Epub 2012 Mar 8.

37.

Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro.

Patel AG, De Lorenzo SB, Flatten KS, Poirier GG, Kaufmann SH.

Clin Cancer Res. 2012 Mar 15;18(6):1655-62. doi: 10.1158/1078-0432.CCR-11-2890. Epub 2012 Jan 30.

38.

Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.

Patel AG, Flatten KS, Schneider PA, Dai NT, McDonald JS, Poirier GG, Kaufmann SH.

J Biol Chem. 2012 Feb 3;287(6):4198-210. doi: 10.1074/jbc.M111.296475. Epub 2011 Dec 12.

39.

Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1.

Pic E, Gagné JP, Poirier GG.

Expert Rev Proteomics. 2011 Dec;8(6):759-74. doi: 10.1586/epr.11.63. Review.

PMID:
22087659
40.

Proteomics reveals a switch in CDK1-associated proteins upon M-phase exit during the Xenopus laevis oocyte to embryo transition.

Marteil G, Gagné JP, Borsuk E, Richard-Parpaillon L, Poirier GG, Kubiak JZ.

Int J Biochem Cell Biol. 2012 Jan;44(1):53-64. doi: 10.1016/j.biocel.2011.09.003. Epub 2011 Sep 21.

41.

Focus on computational proteomics.

Wu FX, Poirier GG.

Proteomics. 2011 Oct;11(19):3771-2. doi: 10.1002/pmic.201190099. No abstract available.

PMID:
21932215
42.

Affinity-based assays for the identification and quantitative evaluation of noncovalent poly(ADP-ribose)-binding proteins.

Gagné JP, Haince JF, Pic E, Poirier GG.

Methods Mol Biol. 2011;780:93-115. doi: 10.1007/978-1-61779-270-0_7.

43.

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.

Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14103-8. doi: 10.1073/pnas.1108799108. Epub 2011 Aug 8.

44.

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death.

Andrabi SA, Kang HC, Haince JF, Lee YI, Zhang J, Chi Z, West AB, Koehler RC, Poirier GG, Dawson TM, Dawson VL.

Nat Med. 2011 Jun;17(6):692-9. doi: 10.1038/nm.2387. Epub 2011 May 22.

45.

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos).

Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL, Dawson TM.

Sci Signal. 2011 Apr 5;4(167):ra20. doi: 10.1126/scisignal.2000902.

46.

A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development.

Rouleau M, Saxena V, Rodrigue A, Paquet ER, Gagnon A, Hendzel MJ, Masson JY, Ekker M, Poirier GG.

PLoS One. 2011 Jan 17;6(1):e15834. doi: 10.1371/journal.pone.0015834.

47.

Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples.

Lachapelle S, Gagné JP, Garand C, Desbiens M, Coulombe Y, Bohr VA, Hendzel MJ, Masson JY, Poirier GG, Lebel M.

J Proteome Res. 2011 Mar 4;10(3):1216-27. doi: 10.1021/pr100990s. Epub 2011 Feb 16.

48.

An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain.

Poitras L, Yu M, Lesage-Pelletier C, Macdonald RB, Gagné JP, Hatch G, Kelly I, Hamilton SP, Rubenstein JL, Poirier GG, Ekker M.

Development. 2010 Sep;137(18):3089-97. doi: 10.1242/dev.051052. Epub 2010 Aug 11.

49.

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry.

Isabelle M, Moreel X, Gagné JP, Rouleau M, Ethier C, Gagné P, Hendzel MJ, Poirier GG.

Proteome Sci. 2010 Apr 13;8:22. doi: 10.1186/1477-5956-8-22.

50.

PARP inhibition: PARP1 and beyond.

Rouleau M, Patel A, Hendzel MJ, Kaufmann SH, Poirier GG.

Nat Rev Cancer. 2010 Apr;10(4):293-301. doi: 10.1038/nrc2812. Epub 2010 Mar 4. Review.

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