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Items: 1 to 50 of 145

1.

Histone demethylases UTX and JMJD3 are required for NKT cell development in mice.

Northrup D, Yagi R, Cui K, Proctor WR, Wang C, Placek K, Pohl LR, Wang R, Ge K, Zhu J, Zhao K.

Cell Biosci. 2017 May 17;7:25. doi: 10.1186/s13578-017-0152-8. eCollection 2017.

2.

Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment.

Chakraborty M, Fullerton AM, Semple K, Chea LS, Proctor WR, Bourdi M, Kleiner DE, Zeng X, Ryan PM, Dagur PK, Berkson JD, Reilly TP, Pohl LR.

Hepatology. 2015 Aug;62(2):546-57. doi: 10.1002/hep.27764. Epub 2015 Mar 25.

3.

Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.

Proctor WR, Chakraborty M, Fullerton AM, Korrapati MC, Ryan PM, Semple K, Morrison JC, Berkson JD, Chea LS, Yang Q, Li AP, Spolski R, West EE, Rochman Y, Leonard WJ, Bourdi M, Pohl LR.

Hepatology. 2014 Nov;60(5):1741-52. doi: 10.1002/hep.27169. Epub 2014 May 20.

4.

Eosinophils mediate the pathogenesis of halothane-induced liver injury in mice.

Proctor WR, Chakraborty M, Chea LS, Morrison JC, Berkson JD, Semple K, Bourdi M, Pohl LR.

Hepatology. 2013 May;57(5):2026-36. doi: 10.1002/hep.26196. Epub 2013 Mar 15.

5.

Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice.

Ryan PM, Bourdi M, Korrapati MC, Proctor WR, Vasquez RA, Yee SB, Quinn TD, Chakraborty M, Pohl LR.

Chem Res Toxicol. 2012 Jan 13;25(1):83-93. doi: 10.1021/tx2003992. Epub 2011 Dec 13.

6.

SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.

Lu Z, Bourdi M, Li JH, Aponte AM, Chen Y, Lombard DB, Gucek M, Pohl LR, Sack MN.

EMBO Rep. 2011 Jul 1;12(8):840-6. doi: 10.1038/embor.2011.121.

7.
8.

Pathologic role of stressed-induced glucocorticoids in drug-induced liver injury in mice.

Masson MJ, Collins LA, Carpenter LD, Graf ML, Ryan PM, Bourdi M, Pohl LR.

Biochem Biophys Res Commun. 2010 Jul 2;397(3):453-8. doi: 10.1016/j.bbrc.2010.05.126. Epub 2010 May 27.

9.

The role of cytokines in the mechanism of adverse drug reactions.

Masson MJ, Collins LA, Pohl LR.

Handb Exp Pharmacol. 2010;(196):195-231. doi: 10.1007/978-3-642-00663-0_8. Review.

PMID:
20020264
10.
11.

Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury.

Bourdi M, Korrapati MC, Chakraborty M, Yee SB, Pohl LR.

Biochem Biophys Res Commun. 2008 Sep 12;374(1):6-10. doi: 10.1016/j.bbrc.2008.06.065. Epub 2008 Jun 27.

12.

Lamotrigine extended-release as adjunctive therapy for partial seizures.

Naritoku DK, Warnock CR, Messenheimer JA, Borgohain R, Evers S, Guekht AB, Karlov VA, Lee BI, Pohl LR.

Neurology. 2007 Oct 16;69(16):1610-8. Erratum in: Neurology. 2009 Jan 13;72(2):201.

PMID:
17938371
13.

Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminophen-induced liver disease.

Yee SB, Bourdi M, Masson MJ, Pohl LR.

Chem Res Toxicol. 2007 May;20(5):734-44. Epub 2007 Apr 18.

PMID:
17439248
14.

Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.

Bourdi M, Eiras DP, Holt MP, Webster MR, Reilly TP, Welch KD, Pohl LR.

Chem Res Toxicol. 2007 Feb;20(2):208-16.

PMID:
17305405
15.

Lymphocyte loss and immunosuppression following acetaminophen-induced hepatotoxicity in mice as a potential mechanism of tolerance.

Masson MJ, Peterson RA, Chung CJ, Graf ML, Carpenter LD, Ambroso JL, Krull DL, Sciarrotta J, Pohl LR.

Chem Res Toxicol. 2007 Jan;20(1):20-6.

PMID:
17226923
16.

Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice.

Welch KD, Reilly TP, Bourdi M, Hays T, Pise-Masison CA, Radonovich MF, Brady JN, Dix DJ, Pohl LR.

Chem Res Toxicol. 2006 Feb;19(2):223-33.

PMID:
16485898
17.

Proteomic identification of potential susceptibility factors in drug-induced liver disease.

Welch KD, Wen B, Goodlett DR, Yi EC, Lee H, Reilly TP, Nelson SD, Pohl LR.

Chem Res Toxicol. 2005 Jun;18(6):924-33.

PMID:
15962927
18.

Tolerogenic role of Kupffer cells in immune-mediated adverse drug reactions.

Ju C, Pohl LR.

Toxicology. 2005 Apr 15;209(2):109-12. Review.

PMID:
15767021
19.

Tolerogenic role of Kupffer cells in allergic reactions.

Ju C, McCoy JP, Chung CJ, Graf ML, Pohl LR.

Chem Res Toxicol. 2003 Dec;16(12):1514-9.

PMID:
14680364
20.

Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease.

Masubuchi Y, Bourdi M, Reilly TP, Graf ML, George JW, Pohl LR.

Biochem Biophys Res Commun. 2003 Apr 25;304(1):207-12.

PMID:
12705907
21.

Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice.

Ju C, Reilly TP, Bourdi M, Radonovich MF, Brady JN, George JW, Pohl LR.

Chem Res Toxicol. 2002 Dec;15(12):1504-13.

PMID:
12482232
22.

Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness.

Bourdi M, Reilly TP, Elkahloun AG, George JW, Pohl LR.

Biochem Biophys Res Commun. 2002 Jun 7;294(2):225-30.

PMID:
12051698
23.

Subcellular localization of trifluoroacetylated liver proteins in association with hepatitis following isoflurane.

Njoku DB, Shrestha S, Soloway R, Duray PR, Tsokos M, Abu-Asab MS, Pohl LR, West AB.

Anesthesiology. 2002 Mar;96(3):757-61. No abstract available.

PMID:
11873055
24.

Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase.

Bourdi M, Masubuchi Y, Reilly TP, Amouzadeh HR, Martin JL, George JW, Shah AG, Pohl LR.

Hepatology. 2002 Feb;35(2):289-98.

PMID:
11826401
25.

Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists.

Njoku DB, Greenberg RS, Bourdi M, Borkowf CB, Dake EM, Martin JL, Pohl LR.

Anesth Analg. 2002 Feb;94(2):243-9, table of contents.

PMID:
11812677
26.

A protective role for cyclooxygenase-2 in drug-induced liver injury in mice.

Reilly TP, Brady JN, Marchick MR, Bourdi M, George JW, Radonovich MF, Pise-Masison CA, Pohl LR.

Chem Res Toxicol. 2001 Dec;14(12):1620-8.

PMID:
11743745
28.

Fatal hepatitis associated with isoflurane exposure and CYP2A6 autoantibodies.

Martin JL, Keegan MT, Vasdev GM, Nyberg SL, Bourdi M, Pohl LR, Plevak DJ.

Anesthesiology. 2001 Aug;95(2):551-3. No abstract available.

PMID:
11506133
29.

Halothane-induced liver injury in outbred guinea pigs: role of trifluoroacetylated protein adducts in animal susceptibility.

Bourdi M, Amouzadeh HR, Rushmore TH, Martin JL, Pohl LR.

Chem Res Toxicol. 2001 Apr;14(4):362-70.

PMID:
11304124
30.

Expression profiling of acetaminophen liver toxicity in mice using microarray technology.

Reilly TP, Bourdi M, Brady JN, Pise-Masison CA, Radonovich MF, George JW, Pohl LR.

Biochem Biophys Res Commun. 2001 Mar 23;282(1):321-8. Erratum in: Biochem Biophys Res Commun 2001 May 4;283(2):536.

PMID:
11264010
31.

Drug enterocyte adducts: possible causal factor for diclofenac enteropathy in rats.

Atchison CR, West AB, Balakumaran A, Hargus SJ, Pohl LR, Daiker DH, Aronson JF, Hoffmann WE, Shipp BK, Treinen-Moslen M.

Gastroenterology. 2000 Dec;119(6):1537-47.

PMID:
11113075
32.

Renal cysteine conjugate beta-lyase and compound A nephrotoxicity: minimal evidence for an association.

Njoku DB, Martin JL, Pohl LR.

Anesthesiology. 1999 Mar;90(3):921-2. No abstract available.

PMID:
10078700
33.

Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.

Shen S, Marchick MR, Davis MR, Doss GA, Pohl LR.

Chem Res Toxicol. 1999 Feb;12(2):214-22.

PMID:
10027801
34.

Immunochemical evidence against the involvement of cysteine conjugate beta-lyase in compound A nephrotoxicity in rats.

Njoku DB, Pohl LR, Sokoloski EA, Marchick MR, Borkowf CB, Martin JL.

Anesthesiology. 1999 Feb;90(2):458-69.

PMID:
9952153
35.
36.

Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons.

Hoet P, Graf ML, Bourdi M, Pohl LR, Duray PH, Chen W, Peter RM, Nelson SD, Verlinden N, Lison D.

Lancet. 1997 Aug 23;350(9077):556-9.

PMID:
9284778
37.

Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins.

Cribb AE, Pohl LR, Spielberg SP, Leeder JS.

J Pharmacol Exp Ther. 1997 Aug;282(2):1064-71. Erratum in: J pharmacol Exp Ther 1998 Jan;284(1):435.

PMID:
9262376
38.

Cytochrome P4502C11 is a target of diclofenac covalent binding in rats.

Shen S, Hargus SJ, Martin BM, Pohl LR.

Chem Res Toxicol. 1997 Apr;10(4):420-3.

PMID:
9114979
39.

Selective protein covalent binding and target organ toxicity.

Cohen SD, Pumford NR, Khairallah EA, Boekelheide K, Pohl LR, Amouzadeh HR, Hinson JA.

Toxicol Appl Pharmacol. 1997 Mar;143(1):1-12. Review.

PMID:
9073586
40.
41.

Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.

Bourdi M, Chen W, Peter RM, Martin JL, Buters JT, Nelson SD, Pohl LR.

Chem Res Toxicol. 1996 Oct-Nov;9(7):1159-66.

PMID:
8902272
42.

Mechanisms, chemical structures and drug metabolism.

Pohl LR, Pumford NR, Martin JL.

Eur J Haematol Suppl. 1996;60:98-104. Review.

PMID:
8987250
43.

Covalent modification of rat liver dipeptidyl peptidase IV (CD26) by the nonsteroidal anti-inflammatory drug diclofenac.

Hargus SJ, Martin BM, George JW, Pohl LR.

Chem Res Toxicol. 1995 Dec;8(8):993-6.

PMID:
8605291
44.
45.

Hepatotoxicity after desflurane anesthesia.

Martin JL, Plevak DJ, Flannery KD, Charlton M, Poterucha JJ, Humphreys CE, Derfus G, Pohl LR.

Anesthesiology. 1995 Nov;83(5):1125-9. No abstract available.

PMID:
7486167
46.
47.

Stereoselective metabolism of halothane enantiomers to trifluoroacetylated liver proteins.

Martin JL, Meinwald J, Radford P, Liu Z, Graf ML, Pohl LR.

Drug Metab Rev. 1995;27(1-2):179-89. No abstract available.

PMID:
7641575
48.

Immunochemical methods of studying the mechanism of diclofenac-induced hepatitis.

Pohl LR, Martin JL, Hargus SJ.

Arthritis Rheum. 1994 Oct;37(10):1557. No abstract available.

PMID:
7945484
49.

Immunochemical methods of studying the mechanism of diclofenac-induced hepatitis [corrected].

Pohl LR, Martin JL, Hargus SJ.

Arthritis Rheum. 1994 Jul;37(7):1112. No abstract available. Corrected and republished in: Arthritis Rheum. 1994 Oct;37(10):1557.

PMID:
8024621
50.

Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac.

Hargus SJ, Amouzedeh HR, Pumford NR, Myers TG, McCoy SC, Pohl LR.

Chem Res Toxicol. 1994 Jul-Aug;7(4):575-82.

PMID:
7981423

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