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Items: 1 to 50 of 190

1.

GSP4PDB: a web tool to visualize, search and explore protein-ligand structural patterns.

Angles R, Arenas-Salinas M, García R, Reyes-Suarez JA, Pohl E.

BMC Bioinformatics. 2020 Mar 11;21(Suppl 2):85. doi: 10.1186/s12859-020-3352-x.

2.

Obtaining Tertiary Protein Structures by the ab Initio Interpretation of Small Angle X-ray Scattering Data.

Prior C, Davies OR, Bruce D, Pohl E.

J Chem Theory Comput. 2020 Mar 10;16(3):1985-2001. doi: 10.1021/acs.jctc.9b01010. Epub 2020 Feb 18.

PMID:
32023061
3.

The Role of Phosphatidylethanolamine Adducts in Modification of the Activity of Membrane Proteins under Oxidative Stress.

Pohl EE, Jovanovic O.

Molecules. 2019 Dec 12;24(24). pii: E4545. doi: 10.3390/molecules24244545. Review.

4.

Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice.

Moschinger M, Hilse KE, Rupprecht A, Zeitz U, Erben RG, Rülicke T, Pohl EE.

Biol Sex Differ. 2019 Dec 5;10(1):56. doi: 10.1186/s13293-019-0267-1.

5.

Molecular Mechanisms Responsible for Pharmacological Effects of Genipin on Mitochondrial Proteins.

Kreiter J, Rupprecht A, Zimmermann L, Moschinger M, Rokitskaya TI, Antonenko YN, Gille L, Fedorova M, Pohl EE.

Biophys J. 2019 Nov 19;117(10):1845-1857. doi: 10.1016/j.bpj.2019.10.021. Epub 2019 Oct 24.

6.

Crystal structures of the Bacillus subtilis prophage lytic cassette proteins XepA and YomS.

Freitag-Pohl S, Jasilionis A, Håkansson M, Svensson LA, Kovačič R, Welin M, Watzlawick H, Wang L, Altenbuchner J, Płotka M, Kaczorowska AK, Kaczorowski T, Nordberg Karlsson E, Al-Karadaghi S, Walse B, Aevarsson A, Pohl E.

Acta Crystallogr D Struct Biol. 2019 Nov 1;75(Pt 11):1028-1039. doi: 10.1107/S2059798319013330. Epub 2019 Nov 1.

7.

FRET Microscopy in Yeast.

Skruzny M, Pohl E, Abella M.

Biosensors (Basel). 2019 Oct 11;9(4). pii: E122. doi: 10.3390/bios9040122. Review.

8.

Assessing Engineering Resilience for Systems with Multiple Performance Measures.

Specking E, Cottam B, Parnell G, Pohl E, Cilli M, Buchanan R, Wade Z, Small C.

Risk Anal. 2019 Sep;39(9):1899-1912. doi: 10.1111/risa.13395. Erratum in: Risk Anal. 2019 Dec;39(12):2790.

PMID:
31487083
9.

Covalent modification of phosphatidylethanolamine by 4-hydroxy-2-nonenal increases sodium permeability across phospholipid bilayer membranes.

Jovanović O, Škulj S, Pohl EE, Vazdar M.

Free Radic Biol Med. 2019 Nov 1;143:433-440. doi: 10.1016/j.freeradbiomed.2019.08.027. Epub 2019 Aug 25.

10.

Outcomes After Onyx Embolization as Primary Treatment for Cranial Dural Arteriovenous Fistula in the Past Decade.

Moenninghoff C, Pohl E, Deuschl C, Wrede K, Jabbarli R, Radbruch A, Sure U, Forsting M, Wanke I.

Acad Radiol. 2019 Aug 21. pii: S1076-6332(19)30370-8. doi: 10.1016/j.acra.2019.07.021. [Epub ahead of print]

PMID:
31445824
11.

Housing and Urban Development-Veterans Affairs Supportive Housing Vouchers and Veterans' Homelessness, 2007-2017.

Evans WN, Kroeger S, Palmer C, Pohl E.

Am J Public Health. 2019 Oct;109(10):1440-1445. doi: 10.2105/AJPH.2019.305231. Epub 2019 Aug 15.

PMID:
31415190
12.

Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells.

Pohl E, Höffken V, Schlatt S, Kliesch S, Gromoll J, Wistuba J.

Andrology. 2019 Nov;7(6):827-839. doi: 10.1111/andr.12665. Epub 2019 Jun 27.

PMID:
31250567
13.

Important Trends in UCP3 Investigation.

Pohl EE, Rupprecht A, Macher G, Hilse KE.

Front Physiol. 2019 Apr 30;10:470. doi: 10.3389/fphys.2019.00470. eCollection 2019. Review.

14.

A C-terminal CXCL8 peptide based on chemokine-glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation.

Martínez-Burgo B, Cobb SL, Pohl E, Kashanin D, Paul T, Kirby JA, Sheerin NS, Ali S.

Immunology. 2019 Jun;157(2):173-184. doi: 10.1111/imm.13063.

PMID:
31013364
15.

Relative Binding Energies Predict Crystallographic Binding Modes of Ethionamide Booster Lead Compounds.

Tatum NJ, Duarte F, Kamerlin SCL, Pohl E.

J Phys Chem Lett. 2019 May 2;10(9):2244-2249. doi: 10.1021/acs.jpclett.9b00741. Epub 2019 Apr 23.

16.

A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii.

Melatti C, Pieperhoff M, Lemgruber L, Pohl E, Sheiner L, Meissner M.

PLoS Pathog. 2019 Apr 4;15(4):e1007512. doi: 10.1371/journal.ppat.1007512. eCollection 2019 Apr.

17.

Glutamine regulates mitochondrial uncoupling protein 2 to promote glutaminolysis in neuroblastoma cells.

Rupprecht A, Moldzio R, Mödl B, Pohl EE.

Biochim Biophys Acta Bioenerg. 2019 May 1;1860(5):391-401. doi: 10.1016/j.bbabio.2019.03.006. Epub 2019 Mar 15.

PMID:
30885735
18.

How to Stabilize Protein: Stability Screens for Thermal Shift Assays and Nano Differential Scanning Fluorimetry in the Virus-X Project.

Bruce D, Cardew E, Freitag-Pohl S, Pohl E.

J Vis Exp. 2019 Feb 11;(144). doi: 10.3791/58666.

PMID:
30799847
19.

Fluorescent Retinoic Acid Analogues as Probes for Biochemical and Intracellular Characterization of Retinoid Signaling Pathways.

Chisholm DR, Tomlinson CWE, Zhou GL, Holden C, Affleck V, Lamb R, Newling K, Ashton P, Valentine R, Redfern C, Erostyák J, Makkai G, Ambler CA, Whiting A, Pohl E.

ACS Chem Biol. 2019 Mar 15;14(3):369-377. doi: 10.1021/acschembio.8b00916. Epub 2019 Feb 13.

PMID:
30707838
20.

A Micro-agar Salt Bridge Electrode for Analyzing the Proton Turnover Rate of Recombinant Membrane Proteins.

Kreiter J, Pohl EE.

J Vis Exp. 2019 Jan 7;(143). doi: 10.3791/58552.

PMID:
30663681
21.

Novel Fluorescence Competition Assay for Retinoic Acid Binding Proteins.

Tomlinson CWE, Chisholm DR, Valentine R, Whiting A, Pohl E.

ACS Med Chem Lett. 2018 Nov 9;9(12):1297-1300. doi: 10.1021/acsmedchemlett.8b00420. eCollection 2018 Dec 13.

22.

Functional Analyses of a Putative, Membrane-Bound, Peroxisomal Protein Import Mechanism from the Apicomplexan Protozoan Toxoplasma gondii.

Mbekeani AJ, Stanley WA, Kalel VC, Dahan N, Zalckvar E, Sheiner L, Schliebs W, Erdmann R, Pohl E, Denny PW.

Genes (Basel). 2018 Aug 29;9(9). pii: E434. doi: 10.3390/genes9090434.

23.

The Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart.

Hilse KE, Rupprecht A, Egerbacher M, Bardakji S, Zimmermann L, Wulczyn AEMS, Pohl EE.

Front Physiol. 2018 Jun 22;9:747. doi: 10.3389/fphys.2018.00747. eCollection 2018.

24.

Mechanism of Long-Chain Free Fatty Acid Protonation at the Membrane-Water Interface.

Pashkovskaya AA, Vazdar M, Zimmermann L, Jovanovic O, Pohl P, Pohl EE.

Biophys J. 2018 May 8;114(9):2142-2151. doi: 10.1016/j.bpj.2018.04.011.

25.

Gene panel testing of 5589 BRCA1/2-negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer.

Hauke J, Horvath J, Groß E, Gehrig A, Honisch E, Hackmann K, Schmidt G, Arnold N, Faust U, Sutter C, Hentschel J, Wang-Gohrke S, Smogavec M, Weber BHF, Weber-Lassalle N, Weber-Lassalle K, Borde J, Ernst C, Altmüller J, Volk AE, Thiele H, Hübbel V, Nürnberg P, Keupp K, Versmold B, Pohl E, Kubisch C, Grill S, Paul V, Herold N, Lichey N, Rhiem K, Ditsch N, Ruckert C, Wappenschmidt B, Auber B, Rump A, Niederacher D, Haaf T, Ramser J, Dworniczak B, Engel C, Meindl A, Schmutzler RK, Hahnen E.

Cancer Med. 2018 Apr;7(4):1349-1358. doi: 10.1002/cam4.1376. Epub 2018 Mar 9.

26.

Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations.

Rebbeck TR, Friebel TM, Friedman E, Hamann U, Huo D, Kwong A, Olah E, Olopade OI, Solano AR, Teo SH, Thomassen M, Weitzel JN, Chan TL, Couch FJ, Goldgar DE, Kruse TA, Palmero EI, Park SK, Torres D, van Rensburg EJ, McGuffog L, Parsons MT, Leslie G, Aalfs CM, Abugattas J, Adlard J, Agata S, Aittomäki K, Andrews L, Andrulis IL, Arason A, Arnold N, Arun BK, Asseryanis E, Auerbach L, Azzollini J, Balmaña J, Barile M, Barkardottir RB, Barrowdale D, Benitez J, Berger A, Berger R, Blanco AM, Blazer KR, Blok MJ, Bonadona V, Bonanni B, Bradbury AR, Brewer C, Buecher B, Buys SS, Caldes T, Caliebe A, Caligo MA, Campbell I, Caputo SM, Chiquette J, Chung WK, Claes KBM, Collée JM, Cook J, Davidson R, de la Hoya M, De Leeneer K, de Pauw A, Delnatte C, Diez O, Ding YC, Ditsch N, Domchek SM, Dorfling CM, Velazquez C, Dworniczak B, Eason J, Easton DF, Eeles R, Ehrencrona H, Ejlertsen B; EMBRACE, Engel C, Engert S, Evans DG, Faivre L, Feliubadaló L, Ferrer SF, Foretova L, Fowler J, Frost D, Galvão HCR, Ganz PA, Garber J, Gauthier-Villars M, Gehrig A; GEMO Study Collaborators, Gerdes AM, Gesta P, Giannini G, Giraud S, Glendon G, Godwin AK, Greene MH, Gronwald J, Gutierrez-Barrera A, Hahnen E, Hauke J; HEBON, Henderson A, Hentschel J, Hogervorst FBL, Honisch E, Imyanitov EN, Isaacs C, Izatt L, Izquierdo A, Jakubowska A, James P, Janavicius R, Jensen UB, John EM, Vijai J, Kaczmarek K, Karlan BY, Kast K, Investigators K, Kim SW, Konstantopoulou I, Korach J, Laitman Y, Lasa A, Lasset C, Lázaro C, Lee A, Lee MH, Lester J, Lesueur F, Liljegren A, Lindor NM, Longy M, Loud JT, Lu KH, Lubinski J, Machackova E, Manoukian S, Mari V, Martínez-Bouzas C, Matrai Z, Mebirouk N, Meijers-Heijboer HEJ, Meindl A, Mensenkamp AR, Mickys U, Miller A, Montagna M, Moysich KB, Mulligan AM, Musinsky J, Neuhausen SL, Nevanlinna H, Ngeow J, Nguyen HP, Niederacher D, Nielsen HR, Nielsen FC, Nussbaum RL, Offit K, Öfverholm A, Ong KR, Osorio A, Papi L, Papp J, Pasini B, Pedersen IS, Peixoto A, Peruga N, Peterlongo P, Pohl E, Pradhan N, Prajzendanc K, Prieur F, Pujol P, Radice P, Ramus SJ, Rantala J, Rashid MU, Rhiem K, Robson M, Rodriguez GC, Rogers MT, Rudaitis V, Schmidt AY, Schmutzler RK, Senter L, Shah PD, Sharma P, Side LE, Simard J, Singer CF, Skytte AB, Slavin TP, Snape K, Sobol H, Southey M, Steele L, Steinemann D, Sukiennicki G, Sutter C, Szabo CI, Tan YY, Teixeira MR, Terry MB, Teulé A, Thomas A, Thull DL, Tischkowitz M, Tognazzo S, Toland AE, Topka S, Trainer AH, Tung N, van Asperen CJ, van der Hout AH, van der Kolk LE, van der Luijt RB, Van Heetvelde M, Varesco L, Varon-Mateeva R, Vega A, Villarreal-Garza C, von Wachenfeldt A, Walker L, Wang-Gohrke S, Wappenschmidt B, Weber BHF, Yannoukakos D, Yoon SY, Zanzottera C, Zidan J, Zorn KK, Hutten Selkirk CG, Hulick PJ, Chenevix-Trench G, Spurdle AB, Antoniou AC, Nathanson KL.

Hum Mutat. 2018 May;39(5):593-620. doi: 10.1002/humu.23406. Epub 2018 Mar 12.

27.

Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids.

Haffez H, Chisholm DR, Tatum NJ, Valentine R, Redfern C, Pohl E, Whiting A, Przyborski S.

Bioorg Med Chem. 2018 May 1;26(8):1560-1572. doi: 10.1016/j.bmc.2018.02.002. Epub 2018 Feb 10.

28.

Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate.

Macher G, Koehler M, Rupprecht A, Kreiter J, Hinterdorfer P, Pohl EE.

Biochim Biophys Acta Biomembr. 2018 Mar;1860(3):664-672. doi: 10.1016/j.bbamem.2017.12.001. Epub 2017 Dec 5.

29.

The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.

Cardew EM, Verlinde CLMJ, Pohl E.

Parasitology. 2018 Feb;145(2):210-218. doi: 10.1017/S0031182017001901. Epub 2017 Dec 1. Review.

30.

New active leads for tuberculosis booster drugs by structure-based drug discovery.

Tatum NJ, Liebeschuetz JW, Cole JC, Frita R, Herledan A, Baulard AR, Willand N, Pohl E.

Org Biomol Chem. 2017 Dec 13;15(48):10245-10255. doi: 10.1039/c7ob00910k.

PMID:
29182187
31.

Air/Liquid Interfacial Nanoassembly of Molecular Building Blocks into Preferentially Oriented Porous Organic Nanosheet Crystals via Hydrogen Bonding.

Makiura R, Tsuchiyama K, Pohl E, Prassides K, Sakata O, Tajiri H, Konovalov O.

ACS Nano. 2017 Nov 28;11(11):10875-10882. doi: 10.1021/acsnano.7b04447. Epub 2017 Oct 24.

PMID:
29061053
32.

Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites.

Mina JG, Thye JK, Alqaisi AQI, Bird LE, Dods RH, Grøftehauge MK, Mosely JA, Pratt S, Shams-Eldin H, Schwarz RT, Pohl E, Denny PW.

J Biol Chem. 2017 Jul 21;292(29):12208-12219. doi: 10.1074/jbc.M117.792374. Epub 2017 Jun 2.

33.

A tight tunable range for Ni(II) sensing and buffering in cells.

Foster AW, Pernil R, Patterson CJ, Scott AJP, Pålsson LO, Pal R, Cummins I, Chivers PT, Pohl E, Robinson NJ.

Nat Chem Biol. 2017 Apr;13(4):409-414. doi: 10.1038/nchembio.2310. Epub 2017 Feb 6.

34.

UCP2 up-regulation within the course of autoimmune encephalomyelitis correlates with T-lymphocyte activation.

Smorodchenko A, Schneider S, Rupprecht A, Hilse K, Sasgary S, Zeitz U, Erben RG, Pohl EE.

Biochim Biophys Acta Mol Basis Dis. 2017 Apr;1863(4):1002-1012. doi: 10.1016/j.bbadis.2017.01.019. Epub 2017 Jan 25.

35.

Mutantelec: An In Silico mutation simulation platform for comparative electrostatic potential profiling of proteins.

Valdebenito-Maturana B, Reyes-Suarez JA, Henriquez J, Holmes DS, Quatrini R, Pohl E, Arenas-Salinas M.

J Comput Chem. 2017 Mar 15;38(7):467-474. doi: 10.1002/jcc.24712.

PMID:
28114729
36.

The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors.

Haffez H, Chisholm DR, Valentine R, Pohl E, Redfern C, Whiting A.

Medchemcomm. 2017 Jan 20;8(3):578-592. doi: 10.1039/c6md00680a. eCollection 2017 Mar 1.

37.

Combined Recognition Imaging and Force Spectroscopy: A New Mode for Mapping and Studying Interaction Sites at Low Lateral Density.

Koehler M, Macher G, Rupprecht A, Zhu R, Gruber HJ, Pohl EE, Hinterdorfer P.

Sci Adv Mater. 2017 Jan 1;9(1):128-134. doi: 10.1166/sam.2017.3066.

38.

Nutrient deprivation in neuroblastoma cells alters 4-hydroxynonenal-induced stress response.

Zimmermann L, Moldzio R, Vazdar K, Krewenka C, Pohl EE.

Oncotarget. 2017 Jan 31;8(5):8173-8188. doi: 10.18632/oncotarget.14132.

39.

Practical synthetic strategies towards lipophilic 6-iodotetrahydroquinolines and -dihydroquinolines.

Chisholm DR, Zhou GL, Pohl E, Valentine R, Whiting A.

Beilstein J Org Chem. 2016 Aug 16;12:1851-1862. eCollection 2016.

40.

Key workers deserve better.

Pohl E.

Nurs Stand. 2016 Aug 10;30(50):30. doi: 10.7748/ns.30.50.30.s28.

PMID:
27507381
41.

The Effectors and Sensory Sites of Formaldehyde-responsive Regulator FrmR and Metal-sensing Variant.

Osman D, Piergentili C, Chen J, Sayer LN, Usón I, Huggins TG, Robinson NJ, Pohl E.

J Biol Chem. 2016 Sep 9;291(37):19502-16. doi: 10.1074/jbc.M116.745174. Epub 2016 Jul 29.

42.

Conjugate Addition of 3-Buytn-2-one to Anilines in Ethanol: Alkene Geometric Insights through In Situ FTIR Monitoring.

Chisholm DR, Valentine R, Pohl E, Whiting A.

J Org Chem. 2016 Sep 2;81(17):7557-65. doi: 10.1021/acs.joc.6b01110. Epub 2016 Aug 10.

PMID:
27467234
43.

Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System.

Hoehn R, Monse M, Pohl E, Wranik S, Wilker B, Keitsch S, Soddemann M, Kornhuber J, Kohnen M, Edwards MJ, Grassmé H, Gulbins E.

Neurosignals. 2016;24(1):48-58. doi: 10.1159/000442611. Epub 2016 Jul 11.

44.

Structural, biological and biophysical properties of glycated and glycoxidized phosphatidylethanolamines.

Annibal A, Riemer T, Jovanovic O, Westphal D, Griesser E, Pohl EE, Schiller J, Hoffmann R, Fedorova M.

Free Radic Biol Med. 2016 Jun;95:293-307. doi: 10.1016/j.freeradbiomed.2016.03.011. Epub 2016 Mar 22.

45.

An alternative interpretation of cellular 'selfish spermatogonial selection'-clusters in the human testis indicates the need for 3-D-analyses.

Pohl E, Gromoll J, Kliesch S, Wistuba J.

Andrology. 2016 Mar;4(2):213-7. doi: 10.1111/andr.12142. Epub 2016 Feb 19.

46.

The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions.

Jovanovic O, Pashkovskaya AA, Annibal A, Vazdar M, Burchardt N, Sansone A, Gille L, Fedorova M, Ferreri C, Pohl EE.

Free Radic Biol Med. 2015 Dec;89:1067-76. doi: 10.1016/j.freeradbiomed.2015.10.422. Epub 2015 Oct 28.

47.

The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue.

Hilse KE, Kalinovich AV, Rupprecht A, Smorodchenko A, Zeitz U, Staniek K, Erben RG, Pohl EE.

Biochim Biophys Acta. 2016 Jan;1857(1):72-78. doi: 10.1016/j.bbabio.2015.10.011. Epub 2015 Oct 27.

48.

Mutations in CDK5RAP2 cause Seckel syndrome.

Yigit G, Brown KE, Kayserili H, Pohl E, Caliebe A, Zahnleiter D, Rosser E, Bögershausen N, Uyguner ZO, Altunoglu U, Nürnberg G, Nürnberg P, Rauch A, Li Y, Thiel CT, Wollnik B.

Mol Genet Genomic Med. 2015 Sep;3(5):467-80. doi: 10.1002/mgg3.158. Epub 2015 May 24.

49.

The importance of open emergency surgery in the treatment of acute mesenteric ischemia.

Duran M, Pohl E, Grabitz K, Schelzig H, Sagban TA, Simon F.

World J Emerg Surg. 2015 Sep 26;10:45. doi: 10.1186/s13017-015-0041-6. eCollection 2015.

50.

RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.

Bögershausen N, Tsai IC, Pohl E, Kiper PÖ, Beleggia F, Percin EF, Keupp K, Matchan A, Milz E, Alanay Y, Kayserili H, Liu Y, Banka S, Kranz A, Zenker M, Wieczorek D, Elcioglu N, Prontera P, Lyonnet S, Meitinger T, Stewart AF, Donnai D, Strom TM, Boduroglu K, Yigit G, Li Y, Katsanis N, Wollnik B.

J Clin Invest. 2015 Sep;125(9):3585-99. doi: 10.1172/JCI80102. Epub 2015 Aug 17.

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