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Active pulmonary targeting against tuberculosis (TB) via triple-encapsulation of Q203, bedaquiline and superparamagnetic iron oxides (SPIOs) in nanoparticle aggregates.

Poh W, Ab Rahman N, Ostrovski Y, Sznitman J, Pethe K, Loo SCJ.

Drug Deliv. 2019 Dec;26(1):1039-1048. doi: 10.1080/10717544.2019.1676841.


BRCA1 Promoter Methylation Is Linked to Defective Homologous Recombination Repair and Elevated miR-155 to Disrupt Myeloid Differentiation in Myeloid Malignancies.

Poh W, Dilley RL, Moliterno AR, Maciejewski JP, Pratz KW, McDevitt MA, Herman JG.

Clin Cancer Res. 2019 Apr 15;25(8):2513-2522. doi: 10.1158/1078-0432.CCR-18-0179. Epub 2019 Jan 28.


Multiple spontaneous tendon ruptures from enthesis failure in primary hyperparathyroidism: a case report and review of imaging findings.

Salah MM, Yong YR, Poh WT, Chong LR.

Skeletal Radiol. 2019 Aug;48(8):1279-1287. doi: 10.1007/s00256-018-3092-4. Epub 2018 Oct 23.


Predictive factors for contrast-induced acute kidney injury in high-risk patients given N-acetylcysteine prophylaxis.

Poh WY, Omar MS, Tan HP.

Ann Saudi Med. 2018 Jul-Aug;38(4):269-276. doi: 10.5144/0256-4947.2018.269.


Gold nanoparticles induce serum amyloid A 1-Toll-like receptor 2 mediated NF-kB signaling in lung cells in vitro.

Ng CT, Yip GWC, Chen ES, Poh WYR, Bay BH, Yung LYL.

Chem Biol Interact. 2018 Jun 1;289:81-89. doi: 10.1016/j.cbi.2018.04.022. Epub 2018 Apr 26.


IFNβ inhibits the development of allergen tolerance and is conducive to the development of asthma on subsequent allergen exposure.

Fear VS, Poh WP, Gorman S, Waithman JC, Fear MW.

Immunol Cell Biol. 2018 Sep;96(8):841-851. doi: 10.1111/imcb.12050. Epub 2018 Apr 17.


Chronic tic disorders in children with ADHD.

Poh W, Payne JM, Gulenc A, Efron D.

Arch Dis Child. 2018 Sep;103(9):847-852. doi: 10.1136/archdischild-2017-314139. Epub 2018 Jan 9.


Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa.

Liu C, Liew CW, Wong YH, Tan ST, Poh WH, Manimekalai MSS, Rajan S, Xin L, Liang ZX, Grüber G, Rice SA, Lescar J.

J Bacteriol. 2018 Jan 10;200(3). pii: e00515-17. doi: 10.1128/JB.00515-17. Print 2018 Feb 1.


Rare germline variants in ATM are associated with chronic lymphocytic leukemia.

Tiao G, Improgo MR, Kasar S, Poh W, Kamburov A, Landau DA, Tausch E, Taylor-Weiner A, Cibulskis C, Bahl S, Fernandes SM, Hoang K, Rheinbay E, Kim HT, Bahlo J, Robrecht S, Fischer K, Hallek M, Gabriel S, Lander ES, Stilgenbauer S, Wu CJ, Kiezun A, Getz G, Brown JR.

Leukemia. 2017 Oct;31(10):2244-2247. doi: 10.1038/leu.2017.201. Epub 2017 Jun 27. No abstract available.


Furoxan Nitric Oxide Donors Disperse Pseudomonas aeruginosa Biofilms, Accelerate Growth, and Repress Pyoverdine Production.

Poh WH, Barraud N, Guglielmo S, Lazzarato L, Rolando B, Fruttero R, Rice SA.

ACS Chem Biol. 2017 Aug 18;12(8):2097-2106. doi: 10.1021/acschembio.7b00256. Epub 2017 Jun 29.


A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia.

Gojo I, Beumer JH, Pratz KW, McDevitt MA, Baer MR, Blackford AL, Smith BD, Gore SD, Carraway HE, Showel MM, Levis MJ, Dezern AE, Gladstone DE, Ji JJ, Wang L, Kinders RJ, Pouquet M, Ali-Walbi I, Rudek MA, Poh W, Herman JG, Karnitz LM, Kaufmann SH, Chen A, Karp JE.

Clin Cancer Res. 2017 Feb 1;23(3):697-706. doi: 10.1158/1078-0432.CCR-16-0984. Epub 2016 Aug 8.


Metachronous cholangiocarcinoma 13 years post resection of choledochal cyst-is long-term follow-up useful?: a case study and review of the literature.

Ng DW, Chiow AK, Poh WT, Tan SS.

Surg Case Rep. 2016 Dec;2(1):60. doi: 10.1186/s40792-016-0187-9. Epub 2016 Jun 16.


An unusual case of recurrent hepatocellular carcinoma presenting as an indeterminate right intrahepatic duct stricture.

Ang TL, Kwek AB, Poh WT.

Endoscopy. 2016;48 Suppl 1:E121-2. doi: 10.1055/s-0042-104280. Epub 2016 Mar 23. No abstract available.


Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.

Pratz KW, Koh BD, Patel AG, Flatten KS, Poh W, Herman JG, Dilley R, Harrell MI, Smith BD, Karp JE, Swisher EM, McDevitt MA, Kaufmann SH.

Clin Cancer Res. 2016 Aug 1;22(15):3894-902. doi: 10.1158/1078-0432.CCR-15-2351. Epub 2016 Mar 15.


DNA Methyltransferase Activity Assays: Advances and Challenges.

Poh WJ, Wee CP, Gao Z.

Theranostics. 2016 Jan 6;6(3):369-91. doi: 10.7150/thno.13438. eCollection 2016. Review.


Timing of excision after a non-severe burn has a significant impact on the subsequent immune response in a murine model.

Fear VS, Poh WP, Valvis S, Waithman JC, Foley B, Wood FM, Fear MW.

Burns. 2016 Jun;42(4):815-24. doi: 10.1016/j.burns.2016.01.013. Epub 2016 Feb 13.


DREAMing: a simple and ultrasensitive method for assessing intratumor epigenetic heterogeneity directly from liquid biopsies.

Pisanic TR 2nd, Athamanolap P, Poh W, Chen C, Hulbert A, Brock MV, Herman JG, Wang TH.

Nucleic Acids Res. 2015 Dec 15;43(22):e154. doi: 10.1093/nar/gkv795. Epub 2015 Aug 24.


Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity.

Yao F, Kausalya JP, Sia YY, Teo AS, Lee WH, Ong AG, Zhang Z, Tan JH, Li G, Bertrand D, Liu X, Poh HM, Guan P, Zhu F, Pathiraja TN, Ariyaratne PN, Rao J, Woo XY, Cai S, Mulawadi FH, Poh WT, Veeravalli L, Chan CS, Lim SS, Leong ST, Neo SC, Choi PS, Chew EG, Nagarajan N, Jacques PÉ, So JB, Ruan X, Yeoh KG, Tan P, Sung WK, Hunziker W, Ruan Y, Hillmer AM.

Cell Rep. 2015 Jul 14;12(2):272-85. doi: 10.1016/j.celrep.2015.06.020. Epub 2015 Jul 2.


Oligopolyphenylenevinylene-conjugated oligoelectrolyte membrane insertion molecules selectively disrupt cell envelopes of Gram-positive bacteria.

Hinks J, Poh WH, Chu JJ, Loo JS, Bazan GC, Hancock LE, Wuertz S.

Appl Environ Microbiol. 2015 Mar;81(6):1949-58. doi: 10.1128/AEM.03355-14. Epub 2015 Jan 9.


Function of the Ryk intracellular domain in C. elegans vulval development.

Poh WC, Shen Y, Inoue T.

Dev Dyn. 2014 Sep;243(9):1074-85. doi: 10.1002/dvdy.24159. Epub 2014 Jul 9.


Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations.

Pillai NE, Okada Y, Saw WY, Ong RT, Wang X, Tantoso E, Xu W, Peterson TA, Bielawny T, Ali M, Tay KY, Poh WT, Tan LW, Koo SH, Lim WY, Soong R, Wenk M, Raychaudhuri S, Little P, Plummer FA, Lee EJ, Chia KS, Luo M, De Bakker PI, Teo YY.

Hum Mol Genet. 2014 Aug 15;23(16):4443-51. doi: 10.1093/hmg/ddu149. Epub 2014 Apr 3.


Modeling cell membrane perturbation by molecules designed for transmembrane electron transfer.

Hinks J, Wang Y, Poh WH, Donose BC, Thomas AW, Wuertz S, Loo SC, Bazan GC, Kjelleberg S, Mu Y, Seviour T.

Langmuir. 2014 Mar 11;30(9):2429-40. doi: 10.1021/la403409t. Epub 2014 Feb 28.


Poly(ADP-ribose) polymerase inhibitor CEP-8983 synergizes with bendamustine in chronic lymphocytic leukemia cells in vitro.

Dilley RL, Poh W, Gladstone DE, Herman JG, Showel MM, Karp JE, McDevitt MA, Pratz KW.

Leuk Res. 2014 Mar;38(3):411-7. doi: 10.1016/j.leukres.2013.12.019. Epub 2013 Dec 30.


Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.

Poh WT, Chadha GS, Gillespie PJ, Kaldis P, Blow JJ.

Open Biol. 2014 Jan 8;4:130138. doi: 10.1098/rsob.130138.


Eosinophilic cholangiopathy: the diagnostic dilemma of a recurrent biliary stricture. Should surgery be offered for all?

Seow-En I, Chiow AK, Tan SS, Poh WT.

BMJ Case Rep. 2014 Jan 3;2014. pii: bcr2013202225. doi: 10.1136/bcr-2013-202225.


Viral quasispecies inference from 454 pyrosequencing.

Poh WT, Xia E, Chin-Inmanu K, Wong LP, Cheng AY, Malasit P, Suriyaphol P, Teo YY, Ong RT.

BMC Bioinformatics. 2013 Dec 5;14:355. doi: 10.1186/1471-2105-14-355.


Whole-exome sequencing of pancreatic neoplasms with acinar differentiation.

Jiao Y, Yonescu R, Offerhaus GJ, Klimstra DS, Maitra A, Eshleman JR, Herman JG, Poh W, Pelosof L, Wolfgang CL, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N, Wood LD.

J Pathol. 2014 Mar;232(4):428-35. doi: 10.1002/path.4310.


A glioblastoma neurosphere line with alternative lengthening of telomeres.

Heaphy CM, Schreck KC, Raabe E, Mao XG, An P, Chu Q, Poh W, Jiao Y, Rodriguez FJ, Odia Y, Meeker AK, Eberhart CG.

Acta Neuropathol. 2013 Oct;126(4):607-8. No abstract available.


HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells.

Shah SN, Cope L, Poh W, Belton A, Roy S, Talbot CC Jr, Sukumar S, Huso DL, Resar LM.

PLoS One. 2013 May 2;8(5):e63419. doi: 10.1371/journal.pone.0063419. Print 2013.


DNA-intercalators causing rapid re-expression of methylated and silenced genes in cancer cells.

Hossain MZ, Healey MA, Lee C, Poh W, Yerram SR, Patel K, Azad NS, Herman JG, Kern SE.

Oncotarget. 2013 Feb;4(2):298-309.


Singapore Pharmacogenomics Portal: a web resource for evaluating human genetic variations of genes responsible for drug responses.

Wong LP, Poh WT, Chan SL, Tan LL, Toh DS, Chia KS, Sung C, Teo YY.

Pharmacogenet Genomics. 2013 Jun;23(6):329-32. doi: 10.1097/FPC.0b013e3283608b0f.


Can granisetron injection used as primary prophylaxis improve the control of nausea and vomiting with low- emetogenic chemotherapy?

Keat CH, Phua G, Abdul Kassim MS, Poh WK, Sriraman M.

Asian Pac J Cancer Prev. 2013;14(1):469-73.


Improving charge collection in Escherichia coli-carbon electrode devices with conjugated oligoelectrolytes.

Wang VB, Du J, Chen X, Thomas AW, Kirchhofer ND, Garner LE, Maw MT, Poh WH, Hinks J, Wuertz S, Kjelleberg S, Zhang Q, Loo JS, Bazan GC.

Phys Chem Chem Phys. 2013 Apr 28;15(16):5867-72. doi: 10.1039/c3cp50437a. Epub 2013 Mar 13.


Deep whole-genome sequencing of 100 southeast Asian Malays.

Wong LP, Ong RT, Poh WT, Liu X, Chen P, Li R, Lam KK, Pillai NE, Sim KS, Xu H, Sim NL, Teo SM, Foo JN, Tan LW, Lim Y, Koo SH, Gan LS, Cheng CY, Wee S, Yap EP, Ng PC, Lim WY, Soong R, Wenk MR, Aung T, Wong TY, Khor CC, Little P, Chia KS, Teo YY.

Am J Hum Genet. 2013 Jan 10;92(1):52-66. doi: 10.1016/j.ajhg.2012.12.005. Epub 2013 Jan 3.


Solitary necrotic nodule of the liver: radiologic-pathologic correlation in a case with unusual imaging features.

Wong KM, Tay TK, Poh WT, Taneja R.

Jpn J Radiol. 2013 Apr;31(4):277-81. doi: 10.1007/s11604-012-0173-5. Epub 2012 Dec 26.


Long span DNA paired-end-tag (DNA-PET) sequencing strategy for the interrogation of genomic structural mutations and fusion-point-guided reconstruction of amplicons.

Yao F, Ariyaratne PN, Hillmer AM, Lee WH, Li G, Teo AS, Woo XY, Zhang Z, Chen JP, Poh WT, Zawack KF, Chan CS, Leong ST, Neo SC, Choi PS, Gao S, Nagarajan N, Thoreau H, Shahab A, Ruan X, Cacheux-Rataboul V, Wei CL, Bourque G, Sung WK, Liu ET, Ruan Y.

PLoS One. 2012;7(9):e46152. doi: 10.1371/journal.pone.0046152. Epub 2012 Sep 28.


Aspirin and non-aspirin non-steroidal anti-inflammatory drug use and risk of lung cancer.

Lim WY, Chuah KL, Eng P, Leong SS, Lim E, Lim TK, Ng A, Poh WT, Tee A, Teh M, Salim A, Seow A.

Lung Cancer. 2012 Aug;77(2):246-51. doi: 10.1016/j.lungcan.2012.03.005. Epub 2012 Apr 3.


Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma.

Poh W, Wong W, Ong H, Aung MO, Lim SG, Chua BT, Ho HK.

Mol Cancer. 2012 Mar 23;11:14. doi: 10.1186/1476-4598-11-14.


A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.

Ng KP, Hillmer AM, Chuah CT, Juan WC, Ko TK, Teo AS, Ariyaratne PN, Takahashi N, Sawada K, Fei Y, Soh S, Lee WH, Huang JW, Allen JC Jr, Woo XY, Nagarajan N, Kumar V, Thalamuthu A, Poh WT, Ang AL, Mya HT, How GF, Yang LY, Koh LP, Chowbay B, Chang CT, Nadarajan VS, Chng WJ, Than H, Lim LC, Goh YT, Zhang S, Poh D, Tan P, Seet JE, Ang MK, Chau NM, Ng QS, Tan DS, Soda M, Isobe K, Nöthen MM, Wong TY, Shahab A, Ruan X, Cacheux-Rataboul V, Sung WK, Tan EH, Yatabe Y, Mano H, Soo RA, Chin TM, Lim WT, Ruan Y, Ong ST.

Nat Med. 2012 Mar 18;18(4):521-8. doi: 10.1038/nm.2713.


Female reproductive factors, gene polymorphisms in the estrogen metabolism pathway, and risk of lung cancer in Chinese women.

Lim WY, Chen Y, Chuah KL, Eng P, Leong SS, Lim E, Lim TK, Ng A, Poh WT, Tee A, Teh M, Salim A, Seow A.

Am J Epidemiol. 2012 Mar 15;175(6):492-503. doi: 10.1093/aje/kwr332. Epub 2012 Feb 13.


Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2).

Bramono DS, Murali S, Rai B, Ling L, Poh WT, Lim ZX, Stein GS, Nurcombe V, van Wijnen AJ, Cool SM.

Bone. 2012 Apr;50(4):954-64. doi: 10.1016/j.bone.2011.12.013. Epub 2011 Dec 28.


A statistical method for region-based meta-analysis of genome-wide association studies in genetically diverse populations.

Wang X, Liu X, Sim X, Xu H, Khor CC, Ong RT, Tay WT, Suo C, Poh WT, Ng DP, Liu J, Aung T, Chia KS, Wong TY, Tai ES, Teo YY.

Eur J Hum Genet. 2012 Apr;20(4):469-75. doi: 10.1038/ejhg.2011.219. Epub 2011 Nov 30.


HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis.

Schuldenfrei A, Belton A, Kowalski J, Talbot CC Jr, Di Cello F, Poh W, Tsai HL, Shah SN, Huso TH, Huso DL, Resar LM.

BMC Genomics. 2011 Nov 4;12:549. doi: 10.1186/1471-2164-12-549.


SgD-CNV, a database for common and rare copy number variants in three Asian populations.

Xu H, Poh WT, Sim X, Ong RT, Suo C, Tay WT, Khor CC, Seielstad M, Liu J, Aung T, Tai ES, Wong TY, Chia KS, Teo YY.

Hum Mutat. 2011 Dec;32(12):1341-9. doi: 10.1002/humu.21601. Epub 2011 Sep 30.


Meat consumption and risk of lung cancer among never-smoking women.

Lim WY, Chuah KL, Eng P, Leong SS, Lim E, Lim TK, Ng A, Poh WT, Tee A, Teh M, Salim A, Seow A.

Nutr Cancer. 2011;63(6):850-9. doi: 10.1080/01635581.2011.589961. Epub 2011 Jul 20.


Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis.

Narasaraju T, Yang E, Samy RP, Ng HH, Poh WP, Liew AA, Phoon MC, van Rooijen N, Chow VT.

Am J Pathol. 2011 Jul;179(1):199-210. doi: 10.1016/j.ajpath.2011.03.013. Epub 2011 May 7.


Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes.

Hillmer AM, Yao F, Inaki K, Lee WH, Ariyaratne PN, Teo AS, Woo XY, Zhang Z, Zhao H, Ukil L, Chen JP, Zhu F, So JB, Salto-Tellez M, Poh WT, Zawack KF, Nagarajan N, Gao S, Li G, Kumar V, Lim HP, Sia YY, Chan CS, Leong ST, Neo SC, Choi PS, Thoreau H, Tan PB, Shahab A, Ruan X, Bergh J, Hall P, Cacheux-Rataboul V, Wei CL, Yeoh KG, Sung WK, Bourque G, Liu ET, Ruan Y.

Genome Res. 2011 May;21(5):665-75. doi: 10.1101/gr.113555.110. Epub 2011 Apr 5.


Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers.

Lim WY, Chen Y, Ali SM, Chuah KL, Eng P, Leong SS, Lim E, Lim TK, Ng AW, Poh WT, Tee A, Teh M, Salim A, Seow A.

Carcinogenesis. 2011 Apr;32(4):522-9. doi: 10.1093/carcin/bgr006. Epub 2011 Jan 20.


A method for identifying haplotypes carrying the causative allele in positive natural selection and genome-wide association studies.

Ong RT, Liu X, Poh WT, Sim X, Chia KS, Teo YY.

Bioinformatics. 2011 Mar 15;27(6):822-8. doi: 10.1093/bioinformatics/btr007. Epub 2011 Jan 6.


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