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Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues.

Lewis L, Chappell GA, Kobets T, O'Brian BE, Sangaraju D, Kosyk O, Bodnar W, Tretyakova NY, Pogribny IP, Rusyn I.

Arch Toxicol. 2018 Dec 14. doi: 10.1007/s00204-018-2374-x. [Epub ahead of print]


Histopathological and molecular signatures of a mouse model of acute-on-chronic alcoholic liver injury demonstrate concordance with human alcoholic hepatitis.

Furuya S, Cichocki JA, Konganti K, Dreval K, Uehara T, Katou Y, Fukushima H, Kono H, Pogribny IP, Argemi J, Bataller R, Rusyn I.

Toxicol Sci. 2018 Dec 4. doi: 10.1093/toxsci/kfy292. [Epub ahead of print]


Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice.

Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2019 Jan 1;167(1):126-137. doi: 10.1093/toxsci/kfy223.


Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells.

Tryndyak V, Kindrat I, Dreval K, Churchwell MI, Beland FA, Pogribny IP.

Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.


Editorial overview of the special issue on genomic toxicology epigenetics.

Rusyn I, Pogribny IP.

Curr Opin Toxicol. 2017 Oct;6:i-iii. doi: 10.1016/j.cotox.2017.11.006. Epub 2017 Nov 30. No abstract available.


Identification of chromatin-accessible domains in non-alcoholic steatohepatitis-derived hepatocellular carcinoma.

Dechassa ML, Tryndyak V, de Conti A, Xiao W, Beland FA, Pogribny IP.

Mol Carcinog. 2018 Aug;57(8):978-987. doi: 10.1002/mc.22818. Epub 2018 Apr 16.


Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells.

Dreval K, Tryndyak V, Kindrat I, Twaddle NC, Orisakwe OE, Mudalige TK, Beland FA, Doerge DR, Pogribny IP.

Toxicol Sci. 2018 Apr 1;162(2):676-687. doi: 10.1093/toxsci/kfx290.


MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis.

de Conti A, Ortega JF, Tryndyak V, Dreval K, Moreno FS, Rusyn I, Beland FA, Pogribny IP.

Oncotarget. 2017 Aug 1;8(51):88517-88528. doi: 10.18632/oncotarget.19774. eCollection 2017 Oct 24.


Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.

Pogribny IP, Dreval K, Kindrat I, Melnyk S, Jimenez L, de Conti A, Tryndyak V, Pogribna M, Ortega JF, James SJ, Rusyn I, Beland FA.

FASEB J. 2018 Mar;32(3):1591-1601. doi: 10.1096/fj.201700866R. Epub 2018 Jan 3.


Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2017 Oct 1;159(2):481. doi: 10.1093/toxsci/kfx158. No abstract available.


Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro.

Kindrat I, Dreval K, Shpyleva S, Tryndyak V, de Conti A, Mudalige TK, Chen T, Erstenyuk AM, Beland FA, Pogribny IP.

Toxicol Lett. 2017 Nov 5;281:65-73. doi: 10.1016/j.toxlet.2017.09.011. Epub 2017 Sep 19.


MicroRNAs as biomarkers for clinical studies.

Pogribny IP.

Exp Biol Med (Maywood). 2018 Feb;243(3):283-290. doi: 10.1177/1535370217731291. Epub 2017 Sep 15. Review.


Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2017 Sep 1;159(1):102-113. doi: 10.1093/toxsci/kfx120. Erratum in: Toxicol Sci. 2017 Oct 1;159(2):481.


The role of epigenomic alterations in furan-induced hepatobiliary pathologies.

de Conti A, Beland FA, Pogribny IP.

Food Chem Toxicol. 2017 Nov;109(Pt 1):677-682. doi: 10.1016/j.fct.2017.07.049. Epub 2017 Jul 26. Review.


Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation.

de Conti A, Dreval K, Tryndyak V, Orisakwe OE, Ross SA, Beland FA, Pogribny IP.

Mol Cancer Res. 2017 Sep;15(9):1163-1172. doi: 10.1158/1541-7786.MCR-17-0109. Epub 2017 May 16.


miR-1247 blocks SOX9-mediated regeneration in alcohol- and fibrosis-associated acute kidney injury in mice.

Dreval K, de Conti A, Furuya S, Beland FA, Rusyn I, Pogribny IP.

Toxicology. 2017 Jun 1;384:40-49. doi: 10.1016/j.tox.2017.03.004. Epub 2017 Mar 8.


Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice.

Cichocki JA, Furuya S, Konganti K, Luo YS, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

J Pharmacol Exp Ther. 2017 Apr;361(1):17-28. doi: 10.1124/jpet.116.238790. Epub 2017 Feb 1.


Editor's Highlight: Organ-Specific Epigenetic Changes Induced by the Nongenotoxic Liver Carcinogen Methapyrilene in Fischer 344 Rats.

Shpyleva S, Dreval K, de Conti A, Kindrat I, Melnyk S, Yan J, Chen T, Beland FA, Pogribny IP.

Toxicol Sci. 2017 Mar 1;156(1):190-198. doi: 10.1093/toxsci/kfw242.


Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study.

Von Tungeln LS, Walker NJ, Olson GR, Mendoza MC, Felton RP, Thorn BT, Marques MM, Pogribny IP, Doerge DR, Beland FA.

Food Chem Toxicol. 2017 Jan;99:170-181. doi: 10.1016/j.fct.2016.11.015. Epub 2016 Nov 18.


New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan.

Nunes J, Martins IL, Charneira C, Pogribny IP, de Conti A, Beland FA, Marques MM, Jacob CC, Antunes AMM.

Toxicol Lett. 2016 Dec 15;264:106-113. doi: 10.1016/j.toxlet.2016.10.018. Epub 2016 Nov 5.


Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure.

de Conti A, Tryndyak V, Doerge DR, Beland FA, Pogribny IP.

Food Chem Toxicol. 2016 Dec;98(Pt A):2-10. doi: 10.1016/j.fct.2016.06.027. Epub 2016 Jun 28.


Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study.

Tryndyak V, de Conti A, Doerge DR, Olson GR, Beland FA, Pogribny IP.

Arch Toxicol. 2017 Mar;91(3):1233-1243. doi: 10.1007/s00204-016-1786-8. Epub 2016 Jul 7.


Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents.

Moreno FS, Heidor R, Pogribny IP.

Nutr Cancer. 2016 Jul;68(5):719-33. doi: 10.1080/01635581.2016.1180410. Epub 2016 Jun 8. Review.


Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review.

Chappell G, Pogribny IP, Guyton KZ, Rusyn I.

Mutat Res Rev Mutat Res. 2016 Apr-Jun;768:27-45. doi: 10.1016/j.mrrev.2016.03.004. Epub 2016 Mar 31. Review.


Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice.

Tryndyak VP, Han T, Fuscoe JC, Ross SA, Beland FA, Pogribny IP.

BMC Genomics. 2016 Apr 22;17:298. doi: 10.1186/s12864-016-2617-2.


Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.

Ortega JF, de Conti A, Tryndyak V, Furtado KS, Heidor R, Horst MA, Fernandes LH, Tavares PE, Pogribna M, Shpyleva S, Beland FA, Pogribny IP, Moreno FS.

Oncotarget. 2016 Apr 26;7(17):24339-47. doi: 10.18632/oncotarget.8248.


MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency.

Tryndyak VP, Marrone AK, Latendresse JR, Muskhelishvili L, Beland FA, Pogribny IP.

J Nutr Biochem. 2016 Feb;28:83-90. doi: 10.1016/j.jnutbio.2015.10.001. Epub 2015 Oct 21.


Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells.

Philchenkov AA, Zavelevich MP, Tryndyak VP, Kuiava LM, Blokhin DY, Miura K, Silvestri R, Pogribny IP.

Cancer Biol Ther. 2015;16(12):1820-9. doi: 10.1080/15384047.2015.1078026.


Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease.

Chappell G, Silva GO, Uehara T, Pogribny IP, Rusyn I.

Cancer Med. 2016 Mar;5(3):574-85. doi: 10.1002/cam4.606. Epub 2016 Jan 18.


MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis.

Kindrat I, Tryndyak V, de Conti A, Shpyleva S, Mudalige TK, Kobets T, Erstenyuk AM, Beland FA, Pogribny IP.

Oncotarget. 2016 Jan 12;7(2):1276-87. doi: 10.18632/oncotarget.6004.


The role of microRNAs in the development and progression of chemical-associated cancers.

Pogribny IP, Beland FA, Rusyn I.

Toxicol Appl Pharmacol. 2016 Dec 1;312:3-10. doi: 10.1016/j.taap.2015.11.013. Epub 2015 Nov 24. Review.


MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells.

Marrone AK, Tryndyak V, Beland FA, Pogribny IP.

Toxicol Sci. 2016 Feb;149(2):496-502. doi: 10.1093/toxsci/kfv253. Epub 2015 Nov 24.


The chemopreventive activity of butyrate-containing structured lipids in experimental rat hepatocarcinogenesis.

Heidor R, de Conti A, Ortega JF, Furtado KS, Silva RC, Tavares PE, Purgatto E, Ract JN, de Paiva SA, Gioielli LA, Pogribny IP, Moreno FS.

Mol Nutr Food Res. 2016 Feb;60(2):420-9. doi: 10.1002/mnfr.201500643. Epub 2015 Dec 2.


Considering maternal dietary modulators for epigenetic regulation and programming of the fetal epigenome.

Chango A, Pogribny IP.

Nutrients. 2015 Apr 14;7(4):2748-70. doi: 10.3390/nu7042748. Review.


Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice.

Marrone AK, Shpyleva S, Chappell G, Tryndyak V, Uehara T, Tsuchiya M, Beland FA, Rusyn I, Pogribny IP.

Mol Carcinog. 2016 May;55(5):808-17. doi: 10.1002/mc.22323. Epub 2015 Apr 11.


Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats.

Camacho L, Basavarajappa MS, Chang CW, Han T, Kobets T, Koturbash I, Surratt G, Lewis SM, Vanlandingham MM, Fuscoe JC, Gamboa da Costa G, Pogribny IP, Delclos KB.

Food Chem Toxicol. 2015 Jul;81:92-103. doi: 10.1016/j.fct.2015.04.009. Epub 2015 Apr 8.


The role for microRNAs in drug toxicity and in safety assessment.

Marrone AK, Beland FA, Pogribny IP.

Expert Opin Drug Metab Toxicol. 2015 Apr;11(4):601-11. doi: 10.1517/17425255.2015.1021687. Epub 2015 Mar 5. Review.


Persistence of furan-induced epigenetic aberrations in the livers of F344 rats.

de Conti A, Kobets T, Tryndyak V, Burnett SD, Han T, Fuscoe JC, Beland FA, Doerge DR, Pogribny IP.

Toxicol Sci. 2015 Apr;144(2):217-26. doi: 10.1093/toxsci/kfu313. Epub 2014 Dec 23.


Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum.

Shpyleva S, Ivanovsky S, de Conti A, Melnyk S, Tryndyak V, Beland FA, James SJ, Pogribny IP.

PLoS One. 2014 Nov 25;9(11):e113712. doi: 10.1371/journal.pone.0113712. eCollection 2014.


Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum.

James SJ, Shpyleva S, Melnyk S, Pavliv O, Pogribny IP.

Transl Psychiatry. 2014 Oct 7;4:e460. doi: 10.1038/tp.2014.87.


Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism.

Shpyleva S, Pogribna M, Cozart C, Bryant MS, Muskhelishvili L, Tryndyak VP, Ross SA, Beland FA, Pogribny IP.

J Nutr Biochem. 2014 Dec;25(12):1235-42. doi: 10.1016/j.jnutbio.2014.06.012. Epub 2014 Aug 19.


Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice.

Chappell G, Kobets T, O'Brien B, Tretyakova N, Sangaraju D, Kosyk O, Sexton KG, Bodnar W, Pogribny IP, Rusyn I.

Toxicol Sci. 2014 Dec;142(2):375-84. doi: 10.1093/toxsci/kfu191. Epub 2014 Sep 18.


The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.

Uehara T, Pogribny IP, Rusyn I.

Curr Protoc Pharmacol. 2014 Sep 2;66:14.30.1-10. doi: 10.1002/0471141755.ph1430s66.


Noncoding RNA response to xenobiotic exposure: an indicator of toxicity and carcinogenicity.

Marrone AK, Beland FA, Pogribny IP.

Expert Opin Drug Metab Toxicol. 2014 Oct;10(10):1409-22. doi: 10.1517/17425255.2014.954312. Epub 2014 Aug 29. Review.


Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver.

de Conti A, Tryndyak V, Churchwell MI, Melnyk S, Latendresse JR, Muskhelishvili L, Beland FA, Pogribny IP.

Toxicology. 2014 Nov 5;325:12-20. doi: 10.1016/j.tox.2014.08.004. Epub 2014 Aug 12.


Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice.

Aissa AF, Tryndyak V, de Conti A, Melnyk S, Gomes TD, Bianchi ML, James SJ, Beland FA, Antunes LM, Pogribny IP.

Mol Nutr Food Res. 2014 Jul;58(7):1502-12. doi: 10.1002/mnfr.201300726. Epub 2014 May 15.


Dose- and time-dependent epigenetic changes in the livers of Fisher 344 rats exposed to furan.

Conti Ad, Kobets T, Escudero-Lourdes C, Montgomery B, Tryndyak V, Beland FA, Doerge DR, Pogribny IP.

Toxicol Sci. 2014 Jun;139(2):371-80. doi: 10.1093/toxsci/kfu044. Epub 2014 Mar 10.


Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis.

Guariento AH, Furtado KS, de Conti A, Campos A, Purgatto E, Carrilho J, Shinohara EM, Tryndyak V, Han T, Fuscoe JC, Ross SA, Beland FA, Pogribny IP, Moreno FS.

Int J Cancer. 2014 Jul 1;135(1):7-18. doi: 10.1002/ijc.28642. Epub 2014 Feb 22.


Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.

Chappell G, Kutanzi K, Uehara T, Tryndyak V, Hong HH, Hoenerhoff M, Beland FA, Rusyn I, Pogribny IP.

Int J Cancer. 2014 Jun 15;134(12):2778-88. doi: 10.1002/ijc.28610. Epub 2013 Dec 14.


Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin.

Chekhun VF, Lukyanova NY, Burlaka CA, Bezdenezhnykh NA, Shpyleva SI, Tryndyak VP, Beland FA, Pogribny IP.

Int J Oncol. 2013 Nov;43(5):1481-6. doi: 10.3892/ijo.2013.2063. Epub 2013 Aug 20.


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