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Items: 1 to 50 of 96

1.

Real-time optical manipulation of cardiac conduction in intact hearts.

Scardigli M, Müllenbroich C, Margoni E, Cannazzaro S, Crocini C, Ferrantini C, Coppini R, Yan P, Loew LM, Campione M, Bocchi L, Giulietti D, Cerbai E, Poggesi C, Bub G, Pavone FS, Sacconi L.

J Physiol. 2018 Sep;596(17):3841-3858. doi: 10.1113/JP276283. Epub 2018 Aug 7.

2.

Defining the diagnostic effectiveness of genes for inclusion in panels: the experience of two decades of genetic testing for hypertrophic cardiomyopathy at a single center.

Mazzarotto F, Girolami F, Boschi B, Barlocco F, Tomberli A, Baldini K, Coppini R, Tanini I, Bardi S, Contini E, Cecchi F, Pelo E, Cook SA, Cerbai E, Poggesi C, Torricelli F, Walsh R, Olivotto I.

Genet Med. 2018 Jun 6. doi: 10.1038/s41436-018-0046-0. [Epub ahead of print]

PMID:
29875424
3.

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy.

Nijenkamp LLAM, Bollen IAE, van Velzen HG, Regan JA, van Slegtenhorst M, Niessen HWM, Schinkel AFL, Krüger M, Poggesi C, Ho CY, Kuster DWD, Michels M, van der Velden J.

Circ Heart Fail. 2018 Jun;11(6):e004133. doi: 10.1161/CIRCHEARTFAILURE.117.004133.

PMID:
29853478
4.

Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.

Ferrantini C, Pioner JM, Mazzoni L, Gentile F, Tosi B, Rossi A, Belardinelli L, Tesi C, Palandri C, Matucci R, Cerbai E, Olivotto I, Poggesi C, Mugelli A, Coppini R.

Br J Pharmacol. 2018 Jul;175(13):2635-2652. doi: 10.1111/bph.14223. Epub 2018 May 3.

5.

Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled Study.

Olivotto I, Camici PG, Merlini PA, Rapezzi C, Patten M, Climent V, Sinagra G, Tomberli B, Marin F, Ehlermann P, Maier LS, Fornaro A, Jacobshagen C, Ganau A, Moretti L, Hernandez Madrid A, Coppini R, Reggiardo G, Poggesi C, Fattirolli F, Belardinelli L, Gensini G, Mugelli A.

Circ Heart Fail. 2018 Jan;11(1):e004124. doi: 10.1161/CIRCHEARTFAILURE.117.004124.

PMID:
29321131
6.

Reply to Entcheva: The impact of T-tubules on action potential propagation in cardiac tissue.

Scardigli M, Crocini C, Ferrantini C, Gabbrielli T, Silvestri L, Coppini R, Tesi C, Rog-Zielinska EA, Kohl P, Cerbai E, Poggesi C, Pavone FS, Sacconi L.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E562-E563. doi: 10.1073/pnas.1720253115. Epub 2018 Jan 5. No abstract available.

7.

Liquid Crystalline Networks toward Regenerative Medicine and Tissue Repair.

Martella D, Paoli P, Pioner JM, Sacconi L, Coppini R, Santini L, Lulli M, Cerbai E, Wiersma DS, Poggesi C, Ferrantini C, Parmeggiani C.

Small. 2017 Dec;13(46). doi: 10.1002/smll.201702677. Epub 2017 Oct 17.

PMID:
29045016
8.

Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models.

Ferrantini C, Coppini R, Pioner JM, Gentile F, Tosi B, Mazzoni L, Scellini B, Piroddi N, Laurino A, Santini L, Spinelli V, Sacconi L, De Tombe P, Moore R, Tardiff J, Mugelli A, Olivotto I, Cerbai E, Tesi C, Poggesi C.

J Am Heart Assoc. 2017 Jul 22;6(7). pii: e005407. doi: 10.1161/JAHA.116.005407.

9.

Quantitative assessment of passive electrical properties of the cardiac T-tubular system by FRAP microscopy.

Scardigli M, Crocini C, Ferrantini C, Gabbrielli T, Silvestri L, Coppini R, Tesi C, Rog-Zielinska EA, Kohl P, Cerbai E, Poggesi C, Pavone FS, Sacconi L.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):5737-5742. doi: 10.1073/pnas.1702188114. Epub 2017 May 15.

10.

Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy.

Coppini R, Mazzoni L, Ferrantini C, Gentile F, Pioner JM, Laurino A, Santini L, Bargelli V, Rotellini M, Bartolucci G, Crocini C, Sacconi L, Tesi C, Belardinelli L, Tardiff J, Mugelli A, Olivotto I, Cerbai E, Poggesi C.

Circ Heart Fail. 2017 Mar;10(3). pii: e003565. doi: 10.1161/CIRCHEARTFAILURE.116.003565.

PMID:
28255011
11.

The Relaxation Properties of Myofibrils Are Compromised by Amino Acids that Stabilize α-Tropomyosin.

Scellini B, Piroddi N, Matyushenko AM, Levitsky DI, Poggesi C, Lehrer SS, Tesi C.

Biophys J. 2017 Jan 24;112(2):376-387. doi: 10.1016/j.bpj.2016.12.013.

12.

Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation.

Crocini C, Ferrantini C, Coppini R, Scardigli M, Yan P, Loew LM, Smith G, Cerbai E, Poggesi C, Pavone FS, Sacconi L.

Sci Rep. 2016 Oct 17;6:35628. doi: 10.1038/srep35628.

13.

T-Tubular Electrical Defects Contribute to Blunted β-Adrenergic Response in Heart Failure.

Crocini C, Coppini R, Ferrantini C, Yan P, Loew LM, Poggesi C, Cerbai E, Pavone FS, Sacconi L.

Int J Mol Sci. 2016 Sep 3;17(9). pii: E1471. doi: 10.3390/ijms17091471.

14.

Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Pioner JM, Racca AW, Klaiman JM, Yang KC, Guan X, Pabon L, Muskheli V, Zaunbrecher R, Macadangdang J, Jeong MY, Mack DL, Childers MK, Kim DH, Tesi C, Poggesi C, Murry CE, Regnier M.

Stem Cell Reports. 2016 Jun 14;6(6):885-896. doi: 10.1016/j.stemcr.2016.04.006. Epub 2016 May 5.

15.

[Molecular targets and novel pharmacological options to prevent myocardial hypertrophic remodeling].

Coppini R, Ferrantini C, Poggesi C, Mugelli A, Olivotto I.

G Ital Cardiol (Rome). 2016 Mar;17(3):189-96. doi: 10.1714/2190.23660. Review. Italian.

PMID:
27029877
16.

Impact of Genotype on the Occurrence of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy.

Bongini C, Ferrantini C, Girolami F, Coppini R, Arretini A, Targetti M, Bardi S, Castelli G, Torricelli F, Cecchi F, Ackerman MJ, Padeletti L, Poggesi C, Olivotto I.

Am J Cardiol. 2016 Apr 1;117(7):1151-9. doi: 10.1016/j.amjcard.2015.12.058. Epub 2016 Jan 14.

PMID:
26869393
17.

Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy.

Crocini C, Ferrantini C, Scardigli M, Coppini R, Mazzoni L, Lazzeri E, Pioner JM, Scellini B, Guo A, Song LS, Yan P, Loew LM, Tardiff J, Tesi C, Vanzi F, Cerbai E, Pavone FS, Sacconi L, Poggesi C.

J Mol Cell Cardiol. 2016 Feb;91:42-51. doi: 10.1016/j.yjmcc.2015.12.013. Epub 2015 Dec 20.

18.

R4496C RyR2 mutation impairs atrial and ventricular contractility.

Ferrantini C, Coppini R, Scellini B, Ferrara C, Pioner JM, Mazzoni L, Priori S, Cerbai E, Tesi C, Poggesi C.

J Gen Physiol. 2016 Jan;147(1):39-52. doi: 10.1085/jgp.201511450. Epub 2015 Dec 14.

19.

Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.

Mastrototaro G, Liang X, Li X, Carullo P, Piroddi N, Tesi C, Gu Y, Dalton ND, Peterson KL, Poggesi C, Sheikh F, Chen J, Bang ML.

Cardiovasc Res. 2015 Jul 15;107(2):216-25. doi: 10.1093/cvr/cvv156. Epub 2015 May 17.

20.

Targets for therapy in sarcomeric cardiomyopathies.

Tardiff JC, Carrier L, Bers DM, Poggesi C, Ferrantini C, Coppini R, Maier LS, Ashrafian H, Huke S, van der Velden J.

Cardiovasc Res. 2015 Apr 1;105(4):457-70. doi: 10.1093/cvr/cvv023. Epub 2015 Jan 29. Review.

21.

Clinical phenotype and outcome of hypertrophic cardiomyopathy associated with thin-filament gene mutations.

Coppini R, Ho CY, Ashley E, Day S, Ferrantini C, Girolami F, Tomberli B, Bardi S, Torricelli F, Cecchi F, Mugelli A, Poggesi C, Tardiff J, Olivotto I.

J Am Coll Cardiol. 2014 Dec 23;64(24):2589-2600. doi: 10.1016/j.jacc.2014.09.059.

22.

Impact of tropomyosin isoform composition on fast skeletal muscle thin filament regulation and force development.

Scellini B, Piroddi N, Flint GV, Regnier M, Poggesi C, Tesi C.

J Muscle Res Cell Motil. 2015 Feb;36(1):11-23. doi: 10.1007/s10974-014-9394-9. Epub 2014 Nov 8.

PMID:
25380572
23.

Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure.

Crocini C, Coppini R, Ferrantini C, Yan P, Loew LM, Tesi C, Cerbai E, Poggesi C, Pavone FS, Sacconi L.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15196-201. doi: 10.1073/pnas.1411557111. Epub 2014 Oct 6.

24.

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation.

Witjas-Paalberends ER, Ferrara C, Scellini B, Piroddi N, Montag J, Tesi C, Stienen GJ, Michels M, Ho CY, Kraft T, Poggesi C, van der Velden J.

J Physiol. 2014 Aug 1;592(15):3257-72. doi: 10.1113/jphysiol.2014.274571. Epub 2014 Jun 13.

25.

Impact of detubulation on force and kinetics of cardiac muscle contraction.

Ferrantini C, Coppini R, Sacconi L, Tosi B, Zhang ML, Wang GL, de Vries E, Hoppenbrouwers E, Pavone F, Cerbai E, Tesi C, Poggesi C, ter Keurs HE.

J Gen Physiol. 2014 Jun;143(6):783-97. doi: 10.1085/jgp.201311125.

26.

HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling.

Demos-Davies KM, Ferguson BS, Cavasin MA, Mahaffey JH, Williams SM, Spiltoir JI, Schuetze KB, Horn TR, Chen B, Ferrara C, Scellini B, Piroddi N, Tesi C, Poggesi C, Jeong MY, McKinsey TA.

Am J Physiol Heart Circ Physiol. 2014 Jul 15;307(2):H252-8. doi: 10.1152/ajpheart.00149.2014. Epub 2014 May 23.

27.

Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations.

Witjas-Paalberends ER, Güçlü A, Germans T, Knaapen P, Harms HJ, Vermeer AM, Christiaans I, Wilde AA, Dos Remedios C, Lammertsma AA, van Rossum AC, Stienen GJ, van Slegtenhorst M, Schinkel AF, Michels M, Ho CY, Poggesi C, van der Velden J.

Cardiovasc Res. 2014 Jul 15;103(2):248-57. doi: 10.1093/cvr/cvu127. Epub 2014 May 16.

PMID:
24835277
28.

Isolation and functional characterization of human ventricular cardiomyocytes from fresh surgical samples.

Coppini R, Ferrantini C, Aiazzi A, Mazzoni L, Sartiani L, Mugelli A, Poggesi C, Cerbai E.

J Vis Exp. 2014 Apr 21;(86). doi: 10.3791/51116.

29.

Muscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation?

Poggesi C, Ho CY.

J Muscle Res Cell Motil. 2014 Feb;35(1):37-45. doi: 10.1007/s10974-014-9374-0. Epub 2014 Feb 4. Review.

30.

Clusters of bound Ca(2+) initiate contraction in fast skeletal muscle.

Brandt PW, Poggesi C.

Arch Biochem Biophys. 2014 Jun 15;552-553:60-7. doi: 10.1016/j.abb.2013.12.013. Epub 2013 Dec 25.

PMID:
24374032
31.

Response to letter regarding article, "Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy".

Coppini R, Ferrantini C, Del Lungo M, Stillitano F, Sartiani L, Tosi B, Suffredini S, Tesi C, Poggesi C, Cerbai E, Mugelli A, Yao L, Fan P, Belardinelli L, Yacoub M, Olivotto I.

Circulation. 2013 Sep 3;128(10):e157. doi: 10.1161/CIRCULATIONAHA.113.004016. No abstract available.

PMID:
24002721
32.

Chronic atrial fibrillation alters the functional properties of If in the human atrium.

Stillitano F, Lonardo G, Giunti G, Del Lungo M, Coppini R, Spinelli V, Sartiani L, Poggesi C, Mugelli A, Cerbai E.

J Cardiovasc Electrophysiol. 2013 Dec;24(12):1391-400. doi: 10.1111/jce.12212. Epub 2013 Jul 19.

PMID:
23869794
33.

The transverse-axial tubular system of cardiomyocytes.

Ferrantini C, Crocini C, Coppini R, Vanzi F, Tesi C, Cerbai E, Poggesi C, Pavone FS, Sacconi L.

Cell Mol Life Sci. 2013 Dec;70(24):4695-710. doi: 10.1007/s00018-013-1410-5. Epub 2013 Jul 12. Review.

PMID:
23846763
34.

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.

Ottenheijm CA, Buck D, de Winter JM, Ferrara C, Piroddi N, Tesi C, Jasper JR, Malik FI, Meng H, Stienen GJ, Beggs AH, Labeit S, Poggesi C, Lawlor MW, Granzier H.

Brain. 2013 Jun;136(Pt 6):1718-31. doi: 10.1093/brain/awt113. Epub 2013 May 28.

35.

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy.

Witjas-Paalberends ER, Piroddi N, Stam K, van Dijk SJ, Oliviera VS, Ferrara C, Scellini B, Hazebroek M, ten Cate FJ, van Slegtenhorst M, dos Remedios C, Niessen HW, Tesi C, Stienen GJ, Heymans S, Michels M, Poggesi C, van der Velden J.

Cardiovasc Res. 2013 Aug 1;99(3):432-41. doi: 10.1093/cvr/cvt119. Epub 2013 May 13.

PMID:
23674513
36.

Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations.

Sequeira V, Wijnker PJ, Nijenkamp LL, Kuster DW, Najafi A, Witjas-Paalberends ER, Regan JA, Boontje N, Ten Cate FJ, Germans T, Carrier L, Sadayappan S, van Slegtenhorst MA, Zaremba R, Foster DB, Murphy AM, Poggesi C, Dos Remedios C, Stienen GJ, Ho CY, Michels M, van der Velden J.

Circ Res. 2013 May 24;112(11):1491-505. doi: 10.1161/CIRCRESAHA.111.300436. Epub 2013 Mar 18. Erratum in: Circ Res. 2013 Sep 27;113(8):e87.

37.

Regulation of intracellular Na(+) in health and disease: pathophysiological mechanisms and implications for treatment.

Coppini R, Ferrantini C, Mazzoni L, Sartiani L, Olivotto I, Poggesi C, Cerbai E, Mugelli A.

Glob Cardiol Sci Pract. 2013 Nov 1;2013(3):222-42. doi: 10.5339/gcsp.2013.30. eCollection 2013. Review.

38.

Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy.

Coppini R, Ferrantini C, Yao L, Fan P, Del Lungo M, Stillitano F, Sartiani L, Tosi B, Suffredini S, Tesi C, Yacoub M, Olivotto I, Belardinelli L, Poggesi C, Cerbai E, Mugelli A.

Circulation. 2013 Feb 5;127(5):575-84. doi: 10.1161/CIRCULATIONAHA.112.134932. Epub 2012 Dec 27.

PMID:
23271797
39.

Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation.

Nixon BR, Liu B, Scellini B, Tesi C, Piroddi N, Ogut O, Solaro RJ, Ziolo MT, Janssen PM, Davis JP, Poggesi C, Biesiadecki BJ.

Arch Biochem Biophys. 2013 Jul 1;535(1):30-8. doi: 10.1016/j.abb.2012.11.010. Epub 2012 Dec 8.

40.

α-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains.

Janco M, Kalyva A, Scellini B, Piroddi N, Tesi C, Poggesi C, Geeves MA.

Biochemistry. 2012 Dec 11;51(49):9880-90. doi: 10.1021/bi301323n. Epub 2012 Nov 30.

41.

Patterns of disease progression in hypertrophic cardiomyopathy: an individualized approach to clinical staging.

Olivotto I, Cecchi F, Poggesi C, Yacoub MH.

Circ Heart Fail. 2012 Jul 1;5(4):535-46. doi: 10.1161/CIRCHEARTFAILURE.112.967026. Review. No abstract available.

PMID:
22811549
42.

Action potential propagation in transverse-axial tubular system is impaired in heart failure.

Sacconi L, Ferrantini C, Lotti J, Coppini R, Yan P, Loew LM, Tesi C, Cerbai E, Poggesi C, Pavone FS.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5815-9. doi: 10.1073/pnas.1120188109. Epub 2012 Mar 26.

43.

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle.

Kreutziger KL, Piroddi N, McMichael JT, Tesi C, Poggesi C, Regnier M.

J Mol Cell Cardiol. 2011 Jan;50(1):165-74. doi: 10.1016/j.yjmcc.2010.10.025. Epub 2010 Oct 28.

44.

Extraction and replacement of the tropomyosin-troponin complex in isolated myofibrils.

Scellini B, Piroddi N, Poggesi C, Tesi C.

Adv Exp Med Biol. 2010;682:163-74. doi: 10.1007/978-1-4419-6366-6_9.

PMID:
20824525
45.

Mechanical and energetic consequences of HCM-causing mutations.

Ferrantini C, Belus A, Piroddi N, Scellini B, Tesi C, Poggesi C.

J Cardiovasc Transl Res. 2009 Dec;2(4):441-51. doi: 10.1007/s12265-009-9131-8. Epub 2009 Oct 9. Review.

PMID:
20560002
46.

Effects of chronic atrial fibrillation on active and passive force generation in human atrial myofibrils.

Belus A, Piroddi N, Ferrantini C, Tesi C, Cazorla O, Toniolo L, Drost M, Mearini G, Carrier L, Rossi A, Mugelli A, Cerbai E, van der Velden J, Poggesi C.

Circ Res. 2010 Jul 9;107(1):144-52. doi: 10.1161/CIRCRESAHA.110.220699. Epub 2010 May 13.

PMID:
20466979
47.

Susceptibility of isolated myofibrils to in vitro glutathionylation: Potential relevance to muscle functions.

Passarelli C, Di Venere A, Piroddi N, Pastore A, Scellini B, Tesi C, Petrini S, Sale P, Bertini E, Poggesi C, Piemonte F.

Cytoskeleton (Hoboken). 2010 Feb;67(2):81-9. doi: 10.1002/cm.20425.

PMID:
20169532
48.

Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying hypothesis.

Olivotto I, Cecchi F, Poggesi C, Yacoub MH.

Nat Rev Cardiol. 2009 Apr;6(4):317-21. doi: 10.1038/nrcardio.2009.9. Review.

PMID:
19352336
49.

Insights into the kinetics of Ca2+-regulated contraction and relaxation from myofibril studies.

Stehle R, Solzin J, Iorga B, Poggesi C.

Pflugers Arch. 2009 Jun;458(2):337-57. doi: 10.1007/s00424-008-0630-2. Epub 2009 Jan 23.

PMID:
19165498
50.

The familial hypertrophic cardiomyopathy-associated myosin mutation R403Q accelerates tension generation and relaxation of human cardiac myofibrils.

Belus A, Piroddi N, Scellini B, Tesi C, D'Amati G, Girolami F, Yacoub M, Cecchi F, Olivotto I, Poggesi C.

J Physiol. 2008 Aug 1;586(15):3639-44. doi: 10.1113/jphysiol.2008.155952. Epub 2008 Jun 19.

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