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2001 1
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2012 5
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149 results

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Page 1
Endothelial POFUT1 controls injury-induced liver fibrosis by repressing fibrinogen synthesis.
He S, Luo Y, Ma W, Wang X, Yan C, Hao W, Fang Y, Su H, Lai B, Liu J, Xiong Y, Bai T, Ren X, Liu E, Han H, Wu Y, Yuan Z, Wang Y. He S, et al. J Hepatol. 2024 Mar 7:S0168-8278(24)00152-1. doi: 10.1016/j.jhep.2024.02.032. Online ahead of print. J Hepatol. 2024. PMID: 38460791 Free article.
BACKGROUND & AIMS: NOTCH signaling in liver sinusoidal endothelial cells (LSECs) regulates liver fibrosis, a pathological feature of chronic liver diseases. POFUT1 is an essential regulator of NOTCH signaling. Here, we investigated the role of LSECs-expressed POFUT1 …
BACKGROUND & AIMS: NOTCH signaling in liver sinusoidal endothelial cells (LSECs) regulates liver fibrosis, a pathological feature of chr …
POFUT1 acts as a tumor promoter in glioblastoma by enhancing the activation of Notch signaling.
Li Q, Wang J, Ma X, Wang M, Zhou L. Li Q, et al. J Bioenerg Biomembr. 2021 Oct;53(5):621-632. doi: 10.1007/s10863-021-09912-5. Epub 2021 Jul 12. J Bioenerg Biomembr. 2021. PMID: 34251584
This work was aimed at evaluating the detailed relevance of POFUT1 in GBM. Here, we demonstrated high levels of POFUT1 in GBM tissue and elucidated that GBM patients with high levels of POFUT1 had a shorter survival rate than those with low levels of POFUT …
This work was aimed at evaluating the detailed relevance of POFUT1 in GBM. Here, we demonstrated high levels of POFUT1 in GBM …
Role of poFUT1 and O-fucosylation in placental angiogenesis.
Liang C, Li Y, Qin H, Ramzan MN, Wang H, Liu S, Yan Q. Liang C, et al. Biol Reprod. 2023 Apr 11;108(4):553-563. doi: 10.1093/biolre/ioad011. Biol Reprod. 2023. PMID: 36723873
Dysfunction of trophoblast leads to defective vascular remodeling and impaired angiogenesis, which is believed as the major cause of placental insufficiency and pregnancy failure. Protein O-fucosyltransferase 1 (poFUT1) is mainly responsible for O-fucosylated glycan biosyn …
Dysfunction of trophoblast leads to defective vascular remodeling and impaired angiogenesis, which is believed as the major cause of placent …
POFUT1 promotes gastric cancer progression through Notch/Wnt dual signaling pathways dependent on the parafibromin-NICD1-beta-catenin complex.
Dong S, Wang Z, Xiong W. Dong S, et al. J Chin Med Assoc. 2023 Sep 1;86(9):806-817. doi: 10.1097/JCMA.0000000000000957. Epub 2023 Jul 28. J Chin Med Assoc. 2023. PMID: 37501238
BACKGROUND: Aberrant glycosylation performed by glycosyltransferases is a leading cause of gastric cancer (GC). Protein O-fucosyltransferase 1 (POFUT1) expression is increased in GC specimens and cells. In this study, the biological effects and mechanisms of POFUT1 …
BACKGROUND: Aberrant glycosylation performed by glycosyltransferases is a leading cause of gastric cancer (GC). Protein O-fucosyltransferase …
POFUT1 is dispensable for structure, function and survival of mouse podocytes.
Zhang S, Yang Q, Liu Z, Shi S. Zhang S, et al. Am J Transl Res. 2020 May 15;12(5):2212-2224. eCollection 2020. Am J Transl Res. 2020. PMID: 32509213 Free PMC article.
Pofut1 is ubiquitously expressed, but its essentiality for most cell types is not known. ...To understand why POFUT1 is dispensable for podocytes, we searched mouse podocyte essential gene candidates (as determined by single-cell RNA-seq) and found only two POFUT …
Pofut1 is ubiquitously expressed, but its essentiality for most cell types is not known. ...To understand why POFUT1 is dispen …
POFUT1 as a Promising Novel Biomarker of Colorectal Cancer.
Chabanais J, Labrousse F, Chaunavel A, Germot A, Maftah A. Chabanais J, et al. Cancers (Basel). 2018 Oct 30;10(11):411. doi: 10.3390/cancers10110411. Cancers (Basel). 2018. PMID: 30380753 Free PMC article.
BACKGROUND: While protein O-fucosyltransferase 1 (POFUT1) overexpression has been recently proposed as a potential biomarker for different cancer types, no study was carried out on POFUT1 implication in colorectal cancer (CRC). ...Then, POFUT1 could represent …
BACKGROUND: While protein O-fucosyltransferase 1 (POFUT1) overexpression has been recently proposed as a potential biomarker for diff …
poFUT1 promotes endometrial decidualization by enhancing the O-fucosylation of Notch1.
Yang Y, Zhang D, Qin H, Liu S, Yan Q. Yang Y, et al. EBioMedicine. 2019 Jun;44:563-573. doi: 10.1016/j.ebiom.2019.05.027. Epub 2019 Jun 11. EBioMedicine. 2019. PMID: 31201143 Free PMC article.
Protein glycosylation is involved in many physiological and pathological processes. Protein O-fucosyltransferase 1 (poFUT1) is the key enzyme for the O-fucosylation of proteins. However, the role and mechanism of poFUT1 in human endometrial stromal cell decidualizat …
Protein glycosylation is involved in many physiological and pathological processes. Protein O-fucosyltransferase 1 (poFUT1) is the ke …
POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling.
Du Y, Li D, Li N, Su C, Yang C, Lin C, Chen M, Wu R, Li X, Hu G. Du Y, et al. Cell Death Dis. 2018 Sep 24;9(10):995. doi: 10.1038/s41419-018-1055-2. Cell Death Dis. 2018. PMID: 30250219 Free PMC article.
In this study, we analyzed the expression of POFUT1 in CRC from cosmic and TCGA databases and confirmed that POFUT1 is highly expressed in CRC. ...We additionally reveal new mechanistic insights into the role of POFUT1 during CRC, through demonstrating that …
In this study, we analyzed the expression of POFUT1 in CRC from cosmic and TCGA databases and confirmed that POFUT1 is highly …
Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer.
Deschuyter M, Pennarubia F, Pinault E, Legardinier S, Maftah A. Deschuyter M, et al. Cancers (Basel). 2020 May 31;12(6):1430. doi: 10.3390/cancers12061430. Cancers (Basel). 2020. PMID: 32486426 Free PMC article.
In rare CRC cases, with no POFUT1 overexpression, seven missense mutations were found in human POFUT1. ...Targeted mass spectrometry (MS) was carried out to quantify the O-fucosyltransferase ability of all POFUT1 proteins. FINDINGS: MS analyses showed a signi …
In rare CRC cases, with no POFUT1 overexpression, seven missense mutations were found in human POFUT1. ...Targeted mass spectr …
POFUT1 mRNA expression as an independent prognostic parameter in muscle-invasive bladder cancer.
Wahby S, Jarczyk J, Fierek A, Heinkele J, Weis CA, Eckstein M, Martini T, Porubsky S, Hafner M, Erben P. Wahby S, et al. Transl Oncol. 2021 Jan;14(1):100900. doi: 10.1016/j.tranon.2020.100900. Epub 2020 Oct 21. Transl Oncol. 2021. PMID: 33099185 Free PMC article.
Thus, the patients with low POFUT1 mRNA were at a 4.9-fold greater risk for cancer-specific death according to the multivariable analysis (p = 0.0001). ...Low levels of POFUT1 mRNA are an independent prognostic indicator for OS and CSS in MIBC patients following rad …
Thus, the patients with low POFUT1 mRNA were at a 4.9-fold greater risk for cancer-specific death according to the multivariable anal …
149 results