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Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.

Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN.

Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. doi: 10.1016/j.chom.2018.08.002. Epub 2018 Aug 30.


A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.

Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63. doi: 10.1073/pnas.1524213113. Epub 2016 Feb 8.


Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity.

Painter MM, Morrison JH, Zoecklein LJ, Rinkoski TA, Watzlawik JO, Papke LM, Warrington AE, Bieber AJ, Matchett WE, Turkowski KL, Poeschla EM, Rodriguez M.

PLoS Pathog. 2015 Dec 3;11(12):e1005311. doi: 10.1371/journal.ppat.1005311. eCollection 2015 Dec.


LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes.

Singh PK, Plumb MR, Ferris AL, Iben JR, Wu X, Fadel HJ, Luke BT, Esnault C, Poeschla EM, Hughes SH, Kvaratskhelia M, Levin HL.

Genes Dev. 2015 Nov 1;29(21):2287-97. doi: 10.1101/gad.267609.115.


TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.

Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM.

J Virol. 2014 Sep 1;88(17):9704-17. doi: 10.1128/JVI.01397-14. Epub 2014 Jun 18.


A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection.

Meehan AM, Saenz DT, Guevera R, Morrison JH, Peretz M, Fadel HJ, Hamada M, van Deursen J, Poeschla EM.

PLoS Pathog. 2014 Feb 20;10(2):e1003969. doi: 10.1371/journal.ppat.1003969. eCollection 2014 Feb.


Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation.

Morrison JH, Guevara RB, Marcano AC, Saenz DT, Fadel HJ, Rogstad DK, Poeschla EM.

J Virol. 2014 Mar;88(6):3255-72. doi: 10.1128/JVI.03814-13. Epub 2014 Jan 3.


High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma.

Bancos I, Bida JP, Tian D, Bundrick M, John K, Holte MN, Her YF, Evans D, Saenz DT, Poeschla EM, Hook D, Georg G, Maher LJ 3rd.

PLoS One. 2013;8(2):e56827. doi: 10.1371/journal.pone.0056827. Epub 2013 Feb 22.


Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).

Xu X, Powell DW, Lambring CJ, Puckett AH, Deschenes L, Prough RA, Poeschla EM, Samuelson DJ.

Mol Carcinog. 2014 Apr;53(4):300-13. doi: 10.1002/mc.21977. Epub 2012 Nov 8.


Construction and testing of orfA +/- FIV reporter viruses.

Fadel HJ, Saenz DT, Poeschla EM.

Viruses. 2012 Jan;4(1):184-99. doi: 10.3390/v4010184. Epub 2012 Jan 23.


Feline immunodeficiency virus-based lentiviral vectors.

Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM.

Cold Spring Harb Protoc. 2012 Jan 1;2012(1):71-6. doi: 10.1101/pdb.ip067579. Review.


Titration of feline immunodeficiency virus-based lentiviral vector preparations.

Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM.

Cold Spring Harb Protoc. 2012 Jan 1;2012(1):126-8. doi: 10.1101/pdb.prot067561.


Production and harvest of feline immunodeficiency virus-based lentiviral vector from cells grown in T75 tissue-culture flasks.

Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM.

Cold Spring Harb Protoc. 2012 Jan 1;2012(1):124-5. doi: 10.1101/pdb.prot067553.


Production, harvest, and concentration of feline immunodeficiency virus-based lentiviral vector from cells grown in CF10 or CF2 devices.

Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM.

Cold Spring Harb Protoc. 2012 Jan 1;2012(1):118-23. doi: 10.1101/pdb.prot067546.


Productive replication and evolution of HIV-1 in ferret cells.

Fadel HJ, Saenz DT, Guevara R, von Messling V, Peretz M, Poeschla EM.

J Virol. 2012 Feb;86(4):2312-22. doi: 10.1128/JVI.06035-11. Epub 2011 Dec 14.


Primate and feline lentiviruses in current intrinsic immunity research: the cat is back.

Poeschla EM.

Vet Immunol Immunopathol. 2011 Oct 15;143(3-4):215-20. doi: 10.1016/j.vetimm.2011.06.014. Epub 2011 Jun 12. Review.


Retroviral restriction and dependency factors in primates and carnivores.

Fadel HJ, Poeschla EM.

Vet Immunol Immunopathol. 2011 Oct 15;143(3-4):179-89. doi: 10.1016/j.vetimm.2011.06.002. Epub 2011 Jun 12. Review.


The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak.

Sainski AM, Natesampillai S, Cummins NW, Bren GD, Taylor J, Saenz DT, Poeschla EM, Badley AD.

J Virol. 2011 Aug;85(16):7965-75. doi: 10.1128/JVI.02515-10. Epub 2011 Jun 8.


LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity.

Meehan AM, Saenz DT, Morrison J, Hu C, Peretz M, Poeschla EM.

J Virol. 2011 Apr;85(7):3570-83. doi: 10.1128/JVI.01295-10. Epub 2011 Jan 26.


The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.

Hu C, Saenz DT, Fadel HJ, Walker W, Peretz M, Poeschla EM.

J Virol. 2010 Nov;84(22):11981-93. doi: 10.1128/JVI.00723-10. Epub 2010 Sep 15.


Productive replication of Vif-chimeric HIV-1 in feline cells.

Stern MA, Hu C, Saenz DT, Fadel HJ, Sims O, Peretz M, Poeschla EM.

J Virol. 2010 Jul;84(14):7378-95. doi: 10.1128/JVI.00584-10. Epub 2010 May 12.


Live-cell coimaging of the genomic RNAs and Gag proteins of two lentiviruses.

Kemler I, Meehan A, Poeschla EM.

J Virol. 2010 Jul;84(13):6352-66. doi: 10.1128/JVI.00363-10. Epub 2010 Apr 14.


Virological and cellular roles of the transcriptional coactivator LEDGF/p75.

Llano M, Morrison J, Poeschla EM.

Curr Top Microbiol Immunol. 2009;339:125-46. doi: 10.1007/978-3-642-02175-6_7. Review.


Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure.

Barraza RA, McLaren JW, Poeschla EM.

Mol Ther. 2010 Mar;18(3):491-501. doi: 10.1038/mt.2009.278. Epub 2009 Dec 1.


An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study.

Lachance DH, Lennon VA, Pittock SJ, Tracy JA, Krecke KN, Amrami KK, Poeschla EM, Orenstein R, Scheithauer BW, Sejvar JJ, Holzbauer S, Devries AS, Dyck PJ.

Lancet Neurol. 2010 Jan;9(1):55-66. doi: 10.1016/S1474-4422(09)70296-0. Epub 2009 Nov 27.


Chromatin tethering and retroviral integration: recent discoveries and parallels with DNA viruses.

Meehan AM, Poeschla EM.

Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):182-91. doi: 10.1016/j.bbagrm.2009.10.001. Epub 2009 Oct 15. Review.


LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors.

Meehan AM, Saenz DT, Morrison JH, Garcia-Rivera JA, Peretz M, Llano M, Poeschla EM.

PLoS Pathog. 2009 Jul;5(7):e1000522. doi: 10.1371/journal.ppat.1000522. Epub 2009 Jul 17.


Prolonged transgene expression with lentiviral vectors in the aqueous humor outflow pathway of nonhuman primates.

Barraza RA, Rasmussen CA, Loewen N, Cameron JD, Gabelt BT, Teo WL, Kaufman PL, Poeschla EM.

Hum Gene Ther. 2009 Mar;20(3):191-200.


Intensive RNAi with lentiviral vectors in mammalian cells.

Miest T, Saenz D, Meehan A, Llano M, Poeschla EM.

Methods. 2009 Apr;47(4):298-303. doi: 10.1016/j.ymeth.2008.11.001. Epub 2008 Nov 28. Review.


Rapid, controlled and intensive lentiviral vector-based RNAi.

Llano M, Gaznick N, Poeschla EM.

Methods Mol Biol. 2009;485:257-70. doi: 10.1007/978-1-59745-170-3_18.


Characterization of monoclonal antibodies against the glaucoma-associated protein myocilin.

Ezzat MK, Howell KG, Bahler CK, Beito TG, Loewen N, Poeschla EM, Fautsch MP.

Exp Eye Res. 2008 Oct;87(4):376-84. doi: 10.1016/j.exer.2008.07.002. Epub 2008 Jul 12.


Human gene therapy vectors derived from feline lentiviruses.

Barraza RA, Poeschla EM.

Vet Immunol Immunopathol. 2008 May 15;123(1-2):23-31. doi: 10.1016/j.vetimm.2008.01.009. Epub 2008 Jan 19. Review.


Integrase, LEDGF/p75 and HIV replication.

Poeschla EM.

Cell Mol Life Sci. 2008 May;65(9):1403-24. doi: 10.1007/s00018-008-7540-5. Review.


Durable, safe, multi-gene lentiviral vector expression in feline trabecular meshwork.

Khare PD, Loewen N, Teo W, Barraza RA, Saenz DT, Johnson DH, Poeschla EM.

Mol Ther. 2008 Jan;16(1):97-106. Epub 2007 Oct 2.


An essential role for LEDGF/p75 in HIV integration.

Llano M, Saenz DT, Meehan A, Wongthida P, Peretz M, Walker WH, Teo W, Poeschla EM.

Science. 2006 Oct 20;314(5798):461-4. Epub 2006 Sep 7.


Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults.

Temesgen Z, Cainelli F, Poeschla EM, Vlahakis SA, Vento S.

Lancet Infect Dis. 2006 Aug;6(8):496-507. Review.


Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

Llano M, Vanegas M, Hutchins N, Thompson D, Delgado S, Poeschla EM.

J Mol Biol. 2006 Jul 21;360(4):760-73. Epub 2006 May 17.


Lentiviral vectors.

Loewen N, Poeschla EM.

Adv Biochem Eng Biotechnol. 2005;99:169-91. Review.


Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor.

Fautsch MP, Bahler CK, Vrabel AM, Howell KG, Loewen N, Teo WL, Poeschla EM, Johnson DH.

Invest Ophthalmol Vis Sci. 2006 Jan;47(1):213-21.


Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins.

Saenz DT, Teo W, Olsen JC, Poeschla EM.

J Virol. 2005 Dec;79(24):15175-88.


Directed evolution of retrovirus envelope protein cytoplasmic tails guided by functional incorporation into lentivirus particles.

Merten CA, Stitz J, Braun G, Poeschla EM, Cichutek K, Buchholz CJ.

J Virol. 2005 Jan;79(2):834-40.


Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase.

Llano M, Delgado S, Vanegas M, Poeschla EM.

J Biol Chem. 2004 Dec 31;279(53):55570-7. Epub 2004 Oct 8.


Long-term, targeted genetic modification of the aqueous humor outflow tract coupled with noninvasive imaging of gene expression in vivo.

Loewen N, Fautsch MP, Teo WL, Bahler CK, Johnson DH, Poeschla EM.

Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3091-8.


Long-term retinal transgene expression with FIV versus adenoviral vectors.

Loewen N, Leske DA, Cameron JD, Chen Y, Whitwam T, Simari RD, Teo WL, Fautsch MP, Poeschla EM, Holmes JM.

Mol Vis. 2004 Apr 13;10:272-80.


Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression.

Nguyen KL, llano M, Akari H, Miyagi E, Poeschla EM, Strebel K, Bour S.

Virology. 2004 Feb 20;319(2):163-75.


Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants.

Saenz DT, Loewen N, Peretz M, Whitwam T, Barraza R, Howell KG, Holmes JM, Good M, Poeschla EM.

J Virol. 2004 Mar;78(6):2906-20.


FIV: from lentivirus to lentivector.

Saenz DT, Poeschla EM.

J Gene Med. 2004 Feb;6 Suppl 1:S95-104. Review.


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