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Hypoxia Regulates MicroRNA Expression in the Human Carotid Body.

Mkrtchian S, Lee KL, Kåhlin J, Ebberyd A, Poellinger L, Fagerlund MJ, Eriksson LI.

Adv Exp Med Biol. 2018;1071:25-33. doi: 10.1007/978-3-319-91137-3_3.


Author Correction: Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.

Sun W, Kato H, Kitajima S, Lee KL, Gradin K, Okamoto T, Poellinger L.

Sci Rep. 2018 Jul 20;8(1):11239. doi: 10.1038/s41598-018-29095-1.


Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells.

Kitajima S, Lee KL, Fujioka M, Sun W, You J, Chia GS, Wanibuchi H, Tomita S, Araki M, Kato H, Poellinger L.

Oncotarget. 2018 Apr 10;9(27):19123-19135. doi: 10.18632/oncotarget.24919. eCollection 2018 Apr 10.


HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters.

Suzuki N, Vojnovic N, Lee KL, Yang H, Gradin K, Poellinger L.

Exp Cell Res. 2018 May 15;366(2):181-191. doi: 10.1016/j.yexcr.2018.03.020. Epub 2018 Mar 21.


Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions.

Nakamura H, Bono H, Hiyama K, Kawamoto T, Kato Y, Nakanishi T, Nishiyama M, Hiyama E, Hirohashi N, Sueoka E, Poellinger L, Tanimoto K.

PLoS One. 2018 Feb 21;13(2):e0192136. doi: 10.1371/journal.pone.0192136. eCollection 2018.


Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells.

Kitajima S, Lee KL, Hikasa H, Sun W, Huang RY, Yang H, Matsunaga S, Yamaguchi T, Araki M, Kato H, Poellinger L.

Oncotarget. 2017 Dec 7;8(70):114481-114494. doi: 10.18632/oncotarget.23010. eCollection 2017 Dec 29.


Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway.

Ho JC, Abdullah LN, Pang QY, Jha S, Chow EK, Yang H, Kato H, Poellinger L, Ueda J, Lee KL.

PLoS One. 2017 Nov 16;12(11):e0188051. doi: 10.1371/journal.pone.0188051. eCollection 2017.


Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.

Sun W, Kato H, Kitajima S, Lee KL, Gradin K, Okamoto T, Poellinger L.

Sci Rep. 2017 Aug 3;7(1):7190. doi: 10.1038/s41598-017-05685-3. Erratum in: Sci Rep. 2018 Jul 20;8(1):11239.


Hypoxia is a Key Driver of Alternative Splicing in Human Breast Cancer Cells.

Han J, Li J, Ho JC, Chia GS, Kato H, Jha S, Yang H, Poellinger L, Lee KL.

Sci Rep. 2017 Jun 22;7(1):4108. doi: 10.1038/s41598-017-04333-0.


A Notch-independent mechanism contributes to the induction of Hes1 gene expression in response to hypoxia in P19 cells.

Zheng X, Narayanan S, Zheng X, Luecke-Johansson S, Gradin K, Catrina SB, Poellinger L, Pereira TS.

Exp Cell Res. 2017 Sep 15;358(2):129-139. doi: 10.1016/j.yexcr.2017.06.006. Epub 2017 Jun 9.


A Molecular Mechanism To Switch the Aryl Hydrocarbon Receptor from a Transcription Factor to an E3 Ubiquitin Ligase.

Luecke-Johansson S, Gralla M, Rundqvist H, Ho JC, Johnson RS, Gradin K, Poellinger L.

Mol Cell Biol. 2017 Jun 15;37(13). pii: e00630-16. doi: 10.1128/MCB.00630-16. Print 2017 Jul 1.


Regulation of hypoxia-inducible gene expression after HIF activation.

Suzuki N, Gradin K, Poellinger L, Yamamoto M.

Exp Cell Res. 2017 Jul 15;356(2):182-186. doi: 10.1016/j.yexcr.2017.03.013. Epub 2017 Mar 9. Review.


Hypoxia regulates microRNA expression in the human carotid body.

Mkrtchian S, Lee KL, Kåhlin J, Ebberyd A, Poellinger L, Fagerlund MJ, Eriksson LI.

Exp Cell Res. 2017 Mar 15;352(2):412-419. doi: 10.1016/j.yexcr.2017.02.027. Epub 2017 Feb 24.


S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.

Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Veliça P, You J, Chia GS, Sim J, Doedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW, Johnson RS.

Nature. 2016 Dec 8;540(7632):236-241. doi: 10.1038/nature20165. Epub 2016 Oct 26.


A Human Pluripotent Stem Cell Model of Facioscapulohumeral Muscular Dystrophy-Affected Skeletal Muscles.

Caron L, Kher D, Lee KL, McKernan R, Dumevska B, Hidalgo A, Li J, Yang H, Main H, Ferri G, Petek LM, Poellinger L, Miller DG, Gabellini D, Schmidt U.

Stem Cells Transl Med. 2016 Sep;5(9):1145-61. doi: 10.5966/sctm.2015-0224. Epub 2016 May 23.


The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer.

Putra AC, Eguchi H, Lee KL, Yamane Y, Gustine E, Isobe T, Nishiyama M, Hiyama K, Poellinger L, Tanimoto K.

PLoS One. 2015 Aug 11;10(8):e0134496. doi: 10.1371/journal.pone.0134496. eCollection 2015.


Increased Serine-Arginine (SR) Protein Phosphorylation Changes Pre-mRNA Splicing in Hypoxia.

Jakubauskiene E, Vilys L, Makino Y, Poellinger L, Kanopka A.

J Biol Chem. 2015 Jul 17;290(29):18079-89. doi: 10.1074/jbc.M115.639690. Epub 2015 May 28.


Consensus toxicity factors for polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls combining in silico models and extensive in vitro screening of AhR-mediated effects in human and rodent cells.

Larsson M, van den Berg M, Brenerová P, van Duursen MB, van Ede KI, Lohr C, Luecke-Johansson S, Machala M, Neser S, Pěnčíková K, Poellinger L, Schrenk D, Strapáčová S, Vondráček J, Andersson PL.

Chem Res Toxicol. 2015 Apr 20;28(4):641-50. doi: 10.1021/tx500434j. Epub 2015 Feb 13.


Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer.

Chien W, Sun QY, Lee KL, Ding LW, Wuensche P, Torres-Fernandez LA, Tan SZ, Tokatly I, Zaiden N, Poellinger L, Mori S, Yang H, Tyner JW, Koeffler HP.

Mol Oncol. 2015 Apr;9(4):889-905. doi: 10.1016/j.molonc.2015.01.002. Epub 2015 Jan 15.


Hypoxia-inducible factor-3α promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the VE-cadherin gene.

Kobayashi S, Yamashita T, Ohneda K, Nagano M, Kimura K, Nakai H, Poellinger L, Ohneda O.

Genes Cells. 2015 Mar;20(3):224-41. doi: 10.1111/gtc.12215. Epub 2015 Jan 28.


HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery.

Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, Rissanen TT, André H, Pereira T, Poellinger L, Alitalo K, Ylä-Herttuala S.

Eur J Clin Invest. 2014 Oct;44(10):989-99. doi: 10.1111/eci.12333.


The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.

Ueda J, Ho JC, Lee KL, Kitajima S, Yang H, Sun W, Fukuhara N, Zaiden N, Chan SL, Tachibana M, Shinkai Y, Kato H, Poellinger L.

Mol Cell Biol. 2014 Oct 1;34(19):3702-20. doi: 10.1128/MCB.00099-14. Epub 2014 Jul 28.


Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells.

Chien W, Ding LW, Sun QY, Torres-Fernandez LA, Tan SZ, Xiao J, Lim SL, Garg M, Lee KL, Kitajima S, Takao S, Leong WZ, Sun H, Tokatly I, Poellinger L, Gery S, Koeffler PH.

Oncotarget. 2014 Jul 15;5(13):4881-94.


In vitro and in silico derived relative effect potencies of ah-receptor-mediated effects by PCDD/Fs and PCBs in rat, mouse, and guinea pig CALUX cell lines.

Ghorbanzadeh M, van Ede KI, Larsson M, van Duursen MB, Poellinger L, Lücke-Johansson S, Machala M, Pěnčíková K, Vondráček J, van den Berg M, Denison MS, Ringsted T, Andersson PL.

Chem Res Toxicol. 2014 Jul 21;27(7):1120-32. doi: 10.1021/tx5001255. Epub 2014 Jun 18.


Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism.

Lindholm ME, Fischer H, Poellinger L, Johnson RS, Gustafsson T, Sundberg CJ, Rundqvist H.

Am J Physiol Regul Integr Comp Physiol. 2014 Aug 1;307(3):R248-55. doi: 10.1152/ajpregu.00036.2013. Epub 2014 Jun 4.


The human carotid body releases acetylcholine, ATP and cytokines during hypoxia.

Kåhlin J, Mkrtchian S, Ebberyd A, Hammarstedt-Nordenvall L, Nordlander B, Yoshitake T, Kehr J, Prabhakar N, Poellinger L, Fagerlund MJ, Eriksson LI.

Exp Physiol. 2014 Aug;99(8):1089-98. doi: 10.1113/expphysiol.2014.078873. Epub 2014 May 30.


Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition.

Ng KP, Manjeri A, Lee KL, Huang W, Tan SY, Chuah CT, Poellinger L, Ong ST.

Blood. 2014 May 22;123(21):3316-26. doi: 10.1182/blood-2013-07-511907. Epub 2014 Apr 4.


Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways.

Aesoy R, Gradin K, Aasrud KS, Hoivik EA, Ruas JL, Poellinger L, Bakke M.

Mol Cancer. 2014 Mar 11;13:54. doi: 10.1186/1476-4598-13-54.


Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response.

Zheng X, Zhou AX, Rouhi P, Uramoto H, Borén J, Cao Y, Pereira T, Akyürek LM, Poellinger L.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2560-5. doi: 10.1073/pnas.1320815111. Epub 2014 Feb 3.


Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations.

Loh KM, Ang LT, Zhang J, Kumar V, Ang J, Auyeong JQ, Lee KL, Choo SH, Lim CY, Nichane M, Tan J, Noghabi MS, Azzola L, Ng ES, Durruthy-Durruthy J, Sebastiano V, Poellinger L, Elefanty AG, Stanley EG, Chen Q, Prabhakar S, Weissman IL, Lim B.

Cell Stem Cell. 2014 Feb 6;14(2):237-52. doi: 10.1016/j.stem.2013.12.007. Epub 2014 Jan 9.


The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms.

Khalesi E, Nakamura H, Lee KL, Putra AC, Fukazawa T, Kawahara Y, Makino Y, Poellinger L, Yuge L, Tanimoto K.

Biochem Biophys Res Commun. 2013 Nov 15;441(2):499-506.


PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells.

Chien W, Lee KL, Ding LW, Wuensche P, Kato H, Doan NB, Poellinger L, Said JW, Koeffler HP.

Br J Cancer. 2013 Oct 1;109(7):1795-804. doi: 10.1038/bjc.2013.531. Epub 2013 Sep 3.


A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo.

Do DV, Ueda J, Messerschmidt DM, Lorthongpanich C, Zhou Y, Feng B, Guo G, Lin PJ, Hossain MZ, Zhang W, Moh A, Wu Q, Robson P, Ng HH, Poellinger L, Knowles BB, Solter D, Fu XY.

Genes Dev. 2013 Jun 15;27(12):1378-90. doi: 10.1101/gad.221176.113.


ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice.

Ikuta T, Kobayashi Y, Kitazawa M, Shiizaki K, Itano N, Noda T, Pettersson S, Poellinger L, Fujii-Kuriyama Y, Taniguchi S, Kawajiri K.

Carcinogenesis. 2013 Jul;34(7):1620-7. doi: 10.1093/carcin/bgt083. Epub 2013 Mar 1.


Hypoxia-induced arterial differentiation requires adrenomedullin and notch signaling.

Lanner F, Lee KL, Ortega GC, Sohl M, Li X, Jin S, Hansson EM, Claesson-Welsh L, Poellinger L, Lendahl U, Farnebo F.

Stem Cells Dev. 2013 May 1;22(9):1360-9. doi: 10.1089/scd.2012.0259. Epub 2013 Feb 12.


Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ.

Jin S, Mutvei AP, Chivukula IV, Andersson ER, Ramsköld D, Sandberg R, Lee KL, Kronqvist P, Mamaeva V, Ostling P, Mpindi JP, Kallioniemi O, Screpanti I, Poellinger L, Sahlgren C, Lendahl U.

Oncogene. 2013 Oct 10;32(41):4892-902. doi: 10.1038/onc.2012.517. Epub 2012 Nov 26.


Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling.

Hao N, Lee KL, Furness SG, Bosdotter C, Poellinger L, Whitelaw ML.

Mol Pharmacol. 2012 Dec;82(6):1082-93. doi: 10.1124/mol.112.078873. Epub 2012 Aug 30.


Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP.

Zheng X, Zheng X, Wang X, Ma Z, Gupta Sunkari V, Botusan I, Takeda T, Björklund A, Inoue M, Catrina SB, Brismar K, Poellinger L, Pereira TS.

Cell Death Dis. 2012 Jun 14;3:e322. doi: 10.1038/cddis.2012.66.


Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signaling.

Shimizu T, Ueda J, Ho JC, Iwasaki K, Poellinger L, Harada I, Sawada Y.

Stem Cells. 2012 Jul;30(7):1394-404. doi: 10.1002/stem.1119.


The constitutively active Ah receptor (CA-AhR) mouse as a model for dioxin exposure - effects in reproductive organs.

Brunnberg S, Andersson P, Poellinger L, Hanberg A.

Chemosphere. 2011 Dec;85(11):1701-6. doi: 10.1016/j.chemosphere.2011.09.015. Epub 2011 Oct 19.


Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop.

Stiehl DP, Bordoli MR, Abreu-Rodríguez I, Wollenick K, Schraml P, Gradin K, Poellinger L, Kristiansen G, Wenger RH.

Oncogene. 2012 May 3;31(18):2283-97. doi: 10.1038/onc.2011.417. Epub 2011 Sep 19.


Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells.

Florczyk U, Czauderna S, Stachurska A, Tertil M, Nowak W, Kozakowska M, Poellinger L, Jozkowicz A, Loboda A, Dulak J.

Free Radic Biol Med. 2011 Nov 15;51(10):1882-92. doi: 10.1016/j.freeradbiomed.2011.08.023. Epub 2011 Aug 30.


Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions.

Lee KL, Lim SK, Orlov YL, Yit le Y, Yang H, Ang LT, Poellinger L, Lim B.

PLoS Genet. 2011 Jun;7(6):e1002130. doi: 10.1371/journal.pgen.1002130. Epub 2011 Jun 23.


The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism.

Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS.

Cell Metab. 2010 May 5;11(5):364-78. doi: 10.1016/j.cmet.2010.03.001. Epub 2010 Apr 15.


Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells.

Main H, Lee KL, Yang H, Haapa-Paananen S, Edgren H, Jin S, Sahlgren C, Kallioniemi O, Poellinger L, Lim B, Lendahl U.

Exp Cell Res. 2010 May 15;316(9):1610-24. doi: 10.1016/j.yexcr.2009.12.012. Epub 2009 Dec 23.


Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state.

Lanner F, Lee KL, Sohl M, Holmborn K, Yang H, Wilbertz J, Poellinger L, Rossant J, Farnebo F.

Stem Cells. 2010 Feb;28(2):191-200. doi: 10.1002/stem.265.


Generating specificity and diversity in the transcriptional response to hypoxia.

Lendahl U, Lee KL, Yang H, Poellinger L.

Nat Rev Genet. 2009 Dec;10(12):821-32. doi: 10.1038/nrg2665. Epub 2009 Nov 3. Review.


Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.

Ruas JL, Berchner-Pfannschmidt U, Malik S, Gradin K, Fandrey J, Roeder RG, Pereira T, Poellinger L.

J Biol Chem. 2010 Jan 22;285(4):2601-9. doi: 10.1074/jbc.M109.021824. Epub 2009 Oct 30.


Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.

Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, Pettersson S, Pollenz RS, Sakaki T, Hirokawa T, Akiyama T, Kurosumi M, Poellinger L, Kato S, Fujii-Kuriyama Y.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13481-6. doi: 10.1073/pnas.0902132106. Epub 2009 Jul 27.


Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.

Ebbesen P, Pettersen EO, Gorr TA, Jobst G, Williams K, Kieninger J, Wenger RH, Pastorekova S, Dubois L, Lambin P, Wouters BG, Van Den Beucken T, Supuran CT, Poellinger L, Ratcliffe P, Kanopka A, Görlach A, Gasmann M, Harris AL, Maxwell P, Scozzafava A.

J Enzyme Inhib Med Chem. 2009 Apr;24 Suppl 1:1-39. doi: 10.1080/14756360902784425. Review.


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