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Items: 16

1.

Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides.

Andersen NM, Poehlsgaard J, Warrass R, Douthwaite S.

Antimicrob Agents Chemother. 2012 Nov;56(11):6033-6. doi: 10.1128/AAC.01250-12. Epub 2012 Aug 27.

2.

Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site.

Poehlsgaard J, Andersen NM, Warrass R, Douthwaite S.

ACS Chem Biol. 2012 Aug 17;7(8):1351-5. doi: 10.1021/cb300105p. Epub 2012 May 14.

PMID:
22563863
3.

A robust force field based method for calculating conformational energies of charged drug-like molecules.

Poehlsgaard J, Harpsøe K, Jørgensen FS, Olsen L.

J Chem Inf Model. 2012 Feb 27;52(2):409-19. doi: 10.1021/ci200345f. Epub 2012 Jan 20.

PMID:
21985436
4.

Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket.

Long KS, Poehlsgaard J, Hansen LH, Hobbie SN, Böttger EC, Vester B.

Mol Microbiol. 2009 Mar;71(5):1218-27. doi: 10.1111/j.1365-2958.2009.06596.x. Epub 2009 Jan 16.

5.

The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics.

Long KS, Poehlsgaard J, Kehrenberg C, Schwarz S, Vester B.

Antimicrob Agents Chemother. 2006 Jul;50(7):2500-5.

6.

Modifications in Thermus thermophilus 23 S ribosomal RNA are centered in regions of RNA-RNA contact.

Mengel-Jørgensen J, Jensen SS, Rasmussen A, Poehlsgaard J, Iversen JJ, Kirpekar F.

J Biol Chem. 2006 Aug 4;281(31):22108-17. Epub 2006 May 26.

7.

The bacterial ribosome as a target for antibiotics.

Poehlsgaard J, Douthwaite S.

Nat Rev Microbiol. 2005 Nov;3(11):870-81. Review.

PMID:
16261170
8.

The archaeon Haloarcula marismortui has few modifications in the central parts of its 23S ribosomal RNA.

Kirpekar F, Hansen LH, Rasmussen A, Poehlsgaard J, Vester B.

J Mol Biol. 2005 May 6;348(3):563-73.

PMID:
15826654
9.

Molecular mechanisms by which rRNA mutations confer resistance to clindamycin.

Poehlsgaard J, Pfister P, Böttger EC, Douthwaite S.

Antimicrob Agents Chemother. 2005 Apr;49(4):1553-5.

11.

Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.

Novotny GW, Jakobsen L, Andersen NM, Poehlsgaard J, Douthwaite S.

Antimicrob Agents Chemother. 2004 Oct;48(10):3677-83.

12.

The structural basis of macrolide-ribosome binding assessed using mutagenesis of 23S rRNA positions 2058 and 2059.

Pfister P, Jenni S, Poehlsgaard J, Thomas A, Douthwaite S, Ban N, Böttger EC.

J Mol Biol. 2004 Oct 1;342(5):1569-81.

PMID:
15364582
13.

The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748.

Douthwaite S, Crain PF, Liu M, Poehlsgaard J.

J Mol Biol. 2004 Apr 9;337(5):1073-7.

PMID:
15046978
14.

Macrolide resistance by ribosomal mutation in clinical isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 study.

Farrell DJ, Douthwaite S, Morrissey I, Bakker S, Poehlsgaard J, Jakobsen L, Felmingham D.

Antimicrob Agents Chemother. 2003 Jun;47(6):1777-83.

15.

Macrolide antibiotic interaction and resistance on the bacterial ribosome.

Poehlsgaard J, Douthwaite S.

Curr Opin Investig Drugs. 2003 Feb;4(2):140-8. Review.

PMID:
12669373
16.

The macrolide binding site on the bacterial ribosome.

Poehlsgaard J, Douthwaite S.

Curr Drug Targets Infect Disord. 2002 Mar;2(1):67-78. Review.

PMID:
12462154

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