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Items: 44

1.

RIG-I activation is critical for responsiveness to checkpoint blockade.

Heidegger S, Wintges A, Stritzke F, Bek S, Steiger K, Koenig PA, Göttert S, Engleitner T, Öllinger R, Nedelko T, Fischer JC, Makarov V, Winter C, Rad R, van den Brink MRM, Ruland J, Bassermann F, Chan TA, Haas T, Poeck H.

Sci Immunol. 2019 Sep 13;4(39). pii: eaau8943. doi: 10.1126/sciimmunol.aau8943.

PMID:
31519811
2.

Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines.

Bek S, Stritzke F, Wintges A, Nedelko T, Böhmer DFR, Fischer JC, Haas T, Poeck H, Heidegger S.

Oncoimmunology. 2019 Feb 11;8(4):e1570779. doi: 10.1080/2162402X.2019.1570779. eCollection 2019.

3.

RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade.

Heidegger S, Kreppel D, Bscheider M, Stritzke F, Nedelko T, Wintges A, Bek S, Fischer JC, Graalmann T, Kalinke U, Bassermann F, Haas T, Poeck H.

EBioMedicine. 2019 Mar;41:146-155. doi: 10.1016/j.ebiom.2019.02.056. Epub 2019 Mar 6.

4.

XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.

Müller N, Fischer JC, Yabal M, Haas T, Poeck H, Jost PJ.

Eur J Immunol. 2019 Mar;49(3):504-507. doi: 10.1002/eji.201847818. Epub 2019 Jan 3.

PMID:
30585320
5.

Regeneration After Radiation- and Immune-Mediated Tissue Injury Is Not Enhanced by Type III Interferon Signaling.

Fischer JC, Lin CC, Heidegger S, Wintges A, Schlapschy M, Beudert M, Combs SE, Bassermann F, Skerra A, Haas T, Poeck H.

Int J Radiat Oncol Biol Phys. 2019 Mar 15;103(4):970-976. doi: 10.1016/j.ijrobp.2018.11.038. Epub 2018 Nov 29.

PMID:
30503785
6.

Targeting RIG-I or STING promotes epithelial regeneration.

Fischer JC, Poeck H.

Oncotarget. 2017 Dec 6;8(70):114418-114419. doi: 10.18632/oncotarget.22994. eCollection 2017 Dec 29. No abstract available.

7.

A20 Restrains Thymic Regulatory T Cell Development.

Fischer JC, Otten V, Kober M, Drees C, Rosenbaum M, Schmickl M, Heidegger S, Beyaert R, van Loo G, Li XC, Peschel C, Schmidt-Supprian M, Haas T, Spoerl S, Poeck H.

J Immunol. 2017 Oct 1;199(7):2356-2365. doi: 10.4049/jimmunol.1602102. Epub 2017 Aug 25.

8.

Minimally manipulated murine regulatory T cells purified by reversible Fab Multimers are potent suppressors for adoptive T-cell therapy.

Mohr F, Fischer JC, Nikolaus M, Stemberger C, Dreher S, Verschoor A, Haas T, Poeck H, Busch DH.

Eur J Immunol. 2017 Dec;47(12):2153-2162. doi: 10.1002/eji.201747137. Epub 2017 Sep 15.

9.

A20 deletion in T cells modulates acute graft-versus-host disease in mice.

Fischer JC, Otten V, Steiger K, Schmickl M, Slotta-Huspenina J, Beyaert R, van Loo G, Peschel C, Poeck H, Haas T, Spoerl S.

Eur J Immunol. 2017 Nov;47(11):1982-1988. doi: 10.1002/eji.201646911. Epub 2017 Sep 15.

10.

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury.

Fischer JC, Bscheider M, Eisenkolb G, Lin CC, Wintges A, Otten V, Lindemans CA, Heidegger S, Rudelius M, Monette S, Porosnicu Rodriguez KA, Calafiore M, Liebermann S, Liu C, Lienenklaus S, Weiss S, Kalinke U, Ruland J, Peschel C, Shono Y, Docampo M, Velardi E, Jenq RR, Hanash AM, Dudakov JA, Haas T, van den Brink MRM, Poeck H.

Sci Transl Med. 2017 Apr 19;9(386). pii: eaag2513. doi: 10.1126/scitranslmed.aag2513.

11.

Assessment of mucosal integrity by quantifying neutrophil granulocyte influx in murine models of acute intestinal injury.

Fischer JC, Wintges A, Haas T, Poeck H.

Cell Immunol. 2017 Jun;316:70-76. doi: 10.1016/j.cellimm.2017.04.003. Epub 2017 Apr 11.

PMID:
28413062
12.

Cutting Edge in IFN Regulation: Inflammatory Caspases Cleave cGAS.

Heidegger S, Haas T, Poeck H.

Immunity. 2017 Mar 21;46(3):333-335. doi: 10.1016/j.immuni.2017.03.004.

13.

Card9 controls Dectin-1-induced T-cell cytotoxicity and tumor growth in mice.

Haas T, Heidegger S, Wintges A, Bscheider M, Bek S, Fischer JC, Eisenkolb G, Schmickl M, Spoerl S, Peschel C, Poeck H, Ruland J.

Eur J Immunol. 2017 May;47(5):872-879. doi: 10.1002/eji.201646775. Epub 2017 Apr 10.

14.

Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.

Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR, Jay HV, Ahr KF, Porosnicu Rodriguez KA, Xu K, Calarfiore M, Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA, Hanash AM, Gyurkocza B, Murphy GF, Gomes C, Liu C, Moss EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink MRM, Jenq RR.

Sci Transl Med. 2016 May 18;8(339):339ra71. doi: 10.1126/scitranslmed.aaf2311.

15.

Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease.

Jenq RR, Taur Y, Devlin SM, Ponce DM, Goldberg JD, Ahr KF, Littmann ER, Ling L, Gobourne AC, Miller LC, Docampo MD, Peled JU, Arpaia N, Cross JR, Peets TK, Lumish MA, Shono Y, Dudakov JA, Poeck H, Hanash AM, Barker JN, Perales MA, Giralt SA, Pamer EG, van den Brink MR.

Biol Blood Marrow Transplant. 2015 Aug;21(8):1373-83. doi: 10.1016/j.bbmt.2015.04.016. Epub 2015 May 11.

16.

Continuous T cell receptor signals maintain a functional regulatory T cell pool.

Vahl JC, Drees C, Heger K, Heink S, Fischer JC, Nedjic J, Ohkura N, Morikawa H, Poeck H, Schallenberg S, Rieß D, Hein MY, Buch T, Polic B, Schönle A, Zeiser R, Schmitt-Gräff A, Kretschmer K, Klein L, Korn T, Sakaguchi S, Schmidt-Supprian M.

Immunity. 2014 Nov 20;41(5):722-36. doi: 10.1016/j.immuni.2014.10.012. Epub 2014 Nov 6.

17.

The role of pattern-recognition receptors in graft-versus-host disease and graft-versus-leukemia after allogeneic stem cell transplantation.

Heidegger S, van den Brink MR, Haas T, Poeck H.

Front Immunol. 2014 Jul 18;5:337. doi: 10.3389/fimmu.2014.00337. eCollection 2014. Review.

18.

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease.

Spoerl S, Mathew NR, Bscheider M, Schmitt-Graeff A, Chen S, Mueller T, Verbeek M, Fischer J, Otten V, Schmickl M, Maas-Bauer K, Finke J, Peschel C, Duyster J, Poeck H, Zeiser R, von Bubnoff N.

Blood. 2014 Jun 12;123(24):3832-42. doi: 10.1182/blood-2013-12-543736. Epub 2014 Apr 7.

19.

The Nlrp3 inflammasome regulates acute graft-versus-host disease.

Jankovic D, Ganesan J, Bscheider M, Stickel N, Weber FC, Guarda G, Follo M, Pfeifer D, Tardivel A, Ludigs K, Bouazzaoui A, Kerl K, Fischer JC, Haas T, Schmitt-Gräff A, Manoharan A, Müller L, Finke J, Martin SF, Gorka O, Peschel C, Ruland J, Idzko M, Duyster J, Holler E, French LE, Poeck H, Contassot E, Zeiser R.

J Exp Med. 2013 Sep 23;210(10):1899-910. doi: 10.1084/jem.20130084. Epub 2013 Aug 26.

20.

Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer.

Ellermeier J, Wei J, Duewell P, Hoves S, Stieg MR, Adunka T, Noerenberg D, Anders HJ, Mayr D, Poeck H, Hartmann G, Endres S, Schnurr M.

Cancer Res. 2013 Mar 15;73(6):1709-20. doi: 10.1158/0008-5472.CAN-11-3850. Epub 2013 Jan 21.

21.

The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome.

Schweneker K, Gorka O, Schweneker M, Poeck H, Tschopp J, Peschel C, Ruland J, Gross O.

Immunobiology. 2013 Apr;218(4):664-73. doi: 10.1016/j.imbio.2012.07.029. Epub 2012 Aug 7.

PMID:
22921586
22.

Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III.

Wenzel M, Wunderlich M, Besch R, Poeck H, Willms S, Schwantes A, Kremer M, Sutter G, Endres S, Schmidt A, Rothenfusser S.

J Immunol. 2012 Jan 1;188(1):394-403. doi: 10.4049/jimmunol.1100523. Epub 2011 Dec 2.

23.

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M.

Nat Neurosci. 2011 Dec 4;15(1):98-106. doi: 10.1038/nn.2964.

PMID:
22138643
24.

5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice.

Ebert G, Poeck H, Lucifora J, Baschuk N, Esser K, Esposito I, Hartmann G, Protzer U.

Gastroenterology. 2011 Aug;141(2):696-706, 706.e1-3. doi: 10.1053/j.gastro.2011.05.001. Epub 2011 May 13.

PMID:
21684282
25.

From virus to inflammation: mechanisms of RIG-I-induced IL-1β production.

Poeck H, Ruland J.

Eur J Cell Biol. 2012 Jan;91(1):59-64. doi: 10.1016/j.ejcb.2011.01.013. Epub 2011 Apr 9. Review.

PMID:
21481488
26.

ITAM receptor signaling and the NLRP3 inflammasome in antifungal immunity.

Poeck H, Ruland J.

J Clin Immunol. 2010 Jul;30(4):496-501. doi: 10.1007/s10875-010-9385-6. Epub 2010 Apr 18. Review.

PMID:
20401526
27.

SYK kinase signaling and the NLRP3 inflammasome in antifungal immunity.

Poeck H, Ruland J.

J Mol Med (Berl). 2010 Aug;88(8):745-52. doi: 10.1007/s00109-010-0631-4. Epub 2010 Apr 17. Review.

PMID:
20401456
28.

Immunostimulatory RNA blocks suppression by regulatory T cells.

Anz D, Koelzer VH, Moder S, Thaler R, Schwerd T, Lahl K, Sparwasser T, Besch R, Poeck H, Hornung V, Hartmann G, Rothenfusser S, Bourquin C, Endres S.

J Immunol. 2010 Jan 15;184(2):939-46. doi: 10.4049/jimmunol.0901245. Epub 2009 Dec 4.

29.

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.

Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J.

Nat Immunol. 2010 Jan;11(1):63-9. doi: 10.1038/ni.1824. Epub 2009 Nov 15. Erratum in: Nat Immunol. 2014 Jan;15(1):109.

PMID:
19915568
30.

Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7.

Bourquin C, Schmidt L, Lanz AL, Storch B, Wurzenberger C, Anz D, Sandholzer N, Mocikat R, Berger M, Poeck H, Hartmann G, Hornung V, Endres S.

J Immunol. 2009 Nov 15;183(10):6078-86. doi: 10.4049/jimmunol.0901594.

31.

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

Besch R, Poeck H, Hohenauer T, Senft D, Häcker G, Berking C, Hornung V, Endres S, Ruzicka T, Rothenfusser S, Hartmann G.

J Clin Invest. 2009 Aug;119(8):2399-411. doi: 10.1172/JCI37155. Epub 2009 Jul 20.

32.

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.

Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G.

Immunity. 2009 Jul 17;31(1):25-34. doi: 10.1016/j.immuni.2009.05.008. Epub 2009 Jul 2.

33.

Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.

Ablasser A, Poeck H, Anz D, Berger M, Schlee M, Kim S, Bourquin C, Goutagny N, Jiang Z, Fitzgerald KA, Rothenfusser S, Endres S, Hartmann G, Hornung V.

J Immunol. 2009 Jun 1;182(11):6824-33. doi: 10.4049/jimmunol.0803001.

34.

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.

Gross O, Poeck H, Bscheider M, Dostert C, Hannesschläger N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J.

Nature. 2009 May 21;459(7245):433-6. doi: 10.1038/nature07965. Epub 2009 Apr 1.

PMID:
19339971
35.

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.

Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Häcker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, Tüting T, Hartmann G.

Nat Med. 2008 Nov;14(11):1256-63. doi: 10.1038/nm.1887. Epub 2008 Nov 2.

PMID:
18978796
36.

TRADD protein is an essential component of the RIG-like helicase antiviral pathway.

Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, König M, Kalinke U, Pasparakis M, Tschopp J.

Immunity. 2008 May;28(5):651-61. doi: 10.1016/j.immuni.2008.03.013. Epub 2008 Apr 24.

37.

Immunostimulatory properties of CpG-oligonucleotides are enhanced by the use of protamine nanoparticles.

Kerkmann M, Lochmann D, Weyermann J, Marschner A, Poeck H, Wagner M, Battiany J, Zimmer A, Endres S, Hartmann G.

Oligonucleotides. 2006 Winter;16(4):313-22.

PMID:
17155907
38.

5'-Triphosphate RNA is the ligand for RIG-I.

Hornung V, Ellegast J, Kim S, Brzózka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G.

Science. 2006 Nov 10;314(5801):994-7. Epub 2006 Oct 12.

39.

Analysis of plasmacytoid and myeloid dendritic cells in nasal epithelium.

Hartmann E, Graefe H, Hopert A, Pries R, Rothenfusser S, Poeck H, Mack B, Endres S, Hartmann G, Wollenberg B.

Clin Vaccine Immunol. 2006 Nov;13(11):1278-86. Epub 2006 Aug 23.

40.

CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells.

Marschner A, Rothenfusser S, Hornung V, Prell D, Krug A, Kerkmann M, Wellisch D, Poeck H, Greinacher A, Giese T, Endres S, Hartmann G.

Eur J Immunol. 2005 Aug;35(8):2347-57.

41.

B-cell lymphomas differ in their responsiveness to CpG oligodeoxynucleotides.

Jahrsdorfer B, Mühlenhoff L, Blackwell SE, Wagner M, Poeck H, Hartmann E, Jox R, Giese T, Emmerich B, Endres S, Weiner GJ, Hartmann G.

Clin Cancer Res. 2005 Feb 15;11(4):1490-9.

42.

Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help.

Poeck H, Wagner M, Battiany J, Rothenfusser S, Wellisch D, Hornung V, Jahrsdorfer B, Giese T, Endres S, Hartmann G.

Blood. 2004 Apr 15;103(8):3058-64. Epub 2003 Dec 30.

43.

IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA.

Wagner M, Poeck H, Jahrsdoerfer B, Rothenfusser S, Prell D, Bohle B, Tuma E, Giese T, Ellwart JW, Endres S, Hartmann G.

J Immunol. 2004 Jan 15;172(2):954-63.

44.

Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells.

Hartmann G, Battiany J, Poeck H, Wagner M, Kerkmann M, Lubenow N, Rothenfusser S, Endres S.

Eur J Immunol. 2003 Jun;33(6):1633-41.

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