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Items: 1 to 50 of 222

1.

Kurt J. Isselbacher, MD (1925-2019).

Friedman LS, Podolsky DK.

Gastroenterology. 2019 Aug 8. pii: S0016-5085(19)41205-5. doi: 10.1053/j.gastro.2019.08.011. [Epub ahead of print] No abstract available.

PMID:
31585068
2.

SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway.

Wei SC, Yang-Yen HF, Tsao PN, Weng MT, Tung CC, Yu LCH, Lai LC, Hsiao JH, Chuang EY, Shun CT, Ni YH, Xavier RJ, Podolsky DK, Yen JJY, Wong JM.

Inflamm Bowel Dis. 2017 Oct;23(10):1730-1740. doi: 10.1097/MIB.0000000000001250.

PMID:
28906292
3.

Gastroenterology, Academic Medicine and a Changing Landscape.

Podolsky DK.

Dig Dis. 2015;33 Suppl 1:57-60. Epub 2015 Sep 14.

PMID:
26367526
4.

Reflections on Mentorship on the Occasion of Dr Kurt J. Isselbacher's 90th Birthday.

Podolsky DK.

Gastroenterology. 2015 Aug;149(2):268-9. doi: 10.1053/j.gastro.2015.06.025. Epub 2015 Jun 26. No abstract available.

PMID:
26122141
5.

Public reporting of patient safety metrics: ready or not?

Podolsky DK, Nagarkar PA, Reed WG, Rohrich RJ.

Plast Reconstr Surg. 2014 Dec;134(6):981e-5e. doi: 10.1097/PRS.0000000000000713.

PMID:
25415121
6.

SLCO3A1, A novel crohn's disease-associated gene, regulates nf-κB activity and associates with intestinal perforation.

Wei SC, Tan YY, Weng MT, Lai LC, Hsiao JH, Chuang EY, Shun CT, Wu DC, Kao AW, Chuang CS, Ni YH, Shieh MJ, Tung CC, Chen Y, Wang CY, Xavier RJ, Podolsky DK, Wong JM.

PLoS One. 2014 Jun 19;9(6):e100515. doi: 10.1371/journal.pone.0100515. eCollection 2014.

7.

Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships.

Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK, Brenner DA, Rustgi AK, Omary MB.

Gastroenterology. 2013 Jul;145(1):16-31. doi: 10.1053/j.gastro.2013.05.019.

PMID:
23806784
8.

Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis.

Ey B, Eyking A, Klepak M, Salzman NH, Göthert JR, Rünzi M, Schmid KW, Gerken G, Podolsky DK, Cario E.

J Immunol. 2013 Jun 1;190(11):5676-88. doi: 10.4049/jimmunol.1201592. Epub 2013 May 1.

9.

Kenji Fujiwara, MD, PhD.

Sugano K, Podolsky DK, Brenner DA, Michalopoulos G, Tsukamoto H.

Gastroenterology. 2013 Apr;144(4):661-3. doi: 10.1053/j.gastro.2013.02.031. Epub 2013 Feb 26. No abstract available.

PMID:
23499284
10.

Increased T-helper 2 cytokines in bile from patients with IgG4-related cholangitis disrupt the tight junction-associated biliary epithelial cell barrier.

Müller T, Beutler C, Picó AH, Otten M, Dürr A, Al-Abadi H, Guckelberger O, Meyer Zum Büschenfelde D, Jöhrens K, Volkmann M, Lankisch T, Voigtländer T, Anders M, Shibolet O, Jefferson DM, Podolsky DK, Fischer A, Veltzke-Schlieker W, Adler A, Baumgart DC, Sturm A, Wiedenmann B, Schott E, Berg T.

Gastroenterology. 2013 May;144(5):1116-28. doi: 10.1053/j.gastro.2013.01.055. Epub 2013 Feb 4.

PMID:
23391819
11.

Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling.

Wei SC, Rosenberg IM, Cao Z, Huett AS, Xavier RJ, Podolsky DK.

Inflamm Bowel Dis. 2012 May;18(5):877-88. doi: 10.1002/ibd.22883. Epub 2012 Jan 23.

12.

Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis.

Mueller T, Beutler C, Picó AH, Shibolet O, Pratt DS, Pascher A, Neuhaus P, Wiedenmann B, Berg T, Podolsky DK.

Liver Int. 2011 Nov;31(10):1574-88. doi: 10.1111/j.1478-3231.2011.02635.x. Epub 2011 Sep 15.

PMID:
22093333
13.

Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer.

Eyking A, Ey B, Rünzi M, Roig AI, Reis H, Schmid KW, Gerken G, Podolsky DK, Cario E.

Gastroenterology. 2011 Dec;141(6):2154-65. doi: 10.1053/j.gastro.2011.08.043. Epub 2011 Sep 12.

14.

LRRK2 is involved in the IFN-gamma response and host response to pathogens.

Gardet A, Benita Y, Li C, Sands BE, Ballester I, Stevens C, Korzenik JR, Rioux JD, Daly MJ, Xavier RJ, Podolsky DK.

J Immunol. 2010 Nov 1;185(9):5577-85. doi: 10.4049/jimmunol.1000548. Epub 2010 Oct 4.

15.

Synthesis of biologically active biotinylated muramyl dipeptides.

Grimes CL, Podolsky DK, O'Shea EK.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6061-3. doi: 10.1016/j.bmcl.2010.08.056. Epub 2010 Aug 17.

16.

In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase.

Xue L, Aihara E, Podolsky DK, Wang TC, Montrose MH.

Gut. 2010 Sep;59(9):1184-91. doi: 10.1136/gut.2009.205625. Epub 2010 Jun 29.

17.

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity.

Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, MacDonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S.

Nature. 2010 Jul 8;466(7303):243-7. doi: 10.1038/nature09115. Epub 2010 Jun 16.

18.

Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.

Charrière GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, Cherayil BJ, Podolsky DK, Kobayashi KS, Silverman N, Lacy-Hulbert A, Stuart LM.

J Biol Chem. 2010 Jun 25;285(26):20147-54. doi: 10.1074/jbc.M110.115584. Epub 2010 Apr 20.

19.

Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.

Beck PL, Ihara E, Hirota SA, MacDonald JA, Meng D, Nanthakumar NN, Podolsky DK, Xavier RJ.

Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G43-53. doi: 10.1152/ajpgi.00228.2009. Epub 2010 Mar 18.

20.

MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function.

Yamamoto-Furusho JK, Barnich N, Hisamatsu T, Podolsky DK.

Inflamm Bowel Dis. 2010 May;16(5):736-42. doi: 10.1002/ibd.21144.

21.

Beyond tumor necrosis factor: next-generation biologic therapy for inflammatory bowel disease.

Podolsky DK.

Dig Dis. 2009;27(3):366-9. doi: 10.1159/000228575. Epub 2009 Sep 24.

PMID:
19786766
22.

TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury.

Ey B, Eyking A, Gerken G, Podolsky DK, Cario E.

J Biol Chem. 2009 Aug 14;284(33):22332-43. doi: 10.1074/jbc.M901619200. Epub 2009 Jun 15.

23.

The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.

Huett A, Leong JM, Podolsky DK, Xavier RJ.

Exp Cell Res. 2009 Jul 15;315(12):2001-11. doi: 10.1016/j.yexcr.2009.04.003. Epub 2009 Apr 14.

24.

A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.

Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly MJ, Podolsky DK, Xavier RJ.

J Immunol. 2009 Apr 15;182(8):4917-30. doi: 10.4049/jimmunol.0803050.

25.

Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency.

Podolsky DK, Gerken G, Eyking A, Cario E.

Gastroenterology. 2009 Jul;137(1):209-20. doi: 10.1053/j.gastro.2009.03.007. Epub 2009 Mar 18.

26.

Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds.

Paulsen FP, Woon CW, Varoga D, Jansen A, Garreis F, Jäger K, Amm M, Podolsky DK, Steven P, Barker NP, Sel S.

J Biol Chem. 2008 May 9;283(19):13418-27. doi: 10.1074/jbc.M800177200. Epub 2008 Mar 7.

27.

TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality.

Mizoguchi E, Hachiya Y, Kawada M, Nagatani K, Ogawa A, Sugimoto K, Mizoguchi A, Podolsky DK.

Gastroenterology. 2008 Feb;134(2):470-80. doi: 10.1053/j.gastro.2007.11.055. Epub 2007 Dec 4.

PMID:
18242213
28.

Innate immunity in inflammatory bowel disease.

Yamamoto-Furusho JK, Podolsky DK.

World J Gastroenterol. 2007 Nov 14;13(42):5577-80. Review.

29.

AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.

Shibolet O, Giallourakis C, Rosenberg I, Mueller T, Xavier RJ, Podolsky DK.

J Biol Chem. 2007 Nov 30;282(48):35308-17. Epub 2007 Sep 18.

30.

Unravelling the pathogenesis of inflammatory bowel disease.

Xavier RJ, Podolsky DK.

Nature. 2007 Jul 26;448(7152):427-34. Review.

PMID:
17653185
31.

TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction.

Shibolet O, Podolsky DK.

Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1469-73. Review.

32.

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases.

De Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Vermeire S, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield GP, Dubois B, Cho JH, Brant SR, Duerr RH, Yang H, Rotter JI, Silverberg MS, Steinhart AH, Daly MJ, Podolsky DK, Louis E, Hafler DA, Rioux JD; Quebec IBD Genetics Consortium; NIDDK IBD Genetics Consortium.

Genes Immun. 2007 Jul;8(5):387-97. Epub 2007 May 31.

33.

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function.

Cario E, Gerken G, Podolsky DK.

Gastroenterology. 2007 Apr;132(4):1359-74. Epub 2007 Feb 25.

PMID:
17408640
34.

Toll-like receptor signaling and its relevance to intestinal inflammation.

Cario E, Podolsky DK.

Ann N Y Acad Sci. 2006 Aug;1072:332-8. Review.

PMID:
17057213
35.

Pride and prejudice: inflammatory bowel disease models and drug development.

Podolsky DK.

Curr Opin Gastroenterol. 2000 Jul;16(4):295-6. No abstract available.

PMID:
17031091
36.

Inflammatory bowel disease 1999: present and future promises.

Podolsky DK.

Curr Opin Gastroenterol. 1999 Jul;15(4):283-4. No abstract available.

PMID:
17023958
37.

Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation.

Yamamoto-Furusho JK, Barnich N, Xavier R, Hisamatsu T, Podolsky DK.

J Biol Chem. 2006 Nov 24;281(47):36060-70. Epub 2006 Sep 27.

38.

Th2 cytokines down-regulate TLR expression and function in human intestinal epithelial cells.

Mueller T, Terada T, Rosenberg IM, Shibolet O, Podolsky DK.

J Immunol. 2006 May 15;176(10):5805-14.

39.

Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance.

Cario E, Golenbock DT, Visintin A, Rünzi M, Gerken G, Podolsky DK.

J Immunol. 2006 Apr 1;176(7):4258-66.

40.

Case records of the Massachusetts General Hospital. Case 8-2006. A 71-year-old woman with Crohn's disease and altered mental status.

Podolsky DK, Gonzalez RG, Hasserjian RP.

N Engl J Med. 2006 Mar 16;354(11):1178-84. No abstract available.

PMID:
16540619
41.

Evolving knowledge and therapy of inflammatory bowel disease.

Korzenik JR, Podolsky DK.

Nat Rev Drug Discov. 2006 Mar;5(3):197-209. Review.

PMID:
16518373
42.

Selective use of selective nonsteroidal anti-inflammatory drugs in inflammatory bowel disease.

Korzenik JR, Podolsky DK.

Clin Gastroenterol Hepatol. 2006 Feb;4(2):157-9. No abstract available.

PMID:
16469674
43.
44.

The effect of prior colonic imaging on endoscopic productivity: potential impact of computed tomographic colonography.

Hur C, Gazelle GS, Hsu EH, Halpern EF, Podolsky DK.

Clin Gastroenterol Hepatol. 2005 Nov;3(11):1124-7.

PMID:
16271344
45.

Selective adhesion-molecule therapy and inflammatory bowel disease--a tale of Janus?

Podolsky DK.

N Engl J Med. 2005 Nov 3;353(18):1965-8. No abstract available.

PMID:
16267329
46.
47.
48.

Intestinal epithelial TOLLerance versus inTOLLerance of commensals.

Cario E, Podolsky DK.

Mol Immunol. 2005 May;42(8):887-93. Epub 2005 Jan 8. Review.

PMID:
15829278
49.

Commensal flora: wolf in sheep's clothing.

Xavier R, Podolsky DK.

Gastroenterology. 2005 Apr;128(4):1122-6. Review. No abstract available.

PMID:
15825094
50.

GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells.

Barnich N, Hisamatsu T, Aguirre JE, Xavier R, Reinecker HC, Podolsky DK.

J Biol Chem. 2005 May 13;280(19):19021-6. Epub 2005 Mar 7.

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