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Items: 35


Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.

Boehm J, Davis R, Murar CE, Li T, McCleland B, Dong S, Yan H, Kerns J, Moody CJ, Wilson AJ, Graves AP, Mentzer M, Qi H, Yonchuk J, Kou JP, Foley J, Sanchez Y, Podolin PL, Bolognese B, Booth-Genthe C, Galop M, Wolfe L, Carr R, Callahan JF.

Bioorg Med Chem. 2019 Feb 15;27(4):579-588. doi: 10.1016/j.bmc.2018.12.026. Epub 2018 Dec 21.


Circadian clock component REV-ERBĪ± controls homeostatic regulation of pulmonary inflammation.

Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW.

J Clin Invest. 2018 Jun 1;128(6):2281-2296. doi: 10.1172/JCI93910. Epub 2018 Apr 30.


Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress.

Yonchuk JG, Foley JP, Bolognese BJ, Logan G, Wixted WE, Kou JP, Chalupowicz DG, Feldser HG, Sanchez Y, Nie H, Callahan JF, Kerns JK, Podolin PL.

J Pharmacol Exp Ther. 2017 Oct;363(1):114-125. doi: 10.1124/jpet.117.241794. Epub 2017 Aug 8.


Hyperpolarized gas diffusion MRI of biphasic lung inflation in short- and long-term emphysema models.

Xin Y, Cereda M, Kadlecek S, Emami K, Hamedani H, Duncan I, Rajaei J, Hughes L, Meeder N, Naji J, Profka H, Bolognese BJ, Foley JP, Podolin PL, Rizi RR.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L305-L312. doi: 10.1152/ajplung.00048.2017. Epub 2017 May 4.


Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs.

Rumsey WL, Bolognese B, Davis AB, Flamberg PL, Foley JP, Katchur SR, Kotzer CJ, Osborn RR, Podolin PL.

Mutagenesis. 2017 May 1;32(3):343-353. doi: 10.1093/mutage/gew063.


Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.

Davies TG, Wixted WE, Coyle JE, Griffiths-Jones C, Hearn K, McMenamin R, Norton D, Rich SJ, Richardson C, Saxty G, Willems HM, Woolford AJ, Cottom JE, Kou JP, Yonchuk JG, Feldser HG, Sanchez Y, Foley JP, Bolognese BJ, Logan G, Podolin PL, Yan H, Callahan JF, Heightman TD, Kerns JK.

J Med Chem. 2016 Apr 28;59(8):3991-4006. doi: 10.1021/acs.jmedchem.6b00228. Epub 2016 Apr 12.


Klotho and smoking--An interplay influencing the skeletal muscle function deficits that occur in COPD.

Patel MS, Donaldson AV, Lewis A, Natanek SA, Lee JY, Andersson YM, Haji G, Jackson SG, Bolognese BJ, Foley JP, Podolin PL, Bruijnzeel PL, Hart N, Hopkinson NS, Man WD, Kemp PR, Polkey MI.

Respir Med. 2016 Apr;113:50-6. doi: 10.1016/j.rmed.2016.02.004. Epub 2016 Feb 15.


Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.

Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, Bottini N, Wicker LS.

J Immunol. 2015 Nov 15;195(10):4841-52. doi: 10.4049/jimmunol.1402654. Epub 2015 Oct 5.


Alveolar Macrophage Distribution in a Mouse Model: The Importance of the Fixation Method.

Wheeldon EB, Podolin PL, Mirabile RC.

Toxicol Pathol. 2015 Dec;43(8):1162-5. doi: 10.1177/0192623315600276. Epub 2015 Sep 8.


In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor.

Podolin PL, Bolognese BJ, Foley JF, Long E 3rd, Peck B, Umbrecht S, Zhang X, Zhu P, Schwartz B, Xie W, Quinn C, Qi H, Sweitzer S, Chen S, Galop M, Ding Y, Belyanskaya SL, Israel DI, Morgan BA, Behm DJ, Marino JP Jr, Kurali E, Barnette MS, Mayer RJ, Booth-Genthe CL, Callahan JF.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:25-31. doi: 10.1016/j.prostaglandins.2013.02.001. Epub 2013 Feb 19.


T cell depletion protects against alveolar destruction due to chronic cigarette smoke exposure in mice.

Podolin PL, Foley JP, Carpenter DC, Bolognese BJ, Logan GA, Long E 3rd, Harrison OJ, Walsh PT.

Am J Physiol Lung Cell Mol Physiol. 2013 Mar 1;304(5):L312-23. doi: 10.1152/ajplung.00152.2012. Epub 2013 Jan 4.


Regional function-structure relationships in lungs of an elastase murine model of emphysema.

Ishii M, Emami K, Xin Y, Barulic A, Kotzer CJ, Logan GA, Chia E, MacDuffie-Woodburn JP, Zhu J, Pickup S, Kuzma N, Kadlecek S, Podolin PL, Rizi RR.

J Appl Physiol (1985). 2012 Jan;112(1):135-48. doi: 10.1152/japplphysiol.01181.2010. Epub 2011 Sep 22.


Azepanone-based inhibitors of human cathepsin S: optimization of selectivity via the P2 substituent.

Kerns JK, Nie H, Bondinell W, Widdowson KL, Yamashita DS, Rahman A, Podolin PL, Carpenter DC, Jin Q, Riflade B, Dong X, Nevins N, Keller PM, Mitchell L, Tomaszek T.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4409-15. doi: 10.1016/j.bmcl.2011.06.045. Epub 2011 Jun 17.


The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity.

Davis TG, Peterson JJ, Kou JP, Capper-Spudich EA, Ball D, Nials AT, Wiseman J, Solanke YE, Lucas FS, Williamson RA, Ferrari L, Wren P, Knowles RG, Barnette MS, Podolin PL.

J Pharmacol Exp Ther. 2009 Sep;330(3):922-31. doi: 10.1124/jpet.109.152454. Epub 2009 Jun 4.


Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement.

Harrison OJ, Foley J, Bolognese BJ, Long E 3rd, Podolin PL, Walsh PT.

Immunol Lett. 2008 Nov 16;121(1):13-21. doi: 10.1016/j.imlet.2008.07.011. Epub 2008 Aug 13.


Inhibition of invariant chain processing, antigen-induced proliferative responses, and the development of collagen-induced arthritis and experimental autoimmune encephalomyelitis by a small molecule cysteine protease inhibitor.

Podolin PL, Bolognese BJ, Carpenter DC, Davis TG, Johanson RA, Fox JH, Long E 3rd, Dong X, Marquis RW, Locastro SM, Terfloth GJ, Kurali E, Peterson JJ, Smith BR, McQueney MS, Yamashita DS, Capper-Spudich EA.

J Immunol. 2008 Jun 15;180(12):7989-8003.


A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit.

Podolin PL, Bolognese BJ, Foley JJ, Schmidt DB, Buckley PT, Widdowson KL, Jin Q, White JR, Lee JM, Goodman RB, Hagen TR, Kajikawa O, Marshall LA, Hay DW, Sarau HM.

J Immunol. 2002 Dec 1;169(11):6435-44.


Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis.

Capper EA, Roshak AK, Bolognese BJ, Podolin PL, Smith T, Dewitt DL, Anderson KM, Marshall LA.

J Pharmacol Exp Ther. 2000 Dec;295(3):1061-9.


Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene?

Podolin PL, Wilusz MB, Cubbon RM, Pajvani U, Lord CJ, Todd JA, Peterson LB, Wicker LS, Lyons PA.

Cytokine. 2000 May;12(5):477-82.


Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3.

Podolin PL, Denny P, Armitage N, Lord CJ, Hill NJ, Levy ER, Peterson LB, Todd JA, Wicker LS, Lyons PA.

Mamm Genome. 1998 Apr;9(4):283-6.


Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.

Podolin PL, Denny P, Lord CJ, Hill NJ, Todd JA, Peterson LB, Wicker LS, Lyons PA.

J Immunol. 1997 Aug 15;159(4):1835-43.


Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.

Denny P, Lord CJ, Hill NJ, Goy JV, Levy ER, Podolin PL, Peterson LB, Wicker LS, Todd JA, Lyons PA.

Diabetes. 1997 Apr;46(4):695-700.


Ultraviolet regulation of neuroendocrine and circadian physiology in rodents.

Brainard GC, Barker FM, Hoffman RJ, Stetson MH, Hanifin JP, Podolin PL, Rollag MD.

Vision Res. 1994 Jun;34(11):1521-33.


Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes.

Wicker LS, Leiter EH, Todd JA, Renjilian RJ, Peterson E, Fischer PA, Podolin PL, Zijlstra M, Jaenisch R, Peterson LB.

Diabetes. 1994 Mar;43(3):500-4.


I-E+ nonobese diabetic mice develop insulitis and diabetes.

Podolin PL, Pressey A, DeLarato NH, Fischer PA, Peterson LB, Wicker LS.

J Exp Med. 1993 Sep 1;178(3):793-803.


Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.

Prins JB, Todd JA, Rodrigues NR, Ghosh S, Hogarth PM, Wicker LS, Gaffney E, Podolin PL, Fischer PA, Sirotina A, et al.

Science. 1993 Apr 30;260(5108):695-8.


Expression of intra-MHC transporter (Ham) genes and class I antigens in diabetes-susceptible NOD mice.

Wicker LS, Podolin PL, Fischer P, Sirotina A, Boltz RC Jr, Peterson LB.

Science. 1992 Jun 26;256(5065):1828-30; author reply 1830-1. No abstract available.


cDNA cloning and characterization of interleukin 2-induced genes in a cloned T helper lymphocyte.

Sabath DE, Podolin PL, Comber PG, Prystowsky MB.

J Biol Chem. 1990 Jul 25;265(21):12671-8.


The suppression of nocturnal pineal melatonin in the Syrian hamster: dose-response curves at 500 and 360 nm.

Podolin PL, Rollag MD, Brainard GC.

Endocrinology. 1987 Jul;121(1):266-70.


Neuroimmunology: modulation of the hamster immune system by photoperiod.

Brainard GC, Knobler RL, Podolin PL, Lavasa M, Lublin FD.

Life Sci. 1987 Mar 30;40(13):1319-26.


Near-ultraviolet radiation suppresses pineal melatonin content.

Brainard GC, Podolin PL, Leivy SW, Rollag MD, Cole C, Barker FM.

Endocrinology. 1986 Nov;119(5):2201-5.


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