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Items: 34


Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis.

Chen Y, Podojil JR, Kunjamma RB, Jones J, Weiner M, Lin W, Miller SD, Popko B.

Brain. 2019 Feb 1;142(2):344-361. doi: 10.1093/brain/awy322.


Overcoming challenges in treating autoimmuntity: Development of tolerogenic immune-modifying nanoparticles.

Pearson RM, Podojil JR, Shea LD, King NJC, Miller SD, Getts DR.

Nanomedicine. 2019 Jun;18:282-291. doi: 10.1016/j.nano.2018.10.001. Epub 2018 Oct 21. Review.


B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex.

Podojil JR, Chiang MY, Ifergan I, Copeland R, Liu LN, Maloveste S, Langermann S, Liebenson D, Balabanov R, Chi H, Chen L, Vignali DAA, Miller SD.

J Immunol. 2018 Aug 1;201(3):897-907. doi: 10.4049/jimmunol.1700811. Epub 2018 Jun 13.


Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy.

Xu D, Robinson AP, Ishii T, Duncan DS, Alden TD, Goings GE, Ifergan I, Podojil JR, Penaloza-MacMaster P, Kearney JA, Swanson GT, Miller SD, Koh S.

J Exp Med. 2018 Apr 2;215(4):1169-1186. doi: 10.1084/jem.20171285. Epub 2018 Feb 27.


APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response.

Glaser AP, Fantini D, Wang Y, Yu Y, Rimar KJ, Podojil JR, Miller SD, Meeks JJ.

Oncotarget. 2017 Dec 16;9(4):4537-4548. doi: 10.18632/oncotarget.23344. eCollection 2018 Jan 12.


ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.

Hecht I, Toporik A, Podojil JR, Vaknin I, Cojocaru G, Oren A, Aizman E, Liang SC, Leung L, Dicken Y, Novik A, Marbach-Bar N, Elmesmari A, Tange C, Gilmour A, McIntyre D, Kurowska-Stolarska M, McNamee K, Leitner J, Greenwald S, Dassa L, Levine Z, Steinberger P, Williams RO, Miller SD, McInnes IB, Neria E, Rotman G.

J Immunol. 2018 Mar 15;200(6):2025-2037. doi: 10.4049/jimmunol.1700325. Epub 2018 Feb 5.


ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance.

Podojil JR, Hecht I, Chiang MY, Vaknin I, Barbiro I, Novik A, Neria E, Rotman G, Miller SD.

J Immunol. 2018 Mar 15;200(6):2013-2024. doi: 10.4049/jimmunol.1700326. Epub 2018 Feb 5.


Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells.

Prasad S, Neef T, Xu D, Podojil JR, Getts DR, Shea LD, Miller SD.

J Autoimmun. 2018 May;89:112-124. doi: 10.1016/j.jaut.2017.12.010. Epub 2017 Dec 16.


Potential targeting of B7-H4 for the treatment of cancer.

Podojil JR, Miller SD.

Immunol Rev. 2017 Mar;276(1):40-51. doi: 10.1111/imr.12530. Review.


Cutting Edge: CD99 Is a Novel Therapeutic Target for Control of T Cell-Mediated Central Nervous System Autoimmune Disease.

Winger RC, Harp CT, Chiang MY, Sullivan DP, Watson RL, Weber EW, Podojil JR, Miller SD, Muller WA.

J Immunol. 2016 Feb 15;196(4):1443-8. doi: 10.4049/jimmunol.1501634. Epub 2016 Jan 15.


Oligodendrocyte death results in immune-mediated CNS demyelination.

Traka M, Podojil JR, McCarthy DP, Miller SD, Popko B.

Nat Neurosci. 2016 Jan;19(1):65-74. doi: 10.1038/nn.4193. Epub 2015 Dec 14.


ER Chaperone BiP/GRP78 Is Required for Myelinating Cell Survival and Provides Protection during Experimental Autoimmune Encephalomyelitis.

Hussien Y, Podojil JR, Robinson AP, Lee AS, Miller SD, Popko B.

J Neurosci. 2015 Dec 2;35(48):15921-33. doi: 10.1523/JNEUROSCI.0693-15.2015.


Pattern of CXCR7 Gene Expression in Mouse Brain Under Normal and Inflammatory Conditions.

Banisadr G, Podojil JR, Miller SD, Miller RJ.

J Neuroimmune Pharmacol. 2016 Mar;11(1):26-35. doi: 10.1007/s11481-015-9616-y. Epub 2015 May 22.


Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.

Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe KR, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ.

Nature. 2015 Jun 11;522(7555):216-20. doi: 10.1038/nature14335. Epub 2015 Apr 20.


Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic.

Way SW, Podojil JR, Clayton BL, Zaremba A, Collins TL, Kunjamma RB, Robinson AP, Brugarolas P, Miller RH, Miller SD, Popko B.

Nat Commun. 2015 Mar 13;6:6532. doi: 10.1038/ncomms7532.


Integrin/Chemokine receptor interactions in the pathogenesis of experimental autoimmune encephalomyelitis.

Banisadr G, Schwartz SR, Podojil JR, Piccinini LA, Lanker S, Miller SD, Miller RJ.

J Neuroimmune Pharmacol. 2014 Jun;9(3):438-45. doi: 10.1007/s11481-014-9521-9. Epub 2014 Jan 30.


B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms.

Podojil JR, Liu LN, Marshall SA, Chiang MY, Goings GE, Chen L, Langermann S, Miller SD.

J Autoimmun. 2013 Aug;44:71-81. doi: 10.1016/j.jaut.2013.04.001. Epub 2013 May 14.


Targeting the B7 family of co-stimulatory molecules: successes and challenges.

Podojil JR, Miller SD.

BioDrugs. 2013 Feb;27(1):1-13. doi: 10.1007/s40259-012-0001-6. Review.


Combination treatment of mice with CRx-153 (nortriptyline and desloratadine) decreases the severity of experimental autoimmune encephalomyelitis.

Podojil JR, Padval MV, Miller SD.

Cell Immunol. 2011;270(2):237-50. doi: 10.1016/j.cellimm.2011.05.015. Epub 2011 May 31.


Virus expanded regulatory T cells control disease severity in the Theiler's virus mouse model of MS.

Richards MH, Getts MT, Podojil JR, Jin YH, Kim BS, Miller SD.

J Autoimmun. 2011 Mar;36(2):142-54. doi: 10.1016/j.jaut.2010.12.005. Epub 2011 Jan 26.


A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination.

Traka M, Arasi K, Avila RL, Podojil JR, Christakos A, Miller SD, Soliven B, Popko B.

Brain. 2010 Oct;133(10):3017-29. doi: 10.1093/brain/awq247. Epub 2010 Sep 17.


TGF-beta-induced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis.

Zhang H, Podojil JR, Chang J, Luo X, Miller SD.

J Immunol. 2010 Jun 15;184(12):6629-36. doi: 10.4049/jimmunol.0904044. Epub 2010 May 7.


Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy.

Podojil JR, Miller SD.

Immunol Rev. 2009 May;229(1):337-55. doi: 10.1111/j.1600-065X.2009.00773.x. Review.


Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease.

Podojil JR, Turley DM, Miller SD.

Adv Exp Med Biol. 2008;640:234-51. doi: 10.1007/978-0-387-09789-3_18. Review.


Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease.

Miller SD, Turley DM, Podojil JR.

Nat Rev Immunol. 2007 Sep;7(9):665-77. Epub 2007 Aug 10. Review.


Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells.

Kohm AP, McMahon JS, Podojil JR, Begolka WS, DeGutes M, Kasprowicz DJ, Ziegler SF, Miller SD.

J Immunol. 2006 Mar 15;176(6):3301-5.


CD28 regulates glucocorticoid-induced TNF receptor family-related gene expression on CD4+ T cells via IL-2-dependent mechanisms.

Kohm AP, Podojil JR, Williams JS, McMahon JS, Miller SD.

Cell Immunol. 2005 May;235(1):56-64. Epub 2005 Aug 30.


CD86 and beta2-adrenergic receptor stimulation regulate B-cell activity cooperatively.

Podojil JR, Sanders VM.

Trends Immunol. 2005 Apr;26(4):180-5. Review.


Adaptive immunity in mice lacking the beta(2)-adrenergic receptor.

Sanders VM, Kasprowicz DJ, Swanson-Mungerson MA, Podojil JR, Kohm AP.

Brain Behav Immun. 2003 Feb;17(1):55-67.


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