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PODNL1 promotes cell migration and regulates the epithelial/mesenchymal transition process in bladder cancer.
Liu X, He Y, Tong Y, Huang Q, Shang H, Chen Z, Tang K. Liu X, et al. Biochem Biophys Res Commun. 2022 Sep 10;620:165-172. doi: 10.1016/j.bbrc.2022.06.094. Epub 2022 Jun 30. Biochem Biophys Res Commun. 2022. PMID: 35797736
In addition, PODNL1 knockdown decreased the proliferation and migration abilities of BLCA cells, while PODNL1 overexpression promoted the proliferation and migration abilities of BLCA cells. ...Thus, these results suggest that PODNL1 regulates EMT process. Ad …
In addition, PODNL1 knockdown decreased the proliferation and migration abilities of BLCA cells, while PODNL1 overexpression p …
Current Challenges and Opportunities in Treating Glioblastoma.
Shergalis A, Bankhead A 3rd, Luesakul U, Muangsin N, Neamati N. Shergalis A, et al. Pharmacol Rev. 2018 Jul;70(3):412-445. doi: 10.1124/pr.117.014944. Pharmacol Rev. 2018. PMID: 29669750 Free PMC article.
We discovered 20 genes, BOC, CLEC4GP1, ELOVL6, EREG, ESR2, FDCSP, FURIN, FUT8-AS1, GZMB, IRX3, LITAF, NDEL1, NKX3-1, PODNL1, PTPRN, QSOX1, SEMA4F, TH, VEGFC, and C20orf166AS1 that are overexpressed in a subpopulation of GBM patients and correlate with poor survival outcome …
We discovered 20 genes, BOC, CLEC4GP1, ELOVL6, EREG, ESR2, FDCSP, FURIN, FUT8-AS1, GZMB, IRX3, LITAF, NDEL1, NKX3-1, PODNL1, PTPRN, Q …
PODNL1 promotes cell proliferation and migration in glioma via regulating Akt/mTOR pathway.
Geng Y, Zuo P, Li XO, Zhang L. Geng Y, et al. J Cancer. 2020 Aug 27;11(21):6234-6242. doi: 10.7150/jca.46901. eCollection 2020. J Cancer. 2020. PMID: 33033506 Free PMC article.
Flow cytometry was utilized to assess the apoptotic rate. Results: The expression of PODNL1 predicted the poor prognosis in glioma patients. Silencing of PODNL1 inhibited cell proliferation, migration, and induced epithelial-like phenotype. In addition, knockdown of …
Flow cytometry was utilized to assess the apoptotic rate. Results: The expression of PODNL1 predicted the poor prognosis in glioma pa …
PODNL1 Methylation Serves as a Prognostic Biomarker and Associates with Immune Cell Infiltration and Immune Checkpoint Blockade Response in Lower-Grade Glioma.
Noor H, Zaman A, Teo C, Sughrue ME. Noor H, et al. Int J Mol Sci. 2021 Nov 22;22(22):12572. doi: 10.3390/ijms222212572. Int J Mol Sci. 2021. PMID: 34830454 Free PMC article.
High PODNL1 expression and low-methylation subgroups of the PODNL1 CpG sites were associated with significantly increased PD-L1, PD-1, and CTLA4 expressions. PODNL1 methylation may thus be a potential indicator of immune checkpoint blockade response, and serv …
High PODNL1 expression and low-methylation subgroups of the PODNL1 CpG sites were associated with significantly increased PD-L …
Small Leucine-Rich Proteoglycan PODNL1 Identified as a Potential Tumor Matrix-Mediated Biomarker for Prognosis and Immunotherapy in a Pan-Cancer Setting.
Dai G, Sun Y, Wei R, Xi L. Dai G, et al. Curr Issues Mol Biol. 2023 Jul 22;45(7):6116-6139. doi: 10.3390/cimb45070386. Curr Issues Mol Biol. 2023. PMID: 37504302 Free PMC article.
PODNL1 was significantly correlated with the poor prognosis and immunotherapeutic responses in various cancers. ...Additionally, the heterogeneity of cancer genotype-phenotype cross-talking was also observed associated with PODNL1. Our systematic study indicates tha …
PODNL1 was significantly correlated with the poor prognosis and immunotherapeutic responses in various cancers. ...Additionally, the …
Characterization of candidate factors associated with the metastasis and progression of high-grade serous ovarian cancer.
Liu H, Zhou L, Cheng H, Wang S, Luan W, Cai E, Ye X, Zhu H, Cui H, Li Y, Chang X. Liu H, et al. Chin Med J (Engl). 2023 Dec 20;136(24):2974-2982. doi: 10.1097/CM9.0000000000002328. Epub 2023 Jun 8. Chin Med J (Engl). 2023. PMID: 37284741 Free PMC article.
RESULTS: Fourteen DEGs, ADIPOQ , ALPK2 , BARX1 , CD37 , CNR2 , COL5A3 , FABP4 , FAP , GPR68 , ITGBL1 , MOXD1 , PODNL1 , SFRP2 , and TRAF3IP3 , were upregulated in metastatic tumors in every database while CADPS , GATA4 , STAR , and TSPAN8 were downregulated. ...
RESULTS: Fourteen DEGs, ADIPOQ , ALPK2 , BARX1 , CD37 , CNR2 , COL5A3 , FABP4 , FAP , GPR68 , ITGBL1 , MOXD1 , PODNL1 , SFRP2 , and T …
Identification of a myofibroblast-specific expression signature in skin wounds.
Bergmeier V, Etich J, Pitzler L, Frie C, Koch M, Fischer M, Rappl G, Abken H, Tomasek JJ, Brachvogel B. Bergmeier V, et al. Matrix Biol. 2018 Jan;65:59-74. doi: 10.1016/j.matbio.2017.07.005. Epub 2017 Aug 7. Matrix Biol. 2018. PMID: 28797711
A unique panel of core matrisome and matrisome-associated genes was differentially expressed in myofibroblasts and several genes not yet known to be linked to myofibroblast-mediated wound healing were found (e.g. Col24a1, Podnl1, Bvcan, Tinagl1, Thbs3, Adamts16, Adamts19, …
A unique panel of core matrisome and matrisome-associated genes was differentially expressed in myofibroblasts and several genes not yet kno …
Reboot: a straightforward approach to identify genes and splicing isoforms associated with cancer patient prognosis.
Dos Santos FRC, Guardia GDA, Dos Santos FF, Ohara DT, Galante PAF. Dos Santos FRC, et al. NAR Cancer. 2021 Jun 15;3(2):zcab024. doi: 10.1093/narcan/zcab024. eCollection 2021 Jun. NAR Cancer. 2021. PMID: 34316711 Free PMC article.
Applying Reboot on data from 154 glioblastoma patients, we identified a three-gene signature (IKBIP, OSMR, PODNL1) whose increased derived risk score was significantly associated with worse patients' prognosis. ...
Applying Reboot on data from 154 glioblastoma patients, we identified a three-gene signature (IKBIP, OSMR, PODNL1) whose increased de …