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Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' résumé.

Krmpotić A, Podlech J, Reddehase MJ, Britt WJ, Jonjić S.

Med Microbiol Immunol. 2019 Aug;208(3-4):415-429. doi: 10.1007/s00430-019-00600-1. Epub 2019 Mar 28. Review.


Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells.

Reuter S, Lemmermann NAW, Maxeiner J, Podlech J, Beckert H, Freitag K, Teschner D, Ries F, Taube C, Buhl R, Reddehase MJ, Holtappels R.

PLoS Pathog. 2019 Mar 7;15(3):e1007595. doi: 10.1371/journal.ppat.1007595. eCollection 2019 Mar.


Stereoelectronic Effects: The γ-Gauche Effect in Sulfoxides.

Jung S, Podlech J.

J Phys Chem A. 2018 Jul 5;122(26):5764-5772. doi: 10.1021/acs.jpca.8b03729. Epub 2018 Jun 22.


Tracking emerging mycotoxins in food: development of an LC-MS/MS method for free and modified Alternaria toxins.

Puntscher H, Kütt ML, Skrinjar P, Mikula H, Podlech J, Fröhlich J, Marko D, Warth B.

Anal Bioanal Chem. 2018 Jul;410(18):4481-4494. doi: 10.1007/s00216-018-1105-8. Epub 2018 May 16.


The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.

Chan B, Gonçalves Magalhães V, Lemmermann NAW, Juranić Lisnić V, Stempel M, Bussey KA, Reimer E, Podlech J, Lienenklaus S, Reddehase MJ, Jonjić S, Brinkmann MM.

PLoS Pathog. 2017 May 25;13(5):e1006382. doi: 10.1371/journal.ppat.1006382. eCollection 2017 May.


IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection.

Popovic B, Golemac M, Podlech J, Zeleznjak J, Bilic-Zulle L, Lukic ML, Cicin-Sain L, Reddehase MJ, Sparwasser T, Krmpotic A, Jonjic S.

PLoS Pathog. 2017 Apr 27;13(4):e1006345. doi: 10.1371/journal.ppat.1006345. eCollection 2017 Apr.


Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion.

Chopra M, Biehl M, Steinfatt T, Brandl A, Kums J, Amich J, Vaeth M, Kuen J, Holtappels R, Podlech J, Mottok A, Kraus S, Jordán-Garrote AL, Bäuerlein CA, Brede C, Ribechini E, Fick A, Seher A, Polz J, Ottmüller KJ, Baker J, Nishikii H, Ritz M, Mattenheimer K, Schwinn S, Winter T, Schäfer V, Krappmann S, Einsele H, Müller TD, Reddehase MJ, Lutz MB, Männel DN, Berberich-Siebelt F, Wajant H, Beilhack A.

J Exp Med. 2016 Aug 22;213(9):1881-900. doi: 10.1084/jem.20151563. Epub 2016 Aug 15.


Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance.

Holtappels R, Lemmermann NA, Podlech J, Ebert S, Reddehase MJ.

Front Immunol. 2016 Jun 14;7:232. doi: 10.3389/fimmu.2016.00232. eCollection 2016.


Non-cognate bystander cytolysis by clonal epitope-specific CTL lines through CD28-CD80 interaction inhibits antibody production: A potential caveat to CD8 T-cell immunotherapy.

Holtappels R, Podlech J, Lemmermann NA, Schmitt E, Reddehase MJ.

Cell Immunol. 2016 Oct;308:44-56. doi: 10.1016/j.cellimm.2015.12.004. Epub 2015 Dec 17.


Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice.

Thomas S, Klobuch S, Podlech J, Plachter B, Hoffmann P, Renzaho A, Theobald M, Reddehase MJ, Herr W, Lemmermann NA.

PLoS Pathog. 2015 Jul 16;11(7):e1005049. doi: 10.1371/journal.ppat.1005049. eCollection 2015 Jul.


Mechanism of tumor remission by cytomegalovirus in a murine lymphoma model: evidence for involvement of virally induced cellular interleukin-15.

Erlach KC, Reddehase MJ, Podlech J.

Med Microbiol Immunol. 2015 Jun;204(3):355-66. doi: 10.1007/s00430-015-0408-z. Epub 2015 Mar 25.


Principles for studying in vivo attenuation of virus mutants: defining the role of the cytomegalovirus gH/gL/gO complex as a paradigm.

Podlech J, Reddehase MJ, Adler B, Lemmermann NA.

Med Microbiol Immunol. 2015 Jun;204(3):295-305. doi: 10.1007/s00430-015-0405-2. Epub 2015 Mar 18. Review.


Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.

Lemmermann NA, Krmpotic A, Podlech J, Brizic I, Prager A, Adler H, Karbach A, Wu Y, Jonjic S, Reddehase MJ, Adler B.

PLoS Pathog. 2015 Feb 6;11(2):e1004640. doi: 10.1371/journal.ppat.1004640. eCollection 2015 Feb.


Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection.

Podlech J, Ebert S, Becker M, Reddehase MJ, Stassen M, Lemmermann NA.

Med Microbiol Immunol. 2015 Jun;204(3):327-34. doi: 10.1007/s00430-015-0386-1. Epub 2015 Feb 4. Review.


Mast cells as rapid innate sensors of cytomegalovirus by TLR3/TRIF signaling-dependent and -independent mechanisms.

Becker M, Lemmermann NA, Ebert S, Baars P, Renzaho A, Podlech J, Stassen M, Reddehase MJ.

Cell Mol Immunol. 2015 Mar;12(2):192-201. doi: 10.1038/cmi.2014.73. Epub 2014 Aug 25.


Determination of the absolute configuration of perylene quinone-derived mycotoxins by measurement and calculation of electronic circular dichroism spectra and specific rotations.

Podlech J, Fleck SC, Metzler M, Bürck J, Ulrich AS.

Chemistry. 2014 Sep 1;20(36):11463-70. doi: 10.1002/chem.201402567. Epub 2014 Jul 23.


Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs.

Ebert S, Becker M, Lemmermann NA, Büttner JK, Michel A, Taube C, Podlech J, Böhm V, Freitag K, Thomas D, Holtappels R, Reddehase MJ, Stassen M.

PLoS Pathog. 2014 Apr 24;10(4):e1004100. doi: 10.1371/journal.ppat.1004100. eCollection 2014 Apr.


Epoxide reduction to an alcohol: a novel metabolic pathway for perylene quinone-type alternaria mycotoxins in mammalian cells.

Fleck SC, Pfeiffer E, Podlech J, Metzler M.

Chem Res Toxicol. 2014 Feb 17;27(2):247-53. doi: 10.1021/tx400366w. Epub 2014 Jan 27.


A Lewis acid-promoted Pinner reaction.

Pfaff D, Nemecek G, Podlech J.

Beilstein J Org Chem. 2013 Aug 2;9:1572-7. doi: 10.3762/bjoc.9.179. eCollection 2013.


The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex.

Wagner FM, Brizic I, Prager A, Trsan T, Arapovic M, Lemmermann NA, Podlech J, Reddehase MJ, Lemnitzer F, Bosse JB, Gimpfl M, Marcinowski L, MacDonald M, Adler H, Koszinowski UH, Adler B.

PLoS Pathog. 2013;9(7):e1003493. doi: 10.1371/journal.ppat.1003493. Epub 2013 Jul 25.


Structure confirmation of altertenuol.

Thomas R, Nemecek G, Podlech J.

Nat Prod Res. 2013;27(21):2053-4. doi: 10.1080/14786419.2013.819509. Epub 2013 Jul 23.


Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection.

Ebert S, Podlech J, Gillert-Marien D, Gergely KM, Büttner JK, Fink A, Freitag K, Thomas D, Reddehase MJ, Holtappels R.

Med Microbiol Immunol. 2012 Nov;201(4):527-39. doi: 10.1007/s00430-012-0258-x. Epub 2012 Sep 13. Review.


Murine cytomegalovirus immune evasion proteins operative in the MHC class I pathway of antigen processing and presentation: state of knowledge, revisions, and questions.

Lemmermann NA, Fink A, Podlech J, Ebert S, Wilhelmi V, Böhm V, Holtappels R, Reddehase MJ.

Med Microbiol Immunol. 2012 Nov;201(4):497-512. doi: 10.1007/s00430-012-0257-y. Epub 2012 Sep 9. Review.


Identification of a polyketide synthase required for alternariol (AOH) and alternariol-9-methyl ether (AME) formation in Alternaria alternata.

Saha D, Fetzner R, Burkhardt B, Podlech J, Metzler M, Dang H, Lawrence C, Fischer R.

PLoS One. 2012;7(7):e40564. doi: 10.1371/journal.pone.0040564. Epub 2012 Jul 6.


Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.

Sacher T, Andrassy J, Kalnins A, Dölken L, Jordan S, Podlech J, Ruzsics Z, Jauch KW, Reddehase MJ, Koszinowski UH.

PLoS Pathog. 2011 Nov;7(11):e1002366. doi: 10.1371/journal.ppat.1002366. Epub 2011 Nov 17.


Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency.

Seckert CK, Schader SI, Ebert S, Thomas D, Freitag K, Renzaho A, Podlech J, Reddehase MJ, Holtappels R.

J Gen Virol. 2011 Sep;92(Pt 9):1994-2005. doi: 10.1099/vir.0.031815-0. Epub 2011 Jun 1.


"Try and fall sick .."-the composer, chemist, and surgeon Aleksandr Borodin.

Podlech J.

Angew Chem Int Ed Engl. 2010 Sep 3;49(37):6490-5. doi: 10.1002/anie.201002023. No abstract available.


Stereoelectronic effects in alpha-carbanions of conformationally constrained sulfides, sulfoxides, and sulfones.

Podlech J.

J Phys Chem A. 2010 Aug 19;114(32):8480-7. doi: 10.1021/jp1063758.


Optimized recombinant dense bodies of human cytomegalovirus efficiently prime virus specific lymphocytes and neutralizing antibodies without the addition of adjuvant.

Becke S, Aue S, Thomas D, Schader S, Podlech J, Bopp T, Sedmak T, Wolfrum U, Plachter B, Reyda S.

Vaccine. 2010 Aug 31;28(38):6191-8. doi: 10.1016/j.vaccine.2010.07.016. Epub 2010 Jul 23.


Enhancerless cytomegalovirus is capable of establishing a low-level maintenance infection in severely immunodeficient host tissues but fails in exponential growth.

Podlech J, Pintea R, Kropp KA, Fink A, Lemmermann NA, Erlach KC, Isern E, Angulo A, Ghazal P, Reddehase MJ.

J Virol. 2010 Jun;84(12):6254-61. doi: 10.1128/JVI.00419-10. Epub 2010 Apr 7.


Stereoelectronic effects in vinyl sulfoxides.

Ulshöfer R, Podlech J.

J Am Chem Soc. 2009 Nov 25;131(46):16618-9. doi: 10.1021/ja904354g.


Total synthesis of dehydroaltenuene A. Revision of the structure and total synthesis of dihydroaltenuene B.

Altemöller M, Podlech J.

J Nat Prod. 2009 Jul;72(7):1288-90. doi: 10.1021/np900265q.


Synergism between the components of the bipartite major immediate-early transcriptional enhancer of murine cytomegalovirus does not accelerate virus replication in cell culture and host tissues.

Kropp KA, Simon CO, Fink A, Renzaho A, Kühnapfel B, Podlech J, Reddehase MJ, Grzimek NK.

J Gen Virol. 2009 Oct;90(Pt 10):2395-401. doi: 10.1099/vir.0.012245-0. Epub 2009 Jun 24.


Glucuronidation of the mycotoxins alternariol and alternariol-9-methyl ether in vitro: chemical structures of glucuronides and activities of human UDP-glucuronosyltransferase isoforms.

Pfeiffer E, Schmit C, Burkhardt B, Altemöller M, Podlech J, Metzler M.

Mycotoxin Res. 2009 Mar;25(1):3-10. doi: 10.1007/s12550-008-0001-z. Epub 2008 Dec 23.


Oxidative in vitro metabolism of the Alternaria toxins altenuene and isoaltenuene.

Pfeiffer E, Herrmann C, Altemöller M, Podlech J, Metzler M.

Mol Nutr Food Res. 2009 Apr;53(4):452-9. doi: 10.1002/mnfr.200700501.


The immune evasion paradox: immunoevasins of murine cytomegalovirus enhance priming of CD8 T cells by preventing negative feedback regulation.

Böhm V, Simon CO, Podlech J, Seckert CK, Gendig D, Deegen P, Gillert-Marien D, Lemmermann NA, Holtappels R, Reddehase MJ.

J Virol. 2008 Dec;82(23):11637-50. doi: 10.1128/JVI.01510-08. Epub 2008 Sep 24.


Activities of human recombinant cytochrome P450 isoforms and human hepatic microsomes for the hydroxylation ofAlternaria toxins.

Pfeiffer E, Burkhardt B, Altemöller M, Podlech J, Metzler M.

Mycotoxin Res. 2008 Sep;24(3):117-23. doi: 10.1007/BF03032337.


Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform.

Fehr M, Pahlke G, Fritz J, Christensen MO, Boege F, Altemöller M, Podlech J, Marko D.

Mol Nutr Food Res. 2009 Apr;53(4):441-51. doi: 10.1002/mnfr.200700379.


Transactivation of cellular genes involved in nucleotide metabolism by the regulatory IE1 protein of murine cytomegalovirus is not critical for viral replicative fitness in quiescent cells and host tissues.

Wilhelmi V, Simon CO, Podlech J, Böhm V, Däubner T, Emde S, Strand D, Renzaho A, Lemmermann NA, Seckert CK, Reddehase MJ, Grzimek NK.

J Virol. 2008 Oct;82(20):9900-16. doi: 10.1128/JVI.00928-08. Epub 2008 Aug 6.


The major virus-producing cell type during murine cytomegalovirus infection, the hepatocyte, is not the source of virus dissemination in the host.

Sacher T, Podlech J, Mohr CA, Jordan S, Ruzsics Z, Reddehase MJ, Koszinowski UH.

Cell Host Microbe. 2008 Apr 17;3(4):263-72. doi: 10.1016/j.chom.2008.02.014.


Nucleophilic additions to alkylidene bis(sulfoxides): stereoelectronic effects in vinyl sulfoxides.

Wedel T, Gehring T, Podlech J, Kordel E, Bihlmeier A, Klopper W.

Chemistry. 2008;14(15):4631-9. doi: 10.1002/chem.200701847.


Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination.

Holtappels R, Simon CO, Munks MW, Thomas D, Deegen P, Kühnapfel B, Däubner T, Emde SF, Podlech J, Grzimek NK, Oehrlein-Karpi SA, Hill AB, Reddehase MJ.

J Virol. 2008 Jun;82(12):5781-96. doi: 10.1128/JVI.00155-08. Epub 2008 Mar 26.


Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues.

Wirtz N, Schader SI, Holtappels R, Simon CO, Lemmermann NA, Reddehase MJ, Podlech J.

Med Microbiol Immunol. 2008 Jun;197(2):151-8. doi: 10.1007/s00430-008-0095-0. Epub 2008 Mar 26.


CD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model.

Holtappels R, Böhm V, Podlech J, Reddehase MJ.

Med Microbiol Immunol. 2008 Jun;197(2):125-34. doi: 10.1007/s00430-008-0093-2. Epub 2008 Mar 15. Review.


Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy.

Böhm V, Podlech J, Thomas D, Deegen P, Pahl-Seibert MF, Lemmermann NA, Grzimek NK, Oehrlein-Karpi SA, Reddehase MJ, Holtappels R.

Med Microbiol Immunol. 2008 Jun;197(2):135-44. doi: 10.1007/s00430-008-0092-3. Epub 2008 Mar 14.


Activation of hepatic natural killer cells and control of liver-adapted lymphoma in the murine model of cytomegalovirus infection.

Erlach KC, Böhm V, Knabe M, Deegen P, Reddehase MJ, Podlech J.

Med Microbiol Immunol. 2008 Jun;197(2):167-78. doi: 10.1007/s00430-008-0084-3. Epub 2008 Feb 29. Review.


Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an antiapoptotic viral gene.

Cicin-Sain L, Ruzsics Z, Podlech J, Bubić I, Menard C, Jonjić S, Reddehase MJ, Koszinowski UH.

J Virol. 2008 Mar;82(5):2056-64. Epub 2007 Dec 19.


Novel oxidative in vitro metabolites of the mycotoxins alternariol and alternariol methyl ether.

Pfeiffer E, Schebb NH, Podlech J, Metzler M.

Mol Nutr Food Res. 2007 Mar;51(3):307-16.


Stereoelectronic effects in cyclic sulfoxides, sulfones, and sulfilimines: application of the Perlin effect to conformational analysis.

Wedel T, Müller M, Podlech J, Goesmann H, Feldmann C.

Chemistry. 2007;13(15):4273-81.


CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation.

Simon CO, Holtappels R, Tervo HM, Böhm V, Däubner T, Oehrlein-Karpi SA, Kühnapfel B, Renzaho A, Strand D, Podlech J, Reddehase MJ, Grzimek NK.

J Virol. 2006 Nov;80(21):10436-56. Epub 2006 Aug 23.

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