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TRPV4 deletion protects against hypokalemia during systemic K+ deficiency.

Tomilin V, Mamenko M, Zaika O, Wingo CS, Pochynyuk O.

Am J Physiol Renal Physiol. 2019 May 1;316(5):F948-F956. doi: 10.1152/ajprenal.00043.2019. Epub 2019 Mar 6.


Urinary concentrating defect in mice lacking Epac1 or Epac2.

Cherezova A, Tomilin V, Buncha V, Zaika O, Ortiz PA, Mei F, Cheng X, Mamenko M, Pochynyuk O.

FASEB J. 2019 Feb;33(2):2156-2170. doi: 10.1096/fj.201800435R. Epub 2018 Sep 25.


Distal tubule basolateral potassium channels: cellular and molecular mechanisms of regulation.

Palygin O, Pochynyuk O, Staruschenko A.

Curr Opin Nephrol Hypertens. 2018 Sep;27(5):373-378. doi: 10.1097/MNH.0000000000000437. Review.


Compromised regulation of the collecting duct ENaC activity in mice lacking AT1a receptor.

Mamenko M, Zaika O, Tomilin V, Jensen VB, Pochynyuk O.

J Cell Physiol. 2018 Sep;233(9):7217-7225. doi: 10.1002/jcp.26552. Epub 2018 Mar 25.


Deficient transient receptor potential vanilloid type 4 function contributes to compromised [Ca2+]i homeostasis in human autosomal-dominant polycystic kidney disease cells.

Tomilin V, Reif GA, Zaika O, Wallace DP, Pochynyuk O.

FASEB J. 2018 Aug;32(8):4612-4623. doi: 10.1096/fj.201701535RR. Epub 2018 Mar 19.


Dietary K+ and Cl- independently regulate basolateral conductance in principal and intercalated cells of the collecting duct.

Tomilin VN, Zaika O, Subramanya AR, Pochynyuk O.

Pflugers Arch. 2018 Feb;470(2):339-353. doi: 10.1007/s00424-017-2084-x. Epub 2017 Nov 13.


Essential role of Kir5.1 channels in renal salt handling and blood pressure control.

Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A.

JCI Insight. 2017 Sep 21;2(18). pii: 92331. doi: 10.1172/jci.insight.92331. eCollection 2017 Sep 21.


Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice.

Prieto MC, Reverte V, Mamenko M, Kuczeriszka M, Veiras LC, Rosales CB, McLellan M, Gentile O, Jensen VB, Ichihara A, McDonough AA, Pochynyuk OM, Gonzalez AA.

Am J Physiol Renal Physiol. 2017 Dec 1;313(6):F1243-F1253. doi: 10.1152/ajprenal.00152.2017. Epub 2017 Aug 16.


The renal TRPV4 channel is essential for adaptation to increased dietary potassium.

Mamenko MV, Boukelmoune N, Tomilin VN, Zaika OL, Jensen VB, O'Neil RG, Pochynyuk OM.

Kidney Int. 2017 Jun;91(6):1398-1409. doi: 10.1016/j.kint.2016.12.010. Epub 2017 Feb 7.


The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate.

Mistry AC, Wynne BM, Yu L, Tomilin V, Yue Q, Zhou Y, Al-Khalili O, Mallick R, Cai H, Alli AA, Ko B, Mattheyses A, Bao HF, Pochynyuk O, Theilig F, Eaton DC, Hoover RS.

Biochem J. 2016 Oct 1;473(19):3237-52. doi: 10.1042/BCJ20160312. Epub 2016 Jul 15.


Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction.

Hu X, Adebiyi MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, Karmouty-Quintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko M, Pochynyuk OM, Kellems RE, Eltzschig HK, Blackburn MR, Walters ET, Huang D, Hu H, Xia Y.

Cell Rep. 2016 Jun 28;16(1):106-119. doi: 10.1016/j.celrep.2016.05.080. Epub 2016 Jun 16.


Correction: Emerging Role of the Calcium-Activated, Small Conductance, SK3 K+ Channel in Distal Tubule Function: Regulation by TRPV4.

Berrout J, Mamenko M, Zaika OL, Chen L, Zhang W, Pochynyuk O, O'Neil RG.

PLoS One. 2016 May 19;11(5):e0156368. doi: 10.1371/journal.pone.0156368. eCollection 2016.


Role and mechanisms of regulation of the basolateral Kir 4.1/Kir 5.1K+ channels in the distal tubules.

Palygin O, Pochynyuk O, Staruschenko A.

Acta Physiol (Oxf). 2017 Jan;219(1):260-273. doi: 10.1111/apha.12703. Epub 2016 May 20. Review.


New perspective of ClC-Kb/2 Cl- channel physiology in the distal renal tubule.

Zaika O, Tomilin V, Mamenko M, Bhalla V, Pochynyuk O.

Am J Physiol Renal Physiol. 2016 May 15;310(10):F923-30. doi: 10.1152/ajprenal.00577.2015. Epub 2016 Jan 20. Review.


Insulin and IGF-1 activate Kir4.1/5.1 channels in cortical collecting duct principal cells to control basolateral membrane voltage.

Zaika O, Palygin O, Tomilin V, Mamenko M, Staruschenko A, Pochynyuk O.

Am J Physiol Renal Physiol. 2016 Feb 15;310(4):F311-21. doi: 10.1152/ajprenal.00436.2015. Epub 2015 Dec 2.


PTH modulation of NCC activity regulates TRPV5 Ca2+ reabsorption.

Hoover RS, Tomilin V, Hanson L, Pochynyuk O, Ko B.

Am J Physiol Renal Physiol. 2016 Jan 15;310(2):F144-51. doi: 10.1152/ajprenal.00323.2015. Epub 2015 Nov 25.


Defective Store-Operated Calcium Entry Causes Partial Nephrogenic Diabetes Insipidus.

Mamenko M, Dhande I, Tomilin V, Zaika O, Boukelmoune N, Zhu Y, Gonzalez-Garay ML, Pochynyuk O, Doris PA.

J Am Soc Nephrol. 2016 Jul;27(7):2035-48. doi: 10.1681/ASN.2014121200. Epub 2015 Nov 16.


S&R Foundation 15th Anniversary.

Staruschenko A, Weber CR, Pochynyuk O, McCole DF.

Physiologist. 2015 Sep;58(5):241-2. No abstract available.


Role of renal TRP channels in physiology and pathology.

Tomilin V, Mamenko M, Zaika O, Pochynyuk O.

Semin Immunopathol. 2016 May;38(3):371-83. doi: 10.1007/s00281-015-0527-z. Epub 2015 Sep 18. Review.


Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium.

Pavlov TS, Ilatovskaya DV, Palygin O, Levchenko V, Pochynyuk O, Staruschenko A.

J Vis Exp. 2015 Sep 1;(103). doi: 10.3791/53035.


Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin.

Mamenko M, Zaika O, Boukelmoune N, Madden E, Pochynyuk O.

Vitam Horm. 2015;98:137-54. doi: 10.1016/bs.vh.2014.12.005. Epub 2015 Feb 14. Review.


Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron.

Mamenko M, Zaika O, Boukelmoune N, O'Neil RG, Pochynyuk O.

Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F275-86. doi: 10.1152/ajprenal.00485.2014. Epub 2014 Dec 10. Review.


IGF-1 and insulin exert opposite actions on ClC-K2 activity in the cortical collecting ducts.

Zaika O, Mamenko M, Boukelmoune N, Pochynyuk O.

Am J Physiol Renal Physiol. 2015 Jan 1;308(1):F39-48. doi: 10.1152/ajprenal.00545.2014. Epub 2014 Oct 22.


Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4.

Berrout J, Mamenko M, Zaika OL, Chen L, Zhang W, Pochynyuk O, O'Neil RG.

PLoS One. 2014 Apr 24;9(4):e95149. doi: 10.1371/journal.pone.0095149. eCollection 2014. Erratum in: PLoS One. 2016;11(5):e0156368.


Direct regulation of ENaC by bradykinin in the distal nephron. Implications for renal sodium handling.

Mamenko M, Zaika O, Pochynyuk O.

Curr Opin Nephrol Hypertens. 2014 Mar;23(2):122-9. doi: 10.1097/01.mnh.0000441053.81339.61. Review.


Chronic angiotensin II infusion drives extensive aldosterone-independent epithelial Na+ channel activation.

Mamenko M, Zaika O, Prieto MC, Jensen VB, Doris PA, Navar LG, Pochynyuk O.

Hypertension. 2013 Dec;62(6):1111-1122. doi: 10.1161/HYPERTENSIONAHA.113.01797. Epub 2013 Sep 23.


Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine.

Zaika OL, Mamenko M, Palygin O, Boukelmoune N, Staruschenko A, Pochynyuk O.

Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1277-87. doi: 10.1152/ajprenal.00363.2013. Epub 2013 Aug 28.


Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C.

Mamenko M, Zaika OL, Boukelmoune N, Berrout J, O'Neil RG, Pochynyuk O.

J Biol Chem. 2013 Jul 12;288(28):20306-14. doi: 10.1074/jbc.M113.466797. Epub 2013 May 24.


Ca2+ Imaging as a tool to assess TRP channel function in murine distal nephrons.

Mamenko M, Zaika O, O'Neil RG, Pochynyuk O.

Methods Mol Biol. 2013;998:371-84. doi: 10.1007/978-1-62703-351-0_29.


Recording ion channels in isolated, split-opened tubules.

Mironova E, Bugay V, Pochynyuk O, Staruschenko A, Stockand JD.

Methods Mol Biol. 2013;998:341-53. doi: 10.1007/978-1-62703-351-0_27.


Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.

Kakoki M, Pochynyuk OM, Hathaway CM, Tomita H, Hagaman JR, Kim HS, Zaika OL, Mamenko M, Kayashima Y, Matsuki K, Hiller S, Li F, Xu L, Grant R, Bertorello AM, Smithies O.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5600-5. doi: 10.1073/pnas.1302641110. Epub 2013 Mar 15.


TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease.

Zaika O, Mamenko M, Berrout J, Boukelmoune N, O'Neil RG, Pochynyuk O.

J Am Soc Nephrol. 2013 Mar;24(4):604-16. doi: 10.1681/ASN.2012050442. Epub 2013 Feb 14.


Novel insights into TRPV4 function in the kidney.

Pochynyuk O, Zaika O, O'Neil RG, Mamenko M.

Pflugers Arch. 2013 Feb;465(2):177-86. doi: 10.1007/s00424-012-1190-z. Epub 2012 Dec 4. Review.


Direct activation of ENaC by angiotensin II: recent advances and new insights.

Zaika O, Mamenko M, Staruschenko A, Pochynyuk O.

Curr Hypertens Rep. 2013 Feb;15(1):17-24. doi: 10.1007/s11906-012-0316-1. Review.


Salt-dependent inhibition of epithelial Na+ channel-mediated sodium reabsorption in the aldosterone-sensitive distal nephron by bradykinin.

Mamenko M, Zaika O, Doris PA, Pochynyuk O.

Hypertension. 2012 Nov;60(5):1234-41. doi: 10.1161/HYPERTENSIONAHA.112.200469. Epub 2012 Oct 1.


Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system.

Berrout J, Jin M, Mamenko M, Zaika O, Pochynyuk O, O'Neil RG.

J Biol Chem. 2012 Mar 16;287(12):8782-91. doi: 10.1074/jbc.M111.308411. Epub 2012 Feb 1.


Angiotensin II increases activity of the epithelial Na+ channel (ENaC) in distal nephron additively to aldosterone.

Mamenko M, Zaika O, Ilatovskaya DV, Staruschenko A, Pochynyuk O.

J Biol Chem. 2012 Jan 2;287(1):660-71. doi: 10.1074/jbc.M111.298919. Epub 2011 Nov 15.


Role of collecting duct AT1a receptors in concentrating urine.

Pochynyuk O, Stockand JD.

J Am Soc Nephrol. 2011 Dec;22(12):2144-5. doi: 10.1681/ASN.2011100960. Epub 2011 Oct 27. No abstract available.


Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron.

Mamenko M, Zaika O, Jin M, O'Neil RG, Pochynyuk O.

PLoS One. 2011;6(8):e22824. doi: 10.1371/journal.pone.0022824. Epub 2011 Aug 5.


Af17 deficiency increases sodium excretion and decreases blood pressure.

Chen L, Wu H, Pochynyuk OM, Reisenauer MR, Zhang Z, Huang L, Zaika OL, Mamenko M, Zhang W, Zhou Q, Liu M, Xia Y, Zhang W.

J Am Soc Nephrol. 2011 Jun;22(6):1076-86. doi: 10.1681/ASN.2010121270. Epub 2011 May 5.


Voltage-dependent gating underlies loss of ENaC function in Pseudohypoaldosteronism type 1.

Kucher V, Boiko N, Pochynyuk O, Stockand JD.

Biophys J. 2011 Apr 20;100(8):1930-9. doi: 10.1016/j.bpj.2011.02.046.


Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron.

Zaika O, Mamenko M, O'Neil RG, Pochynyuk O.

Am J Physiol Renal Physiol. 2011 May;300(5):F1105-15. doi: 10.1152/ajprenal.00606.2010. Epub 2011 Feb 16.


Acute cholesterol-induced anti-natriuretic effects: role of epithelial Na+ channel activity, protein levels, and processing.

Awayda MS, Awayda KL, Pochynyuk O, Bugaj V, Stockand JD, Ortiz RM.

J Biol Chem. 2011 Jan 21;286(3):1683-95. doi: 10.1074/jbc.M110.159194. Epub 2010 Nov 1.


Purinergic inhibition of ENaC produces aldosterone escape.

Stockand JD, Mironova E, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyuk O.

J Am Soc Nephrol. 2010 Nov;21(11):1903-11. doi: 10.1681/ASN.2010040377. Epub 2010 Sep 2.


Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2.

Pavlov TS, Chahdi A, Ilatovskaya DV, Levchenko V, Vandewalle A, Pochynyuk O, Sorokin A, Staruschenko A.

J Am Soc Nephrol. 2010 May;21(5):833-43. doi: 10.1681/ASN.2009080885. Epub 2010 Mar 25.


Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone.

Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V.

FASEB J. 2010 Jun;24(6):2056-65. doi: 10.1096/fj.09-151506. Epub 2010 Jan 22.


Activation of the epithelial Na+ channel in the collecting duct by vasopressin contributes to water reabsorption.

Bugaj V, Pochynyuk O, Stockand JD.

Am J Physiol Renal Physiol. 2009 Nov;297(5):F1411-8. doi: 10.1152/ajprenal.00371.2009. Epub 2009 Aug 19.


Intrinsic voltage dependence of the epithelial Na+ channel is masked by a conserved transmembrane domain tryptophan.

Pochynyuk O, Kucher V, Boiko N, Mironova E, Staruschenko A, Karpushev AV, Tong Q, Hendron E, Stockand J.

J Biol Chem. 2009 Sep 18;284(38):25512-21. doi: 10.1074/jbc.M109.015917. Epub 2009 Jul 20.


Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity.

Vallon V, Hummler E, Rieg T, Pochynyuk O, Bugaj V, Schroth J, Dechenes G, Rossier B, Cunard R, Stockand J.

J Am Soc Nephrol. 2009 Apr;20(4):721-9. doi: 10.1681/ASN.2008040415. Epub 2009 Jan 21.


Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone.

Pochynyuk O, Bugaj V, Rieg T, Insel PA, Mironova E, Vallon V, Stockand JD.

J Biol Chem. 2008 Dec 26;283(52):36599-607. doi: 10.1074/jbc.M807129200. Epub 2008 Nov 3.

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