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Items: 1 to 50 of 355

1.

Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ-Primed Human Endothelium.

Xie CB, Qin L, Li G, Fang C, Kirkiles-Smith NC, Tellides G, Pober JS, Jane-Wit D.

Circ Res. 2019 Jun 7;124(12):1747-1759. doi: 10.1161/CIRCRESAHA.119.314845. Epub 2019 Apr 22.

PMID:
31170059
2.

ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes.

Fang C, Manes TD, Liu L, Liu K, Qin L, Li G, Tobiasova Z, Kirkiles-Smith NC, Patel M, Merola J, Fu W, Liu R, Xie C, Tietjen GT, Nigrovic PA, Tellides G, Pober JS, Jane-Wit D.

Nat Commun. 2019 May 21;10(1):2247. doi: 10.1038/s41467-019-10041-2.

3.

Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis.

Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR.

JCI Insight. 2019 May 16;4(10). pii: 127456. doi: 10.1172/jci.insight.127456. eCollection 2019 May 16.

4.

Poly(amine-co-ester) nanoparticles for effective Nogo-B knockdown in the liver.

Cui J, Piotrowski-Daspit AS, Zhang J, Shao M, Bracaglia LG, Utsumi T, Seo YE, DiRito J, Song E, Wu C, Inada A, Tietjen GT, Pober JS, Iwakiri Y, Saltzman WM.

J Control Release. 2019 Jun 28;304:259-267. doi: 10.1016/j.jconrel.2019.04.044. Epub 2019 May 1.

PMID:
31054286
5.

Divergent TCR-Initiated Calcium Signals Govern Recruitment versus Activation of Human Alloreactive Effector Memory T Cells by Endothelial Cells.

Manes TD, Wang V, Pober JS.

J Immunol. 2018 Dec 1;201(11):3167-3174. doi: 10.4049/jimmunol.1800223. Epub 2018 Oct 19.

PMID:
30341183
6.

Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation.

Pellowe AS, Sauler M, Hou Y, Merola J, Liu R, Calderon B, Lauridsen HM, Harris MR, Leng L, Zhang Y, Tilstam PV, Pober JS, Bucala R, Lee PJ, Gonzalez AL.

FASEB J. 2019 Feb;33(2):2171-2186. doi: 10.1096/fj.201800480R. Epub 2018 Sep 25.

PMID:
30252532
7.

Regulation of human T cell responses by dNP2-ctCTLA-4 inhibits human skin and microvessel graft rejection.

Lim S, Kirkiles-Smith NC, Pober JS, Bothwell ALM, Choi JM.

Biomaterials. 2018 Nov;183:128-138. doi: 10.1016/j.biomaterials.2018.08.049. Epub 2018 Aug 21.

PMID:
30165256
8.

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway.

Wang J, Ferreira R, Lu W, Farrow S, Downes K, Jermutus L, Minter R, Al-Lamki RS, Pober JS, Bradley JR.

Sci Rep. 2018 Aug 13;8(1):12079. doi: 10.1038/s41598-018-30621-4.

9.

Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts.

Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK.

FASEB J. 2018 Jun 15:fj201800458. doi: 10.1096/fj.201800458. [Epub ahead of print]

PMID:
29906242
10.

Focus on Fundamentals: Achieving Effective Nanoparticle Targeting.

Tietjen GT, Bracaglia LG, Saltzman WM, Pober JS.

Trends Mol Med. 2018 Jul;24(7):598-606. doi: 10.1016/j.molmed.2018.05.003. Epub 2018 Jun 5. Review.

11.

Sera From Children After Cardiopulmonary Bypass Reduces Permeability of Capillary Endothelial Cell Barriers.

Pierce RW, Zahr RA, Kandil S, Faustino EVS, Pober JS.

Pediatr Crit Care Med. 2018 Jul;19(7):609-618. doi: 10.1097/PCC.0000000000001553.

12.

Interferon-γ converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1.

Liu R, Merola J, Manes TD, Qin L, Tietjen GT, López-Giráldez F, Broecker V, Fang C, Xie C, Chen PM, Kirkiles-Smith NC, Jane-Wit D, Pober JS.

JCI Insight. 2018 Mar 8;3(5). pii: 97881. doi: 10.1172/jci.insight.97881.

13.

Antigen Presentation by Vascular Cells.

Pober JS, Merola J, Liu R, Manes TD.

Front Immunol. 2017 Dec 22;8:1907. doi: 10.3389/fimmu.2017.01907. eCollection 2017. Review.

14.

Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys.

Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, Kraehling JR, Piotrowski-Daspit AS, Kirkiles-Smith NC, Al-Lamki R, Thiru S, Bradley JA, Saeb-Parsy K, Bradley JR, Nicholson ML, Saltzman WM, Pober JS.

Sci Transl Med. 2017 Nov 29;9(418). pii: eaam6764. doi: 10.1126/scitranslmed.aam6764.

15.

A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome.

Pierce RW, Merola J, Lavik JP, Kluger MS, Huttner A, Khokha MK, Pober JS.

J Exp Med. 2017 Dec 4;214(12):3497-3505. doi: 10.1084/jem.20162143. Epub 2017 Nov 2.

16.

Human Organ Culture: Updating the Approach to Bridge the Gap from In Vitro to In Vivo in Inflammation, Cancer, and Stem Cell Biology.

Al-Lamki RS, Bradley JR, Pober JS.

Front Med (Lausanne). 2017 Sep 11;4:148. doi: 10.3389/fmed.2017.00148. eCollection 2017. Review.

17.

Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.

Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y.

Biomaterials. 2017 Dec;147:116-132. doi: 10.1016/j.biomaterials.2017.09.019. Epub 2017 Sep 19.

18.

A 3D tri-culture system reveals that activin receptor-like kinase 5 and connective tissue growth factor drive human glomerulosclerosis.

Waters JP, Richards YC, Skepper JN, Southwood M, Upton PD, Morrell NW, Pober JS, Bradley JR.

J Pathol. 2017 Nov;243(3):390-400. doi: 10.1002/path.4960. Epub 2017 Oct 3.

19.

Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells.

Cui J, Qin L, Zhang J, Abrahimi P, Li H, Li G, Tietjen GT, Tellides G, Pober JS, Mark Saltzman W.

Nat Commun. 2017 Aug 4;8(1):191. doi: 10.1038/s41467-017-00297-x.

20.

Endothelial Cell Function and Dysfunction in Critically Ill Children.

Pierce RW, Giuliano JS Jr, Pober JS.

Pediatrics. 2017 Jul;140(1). pii: e20170355. doi: 10.1542/peds.2017-0355. Epub 2017 Jun 1. Review.

21.

The outstanding questions in transplantation: It's about time….

Azzi J, Raimondi G, Mas V, Riella LV, Elfadawy N, Safa K, Wojciechowski D, Kanak M, Nog R, Maltzman JS, Ford ML, Pober JS, Luo XR, Rothstein D, Miller ML, Matthews D, Burlingham W, Levings M, Heeger P, Higdon L, Gill J, Gill RG, Alegre ML.

Am J Transplant. 2018 Jan;18(1):271-272. doi: 10.1111/ajt.14450. Epub 2017 Sep 2. No abstract available.

22.

Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages.

Araldi E, Fernández-Fuertes M, Canfrán-Duque A, Tang W, Cline GW, Madrigal-Matute J, Pober JS, Lasunción MA, Wu D, Fernández-Hernando C, Suárez Y.

Cell Rep. 2017 Jun 27;19(13):2743-2755. doi: 10.1016/j.celrep.2017.05.093.

23.

Tumor Necrosis Factor-α and IL-17A Activation Induces Pericyte-Mediated Basement Membrane Remodeling in Human Neutrophilic Dermatoses.

Lauridsen HM, Pellowe AS, Ramanathan A, Liu R, Miller-Jensen K, McNiff JM, Pober JS, Gonzalez AL.

Am J Pathol. 2017 Aug;187(8):1893-1906. doi: 10.1016/j.ajpath.2017.04.008. Epub 2017 Jun 10.

24.

Quantitative microscopy-based measurements of circulating nanoparticle concentration using microliter blood volumes.

Tietjen GT, DiRito J, Pober JS, Saltzman WM.

Nanomedicine. 2017 Aug;13(6):1863-1867. doi: 10.1016/j.nano.2017.04.003. Epub 2017 Apr 13.

PMID:
28412144
25.

Recent advances in allograft vasculopathy.

Merola J, Jane-Wit DD, Pober JS.

Curr Opin Organ Transplant. 2017 Feb;22(1):1-7. doi: 10.1097/MOT.0000000000000370. Review.

26.

IL-17 Promotes Neutrophil-Mediated Immunity by Activating Microvascular Pericytes and Not Endothelium.

Liu R, Lauridsen HM, Amezquita RA, Pierce RW, Jane-Wit D, Fang C, Pellowe AS, Kirkiles-Smith NC, Gonzalez AL, Pober JS.

J Immunol. 2016 Sep 15;197(6):2400-8. doi: 10.4049/jimmunol.1600138. Epub 2016 Aug 17.

27.

ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction.

Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y.

JCI Insight. 2016 Jul 7;1(10). pii: 80920. doi: 10.1172/jci.insight.80920.

28.

Eculizumab Therapy for Chronic Antibody-Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial.

Kulkarni S, Kirkiles-Smith NC, Deng YH, Formica RN, Moeckel G, Broecker V, Bow L, Tomlin R, Pober JS.

Am J Transplant. 2017 Mar;17(3):682-691. doi: 10.1111/ajt.14001. Epub 2016 Sep 16.

29.

Significant Differences in Antigen-Induced Transendothelial Migration of Human CD8 and CD4 T Effector Memory Cells.

Manes TD, Pober JS.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1910-8. doi: 10.1161/ATVBAHA.116.308039. Epub 2016 Jul 21.

30.

Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis.

Al-Lamki RS, Lu W, Manalo P, Wang J, Warren AY, Tolkovsky AM, Pober JS, Bradley JR.

Cell Death Dis. 2016 Jun 30;7(6):e2287. doi: 10.1038/cddis.2016.184.

31.

Complement C5 Inhibition Reduces T Cell-Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice.

Qin L, Li G, Kirkiles-Smith N, Clark P, Fang C, Wang Y, Yu ZX, Devore D, Tellides G, Pober JS, Jane-Wit D.

Am J Transplant. 2016 Oct;16(10):2865-2876. doi: 10.1111/ajt.13834. Epub 2016 Jun 14.

32.

TGF-β receptor 1 inhibition prevents stenosis of tissue-engineered vascular grafts by reducing host mononuclear phagocyte activation.

Lee YU, de Dios Ruiz-Rosado J, Mahler N, Best CA, Tara S, Yi T, Shoji T, Sugiura T, Lee AY, Robledo-Avila F, Hibino N, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK.

FASEB J. 2016 Jul;30(7):2627-36. doi: 10.1096/fj.201500179R. Epub 2016 Apr 8.

33.

Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma.

Al-Lamki RS, Wang J, Yang J, Burrows N, Maxwell PH, Eisen T, Warren AY, Vanharanta S, Pacey S, Vandenabeele P, Pober JS, Bradley JR.

Oncotarget. 2016 Apr 26;7(17):24111-24. doi: 10.18632/oncotarget.8125.

34.

Blocking MHC class II on human endothelium mitigates acute rejection.

Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS.

JCI Insight. 2016;1(1). pii: e85293. Epub 2016 Jan 21.

35.

Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli.

Chang WG, Fornoni A, Tietjen G, Mendez JJ, Niklason LE, Saltzman WM, Pober JS.

Tissue Eng Part A. 2015 Nov;21(21-22):2673-9. doi: 10.1089/ten.TEA.2015.0060. Epub 2015 Oct 1.

36.

Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients.

Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Yun JJ, Sadeghi MM, Giordano FJ, Pober JS, Tellides G.

Circ Res. 2015 Nov 6;117(11):943-55. doi: 10.1161/CIRCRESAHA.115.306932. Epub 2015 Sep 23.

37.

Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes.

Jane-wit D, Surovtseva YV, Qin L, Li G, Liu R, Clark P, Manes TD, Wang C, Kashgarian M, Kirkiles-Smith NC, Tellides G, Pober JS.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9686-91. doi: 10.1073/pnas.1503535112. Epub 2015 Jul 20.

38.

Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9.

Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS.

Circ Res. 2015 Jul 3;117(2):121-8. doi: 10.1161/CIRCRESAHA.117.306290. Epub 2015 May 4.

39.

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases.

Clark PR, Kim RK, Pober JS, Kluger MS.

PLoS One. 2015 Mar 27;10(3):e0120075. doi: 10.1371/journal.pone.0120075. eCollection 2015.

40.

Blood Vessels in Allotransplantation.

Abrahimi P, Liu R, Pober JS.

Am J Transplant. 2015 Jul;15(7):1748-54. doi: 10.1111/ajt.13242. Epub 2015 Mar 23. Review.

41.

Inflammatory and immune responses in the arterial media.

Tellides G, Pober JS.

Circ Res. 2015 Jan 16;116(2):312-22. doi: 10.1161/CIRCRESAHA.116.301312. Review.

PMID:
25593276
42.

CyTOF supports efficient detection of immune cell subsets from small samples.

Yao Y, Liu R, Shin MS, Trentalange M, Allore H, Nassar A, Kang I, Pober JS, Montgomery RR.

J Immunol Methods. 2014 Dec 15;415:1-5. doi: 10.1016/j.jim.2014.10.010. Epub 2014 Nov 4.

43.

TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells.

Wang J, Al-Lamki RS, Zhu X, Liu H, Pober JS, Bradley JR.

BMC Nephrol. 2014 Nov 16;15:178. doi: 10.1186/1471-2369-15-178.

44.

Inflammation and the blood microvascular system.

Pober JS, Sessa WC.

Cold Spring Harb Perspect Biol. 2014 Oct 23;7(1):a016345. doi: 10.1101/cshperspect.a016345. Review.

45.

Polarized granzyme release is required for antigen-driven transendothelial migration of human effector memory CD4 T cells.

Manes TD, Pober JS.

J Immunol. 2014 Dec 15;193(12):5809-15. doi: 10.4049/jimmunol.1401665. Epub 2014 Nov 3.

46.

Is hypertension an autoimmune disease?

Pober JS.

J Clin Invest. 2014 Oct;124(10):4234-6. doi: 10.1172/JCI77766. Epub 2014 Sep 17.

47.

Interacting mechanisms in the pathogenesis of cardiac allograft vasculopathy.

Pober JS, Jane-wit D, Qin L, Tellides G.

Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1609-14. doi: 10.1161/ATVBAHA.114.302818. Epub 2014 Jun 5. Review.

48.

Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2.

Wang C, Qin L, Manes TD, Kirkiles-Smith NC, Tellides G, Pober JS.

J Exp Med. 2014 Mar 10;211(3):395-404. doi: 10.1084/jem.20131125. Epub 2014 Feb 10.

49.

Infantile hemangiomas exhibit neural crest and pericyte markers.

Spock CL, Tom LK, Canadas K, Sue GR, Sawh-Martinez R, Maier CL, Pober JS, Galan A, Schultz B, Waner M, Narayan D.

Ann Plast Surg. 2015 Feb;74(2):230-6. doi: 10.1097/SAP.0000000000000080.

PMID:
24401806
50.

A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment.

Lauridsen HM, Pober JS, Gonzalez AL.

FASEB J. 2014 Mar;28(3):1166-80. doi: 10.1096/fj.13-240986. Epub 2013 Dec 2.

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