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Items: 31


Sensitivity of pituitary gonadotropes to hyperglycemia leads to epigenetic aberrations and reduced follicle-stimulating hormone levels.

Feldman A, Saleh A, Pnueli L, Qiao S, Shlomi T, Boehm U, Melamed P.

FASEB J. 2019 Jan;33(1):1020-1032. doi: 10.1096/fj.201800943R. Epub 2018 Aug 3.


Tet Enzymes, Variants, and Differential Effects on Function.

Melamed P, Yosefzon Y, David C, Tsukerman A, Pnueli L.

Front Cell Dev Biol. 2018 Mar 5;6:22. doi: 10.3389/fcell.2018.00022. eCollection 2018. Review.


Multifaceted Targeting of the Chromatin Mediates Gonadotropin-Releasing Hormone Effects on Gene Expression in the Gonadotrope.

Melamed P, Haj M, Yosefzon Y, Rudnizky S, Wijeweera A, Pnueli L, Kaplan A.

Front Endocrinol (Lausanne). 2018 Feb 27;9:58. doi: 10.3389/fendo.2018.00058. eCollection 2018. Review.


Mitogen- and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone-mediated activation of gonadotropin α-subunit expression.

Haj M, Wijeweera A, Rudnizky S, Taunton J, Pnueli L, Melamed P.

J Biol Chem. 2017 Dec 15;292(50):20720-20731. doi: 10.1074/jbc.M117.797845. Epub 2017 Oct 20.


An epigenetic switch repressing Tet1 in gonadotropes activates the reproductive axis.

Yosefzon Y, David C, Tsukerman A, Pnueli L, Qiao S, Boehm U, Melamed P.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10131-10136. doi: 10.1073/pnas.1704393114. Epub 2017 Aug 30.


Nucleosome mobility and the regulation of gene expression: Insights from single-molecule studies.

Rudnizky S, Malik O, Bavly A, Pnueli L, Melamed P, Kaplan A.

Protein Sci. 2017 Jul;26(7):1266-1277. doi: 10.1002/pro.3159. Epub 2017 Apr 2. Review.


H2A.Z controls the stability and mobility of nucleosomes to regulate expression of the LH genes.

Rudnizky S, Bavly A, Malik O, Pnueli L, Melamed P, Kaplan A.

Nat Commun. 2016 Sep 22;7:12958. doi: 10.1038/ncomms12958.


Transcriptional enhancers: Transcription, function and flexibility.

Melamed P, Yosefzon Y, Rudnizky S, Pnueli L.

Transcription. 2016;7(1):26-31. doi: 10.1080/21541264.2015.1128517.


The elongation factor eEF3 (Yef3) interacts with mRNA in a translation independent manner.

Samra N, Atir-Lande A, Pnueli L, Arava Y.

BMC Mol Biol. 2015 Sep 24;16:17. doi: 10.1186/s12867-015-0045-5.


RNA transcribed from a distal enhancer is required for activating the chromatin at the promoter of the gonadotropin α-subunit gene.

Pnueli L, Rudnizky S, Yosefzon Y, Melamed P.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4369-74. doi: 10.1073/pnas.1414841112. Epub 2015 Mar 25.


Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin.

Wijeweera A, Haj M, Feldman A, Pnueli L, Luo Z, Melamed P.

Biochim Biophys Acta. 2015 Mar;1849(3):328-41. doi: 10.1016/j.bbagrm.2015.01.001. Epub 2015 Jan 13.


Gonadotrophin-releasing hormone signalling downstream of calmodulin.

Melamed P, Savulescu D, Lim S, Wijeweera A, Luo Z, Luo M, Pnueli L.

J Neuroendocrinol. 2012 Dec;24(12):1463-75. doi: 10.1111/j.1365-2826.2012.02359.x. Review.


Calcineurin mediates the gonadotropin-releasing hormone effect on expression of both subunits of the follicle-stimulating hormone through distinct mechanisms.

Pnueli L, Luo M, Wang S, Naor Z, Melamed P.

Mol Cell Biol. 2011 Dec;31(24):5023-36. doi: 10.1128/MCB.06083-11. Epub 2011 Oct 10.


SpRET: highly sensitive and reliable spectral measurement of absolute FRET efficiency.

Levy S, Wilms CD, Brumer E, Kahn J, Pnueli L, Arava Y, Eilers J, Gitler D.

Microsc Microanal. 2011 Apr;17(2):176-90. doi: 10.1017/S1431927610094493. Epub 2011 Feb 21.


Functional dissection of IME1 transcription using quantitative promoter-reporter screening.

Kahana S, Pnueli L, Kainth P, Sassi HE, Andrews B, Kassir Y.

Genetics. 2010 Nov;186(3):829-41. doi: 10.1534/genetics.110.122200. Epub 2010 Aug 25.


Tom20 mediates localization of mRNAs to mitochondria in a translation-dependent manner.

Eliyahu E, Pnueli L, Melamed D, Scherrer T, Gerber AP, Pines O, Rapaport D, Arava Y.

Mol Cell Biol. 2010 Jan;30(1):284-94. doi: 10.1128/MCB.00651-09.


Negative feedback governs gonadotrope frequency-decoding of gonadotropin releasing hormone pulse-frequency.

Lim S, Pnueli L, Tan JH, Naor Z, Rajagopal G, Melamed P.

PLoS One. 2009 Sep 29;4(9):e7244. doi: 10.1371/journal.pone.0007244.


Yeast translational response to high salinity: global analysis reveals regulation at multiple levels.

Melamed D, Pnueli L, Arava Y.

RNA. 2008 Jul;14(7):1337-51. doi: 10.1261/rna.864908. Epub 2008 May 21.


The 3'-UTR mediates the cellular localization of an mRNA encoding a short plasma membrane protein.

Loya A, Pnueli L, Yosefzon Y, Wexler Y, Ziv-Ukelson M, Arava Y.

RNA. 2008 Jul;14(7):1352-65. doi: 10.1261/rna.867208. Epub 2008 May 20.


Faithful modeling of transient expression and its application to elucidating negative feedback regulation.

Rubinstein A, Gurevich V, Kasulin-Boneh Z, Pnueli L, Kassir Y, Pinter RY.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6241-6. Epub 2007 Mar 30.


The role and regulation of the preRC component Cdc6 in the initiation of premeiotic DNA replication.

Ofir Y, Sagee S, Guttmann-Raviv N, Pnueli L, Kassir Y.

Mol Biol Cell. 2004 May;15(5):2230-42. Epub 2004 Mar 5.


Molecular and biochemical mechanisms associated with dormancy and drought tolerance in the desert legume Retama raetam.

Pnueli L, Hallak-Herr E, Rozenberg M, Cohen M, Goloubinoff P, Kaplan A, Mittler R.

Plant J. 2002 Aug;31(3):319-30.


Tomato SP-interacting proteins define a conserved signaling system that regulates shoot architecture and flowering.

Pnueli L, Gutfinger T, Hareven D, Ben-Naim O, Ron N, Adir N, Lifschitz E.

Plant Cell. 2001 Dec;13(12):2687-702.


The SELF-PRUNING gene of tomato regulates vegetative to reproductive switching of sympodial meristems and is the ortholog of CEN and TFL1.

Pnueli L, Carmel-Goren L, Hareven D, Gutfinger T, Alvarez J, Ganal M, Zamir D, Lifschitz E.

Development. 1998 Jun;125(11):1979-89.


The TM5 MADS Box Gene Mediates Organ Differentiation in the Three Inner Whorls of Tomato Flowers.

Pnueli L, Hareven D, Broday L, Hurwitz C, Lifschitz E.

Plant Cell. 1994 Feb;6(2):175-186.


Isolation of the tomato AGAMOUS gene TAG1 and analysis of its homeotic role in transgenic plants.

Pnueli L, Hareven D, Rounsley SD, Yanofsky MF, Lifschitz E.

Plant Cell. 1994 Feb;6(2):163-73.


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