Sort by
Items per page

Send to

Choose Destination

Search results

Items: 32


Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells.

Sauzay C, Louandre C, Bodeau S, Anglade F, Godin C, Saidak Z, Fontaine JX, Usureau C, Martin N, Molinie R, Pascal J, Mesnard F, Pluquet O, Galmiche A.

Oncotarget. 2018 Jan 3;9(9):8400-8414. doi: 10.18632/oncotarget.23843. eCollection 2018 Feb 2.


Dual IRE1 RNase functions dictate glioblastoma development.

Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F, Bourien H, Logotheti M, Jégou G, Pallares-Lupon N, Schmit K, Le Reste PJ, Etcheverry A, Mosser J, Barroso K, Vauléon E, Maurel M, Samali A, Patterson JB, Pluquet O, Hetz C, Quillien V, Chatziioannou A, Chevet E.

EMBO Mol Med. 2018 Mar;10(3). pii: e7929. doi: 10.15252/emmm.201707929.


The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway.

Cormenier J, Martin N, Deslé J, Salazar-Cardozo C, Pourtier A, Abbadie C, Pluquet O.

Mech Ageing Dev. 2018 Mar;170:82-91. doi: 10.1016/j.mad.2017.08.003. Epub 2017 Aug 10.


Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses?

Abbadie C, Pluquet O, Pourtier A.

Cell Mol Life Sci. 2017 Dec;74(24):4471-4509. doi: 10.1007/s00018-017-2587-9. Epub 2017 Jul 13. Review.


A potential role of the unfolded protein response in post-transplant cancer.

Bodeau S, Sauzay C, Pluquet O, Choukroun G, Galmiche A.

Clin Sci (Lond). 2017 Jun 22;131(13):1429-1436. doi: 10.1042/CS20170152. Print 2017 Jul 1. Review.


Role of the unfolded protein response in tumor cell characteristics and cancer outcome.

Galmiche A, Sauzay C, Chevet E, Pluquet O.

Curr Opin Oncol. 2017 Jan;29(1):41-47. Review.


ATF6α regulates morphological changes associated with senescence in human fibroblasts.

Druelle C, Drullion C, Deslé J, Martin N, Saas L, Cormenier J, Malaquin N, Huot L, Slomianny C, Bouali F, Vercamer C, Hot D, Pourtier A, Chevet E, Abbadie C, Pluquet O.

Oncotarget. 2016 Oct 18;7(42):67699-67715. doi: 10.18632/oncotarget.11505.


Probing Tumour Proteostasis and the UPR with Serum Markers.

Galmiche A, Sauzay C, Houessinon A, Chauffert B, Pluquet O.

Trends Cancer. 2016 May;2(5):219-221. doi: 10.1016/j.trecan.2016.04.004. Epub 2016 Apr 28.


Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells.

Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, Bouali F, Sabatier L, Wernert N, Pinte S, Gilson E, Pourtier A, Pluquet O, Abbadie C.

Nat Commun. 2016 Jan 29;7:10399. doi: 10.1038/ncomms10399.


Alpha-fetoprotein is a biomarker of unfolded protein response and altered proteostasis in hepatocellular carcinoma cells exposed to sorafenib.

Houessinon A, Gicquel A, Bochereau F, Louandre C, Nyga R, Godin C, Degonville J, Fournier E, Saidak Z, Drullion C, Barbare JC, Chauffert B, François C, Pluquet O, Galmiche A.

Cancer Lett. 2016 Jan 28;370(2):242-9. doi: 10.1016/j.canlet.2015.10.032. Epub 2015 Nov 3.


The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease.

Pluquet O, Pourtier A, Abbadie C.

Am J Physiol Cell Physiol. 2015 Mar 15;308(6):C415-25. doi: 10.1152/ajpcell.00334.2014. Epub 2014 Dec 24. Review.


Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion.

Deruy E, Nassour J, Martin N, Vercamer C, Malaquin N, Bertout J, Chelli F, Pourtier A, Pluquet O, Abbadie C.

Cell Death Dis. 2014 Dec 18;5:e1577. doi: 10.1038/cddis.2014.533.


Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes.

Martin N, Salazar-Cardozo C, Vercamer C, Ott L, Marot G, Slijepcevic P, Abbadie C, Pluquet O.

Mol Cancer. 2014 Jun 14;13:151. doi: 10.1186/1476-4598-13-151.


Watching the clock: endoplasmic reticulum-mediated control of circadian rhythms in cancer.

Pluquet O, Dejeans N, Chevet E.

Ann Med. 2014 Jun;46(4):233-43. doi: 10.3109/07853890.2013.874664. Epub 2014 Feb 4. Review.


Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts.

Martien S, Pluquet O, Vercamer C, Malaquin N, Martin N, Gosselin K, Pourtier A, Abbadie C.

Biochim Biophys Acta. 2013 Jul;1831(7):1217-27.


Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα.

Pluquet O, Dejeans N, Bouchecareilh M, Lhomond S, Pineau R, Higa A, Delugin M, Combe C, Loriot S, Cubel G, Dugot-Senant N, Vital A, Loiseau H, Gosline SJ, Taouji S, Hallett M, Sarkaria JN, Anderson K, Wu W, Rodriguez FJ, Rosenbaum J, Saltel F, Fernandez-Zapico ME, Chevet E.

Cancer Res. 2013 Aug 1;73(15):4732-43. doi: 10.1158/0008-5472.CAN-12-3989. Epub 2013 Jun 10.


Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA.

Dejeans N, Pluquet O, Lhomond S, Grise F, Bouchecareilh M, Juin A, Meynard-Cadars M, Bidaud-Meynard A, Gentil C, Moreau V, Saltel F, Chevet E.

J Cell Sci. 2012 Sep 15;125(Pt 18):4278-87. doi: 10.1242/jcs.099291. Epub 2012 Jun 20.


AlphaScreen-based characterization of the bifunctional kinase/RNase IRE1alpha: a novel and atypical drug target.

Bouchecareilh M, Caruso ME, Roby P, Parent S, Rouleau N, Taouji S, Pluquet O, Bossé R, Moenner M, Chevet E.

J Biomol Screen. 2010 Apr;15(4):406-17. doi: 10.1177/1087057110363823. Epub 2010 Mar 17.


Calnexin phosphorylation attenuates the release of partially misfolded alpha1-antitrypsin to the secretory pathway.

Cameron PH, Chevet E, Pluquet O, Thomas DY, Bergeron JJ.

J Biol Chem. 2009 Dec 11;284(50):34570-9. doi: 10.1074/jbc.M109.053165. Epub 2009 Oct 8.


Integrated endoplasmic reticulum stress responses in cancer.

Moenner M, Pluquet O, Bouchecareilh M, Chevet E.

Cancer Res. 2007 Nov 15;67(22):10631-4. Review.


Dengue virus serotype infection specifies the activation of the unfolded protein response.

Umareddy I, Pluquet O, Wang QY, Vasudevan SG, Chevet E, Gu F.

Virol J. 2007 Sep 24;4:91.


The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

Baltzis D, Pluquet O, Papadakis AI, Kazemi S, Qu LK, Koromilas AE.

J Biol Chem. 2007 Oct 26;282(43):31675-87. Epub 2007 Sep 4.


A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway.

Kazemi S, Mounir Z, Baltzis D, Raven JF, Wang S, Krishnamoorthy JL, Pluquet O, Pelletier J, Koromilas AE.

Mol Biol Cell. 2007 Sep;18(9):3635-44. Epub 2007 Jun 27.


Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.

Qu L, Huang S, Baltzis D, Rivas-Estilla AM, Pluquet O, Hatzoglou M, Koumenis C, Taya Y, Yoshimura A, Koromilas AE.

Genes Dev. 2004 Feb 1;18(3):261-77. Epub 2004 Jan 26.


The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.

Pluquet O, North S, Bhoumik A, Dimas K, Ronai Z, Hainaut P.

J Biol Chem. 2003 Apr 4;278(14):11879-87. Epub 2003 Jan 16.


Genotoxic and non-genotoxic pathways of p53 induction.

Pluquet O, Hainaut P.

Cancer Lett. 2001 Dec 10;174(1):1-15. Review.


Nitric oxide prevents gamma-radiation-induced cell cycle arrest by impairing p53 function in MCF-7 cells.

Chazotte-Aubert L, Pluquet O, Hainaut P, Ohshima H.

Biochem Biophys Res Commun. 2001 Mar 2;281(3):766-71.


The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.

North S, El-Ghissassi F, Pluquet O, Verhaegh G, Hainaut P.

Oncogene. 2000 Feb 24;19(9):1206-14.

Supplemental Content

Loading ...
Support Center